'Dry orgasm' pill

[Starsky]

Did someone tried some pills that could inhibit the contraction of vas deference and stop sperm from moving to the prostate? Silodosin, Tamoulosin or others?

[Vincent M]

I believe 2 of our members tried silodosin a while back. One had positive results, but the silodosin made them tired so I think they decided it wasn't worth it. It was ineffective for the other I think.

Here are a lot of results for a search of the NSF forum for silodosin:

https://www.google.com/search?sugexp=chrome,mod=13&sourceid=chrome&ie=UTF-8&q=POIS+silodosin+site%3Awww.thenakedscientists.com

[Habibou]

I tried Silodosin but the fact that the semen stayed inside the body made me feel so much worse compared to what I was before...

[rollercoaster]

My doc prescribed me silodosin. I wanted to time my sexual activity after a few days but yesterday I ejaculated inadvertently while masturbating in the heat of the moment. I immediately took silodosin. Today morning I don't have any pois related symptoms.

So, how did silodosin work if I took it AFTER  ejaculation? This is was the first time I ever took it.

[Prospero]

Interesting experience. Silodosin blocks alpha-1 adrenergic receptors (noradrenaline receptors), which have been discussed here, in particular by nanna, so this is not really a new topic.

[hurray]

Interesting experience. Silodosin blocks alpha-1 adrenergic receptors (noradrenaline receptors), which have been discussed here, in particular by nanna, so this is not really a new topic.

It would be useful to link to or quote some of the discussion you refer to. I wasn't aware that nanna had discussed the specific pharmacology of silodosin? It's an interesting topic that deserves more discussion - simply saying "nanna's theory covers this, it's not a new topic" doesn't do the topic justice in my opinion.

I agree that it's a good theory. I trialled silodosin for a month myself.

[berlin1984]

Admin note: merged this with an older thread so we can keep the discussion of one chemical substance in one thread :-)
(I don't merge older threads because it would break links)

More threads:
https://poiscenter.com/forums/index.php?topic=1007
https://poiscenter.com/forums/index.php?topic=3127.msg34852#msg34852
https://poiscenter.com/forums/index.php?topic=1073


Or via search function.

[Mushnikk]

I took Silodosin once and it completely removed my symptoms. I developed fever from a HHV-6 reactivation a few days later though, I dont know if this is related in any way.

[Prospero]

Interesting experience. Silodosin blocks alpha-1 adrenergic receptors (noradrenaline receptors), which have been discussed here, in particular by nanna, so this is not really a new topic.

It would be useful to link to or quote some of the discussion you refer to. I wasn't aware that nanna had discussed the specific pharmacology of silodosin? It's an interesting topic that deserves more discussion - simply saying "nanna's theory covers this, it's not a new topic" doesn't do the topic justice in my opinion.

I agree that it's a good theory. I trialled silodosin for a month myself.

I was speaking of nanna's discussion of the role of alpha1 A receptors, not silodosin. Most of this can be found in the exchanges here : https://poiscenter.com/forums/index.php?topic=2502.0.
See notably this for a theory of a1a overexpression: https://poiscenter.com/forums/index.php?topic=2502.msg26874;topicseen#msg26874 // https://poiscenter.com/forums/index.php?topic=2502.msg26939;topicseen#msg26939
The success of alpha blockers similar to silodosin was mentioned here : https://poiscenter.com/forums/index.php?topic=2502.msg32719;topicseen#msg32719

Berlin pointed to other threads in the forum discussing Silodosin.

[hurray]

I was speaking of nanna's discussion of the role of alpha1 A receptors, not silodosin. Most of this can be found in the exchanges here : https://poiscenter.com/forums/index.php?topic=2502.0.
See notably this for a theory of a1a overexpression: https://poiscenter.com/forums/index.php?topic=2502.msg26874;topicseen#msg26874 // https://poiscenter.com/forums/index.php?topic=2502.msg26939;topicseen#msg26939
The success of alpha blockers similar to silodosin was mentioned here : https://poiscenter.com/forums/index.php?topic=2502.msg32719;topicseen#msg32719

Berlin pointed to other threads in the forum discussing Silodosin.

Thanks Prospero, some excellent links there explaining your thought process.

I find the last comment from nanna interesting:

these results seem to confirm that epinephrine and norepinephrine are the chemical triggers for Post Orgasmic Illness Syndrome.

Which leads me to wonder, why aren't we talking about this more? An NRI (milnacipran) has led to the complete resolution of my POIS symptoms.

Norepinephrine reuptake inhibitor

A norepinephrine reuptake inhibitor (NRI, NERI) or noradrenaline reuptake inhibitor or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET). This in turn leads to increased extracellular concentrations of norepinephrine and epinephrine and therefore can increase adrenergic neurotransmission.

https://en.wikipedia.org/wiki/Norepinephrine_reuptake_inhibitor

It's great having a forum where everyone can discuss their own theories and issues, but as a community we seem to struggle to focus on any given topic for more than a few days.

[Hopeoneday]

https://www.reddit.com/r/POIS/comments/yd9ke0/try_this_cure_solved_my_pois/

Intresting, 1,5y zero pois for him on silodosin.

How to prove, is this from alpha blocking cascade or
from zero sperm relese?

[demografx]

https://www.reddit.com/r/POIS/comments/yd9ke0/try_this_cure_solved_my_pois/

Intresting, 1,5y zero pois for him on silodosin.

How to prove, is this from alpha blocking cascade or
from zero sperm [and/or semen] release?[“zero sperm [and/or…] release” bolded emphasis is mine - Demo]

Very interesting. Forum member Animus attributes his POIS Cure to dry orgasm. With surgery.

Hopefully, silosodin can accomplish a similar effect without surgery!

[Warrior]

A POIS specialist I saw recommended me to try silodosin. Must be a relatively known potential remedy for POIS amongst specialists.

[demografx]

…[Silodosin m]ust be a relatively known potential remedy for POIS amongst specialists.

I don’t think so!

Thank you for posting.

[hurray]

A POIS specialist I saw recommended me to try silodosin. Must be a relatively known potential remedy for POIS amongst specialists.

Your specialist had probably read this paper, the results were very encouraging:

Silodosin, a highly selective alpha1A-blocker, which actually causes anejaculation, was effective treatment in 57% of the patients.

https://sci-hub.se/10.1038/s41443-020-0314-9

[demografx]

A POIS specialist I saw recommended me to try silodosin. Must be a relatively known potential remedy for POIS amongst specialists.

Your specialist had probably read this paper, the results were very encouraging:

Silodosin, a highly selective alpha1A-blocker, which actually causes anejaculation, was effective treatment in 57% of the patients.

https://sci-hub.se/10.1038/s41443-020-0314-9

Wow, thanks, hurray! Impressive!

Sent to our POIS Research Team.

[Hopeoneday]

Retrograde ejaculation, no pois...
https://poiscenter.com/forums/index.php?topic=1192.msg45849#msg45849

https://poiscenter.com/forums/index.php?topic=1073.msg9703#msg9703

https://poiscenter.com/forums/index.php?topic=3365.msg35405#msg35405

https://poiscenter.com/forums/index.php?topic=1007.msg9162#msg9162