Post Orgasmic Illness Syndrome (P.O.I.S.)

General Category => Poll Center => Topic started by: Muon on August 02, 2020, 03:04:10 PM

Title: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on August 02, 2020, 03:04:10 PM
The question is based on this setup: Solution: Lactulose. Gases: Hydrogen and Methane. If you have only used one of these gases then the first two options still apply. However when using different gases and/or solution(s) then one have to pick the 'elaborate in the comments' option.

Positive means abnormal result.
Negative means normal result.

Votes can be changed as usual.

Huge database of papers: https://www.siboinfo.com/studies.html

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Cross-linking polls/posts that might be relevant:

Vitamin D Poll (https://poiscenter.com/forums/index.php?topic=257.0)

Vitamins & Minerals Poll (https://poiscenter.com/forums/index.php?topic=3201.0)

SIBO related post (https://poiscenter.com/forums/index.php?topic=2695.msg35639#msg35639)

Human beta-Defensin-2 (https://poiscenter.com/forums/index.php?topic=3188.msg32995#msg32995)

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Bonebroth (https://poiscenter.com/forums/index.php?topic=2684.msg35348#msg35348)
Mushnikk (https://poiscenter.com/forums/index.php?topic=3385.msg39302#msg39302)

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Yeast/Candida

CharlesB, dead yeast in stool (microscope test, culture test is worthless):
https://poiscenter.com/forums/index.php?topic=3643.msg38774#msg38774

Iwillbeatthis, high arabinose (https://en.wikipedia.org/wiki/Arabinose) in urine, 44 mmol/mol creatinine (<20):
https://poiscenter.com/forums/index.php?topic=2684.msg39410#msg39410

Muon, a clear T-lymphocyte cell mediated response to Candida Albicans, LTT:
1 ug/ml Candida: SI=26.5, 0.5 ug/ml Candida: SI=19.9 (this is the average value of 3 parallel tests, more cells have been multiplied proportional to the SI value, which is the ratio of the amount of candida stimulated T-cells and unstimulated T-cells). This could indicate Candida induced T-cell infiltration in the GI tract.
https://poiscenter.com/forums/index.php?topic=2545.0
 
Cj.in.la, high Candida specific IgG4 response:
https://poiscenter.com/forums/index.php?topic=2927.msg27543#msg27543

Bream, Potential (https://www.mdpi.com/2073-4409/8/7/707) innate response against Candida albicans via hBD-2:
https://poiscenter.com/forums/index.php?topic=146.msg31902#msg31902

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Same poll on ME/CFS forum:
https://forums.phoenixrising.me/threads/poll-small-intestinal-bacterial-overgrowth-sibo.82265/

D-lactic acidosis discussion (https://forums.phoenixrising.me/threads/me-cfs-for-18-years-recently-diagnosed-with-d-lactic-acidosis-as-cause-of-symptoms-and-illness.57613/)

Discussion forum: https://forums.phoenixrising.me/forums/the-gut-ibs-sibo-leaky-gut-gastroparesis.9/

Fungal discussion: https://forums.phoenixrising.me/forums/fungal-infection-yeast-candida.129/

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IBS testing:
Anti-CdtB autoantibodies
Anti-vinculin autoantibodies
https://www.ibssmart.com/
https://chriskresser.com/is-ibs-an-autoimmune-disease/
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on November 22, 2020, 05:53:51 AM
https://forums.phoenixrising.me/threads/is-sibo-caused-by-dysautonomic-gastrointestinal-motility.81362/

https://www.siboinfo.com/

Studies: https://www.siboinfo.com/studies.html
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: berlin1984 on November 22, 2020, 02:35:31 PM
https://forums.phoenixrising.me/threads/is-sibo-caused-by-dysautonomic-gastrointestinal-motility.81362/

I had bad gut motility too and still have it if I don't watch my behaviour. At times I was also thinking I had sibo, although I never did any test for it.
I had called it "slow transit constipation" because I didn't know the correct terms. My ways of solving it I described in this thread (https://poiscenter.com/forums/index.php?topic=3293.msg36922#msg36922).

I see this part of my health issue as kind of solved, did not influence POIS though I think.

I think this post was useful for me: https://integrative.ca/blog/gut-motility
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Hopeoneday on November 22, 2020, 06:50:08 PM
https://medlineplus.gov/genetics/condition/mitochondrial-neurogastrointestinal-encephalopathy-disease/
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on November 22, 2020, 06:57:47 PM
''The aim of low antigen content diet (LAC-diet) is the reduction of the high-molecular-weight exogenous substances crossing the mucosal barrier of the gut.''

