Post Orgasmic Illness Syndrome (P.O.I.S.)
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+  Post Orgasmic Illness Syndrome (P.O.I.S.)
|-+  POIS Cause/Treatment Discussions
| |-+  Hormonal Causes and Treatments
| | |-+  Low cortisole
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: Low cortisole  ( 709 )
BoneBroth
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« #15 : July 12, 2019, 05:59:12 AM »

See also part 2 of Dr Hertoghes article in Townsend letter with suggestions on how to increase cortisol leveles, naturally and with cortisol supplementation:
https://www.thetownsendletter.com/4156-cortisol-deficiency-hertoghe-dhea-treatment

Frequency analysis techniques (like QRMA) has been invaluable in the evaluation of my body's condition and treatment. It's freaking Star Trek man! Make a test and put your results here if If you can!
Muon
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« #16 : July 12, 2019, 08:31:55 AM »

There is no evidence of low cortisol in poisers.
demografx
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« #17 : July 12, 2019, 09:02:51 AM »

Wow. Where does that come from, Muon?

10 years of major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.
Muon
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« #18 : July 12, 2019, 09:37:30 AM »

Wow. Where does that come from, Muon?
What do you mean? I have said that because there are a bunch of members who have been tested for cortisol. A few of them have slightly elevated levels instead of low but not sufficient in numbers to make the link with POIS.
« : July 12, 2019, 09:46:39 AM Muon »
Vandemolen
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« #19 : July 12, 2019, 07:55:17 PM »

My cortisol has been checked twice. Both times it was way too high.

POIS since 2000. Very bad since 2008. I knew that I have POIS since June 2010. Desensitization since March 2011. I stopped with desens in July 2016. I have 50% less POIS. And only 1 day of POIS. Purified CBD works for me, but I am allergic for CBD.
demografx
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« #20 : July 12, 2019, 09:35:57 PM »

Wow. Where does that come from, Muon?
What do you mean? I have said that because there are a bunch of members who have been tested for cortisol. A few of them have slightly elevated levels instead of low but not sufficient in numbers to make the link with POIS.
Don’t take it wrong. I was surprised w/your statement. Then curious what you based it on. Thx for explaining, I hadn’t kept up with cortisol info here.
« : July 13, 2019, 06:12:20 AM demografx »

10 years of major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.
Muon
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« #21 : July 13, 2019, 06:18:29 AM »

No problem Demografx.
BoneBroth
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« #22 : July 14, 2019, 06:33:10 AM »

I don't think that you got my point. During POIS there is an secretion of inflammatory substances (probably hormones). And when the body is inflamed the cortisol level will go up to restore the body to a non-inflammatory state. Hence you might (in best case) have a higher cortisol level when tested during a POIS week or more. However not hight enougt! During all stresses the cortisol levels skyrock to battle the inflammation. The extra storage of cortisol in the adrenals might not be hight enought in POIS'ers and thats why they are suffering in the inflammation state for so long time. There is not enought cortisol storage in the adrenal glands and they cannot produce enought of it on-the-fly! Thats why some POIS'ers get better when they eat a lot of eggs (upp to 10 a day or more)  - eggs (raw or softboiled) is one of the best sources for the raw material for making cortisol - fat and protein! And those who get better with hard exercise that is good for long term adrenal function and cortisol levels, and those who meditate (also good for cortisol levels), and even those who make it out with coffee that increases the cortisol (though coffee could weaken the adrenals in the long term) etcetera. Dr Hertoghe sais that you can even make a flu dissapear when taking cortisol supplements on the first signs of breakout. He also emphasis that cortisol must be secreted (or supplemented) together with equal amounts of DHEA not to cause damage. Have anyone tryed taking cortisol supplements during POIS?
« : July 15, 2019, 09:33:00 AM BoneBroth »

Frequency analysis techniques (like QRMA) has been invaluable in the evaluation of my body's condition and treatment. It's freaking Star Trek man! Make a test and put your results here if If you can!
swell
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« #23 : July 14, 2019, 02:40:06 PM »

Your post is intriguing, I tend to agree.  This has been my observation that most folks (including careless docs) confuse hormonal levels as high and low while not realizing that their conclusion might be the opposite from actual situation/truth.  For e.g. cholesterol and healthy fats, are the mother of all hormones, and just because they are "associated" with diseases does not mean cholesterol is bad and  fats.  In fact truth might be the exact opposite.

