Milnacipran - completely stopping my brain fog

[hurray]

That's an interesting theory Muon. The one reservation I would have with it is that beta-amyloid plaque formation takes place over a long time period, whereas testosterone's effect on (future) POIS symptoms is immediate.

These ?-sheets further accumulate and become deposited as plaques. It is not clear how long this entire process takes, but some researchers hypothesize that it occurs over many years.

https://www.sciencedirect.com/topics/neuroscience/beta-amyloid

[hurray]

Still no brain fog 

[drop247]

Do you have any POIS symptoms while using Milnacipran? Did you before?

[hurray]

Do you have any POIS symptoms while using Milnacipran? Did you before?

In the last 2 months I have been experimenting with taking 25mg doses as opposed to 50mg doses. 25mg works fine for me if taken 1-2 hours before O, but I have twice had relatively mild POIS symptoms when I delayed several hours before O.

Milnacipran has a short half-life of 6-8 hours, so it wears off fairly quickly. For that reason, 50mg doses last longer, but they can also make me feel slightly nauseous.

Properly timed, 25mg has never let me down.

[demografx]

Properly timed, 25mg has never let me down.

hurray, thanks for this amazing news! You’ve been at it, like me, for MANY, many years!

[berlin1984]

hurray, thanks for this amazing news! You’ve been at it, like me, for MANY, many years!

hurray Lab1
Date Registered:
    April 02, 2011, 03:12:06 AM

!!!

[hurray]

Properly timed, 25mg has never let me down.

hurray, thanks for this amazing news! You’ve been at it, like me, for MANY, many years!

Thanks Demo - we have both been battling POIS for a long long time 

[drop247]

What dosage did you try first? Straight to 50 mg? The packaging seems to suggest starting much lower but that's if you're going to use it daily.

"Initial dose on day 1: 12.5 mg orally once
-Days 2 and 3: 12.5 mg orally 2 times a day
-Days 4 through 7: 25 mg orally 2 times a day
-After day 7: 50 mg orally 2 times a day"

[hurray]

What dosage did you try first? Straight to 50 mg? The packaging seems to suggest starting much lower but that's if you're going to use it daily.

"Initial dose on day 1: 12.5 mg orally once
-Days 2 and 3: 12.5 mg orally 2 times a day
-Days 4 through 7: 25 mg orally 2 times a day
-After day 7: 50 mg orally 2 times a day"

I originally ordered 50mg Milza capsules, so that was the first dose I tried. They worked, but they gave me a feeling of nausea. In hindsight, I wish I'd started off with the 25mg capsules that I now order.

[drop247]

Here is my report about my first trial of Milnacipran.

I took 25 mg and waited 2 hours before O. I have 50mg gel caps so I just opened one and took approximately half the powder. I think this is okay since it's not a time release capsule. I'm glad I didn't take all 50 mg because I did experience some nausea that peaked about an hour after ingestion and quickly dissipated. Not pleasant but not terrible either. My O was through masturbation to an erotic non-nude video.

My normal masturbation involves my body temperature dropping significantly and shivering when viewing highly stimulating erotic material. I don't know if anyone else with POIS experiences this. I get so cold feeling that even under my blankets I will experience shivering, shaking, and teeth chattering. I'm not sure what causes this but it may be due to viewing erotic material and perhaps linked to my POIS, but I'm not sure. Then, right after O, I normally experience a great increase in body temperature. So much so that I am usually sweating and have a difficult time falling asleep because I'm so hot.

With Milnacipran I still felt very cold and shaky before O but unusually I didn't get hot afterwards. I just kind of slowly returned to normal body temperature. This made falling asleep after O very easy.

I did experience a bit of ED at the beginning which is unusual for me normally but not unusual when I take serotonin enhancing substances before O such as Niacin, Niacinamide, 5-HTP, or Tryptophan. So I suspect the extra serotonin from Milnacipran made it a little harder (heh) to obtain an erection.

The mechanics of my orgasm seemed significantly different. As others have mentioned the intensity of the orgasm was higher. I expected that to mean more pleasurable feelings but in my case it just meant much stronger contractions of the muscles involved in ejaculation. It wasn't painful really but it was uncomfortable a little. Usually after I ejaculate my penis loses erection sort of slowly and semen continues to leak out a little for some time after. With Milnacipran I lost my erection almost immediately after the intense ejaculation and to my surprise there was little to no semen leakage afterwards. The muscles in my pelvic floor felt a bit sore afterwards from such contractions.

I slept normally for around 8 hours with my regular highly vivid and unusual dreams. When I woke I felt fine. That's not that unusual since onset of the worst of POIS for me usually takes about 12 hours or so. The test is always after I eat breakfast since that seems to bring out POIS symptoms in me. This time I did feel some anxiety begin after I finished eating a meal of eggs and potatoes. I chalked it up to perhaps the histamine releasing properties of the egg whites. I took some Vitamin C to try and counteract this.