Low-Antigen-Content Diet (http://web.tiscali.it/infolabsas/apher/write/diet.htm)
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Hopeoneday on November 23, 2020, 09:24:56 AM
When i reasarching CFS-ME forum, a lot of them hawe POTS- while haweing POTS ,a
lot of them hawe SIBO, sibo can backing gasses from small intesines back in
stomach, stomach is then pushed up,  that can put presure on heart , aorta, vagus nerve, changing vagal tone and by then changing heart2 rate etc(palpilations)... and in
pois, my vagal tone is hipersensitive when hit me hard.
I learned this from expirience , because in pois all this incriese badly.
And if you dont relese that bulded gasses ,
you must burp that gasses somehow, you can be in
trouble with heart and breathing, specialy when you in pois state.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Prospero on November 23, 2020, 10:07:13 AM
That's also my own experience, HOD, though I don't know if I have SIBO (will try to convince someone that I need a test). I didn't know that this idea of a pushed-up stomach which pressures the heart etc was something that was discussed seriously by other people, but I had this impression.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on November 23, 2020, 04:41:50 PM
https://secure.vagusnervesupport.com/blogs/news/sibo-help

"Stomach Acid Must Be Maintained To Prevent SIBO/SIFO"
This is a problem for me. Also digestion can draw blood from elsewhere, blood volume might already be low. Big heavy meals can induce POTS like symptoms.

Small intestinal bacterial and fungal overgrowth (2020) (https://sci-hub.se/https://www.sciencedirect.com/science/article/pii/B9780128130377000248)

Also SIBO discussion here: https://poiscenter.com/forums/index.php?topic=3098.msg31156#msg31156
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: BoneBroth on November 23, 2020, 05:34:19 PM
I feel bad after heavy meals now and the blood pressure drops, yes thats probably because blood is going to the digest area.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Journey on November 24, 2020, 06:01:04 AM
When i reasarching CFS-ME forum, a lot of them hawe POTS- while haweing POTS ,a
lot of them hawe SIBO, sibo can backing gasses from small intesines back in
stomach, stomach is then pushed up,  that can put presure on heart , aorta, vagus nerve, changing vagal tone and by then changing heart2 rate etc(palpilations)... and in
pois, my vagal tone is hipersensitive when hit me hard.
I learned this from expirience , because in pois all this incriese badly.
And if you dont relese that bulded gasses ,
you must burp that gasses somehow, you can be in
trouble with heart and breathing, specialy when you in pois state.
That'd explain why I have this narrower breathing type feeling and gases and reduced appetite and getting nauseous fast by fatty and salty foods in POIS state the question is does POIS cause SIBO or viceversa by chronical gases the nerves and other systems were altered leading to POIS I wonder how these gases can be made to go out in the most efficient ways.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on November 24, 2020, 07:22:11 PM
Amateur cyclist dramatically improves performance to become a pro after FMT from another competitive cyclist (https://forums.phoenixrising.me/threads/amateur-cyclist-dramatically-improves-performance-to-become-a-pro-after-fmt-from-another-competitive-cyclist.82140/)

FMT thread: https://poiscenter.com/forums/index.php?topic=2800.0
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on November 26, 2020, 10:55:44 AM
Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases (https://www.preprints.org/manuscript/202011.0276/v1)

"The intestinal dysbiosis is related to a reduction in butyrate-producing species, impairing the anti-inflammatory response of the immune system, and is commonly associated with micronutrients deficiency, e.g. vitamin D hypovitaminosis."

16S Microbiome test from Atlas Biomed (I don't have any printout of results, they are visible in a webpage with diagrams, so I can't post all of it)
- I am missing a number of important butyrate-producing bacteria such as faecalibacterium, roseburia, coprococcus, akkermansia. I also have very low eubacterium.
- I am also missing a non-butyrate bacteria called Lactobacillus.
- Bifidobacteria is about 2.4%.

Butyrate maintains the gut lining, it also produces regulatory immune cells that prevent autoimmune disease. People with Celiac disease and IBS have been found to have low butyrate bacteria. I think when we orgasm, oxidative stress rises and our butyrate bacteria cannot produce enough butyrate to suppress it so we get damage to the body.
I've been ill since aged 14 so maybe being sexually active started all of this for me. Initial symptoms were chronic fatigue but have progressed since then.

A year ago at age 30, I was on a course of a dangerous antibiotic called Ciprofloxacin. I have since developed a large number of symptoms like fibromyalgia, connective tissue damage, joint pain, fat padding loss. All of it worsens after an orgasm and the worst of it persists for about a week.

I believe high oxidative stress is the action in this illness.

The Causes of Intestinal Dysbiosis: A Review (http://www.anaturalhealingcenter.com/documents/Thorne/articles/intestinal_dysbiosis9-2.pdf)

Table 1C: Ciprofloxacin: Other: yeast colonization: increase in number of organisms during therapy.

