Author Topic: Small intestinal bacterial overgrowth (SIBO) (Read 29950 times)

Iwillbeatthis · « **Reply #20 on:** December 06, 2020, 01:24:21 PM »

Quote from: Muon on December 06, 2020, 01:20:53 PM

Quote from: Iwillbeatthis on December 06, 2020, 12:42:59 PM
Is small intestine permeability a good test for SIBO?

Nope

Why does that not surprise me... The NHS only do the bad tests

Journey · « **Reply #21 on:** December 06, 2020, 05:33:33 PM »

In the past few days I have had to eat less and very little dairy and I took an activated charcoal tablet yesterday and haven't had a stool exit today which never has happened ever before and I feel calmer and better overall however I am afraid to test if the POIS symptoms have changed because if they haven't I will be back in POIS state and will have to start building up this abstinence streak again.

Muon · « **Reply #22 on:** December 07, 2020, 07:16:50 AM »

Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a "pro-inflammatory" state associated with atherosclerosis and autoimmunity

Iwillbeatthis · « **Reply #23 on:** December 07, 2020, 07:28:02 AM »

Quote from: Journey on December 06, 2020, 05:33:33 PM

In the past few days I have had to eat less and very little dairy and I took an activated charcoal tablet yesterday and haven't had a stool exit today which never has happened ever before and I feel calmer and better overall however I am afraid to test if the POIS symptoms have changed because if they haven't I will be back in POIS state and will have to start building up this abstinence streak again.

Carry on the abstinence one charcoal tablet isn't going to stop your POIS I highly doubt. I've gone through nearly a whole tub of charcoal capsules and still had POIS , it can be helpful if you have mould issues but its best to combine with glutathione which will release the toxins from your cell and charcoal will bind to them, I think its also helpful to take with bentonite which is much more heavy binder. Also don't take the charcoal close to your meal times as it will interfere with the absorption of nutrients

mike_sweden · « **Reply #24 on:** December 08, 2020, 03:42:19 PM »

i am starting probi mage, a swedish probiotic for the gut

a link for anyone interested

https://www.apotea.se/probimage-80-kapslar

Muon · « **Reply #25 on:** December 10, 2020, 07:00:54 PM »

Video about Marian Lemle's Hydrogen Sulfide theory

I get the impression that POIS puts you into a state of semi-hibernation. I believe a few POISers here said the same thing.

Slide at 18:00 Talking about Heme, iron. Is the temporary loss of iron in the case of IronFeather a protective mechanism?

Quote from: IronFeather on November 26, 2019, 01:52:52 PM

I've had blood tests done multiple times during my worst fever episodes, and everything comes back normal except for very low levels of iron (I usually have normal or even high iron and hemoglobin levels), and through-the-roof amounts of C-reactive protein. This led doctors to think I could have mononucleosis or some kind of bacterial infection, but all specific tests came back negative. They put me on antibiotics anyway, and that solved most symptoms almost immediately and made me able to get out of bed and finally get better during the worst episode I've ever had. That's why I've always thought it must be some kind of infection by some pathogen, even when I used to believe an autoinmune reaction must be the cause. Now I don't even know what to believe or what to do.

Slide 19:18: Possible vagus nerve involvement?

H2S could be investigated as well aside from hydrogen and methane.

Journey · « **Reply #26 on:** December 11, 2020, 09:25:16 AM »

Quote from: Muon on December 10, 2020, 07:00:54 PM

Video about Marian Lemle's Hydrogen Sulfide theory

I get the impression that POIS puts you into a state of semi-hibernation. I believe a few POISers here said the same thing.

Slide at 18:00 Talking about Heme, iron. Is the temporary loss of iron in the case of IronFeather a protective mechanism?

Quote from: IronFeather on November 26, 2019, 01:52:52 PM
I've had blood tests done multiple times during my worst fever episodes, and everything comes back normal except for very low levels of iron (I usually have normal or even high iron and hemoglobin levels), and through-the-roof amounts of C-reactive protein. This led doctors to think I could have mononucleosis or some kind of bacterial infection, but all specific tests came back negative. They put me on antibiotics anyway, and that solved most symptoms almost immediately and made me able to get out of bed and finally get better during the worst episode I've ever had. That's why I've always thought it must be some kind of infection by some pathogen, even when I used to believe an autoinmune reaction must be the cause. Now I don't even know what to believe or what to do.

Slide 19:18: Possible vagus nerve involvement?

H2S could be investigated as well aside from hydrogen and methane.

My C Reactive Protein the only time I measured that was 1.9

Iwillbeatthis · « **Reply #27 on:** December 15, 2020, 02:33:30 PM »

I've noticed something recently when I have to pass stools and then pee soon after it feels like a burning sensation when I pee(not painful).

I've also noticed that when I take magnesium supplements I've tried two different ones of the most absorbable forms, every time they set off a bad reaction of pain 10 cm down from belly button I guess in bladder/pelvic region and I find it very difficult to sleep with this pain. Anyone know what this could mean?

Muon · « **Reply #28 on:** December 15, 2020, 02:42:55 PM »

Release of neuropeptides? MCA? Interstitial cystitis?