The rest of the day I maintained that low level of anxiety and brain fog which peaked after lunch. I didn't get a ton of brain fog but I definitely did have a little. My normal post orgasm depression was there but not as pronounced, and my irritability seemed much lower than normal. I took some Ashwanganda to try to improve my anxiety and mood and that seemed to work a little. My normal POIS aches and pains seemed almost completely absent. Later I took some curcumin to combat any inflammation that may have been happening. After the curcumin and a quick trip to the tanning salon for some Vitamin D at 5:30pm I felt POIS was almost completely over. I had a surge in energy and went for a long bike ride and a short body weight workout.

Overall I'd rate Milnacipran an 8/10. Very few side effects and very effective. I will use at as my go to treatment from now on. Next time I might try combining it with one, or more, of my other treatments such as anti-histamines, anti-inflammatories, or GABA enhancing substances.

Thanks to hurray for bringing it to our attention!

[Nas]

Overall I'd rate Milnacipran an 8/10. Very few side effects and very effective. I will use at as my go to treatment from now on. Next time I might try combining it with one, or more, of my other treatments such as anti-histamines, anti-inflammatories, or GABA enhancing substances.

Thanks to hurray for bringing it to our attention!

Glad this worked well for you.
Is there any chance increasing the dose to 50 would be even more beneficial? The nausea can be counteracted with nausea medications, as I used to do with bromocriptine and Levodopa.
Hopefully more people can try this medication and report.
Also drop do you suffer from Premature Ejaculation and did it help with that?

[drop247]

That's a good idea. I might try some ginger with my next 25 mg dose and if it reduces the nausea significantly I'll try it with 50 mg. I very rarely have PE and Milnacipran didn't seem to extend the time it took for orgasm, other than the delay obtaining an erection.

[Nas]

That's a good idea. I might try some ginger with my next 25 mg dose and if it reduces the nausea significantly I'll try it with 50 mg. I very rarely have PE and Milnacipran didn't seem to extend the time it took for orgasm, other than the delay obtaining an erection.

How much did it take you to orgasm last time?
Also obviously OTC medications are more effective for nausea than bloody ginger lol.

[hurray]

Here is my report about my first trial of Milnacipran.

I took 25 mg and waited 2 hours before O. I have 50mg gel caps so I just opened one and took approximately half the powder. I think this is okay since it's not a time release capsule. I'm glad I didn't take all 50 mg because I did experience some nausea that peaked about an hour after ingestion and quickly dissipated. Not pleasant but not terrible either. My O was through masturbation to an erotic non-nude video.

My normal masturbation involves my body temperature dropping significantly and shivering when viewing highly stimulating erotic material. I don't know if anyone else with POIS experiences this. I get so cold feeling that even under my blankets I will experience shivering, shaking, and teeth chattering. I'm not sure what causes this but it may be due to viewing erotic material and perhaps linked to my POIS, but I'm not sure. Then, right after O, I normally experience a great increase in body temperature. So much so that I am usually sweating and have a difficult time falling asleep because I'm so hot.

With Milnacipran I still felt very cold and shaky before O but unusually I didn't get hot afterwards. I just kind of slowly returned to normal body temperature. This made falling asleep after O very easy.

I did experience a bit of ED at the beginning which is unusual for me normally but not unusual when I take serotonin enhancing substances before O such as Niacin, Niacinamide, 5-HTP, or Tryptophan. So I suspect the extra serotonin from Milnacipran made it a little harder (heh) to obtain an erection.

The mechanics of my orgasm seemed significantly different. As others have mentioned the intensity of the orgasm was higher. I expected that to mean more pleasurable feelings but in my case it just meant much stronger contractions of the muscles involved in ejaculation. It wasn't painful really but it was uncomfortable a little. Usually after I ejaculate my penis loses erection sort of slowly and semen continues to leak out a little for some time after. With Milnacipran I lost my erection almost immediately after the intense ejaculation and to my surprise there was little to no semen leakage afterwards. The muscles in my pelvic floor felt a bit sore afterwards from such contractions.

I slept normally for around 8 hours with my regular highly vivid and unusual dreams. When I woke I felt fine. That's not that unusual since onset of the worst of POIS for me usually takes about 12 hours or so. The test is always after I eat breakfast since that seems to bring out POIS symptoms in me. This time I did feel some anxiety begin after I finished eating a meal of eggs and potatoes. I chalked it up to perhaps the histamine releasing properties of the egg whites. I took some Vitamin C to try and counteract this.

The rest of the day I maintained that low level of anxiety and brain fog which peaked after lunch. I didn't get a ton of brain fog but I definitely did have a little. My normal post orgasm depression was there but not as pronounced, and my irritability seemed much lower than normal. I took some Ashwanganda to try to improve my anxiety and mood and that seemed to work a little. My normal POIS aches and pains seemed almost completely absent. Later I took some curcumin to combat any inflammation that may have been happening. After the curcumin and a quick trip to the tanning salon for some Vitamin D at 5:30pm I felt POIS was almost completely over. I had a surge in energy and went for a long bike ride and a short body weight workout.