All of it worsens after an orgasm and the worst of it persists for about a week.

Funny how it's the same number as the normalization period post administration of Ciprofloxacin...as if POIS is doing something similar as Ciprofloxacin.
Table 1C: Days to normalization of flora (postadministration): 7

As if Cipro modulates immune parameters that benefit yeast growth and perhaps the same modulation might be true for POIS as well.

Assessment of oral ciprofloxacin impaired gut barrier integrity on gut bacteria in mice (https://www.sciencedirect.com/science/article/pii/S1567576919326426)

"High CPFX disturbed the bacteria community structure, reduced indole and butyrate."

"Further, the High CPFX treatment increased pro-inflammatory cytokine IL-1beta in intestinal tract, decreased IL-17A of duodenum but increased IL-17A of colon at day 37."

IL-17a is a critical defensive parameter against fungi/yeast. If yeast is a problem then the duodenum might be involved.

IL-17: https://poiscenter.com/forums/index.php?topic=2545.msg32239#msg32239
Also brother got a decreased level. May lead to other things---> https://poiscenter.com/forums/index.php?topic=2545.msg37628#msg37628

Hypothesis: Is a decreased level of certain butyrate species involved in the pathophysiology of POIS?
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on November 29, 2020, 03:13:48 PM
I feel bad after heavy meals now and the blood pressure drops, yes thats probably because blood is going to the digest area.

This is probably the reason why my heart stopped beating and turned blue when receiving breast milk (age 2 days). Blood being drawn from vital organs to the digestive area.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: BoneBroth on November 29, 2020, 04:46:14 PM
Well one could think that a baby's body should not fail on just feeding breast milk, unless there is a defect in the oxygen transportation in the blood (heart defect, blocked breading etc). Anyway, if we poisers experience POTS after meals, we should probably benefit from eating smaller meals more often and let the intestines rest for 14-16 hours every day (not eating meals between 6 pm and 9 am.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on November 29, 2020, 08:38:23 PM
When i reasarching CFS-ME forum, a lot of them hawe POTS- while haweing POTS ,a
lot of them hawe SIBO, sibo can backing gasses from small intesines back in
stomach, stomach is then pushed up,  that can put presure on heart , aorta, vagus nerve, changing vagal tone and by then changing heart2 rate etc(palpilations)... and in
pois, my vagal tone is hipersensitive when hit me hard.
I learned this from expirience , because in pois all this incriese badly.
And if you dont relese that bulded gasses ,
you must burp that gasses somehow, you can be in
trouble with heart and breathing, specialy when you in pois state.

https://en.wikipedia.org/wiki/Roemheld_syndrome
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Hopeoneday on November 30, 2020, 05:03:58 PM
Cervical spine instability as a cause of your digestive disorders
https://www.caringmedical.com/prolotherapy-news/gerd-neck/

Muon-roemheld
https://poiscenter.com/forums/index.php?topic=2793.msg25253#msg25253
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on November 30, 2020, 05:05:04 PM
Vagus nerve compression
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on December 05, 2020, 11:00:44 AM
SIBO testing in POISers would be interesting (research?).
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Iwillbeatthis on December 06, 2020, 12:42:59 PM
Is small intestine permeability a good test for SIBO? I had it done a month ago with the gastro specialist waiting for the results but this was after my stools had improved from berberine and oregano oil so maybe nothing will show...
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on December 06, 2020, 01:20:53 PM
Is small intestine permeability a good test for SIBO?

Nope
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Iwillbeatthis on December 06, 2020, 01:24:21 PM
Is small intestine permeability a good test for SIBO?

Nope

Why does that not surprise me... The NHS only do the bad tests
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Journey on December 06, 2020, 05:33:33 PM
In the past few days I have had to eat less and very little dairy and I took an activated charcoal tablet yesterday and haven't had a stool exit today which never has happened ever before and I feel calmer and better overall however I am afraid to test if the POIS symptoms have changed because if they haven't I will be back in POIS state and will have to start building up this abstinence streak again.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on December 07, 2020, 07:16:50 AM
Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a "pro-inflammatory" state associated with atherosclerosis and autoimmunity (https://sci-hub.se/10.1016/j.mehy.2016.07.007)
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Iwillbeatthis on December 07, 2020, 07:28:02 AM
In the past few days I have had to eat less and very little dairy and I took an activated charcoal tablet yesterday and haven't had a stool exit today which never has happened ever before and I feel calmer and better overall however I am afraid to test if the POIS symptoms have changed because if they haven't I will be back in POIS state and will have to start building up this abstinence streak again.

