Thanks, Prospero ! I am sure it means a lot of work to create a compilation like this one.
I suppose not everyone is familiar with genetic polymorphisms results. Could you confirm that, in your chart, a "+" means that the person has the allele that is less common, so that a +/+ means that this individual has 2 genes of the rarer variant ( homozygote SNP )? Having the rarer variant/allele can potentially mean that a protein in this individual body and metabolism, like an enzyme, a cellular receptor, or another type of protein, is not functioning like in the majority of the human population, because one amino acid, which means one of the building blocks in the chain, is not the same. A +/- means that one of the the 2 genes someone has for the same loci is the more common variant, and the other one is the rarer one. We all have 2 copies of all our genes, one copy from eahc of our parents. An heterozygote result usually has less impact on the individual's biology, but may be halfway between the common function for the majority of the population and those who have 2 copies of the rarer gene.
A rarer variant is also called a SNP (Single Nucleotide Permutation), and is found in more than 1% of the population ( if the variant is rarer still, less than 1% , it is rather called a
mutation ).
If what I have written above is in line with your notation, Prospero, a "-/-" result means that the individual has the more common allele/variant in both of his genes for this loci, for this particular location on a particular gene, so has likely the normal/usual function for whatever is coded by this gene.
A gene loci is usually named by a series of capitalized letters, like "COMT". You can search these specific gene names on the net to know more about what is known about each one of them.
A "rs" followed by a serie of numbers, like "rs4680" is used to define a specific SNP. It stands for Reference SNP cluster ID. For example, rs4680 refers to a specific SNP found in the COMT gene. It is also called COMT V158M, the V158M part referring to the amino acid change that this nucleotide permutation will produce ( I spare you all the details, but if you are interest in genetics, DNA structure, and how it encodes for amino acids and leads to proteins synthesis, you will surely find all the details over the net)
It is useful to know that all these SNPs can be searched with their rs ID, There are great internet databases for that. For example, you can search rs4680 on sites like snpedia.com. (
https://www.snpedia.com/index.php/SNPedia) Of course, you can also make your search with COMT V158M and will also get the the right information. You just have to get used to the fact that a single SNP can go by multiple names and types of notation.
Don't worry, if you are not familiar with biology and genetics, it is normal that, at first, all this information seems really confusing and hard to understand. Just go slowly, and you can always use Wikipedia to search any individual term, and know more about it ( like, "SNP", "mutation", "gene" "COMT", and even well known SNPs will have their own entry, like "rs4680" -
https://en.wikipedia.org/wiki/Rs4680 )