Iwillbeatthis · « **Reply #29 on:** December 15, 2020, 03:50:59 PM »

Yeah probably Interstitial cystitis/mcas, I had bad Interstitial cystitis symptoms for a year before my POIS began but now they've cleared up mostly- I just need to avoid any triggers. I do want to heal this area badly as I think its the epicenter of all my health problems and the human body does contain the power to heal itself with the right guidance, I was thinking about taking cystoprotek possibly

Muon · « **Reply #30 on:** December 16, 2020, 02:34:13 PM »

Researchers will not tinker with GI/microbiome measurements. Urologists, immunologists, allergologists, neurologists, sexual medicine doctors etc won't take a step outside their territory. I think you can forget about SIBO testing in literature, these type of measurements are likely to come from the community itself.

Muon · « **Reply #31 on:** December 17, 2020, 12:53:44 PM »

Quote from: Igy78 on December 16, 2020, 05:07:41 PM

Bile regulates good/bad bacteria, it prevents SIBO, if the colon has bad bacteria i get POIS due to undigested food get to colon and bad bacteria making gasses like methane and hydrogen sulfide, which is getting to blood and into brain and then i get POIS symptoms.

POISers with history of low iron:

Intracellular iron regulation, infections and the effect of LPS endotoxins

"Withholding iron from potential pathogens is a host defense strategy."

"As alluded to earlier, iron is essential for the survival and growth of almost all organisms. Furthermore, an important strategy of mammalian antimicrobial defense is based on depriving pathogens of this essential nutrient"

Muon · « **Reply #32 on:** December 18, 2020, 02:31:57 PM »

Not your typical blood tests:
Results from 3 studies (4 papers) Investigating Metabolites and Metabolomics

Muon · « **Reply #33 on:** December 26, 2020, 09:10:35 PM »

I wonder if POISers, who developed POIS gradually over the years, have a dysbiosis which took some time to develop in the intestines. Does worsening of the dysbiosis correlates with the intensity/duration of POIS symptoms? I also wonder whether the response to a dysbiosis is spatially selective. Perhaps there is a response in the Reproductive system as well while there isn't anything to fight.

Muon · « **Reply #34 on:** January 02, 2021, 03:16:00 PM »

ME/CFS for 18 years, recently diagnosed with D-Lactic acidosis as cause of symptoms and illness.

Muon · « **Reply #35 on:** January 03, 2021, 11:20:01 PM »

Food sensitivity, one could take a look for a generalized mechanism regarding food sensitization via gut mucosal breakdown:

Gastrointestinal Candida colonisation promotes sensitisation against food antigens by affecting the mucosal barrier in mice

IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut

Muon · « **Reply #36 on:** January 18, 2021, 10:12:36 PM »

Quote from: CharlesB on January 12, 2021, 10:16:28 PM

Quote from: drop247 on January 12, 2021, 12:36:43 PM
Quote from: CharlesB on December 29, 2020, 01:34:46 PM
I started taking Azithromycin today (I know it is a long shot, but I?m at the point where it?s promising enough to give a try), 5 day duration. Will update in a couple weeks if it helped at all.

Any update CharlesB?

Unfortunately I don?t think the Azithromycin did much for me, I still have very strong symptoms even on arousal. Would have posted sooner but wanted to give it a full couple of weeks.

I did get a stool test back after I posted about starting Azithromycin, which stated that there was a large amount of fungus/yeast that was microscopically visible in my stool - much more than the baseline expectation for yeast in a stool sample - but it was unable to be cultured potentially because the yeast didn?t survive the GI tract (other stool tests have said no yeast detectable, but those previous ones only checked for culture, not under a microscope).

Not sure what the implications of the large amount of dead yeast in my stool (maybe it was from small intestine... SIFO?), other than I will now start an antifungal regimen and hope it somehow helps.

Muon · « **Reply #37 on:** January 19, 2021, 03:00:50 PM »

From IBS to POIS - The dysbiotic march hypothesis

Muon · « **Reply #38 on:** February 10, 2021, 02:54:12 PM »

Fungal dysbiosis: immunity and interactions at mucosal barriers

Quote from: aswinpras06 on November 28, 2020, 11:02:38 PM

Thanks muon. My pulmonologist thinks Omalizumab is too risky during covid and has given oral itraconazole for aspergilloses.

In addition, a role of CARD9 in the late stages of mucosal immunity to fungi has been described during Aspergillus fumigatus lung infection.

Muon: Oral fungal infection, Brother: decreased IL-17. Aunt: Vaginal Candida infection.

Although some CARD9 mutations are accompanied by a defect in the production of IL-17.

Candida can downregulate IL-17 and tryptophan.

Mushnikk · « **Reply #39 on:** February 10, 2021, 04:44:32 PM »

I was recently diagnosed with SIBO and will report back after treatment. I also strongly believe that I suffer from transient episodes of D-Lactac acidosis as part of a larger gut dysbiosis.

News:

Poll

What was the result of your SIBO test?

Author Topic: Small intestinal bacterial overgrowth (SIBO) (Read 29950 times)