Carry on the abstinence one charcoal tablet isn't going to stop your POIS I highly doubt. I've gone through nearly a whole tub of charcoal capsules and still had POIS , it can be helpful if you have mould issues but its best to combine with glutathione which will release the toxins from your cell and charcoal will bind to them, I think its also helpful to take with bentonite which is much more heavy binder. Also don't take the charcoal close to your meal times as it will interfere with the absorption of nutrients
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: mike_sweden on December 08, 2020, 03:42:19 PM
i am starting probi mage, a swedish probiotic for the gut

a link for anyone interested

https://www.apotea.se/probimage-80-kapslar
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on December 10, 2020, 07:00:54 PM
Video about Marian Lemle's Hydrogen Sulfide theory (https://forums.phoenixrising.me/threads/video-about-marian-lemles-hydrogen-sulfide-theory.82322/)

I get the impression that POIS puts you into a state of semi-hibernation. I believe a few POISers here said the same thing.

Slide at 18:00 Talking about Heme, iron. Is the temporary loss of iron in the case of IronFeather a protective mechanism?

I've had blood tests done multiple times during my worst fever episodes, and everything comes back normal except for very low levels of iron (I usually have normal or even high iron and hemoglobin levels), and through-the-roof amounts of C-reactive protein. This led doctors to think I could have mononucleosis or some kind of bacterial infection, but all specific tests came back negative. They put me on antibiotics anyway, and that solved most symptoms almost immediately and made me able to get out of bed and finally get better during the worst episode I've ever had. That's why I've always thought it must be some kind of infection by some pathogen, even when I used to believe an autoinmune reaction must be the cause. Now I don't even know what to believe or what to do.

Slide 19:18: Possible vagus nerve involvement?

H2S could be investigated as well aside from hydrogen and methane.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Journey on December 11, 2020, 09:25:16 AM
Video about Marian Lemle's Hydrogen Sulfide theory (https://forums.phoenixrising.me/threads/video-about-marian-lemles-hydrogen-sulfide-theory.82322/)

I get the impression that POIS puts you into a state of semi-hibernation. I believe a few POISers here said the same thing.

Slide at 18:00 Talking about Heme, iron. Is the temporary loss of iron in the case of IronFeather a protective mechanism?

I've had blood tests done multiple times during my worst fever episodes, and everything comes back normal except for very low levels of iron (I usually have normal or even high iron and hemoglobin levels), and through-the-roof amounts of C-reactive protein. This led doctors to think I could have mononucleosis or some kind of bacterial infection, but all specific tests came back negative. They put me on antibiotics anyway, and that solved most symptoms almost immediately and made me able to get out of bed and finally get better during the worst episode I've ever had. That's why I've always thought it must be some kind of infection by some pathogen, even when I used to believe an autoinmune reaction must be the cause. Now I don't even know what to believe or what to do.

Slide 19:18: Possible vagus nerve involvement?

H2S could be investigated as well aside from hydrogen and methane.
My C Reactive Protein the only time I measured that was 1.9
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Iwillbeatthis on December 15, 2020, 02:33:30 PM
I've noticed something recently when I have to pass stools and then pee soon after it feels like a burning sensation when I pee(not painful).

I've also noticed that when I take magnesium supplements I've tried two different ones of the most absorbable forms, every time they set off a bad reaction of pain 10 cm down from belly button I guess in bladder/pelvic region and I find it very difficult to sleep with this pain. Anyone know what this could mean?
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on December 15, 2020, 02:42:55 PM
Release of neuropeptides? MCA? Interstitial cystitis (https://en.wikipedia.org/wiki/Interstitial_cystitis)?
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Iwillbeatthis on December 15, 2020, 03:50:59 PM
Yeah probably Interstitial cystitis/mcas, I had bad Interstitial cystitis symptoms for a year before my POIS began but now they've cleared up mostly-  I just need to avoid any triggers. I do want to heal this area badly as I think its the epicenter of all my health problems and the human body does contain the power to heal itself with the right guidance, I was thinking about taking cystoprotek possibly
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on December 16, 2020, 02:34:13 PM
Researchers will not tinker with GI/microbiome measurements. Urologists, immunologists, allergologists, neurologists, sexual medicine doctors etc won't take a step outside their territory. I think you can forget about SIBO testing in literature, these type of measurements are likely to come from the community itself.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on December 17, 2020, 12:53:44 PM
Bile regulates good/bad bacteria, it prevents SIBO, if the colon has bad bacteria i get POIS due to undigested food get to colon and bad bacteria making gasses like methane and hydrogen sulfide, which is getting to blood and into brain and then i get POIS symptoms.

POISers with history of low iron:

Intracellular iron regulation, infections and the effect of LPS endotoxins (https://forums.phoenixrising.me/threads/intracellular-iron-regulation-infections-and-the-effect-of-lps-endotoxins.53819/)

"Withholding iron from potential pathogens is a host defense strategy."