Overall I'd rate Milnacipran an 8/10. Very few side effects and very effective. I will use at as my go to treatment from now on. Next time I might try combining it with one, or more, of my other treatments such as anti-histamines, anti-inflammatories, or GABA enhancing substances.

Thanks to hurray for bringing it to our attention!

That's excellent news 

I too had a feeling of nausea after 60-75 minutes when I started taking milnacipran, but after a couple of months of taking it on-demand, the feeling was much weaker.

My normal POIS aches and pains seemed almost completely absent.

Yes, it takes away my mild physical POIS symptoms too.

After the curcumin and a quick trip to the tanning salon for some Vitamin D at 5:30pm I felt POIS was almost completely over. I had a surge in energy and went for a long bike ride and a short body weight workout.

Wow, that's impressive. I don't do too much formal exercise, but I have no problems doing physical activity after O when I use milnacipran.

Thanks for the detailed write-up. Your experiences with milnacipran sound a lot like mine. I'm really happy that milnacipran helped you 

[Journey]

As it give strong O, could POIS be due to unfull ejac?

[drop247]

Due to it's large effect on the mechanics of ejaculation it certainly made me wonder that. A few ideas I came up with:

1. We have a high amounts of bacteria in the prostate that the intense contractions help clear out
2. We have a problem with semen flowing backwards and into the bladder causing a reaction
3. We have an allergy or intolerance of seminal fluid and the intense contractions helps to flush it out of the body more completely

Of course none of these could be correct and it is simply the neurotransmitter effects of the drug providing relief.

[demografx]

Nice to see this about milnacipran

[Monte]

From my topic:

Today I have discovered new thing! I had no POIS since 2 months and today first time in my life I put on a glove and looked for a prostate. I touched, but didn't massage too much. I did it delicately, but after that I felt a slight burning sensation around my penis (last months I had no sympoms of prostatis, but of course touching prostate can make little irritate, so that`s normal) . But know the most important thing - few hours later I felt 30% POIS (but only brainfog, irritation and intellectual decline, no body pain). I think touching my prostate cased moving fluid in that area (but no leakage to the outside) and then has arisen inflammation (without pain). Maybe many of you have bacteria inflammation  and don`t know about it. I have taken 2 pills of drotaverine (probably is not as good as Prednisone but it`s the only thing I have) and now my brainfog is much smaller. I think I made an mistake touching prostate not being in POIS. I should make it (better drainage) only when I`m after sex (the prostate is anyway irritated so after sex probably  I'm not losing anything by massaging prostate). Anyway, good to know that there such a strange mechanism (maybe not the only one, but definitely contributing) causing my POIS. Now all make sense. Maybe that`s because people have good result after using Prednisone (reducing inflammation) and milnacipran (affecting the effective removal of secretions outside), even magnesium (making good perineal muscles action).

[berlin1984]

To the guys that confirmed Milnacipran works for them:

* Do you drink coffee daily? (chronic consumption) (or high amount of cola, energy drinks etc)
* Do you smoke? (or other forms of nicotine)
* Anything else that messes with Neurotransmitters?

[drop247]

No coffee or caffeine for me. I makes me feel too anxious and strung out and gives me absolutely terrible silent reflux. No smoking or street drugs either. Though I did use marijuana almost daily for about 10 years, though I haven't touched it in more than 3 years.

I did another trial of 25 mg Milnacipran. This time with 10 mg of Loratadine along with it about 2 hours before O. I thought I felt POIS coming on before I went to sleep after O, but when I woke the next morning I had basically no symptoms (besides a bit of grogginess from the Loratadine). POIS symptoms didn't seem to come on much at all (if they did it was less than 10% of my previous untreated POIS). I might try Milnacipran with a less powerful anti-histamine like Fexofenadine next time just to avoid the grogginess side effect.

A weird thing happened later though. Due to some upcoming hormonal profile blood work I wanted to induce a regular POIS state, to see what my hormones are like while in full blown POIS. So I had an O without any pre-treatment. No Milnacipran or anti-histamines. No supplements at all actually. To my surprise my POIS while untreated was extremely mild. Just a bit of back pain, minor brain fog, and minor anxiety. By 5:00 pm the next day I was practically back to normal (less than 24 hours after O). Usually my POIS is 7 days of awful symptoms. I barely want to get out of bed for the first 3 days. I can barely think, I don't want to see or hear anyone, and I'm in aching body pains.

That O was at least 3 days since my last Milnacipran dosing. I've only taken it twice in my life. Is it possible it was still providing some protection? Is two doses enough to provide lasting effects on my neurotransmitter levels? Or is it possible that two strong orgasms that I had has done something to help clear a possible infection in my prostate? This O was completely normal in terms of physical action. Not elevated intensity in physical strength.

I did notice a weird symptom in my perineum area after that last untreated orgasm. A bit of an itching feeling inside my body on the left side and back towards my anus. I've felt this itching sensation before during the last 10 years, but it's always on my right side and near the very front of my perineum near where the vas deferens enters my body. It usually happens when I haven't O'd in a long time. So it was weird to have the same sensation in a different area. Maybe it was just a fluke but I'll report back if I notice any such feeling again.