I don't think that you got my point. During POIS there is an secretion of inflammatory substances (probably hormones). And when the body is inflamed the cortisol level will go up to restore the body to a non-imflammatory state. Hence you might (in best case) have a higher cortisol level when tested during a POIS week or more. However not hight enougt! During all stresses the cortisol levels skyrock to battle the inflammation. The extra storage of cortisol in the adrenals might not be hight enought in POIS'ers and thats why they are suffering in the inflammatgion state for so long time. There is not enought cortisol! No punch in the adrenal glands! Thats why some POIS'ers get better when they eat a lot of eggs (upp to 10 a day day or more)  - eggs is one of the best sources for the raw material for making cortisol - fat and protein! And those who get better with hard exercise that is good for long term adrenal function and cortisol levels, and those who meditate (also good for cortisol levels), and even those who make it out with coffee that increases the cortisol (though coffee could weaken the adrenals in the long term) etcetera. Dr Hertoghe sais that you can even make a flu dissapear when taking cortisol supplements on the first signs of breakout. He also emphasis that cortisol must be secreted (or supplemented) together with equal amounts of DHEA not to cause damage. Have anyone tryed taking cortisol supplements during POIS?
BoneBroth
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« #24 : July 15, 2019, 09:24:03 AM »

The claim that dietary colesterol is bad for health is since long scientifically debunked (though yet too many doctors hold on to old school science). Cholesterol is essential for health (specific hormon production) in a western-standard-lifestyle (human fruitivores might though get a long with minimum cholesterol since their metabolism is optimized to use the little they get from fruits, which might be the most optimal human diet, provided the fruits are grown in mineral rich soils and do not contain pesticides)! It is the opposite. Cholesterol lowering drugs are causing more heart attacks then they are preventing. Its not the cholesterol that damage the blood vessels, it's the inflammation that is caused by wrong diet - too much carbohydrates/sugar and to little antioxidants (mainly vitamin C). Arteriosclerosis is bascically old classic scurvy (in an early state) inside your blood vessels! Cholesterol is the bodys bandage-for-the-wounds. Finally the bandage becomes too thick and then the bandage got the blame instead of the cause of the underlaying wound. Stupid doctors!

Anyway this low-colesterol theory might only explain the effects of POIS and what to do to relieve symptoms, not why it started from the beginning. Even if our adrenals are "live and kicking", pumping out huge amounts of cortisol (and the simultaneous important anabolic hormones like DHEA) to keep inflammation down, there is still a continus tearing battle in our bodies between the effects of inflammatory and non-inflammatory substances, and that might be hard on the body in the long run.

So how do we test this? Well for you who live in USA it's easy. Cortisol is an over-the-counter drug with amounts similar to Dr Hertoghes recommendations (read carefully his advice on how to safe administer orally cortisol in his articles above). For us who live in Europe it might be harder. Here cortisol is a prescription drug and I have to import it. I dont know if it will be seized in customs! Just applying his advice on how to naturally increase the cortisol levels might do some good but does not seem to be enought for most people.
   
« : July 15, 2019, 09:56:18 AM BoneBroth »

Frequency analysis techniques (like QRMA) has been invaluable in the evaluation of my body's condition and treatment. It's freaking Star Trek man! Make a test and put your results here if If you can!
Muon
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« #25 : July 15, 2019, 10:14:34 AM »

My brother got elevated Lp-PLA2 activity which is related to Atherosclerosis/endothelial inflammation. POIS might invoke an inflammatory response in the endothelium. Other molecules that can be investigated are ICAM, VCAM, selectins, Heparanase and more.

First step is to find a (inflammatory) marker in POIS. This probably isn't a cause but you can work your way backwards. We can organize group testing for a bunch of parameters. The only thing you will need is money. Testkits cost 500 to a few thousand dollars and these have room for multiple samples per patient. It can be done.
demografx
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« #26 : July 15, 2019, 11:51:16 AM »

Thanks, BoneBroth

10 years of major POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks associated with it.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.
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