"As alluded to earlier, iron is essential for the survival and growth of almost all organisms. Furthermore, an important strategy of mammalian antimicrobial defense is based on depriving pathogens of this essential nutrient"
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on December 18, 2020, 02:31:57 PM
Not your typical blood tests:
Results from 3 studies (4 papers) Investigating Metabolites and Metabolomics (https://link.springer.com/article/10.1186/s12891-020-03201-9/tables/5)
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on December 26, 2020, 09:10:35 PM
I wonder if POISers, who developed POIS gradually over the years, have a dysbiosis which took some time to develop in the intestines. Does worsening of the dysbiosis correlates with the intensity/duration of POIS symptoms? I also wonder whether the response to a dysbiosis is spatially selective. Perhaps there is a response in the Reproductive system as well while there isn't anything to fight.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on January 02, 2021, 03:16:00 PM
ME/CFS for 18 years, recently diagnosed with D-Lactic acidosis as cause of symptoms and illness. (https://forums.phoenixrising.me/threads/me-cfs-for-18-years-recently-diagnosed-with-d-lactic-acidosis-as-cause-of-symptoms-and-illness.57613/)
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on January 03, 2021, 11:20:01 PM
Food sensitivity, one could take a look for a generalized mechanism regarding food sensitization via gut mucosal breakdown:

Gastrointestinal Candida colonisation promotes sensitisation against food antigens by affecting the mucosal barrier in mice (https://gut.bmj.com/content/55/7/954.short)

IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut (https://www.sciencedirect.com/science/article/pii/S2211124718305783)
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on January 18, 2021, 10:12:36 PM
I started taking Azithromycin today (I know it is a long shot, but I?m at the point where it?s promising enough to give a try), 5 day duration.   Will update in a couple weeks if it helped at all.

Any update CharlesB?

Unfortunately I don?t think the Azithromycin did much for me, I still have very strong symptoms even on arousal.  Would have posted sooner but wanted to give it a full couple of weeks.

I did get a stool test back after I posted about starting Azithromycin, which stated that there was a large amount of fungus/yeast that was microscopically visible in my stool - much more than the baseline expectation for yeast in a stool sample - but it was unable to be cultured potentially because the yeast didn?t survive the GI tract (other stool tests have said no yeast detectable, but those previous ones only checked for culture, not under a microscope).

Not sure what the implications of the large amount of dead yeast in my stool (maybe it was from small intestine... SIFO?), other than I will now start an antifungal regimen and hope it somehow helps.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on January 19, 2021, 03:00:50 PM
From IBS to POIS - The dysbiotic march hypothesis (https://www.sciencedirect.com/science/article/pii/S0306987720301559?via%3Dihub)
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on February 10, 2021, 02:54:12 PM
Fungal dysbiosis: immunity and interactions at mucosal barriers (https://sci-hub.se/https://www.nature.com/articles/nri.2017.55)

Thanks muon.  My pulmonologist  thinks Omalizumab is too risky during covid and has given oral itraconazole for aspergilloses.

In addition, a role of CARD9 in the late stages of mucosal immunity to fungi has been described during Aspergillus fumigatus lung infection.

Muon: Oral fungal infection, Brother: decreased IL-17. Aunt: Vaginal Candida infection.

Although some CARD9 mutations are accompanied by a defect in the production of IL-17.

Candida can downregulate IL-17 and tryptophan.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Mushnikk on February 10, 2021, 04:44:32 PM
I was recently diagnosed with SIBO and will report back after treatment. I also strongly believe that I suffer from transient episodes of D-Lactac acidosis as part of a larger gut dysbiosis.       
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on February 10, 2021, 04:53:31 PM
I was recently diagnosed with SIBO and will report back after treatment. I also strongly believe that I suffer from transient episodes of D-Lactac acidosis as part of a larger gut dysbiosis.     
https://en.wikipedia.org/wiki/D-lactate_dehydrogenase
This enzyme catalyses the following chemical reaction: (R)-lactate + NAD+ <----> pyruvate + NADH
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Mushnikk on February 10, 2021, 05:07:35 PM
I was recently diagnosed with SIBO and will report back after treatment. I also strongly believe that I suffer from transient episodes of D-Lactac acidosis as part of a larger gut dysbiosis.     
https://en.wikipedia.org/wiki/D-lactate_dehydrogenase
This enzyme catalyses the following chemical reaction: (R)-lactate + NAD+ <----> pyruvate + NADH

Your point being? :)
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on February 10, 2021, 05:13:55 PM
Linking stuff:
https://poiscenter.com/forums/index.php?topic=3551.msg38867#msg38867
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on February 10, 2021, 05:39:13 PM
I was recently diagnosed with SIBO and will report back after treatment. I also strongly believe that I suffer from transient episodes of D-Lactac acidosis as part of a larger gut dysbiosis.     

