Extremely fatigued before bowel movement (slow transit constipation)

[berlin1984]

I am wondering if there is a correlation with pois as this can be worked around with Tryptophan/5HTP which gets the gut nerves moving.
And some people report improvements with Tryptophan/5HTP (even if it is just for repleneshing serotonine or whatever it does..)

[Muon]

Are you located in Berlin, hence the name?

[demografx]

berlin1984, welcome to the forum!

[berlin1984]

Yes, Berlin. Note that there is multiple in the whole world, I'm in the biggest one ;-)

Thanks for the welcome. I've known this forum for many years, but only registered now.

[Muon]

Just so you be aware, there is a lab in Berlin where you can order tests quite easily:

https://poiscenter.com/forums/index.php?topic=3207.0

[berlin1984]

there is a lab in Berlin where you can order tests quite easily:

Thanks this sounds great. The corona test picture on their web page scares me a bit, I will postpone this for some months.

[Muon]

Let us know on the forum if you decide to proceed with the testing by that time. People could give you their opinion about testing for certain parameters regarding various theories. You will get a view from multiple angles that way which can help you in making a final selection.

[Hopeoneday]

Hi Berlin, in pois i hawe sometimes some sort of anaphalaxsis, is suspect because bovel put presure on lower back erea on prostate wich is in pain and feels inflamed. And some times , only arousall with no OE, induce contipation next day.
(neurodigestive isues is linked to pois in my case).

By the way, me , Muon and crew did searching for man in Germay who will be capable to do some "special" testings.

[berlin1984]

Other constipation poll: https://poiscenter.com/forums/index.php?topic=1513.0

[berlin1984]

I now believe this can be greatly improved by doing two things:

Drink a glass of warm water after waking up (drink it fast)
https://www.google.com/search?client=firefox-b-d&q=drinking+water+fast+in+morning

Eat yoghurt.
https://poiscenter.com/forums/index.php?topic=2775.msg35284#msg35284

Take physalis berries (Cape gooseberry, goldenberry).
https://poiscenter.com/forums/index.php?topic=3306.msg35444#msg35444

[berlin1984]

Forum keyword: "motility"
Google keywords: "gut motility",  "GI motility" or "Gastrointestinal motility"

Apparantly low motility is one of the triggers for SIBO.

[berlin1984]

Things that are also supposed to help:

* Magnesium (general good thing to take..)

* Choline (supplement forms or egg yolk)

* Vagus Nerve exercises (gargling, ..)

[berlin1984]

Nicotinamide adenine dinucleotide replenishment rescues colon degeneration in aged mice
https://www.nature.com/articles/sigtrans201717
"Notably, this colonic degeneration was accompanied with reduced key NAD+-generating enzyme expression and lowered NAD+/NADH ratio in aged colon. Three-month continuous administration of beta nicotinamide mononucleotide, a NAD+ precursor, elevated colonic NAD+ level and improved defecation in aged mice. "
beta nicotinamide mononucleotide = NMN.
For humans, it might(!) work to take NADH sublingual or Nicotinamide riboside (NR).
Niacin = nicotinic acid

[berlin1984]

Ribose Accelerates Gut Motility and Suppresses Mouse Body Weight Gaining
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870713/
"Ribose oral treatment in wild type mice also enhanced bowel motility and rendered mice resistance to high fat diets. The suppressed weight gain was resulted from enhanced ingested food excretion"
(Obviously we don't want too much motility)

[berlin1984]

Forum keyword: "motility"
Google keywords: "gut motility",  "GI motility" or "Gastrointestinal motility"

Apparantly low motility is one of the triggers for SIBO.

If you feel that you're fatigued before eating or after eating or around your usual toilet time:
20 drops of Iberogast and one cup of warm water with ginger powder.
Really works wonders.

[berlin1984]

Gastric emptying is slow in chronic fatigue syndrome
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-4-32
These observations indicate that there is measurable disturbance in upper gut motility corresponding with symptoms in CFS

Gut inflammation in chronic fatigue syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964729/
Probiotics also have the potential to improve gut motility, which is dysfunctional in many CFS patien

(Obvious disclaimer: CFS is not the same as POIS, not everyone with POIS has CFS, but the symptoms overlap and more women than men have CFS... see other threads for this topic..)

[berlin1984]

I stopped SJW (St. John's Wort) because it leads to low gut motility.
(TODO: Insert source link, I also experienced it myself)

I still like Iberogast a lot.
Iberogast (STW 5-II) is recommended in "The gastrointestinal symptoms present in patients with postural tachycardia syndrome: A review of the literature and overview of treatment".
https://www.autonomicneuroscience.com/article/S1566-0702(18)30052-3/pdf


EDIT:
Taking sublingual NADH also seems to start motility and kill my fatigue

I stopped taking a greens poweder containing spirulina, I think Spirulina creates constipation.

[nebraska]

i have no constipation at all but very rare bowel movements like 1-2 times a week. so when my pois is getting better on any drugs this condition is much improved(1 bowel movement a day).
and i see when i add gallbladder supp to my diet my movements improves too

now im trying prucalopride 0.5mg for sibo cure(i have much flatulence and bloating after fodmap foods) and my pois is noticeably improved.

my theory at the moment is that many people have pois due sibo or smth gut imbalance

so motor complex is great major problem for many of sibo sufferers

[berlin1984]

When I last week started again to force myself to drink more mineral water (from real mineral springs, not carbonated tap water from the soda streamer) and additionally forced myself to take some electrolyte powders/pills (and just table salt), I felt better.
Also my gut transit problems improved a lot.

Maybe the goal is also to drink the water quickly, e.g. google for "salt water flush", it's about salt water with lemon.

[berlin1984]

It's too early to say for sure, but I think I fixed this problem 95%ish with a combination of:

* Stopping coffee, having one only once in a few days. Chronic coffee messes with receptors in gut/brain/who-knows-where-else
* Drinking mineral water instead of tap water
* Drinking alcohol free wheat beer for hydration. (isotonic drink)
* Season now being in autumn, e.g. less dehydration in general
* (I also had the antibiotics treatment, but it did not affect this issue, I'm quite sure about that because as soon as I don't drink enough or take coffee daily, problems come back)

If I sometimes feel this fatigue is coming on, I'll start chug down mineral water, this shakes something up in my gut, then bowel movement, then fine.
Those lifestyle changes above also seemed to fix my "standing intolerance" (Orthostatic intolerance, always self diagnosed, not my doctor).

Over the years, I also often had heightened uric acid levels (with pain in joints/bones/whatever) which I think are just correlated with dehydration (and alcohol consumption, I stopped alcohol in february already).

I restarted SJW (St. John's Wort) because I'm curious about the potential it has for drive/motivation in general and also for POIS)

TODO: I'll link to the relevant threads here in the forum as most of the ideas I got from the forum here
EDIT: Of course magnesium helps too, daily mangesium in low dose should be good..