What kind of test did you do for SIBO?
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Mushnikk on February 12, 2021, 04:03:33 AM
I was recently diagnosed with SIBO and will report back after treatment. I also strongly believe that I suffer from transient episodes of D-Lactac acidosis as part of a larger gut dysbiosis.     

What kind of test did you do for SIBO?

Lactulose breath test for both hydrogen and methane. Borderline positive for hydrogen and definitely positive for methane. See: https://i.imgur.com/GBp5YRV.jpg
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on February 13, 2021, 10:09:33 AM
Lactulose breath test for both hydrogen and methane. Borderline positive for hydrogen and definitely positive for methane. See: https://i.imgur.com/GBp5YRV.jpg

Seems like methane producing species are dominant. Methane breathers are harder to threat than hydrogen breathers. Hydrogen breathers respond more often positively to non-systemic antibiotics like Rifaximin.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Journey on February 13, 2021, 11:55:25 AM
Lactulose breath test for both hydrogen and methane. Borderline positive for hydrogen and definitely positive for methane. See: https://i.imgur.com/GBp5YRV.jpg

Seems like methane producing species are dominant. Methane breathers are harder to threat than hydrogen breathers. Hydrogen breathers respond more often positively to non-systemic antibiotics like Rifaximin.
How could  the SIBO be causing the POIS could SIBO be the root cause for the Mast Cell Activation Disorder which then gives the POIS?
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Mushnikk on February 13, 2021, 01:00:20 PM
Lactulose breath test for both hydrogen and methane. Borderline positive for hydrogen and definitely positive for methane. See: https://i.imgur.com/GBp5YRV.jpg

Seems like methane producing species are dominant. Methane breathers are harder to threat than hydrogen breathers. Hydrogen breathers respond more often positively to non-systemic antibiotics like Rifaximin.

That's also what I have read. Neomycin or Flagyl are often used for methane dominant SIBO, but I am not really sure if nuking/resetting my gut is a good or a bad thing. It is not something one simply tries, there could be irreversible changes the microbiome. Plus AB just have a lot of awful side effects. I will definitely follow a SIBO diet (and perhaps) herbal antibiotics and will report back.

There is definitely a dysbiosis in my gut...

What is worth noting is that carbs before and after O increase the severity of my POIS.

Also I currently looking for a lab to test D-lactate, I inquired a couple of labs: they all only measure L-lactate...
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Mushnikk on February 13, 2021, 01:04:15 PM
Lactulose breath test for both hydrogen and methane. Borderline positive for hydrogen and definitely positive for methane. See: https://i.imgur.com/GBp5YRV.jpg

Seems like methane producing species are dominant. Methane breathers are harder to threat than hydrogen breathers. Hydrogen breathers respond more often positively to non-systemic antibiotics like Rifaximin.
How could  the SIBO be causing the POIS could SIBO be the root cause for the Mast Cell Activation Disorder which then gives the POIS?

SIBO can cause malobsorption of nutrients and a compromised immune system as a possible cause of POIS. Or act on the gut-brain-axis, or could diminish a population of necessary gut bacteria which build neurotransmitters that are involved in regulating the autonomous nervous system, orgasms, ...
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on February 13, 2021, 01:07:04 PM
Also I currently looking for a lab to test D-lactate, I inquired a couple of labs: they all only measure L-lactate...
Redlabs Belgium provides that test: https://drive.google.com/file/d/1YBnZhO7yWYWHf17H23SimWHUOTzD_DA-/view
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: berlin1984 on February 13, 2021, 02:08:27 PM
That's also what I have read. Neomycin or Flagyl are often used for methane dominant SIBO, but I am not really sure if nuking/resetting my gut is a good or a bad thing. It is not something one simply tries, there could be irreversible changes the microbiome.

Please google for: SIBO gut motility

From what I read, improving gut motility (many methods, e.g. more fasting between meals, motility supplements or medicine, more stomach acid, ...) and starving the critters a bit (low FODMAP diet) could already help?

I did some experiments (https://poiscenter.com/forums/index.php?topic=3293.msg36922#msg36922) in that direction, even though I don't think I have SIBO.

(Sidenote: However something diagnosed as SIBO might actually be unrelated to SmallIntestine(BO) but a general disbyosis which needs to be tackled...)
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on February 13, 2021, 03:57:19 PM
Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006167/)

"D-lactic acidosis is characterized by brain fogginess (BF) and elevated D-lactate and occurs in short bowel syndrome."

"We found that over 2/3rd of patients with brain fogginess demonstrated D-lactic acidosis,along with significantly higher prevalence of SIBO when compared to those without brain fogginess."

This number is quite large.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on February 20, 2021, 08:06:57 AM
Childhood diet has lifelong impact (https://www.sciencedaily.com/releases/2021/02/210203090458.htm)

Eating too much fat and sugar as a child can alter your microbiome for life, even if you later learn to eat healthier, a new study in mice suggests.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on February 21, 2021, 06:37:35 AM
Discussion:

Irritable Bowel Syndrome caused by MCAS? New report. (https://forums.phoenixrising.me/threads/irritable-bowel-syndrome-caused-by-mcas-new-report.83001/)

"A proportion of patients will experience SIBO after a severe bout of food poisoning either from Campylbacteor, E Coli, Shingella or Salmonella. These bacteria create a bacterial toxin called Cytolethal Distending Toxin (CdtB) with can lead to autoimmunity with anti-vincolin antibodies developing.

the anti-vincolin antibodies which cause a loss of function of the Migrating Motor Complex and also nerve damage which will result in bacterial overgrowth
"

Edit:
Well, about 4 months ago I came down with a salmonella infection and got quite sick. I had a fever for a few days and felt very miserable. I had diarrhea and lots of it. Whatever was coming out of me was black and disgusting, perhaps blood in the diarrhea. After I recovered from the fever the diarrhea persisted and I had to go on antibiotics (azithromycin) to kill off most of the salmonella.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on February 21, 2021, 06:58:47 AM
The structural homology (molecular mimicry) between pathogen and host proteins can result in "collateral damage" to surrounding human tissue.

Host proteins as in seminal fluid proteins?
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on February 23, 2021, 08:11:23 AM
A Zero Carbohydrate, Carnivore Diet can Normalize Hydrogen Positive Small Intestinal Bacterial Overgrowth Lactulose Breath Tests: A Case Report (https://www.researchsquare.com/article/rs-148500/latest.pdf) (2021)
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: BoneBroth on February 23, 2021, 08:36:23 AM
A carnivore diet (eat only meat) is what my SIBO-terapeut say I should try if the FODMAP doesnt work. I have eat a lot of steamed broccoli for some time but now I suspect that it is partly responsible for the gas-production since my faher experience the same thing (all vegetables). After periods of bad smelly gas POIS symptoms always comes after. I think the inflammatory substances of orgasm also weakens the intestines.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on February 24, 2021, 10:56:00 AM
Intriguing Gastrointestinal Properties of Bismuth: A Folk Remedy Brought into the Realm of Clinical and Investigative Medicine (https://www.hindawi.com/journals/cjgh/1998/787926/)

"BSS is almost completely hydrolyzed in the stomach to form bismuth oxychloride and salicylic acid. The bismuth released exerts its cytoprotective action not only by coating the gastric lining but also by stimulating prostoglandin synthesis. Very little bismuth (less than 1%) is absorbed by the small intestine. In the colon, bismuth salts react with hydrogen sulphide produced by anaerobic bacteria to produce bismuth sulphide, a highly insoluble black salt responsible for the often noted darkening of the stool. This reaction does not interfere with standard tests to detect occult blood. Salicylate derived from BSS is almost completely absorbed from the GI tract."

"The downside of bismuth relates to the sequestration of this heavy metal in multiple tissue sites"

Bismuth Table 1:
Review article: microscopic colitis - lymphocytic, collagenous and 'mast cell' colitis (https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2036.2011.04686.x)

Loperamide used for lymphocytic colitis:
https://www.sciencedirect.com/science/article/abs/pii/S0002927002054473

One POISer in literature uses Loperamide for IBS. IBS caused by infiltration of the GI tract with leukocytes?

Infiltration:
https://poiscenter.com/forums/index.php?topic=2695.msg39394#msg39394

never had any intense reactions except for stomach problems, and it took me years to realize that soy was the cause. It got worse when (around 10 years old) I incorporated new foods with soy into my diet and my digestive system couldn't take it anymore: I spent 4 months with colitis and lost half of my weight until thankfully my mother deduced that soy was the culprit. So I believe that, if it was a true allergy, I'd have had a more intense reaction. And yes, I've never tolerated soy well, and I've had that problem for as long as I can remember.

All lymphocytes or are mast cells hiding as well? Quote from a book in this post:
https://poiscenter.com/forums/index.php?topic=2695.msg39141#msg39141

Pepto Bismol thread: https://poiscenter.com/forums/index.php?topic=3316.0
John reacts to pepto bismol as well as antibiotics:
It seems my POIS is gone, hopefully forever.  I can explain how I believe it happened although I don't really understand what happened.  In my previous posts I explained how Pepto Bismol prevented POIS when taken before O. This made me wonder if maybe there was something in the gut that was happening  to cause the POIS symptoms. Well, about 4 months ago I came down with a salmonella infection and got quite sick. I had a fever for a few days and felt very miserable. I had diarrhea and lots of it. Whatever was coming out of me was black and disgusting, perhaps blood in the diarrhea. After I recovered from the fever the diarrhea persisted and I had to go on antibiotics (azithromycin) to kill off most of the salmonella. I started eating yogurt, kefir, and sauerkraut to try to re-establish a healthy gut microbiome. The diarrhea went away and my system normalized. But even now, almost 4 months afterward, it seems that my digestive system is different than it was before the food poisoning.

Black stool but without pepto bismol? Check first quote of this post about peptobismol: "a highly insoluble black salt responsible for the often noted darkening of the stool."

Discussion:

Irritable Bowel Syndrome caused by MCAS? New report. (https://forums.phoenixrising.me/threads/irritable-bowel-syndrome-caused-by-mcas-new-report.83001/)

"A proportion of patients will experience SIBO after a severe bout of food poisoning either from Campylbacteor, E Coli, Shingella or Salmonella. These bacteria create a bacterial toxin called Cytolethal Distending Toxin (CdtB) with can lead to autoimmunity with anti-vincolin antibodies developing.

the anti-vincolin antibodies which cause a loss of function of the Migrating Motor Complex and also nerve damage which will result in bacterial overgrowth
"
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on March 13, 2021, 03:55:03 PM
ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth (https://sci-hub.se/10.14309/ajg.0000000000000501)

8. Methanobrevibacter smithii appears to be the key methanogen responsible for breath methane production.

Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on March 17, 2021, 06:33:09 PM
GPR109a: The Missing Link between Microbiome and Good Health? (https://www.sciencedirect.com/science/article/pii/S1074761313005669)
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on March 24, 2021, 10:20:32 AM
Low BMI, Body Weight Loss, Low Muscle Mass, Low Appetite and Gut Microbiota:

Targeting the Gut Microbiota to Treat Cachexia (https://www.frontiersin.org/articles/10.3389/fcimb.2019.00305/full)

16S Microbiome test from Atlas Biomed (I don't have any printout of results, they are visible in a webpage with diagrams, so I can't post all of it)
- I am missing a number of important butyrate-producing bacteria such as faecalibacterium, roseburia, coprococcus, akkermansia. I also have very low eubacterium.
- I am also missing a non-butyrate bacteria called Lactobacillus.
- Bifidobacteria is about 2.4%.
I initially started treatment due to suspected SIBO, however a breath test during my most recent slump revealed only a minor methanogenic overgrowth (11 ppm methane, <10 reference range). According to a stool test, I have high levels of two known potential pathogens, klebsiella pneumoniae and citrobacter brakii, in addition to an overgrowth of bacteroidetes in my large intestine.
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on March 28, 2021, 10:28:56 AM
I was recently diagnosed with SIBO and will report back after treatment. I also strongly believe that I suffer from transient episodes of D-Lactac acidosis as part of a larger gut dysbiosis.     

What kind of test did you do for SIBO?

Lactulose breath test for both hydrogen and methane. Borderline positive for hydrogen and definitely positive for methane. See: https://i.imgur.com/GBp5YRV.jpg
Do you have premature ejaculation?

Yes!
Back to the Source: Molecular Identification of Methanogenic Archaea as Markers of Colonic Methane Production (https://link.springer.com/article/10.1007/s10620-021-06839-0)
"breath methane excretion is elevated in constipation-predominant irritable bowel syndrome (IBS-C) patients, who also have lower postprandial serotonin levels than non-methane excreting IBS patients who excrete elevated H2"
https://en.wikipedia.org/wiki/Archaea
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on March 30, 2021, 07:01:53 AM
MAST CELL ACTIVATION SYNDROME (MCAS) and the Microbiome (https://cfsremission.com/2020/12/17/mast-cell-activation-syndrome-mcas-and-the-microbiome/)
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on April 13, 2021, 05:31:58 PM
https://www.the-scientist.com/news-opinion/mysterious-immune-cells-change-the-gut-lining-to-accommodate-diet-68641
Title: Re: Small intestinal bacterial overgrowth (SIBO)
Post by: Muon on April 26, 2021, 11:20:59 AM
Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function: Assessment, Treatment and Classification Implications (https://www.ingentaconnect.com/content/ben/ctmc/2020/00000020/00000007/art00005)

Overall, gut dysbiosis and increased gut permeability have significant impacts on central and systemic homeostasis via the regulation of mitochondrial function, especially in central glia and systemic immune cells.