Castration, why did it work

[Nas]

I think there is a reaction happening between surface tissue in the genitourinary system and fluids from the cowper glands/seminal vesicles . The body might be in an abnormal state that causes this interaction. He probably got rid of the symptoms because the fluid cannot reach that particular area of tissue anymore. I suspect his body is still in an abnormal state even if he doesn't experience any symptoms. I wouldn't be surprised when he tests positive for a POIS biomarker (when one is discovered).

Based on what are you saying that? I mean what made you reach this conclusion; other than just assuming auto-immunity?

[Nas]

Dry ejaculation means it's spermless right? Cause I also know ejaculation means no semenal fluid at all.

Just re-emphasizing this question

[Muon]

Based on what are you saying that? I mean what made you reach this conclusion; other than just assuming auto-immunity?

I'm not concluding, I'm speculating. Based on the fact I get POIS symptoms from release of pre-ejaculate.

[Nas]

I'm not concluding, I'm speculating. Based on the fact I get POIS symptoms from release of pre-ejaculate.

Ok, well can you explain further on your speculation?

[Muon]

I'm not concluding, I'm speculating. Based on the fact I get POIS symptoms from release of pre-ejaculate.

Ok, well can you explain further on your speculation?

He still got orgasms right? But no POIS symptoms. So does this mean orgasm isn't involved in POIS? Does this take arousal also out of the question? I get symptoms from my pre-ejaculate but this is always accompanied by arousal. Now when I hear his story, I assume he is still aroused during sexual activity but no POIS symptoms present. So this might take arousal out of the picture if you translate his problem to mine. So the trigger (but probably not the cause) must be ejaculatory/contact based. I think the trigger is a consequence of a cause, some kind of state where the body is in.

[demografx]

Thanks, Muon

[Nas]

He still got orgasms right? But no POIS symptoms. So does this mean orgasm isn't involved in POIS? Does this take arousal also out of the question? I get symptoms from my pre-ejaculate but this is always accompanied by arousal. Now when I hear his story, I assume he is still aroused during sexual activity but no POIS symptoms present. So this might take arousal out of the picture if you translate his problem to mine. So the trigger (but probably not the cause) must be ejaculatory/contact based. I think the trigger is a consequence of a cause, some kind of state where the body is in.

Yes, well, that's why I thought at first it's the prostatic fluid that is auto-immunogenic, I think we need inflammation test before and after arousal to see if prostate gets attacked when aroused. But since he removed his testicles - correct? - this might suggest that his case is auto-immunity towards sperms - or any other type of immune response we need anti-bodies proof for that.
So yes, orgasm is not involved ( in his case).
A really simple bio-marker would be anti-body for semen/sperms related to POIS, which hopefully the current research team shall tackle.

[Muon]

Thanks, Muon

No problem 

[Limejuice]

Thank you Demo for touching with Animus. It’s interesting to hear that he feels good after all these years. Happy for the guy!

[demografx]

Thanks, Limejuice!

Dry ejaculation studied further as a POIS cure just *might* help us unlock some of the mysterious secrets of this scourge. At least for some POISers.

I might be wrong, but few things that we’ve explored here have gotten me this hopeful!

[Nas]

The more we have concrete facts about POIS the more we get closer to the truth. I'll be looking forward to what the research team thinks about this particular finding.

[Animus]

I think most of us have seen the YouTube clip where an American architect underwent castration and also took testosterone supplements and this cured his POIS

why did this work?

Hi everyone,
I heard the group was curious about a follow-up from my "Animus solution" haha. from 2009. 
Demo, and Quantum, you guys are doing a great job on here. and I really like the quality of dialogue.
Thanks to Demo for making this happen!
I just re-watched that video from 10 years ago, and that date at the end with the girl, they told me to tell her everything about my illness... so it's a little embarrassing to watch that. Because I would not say things in the same manner again.!.. haha.
I think 10 years on, I am looking back, and I am truly grateful that my troubles are over.
To be honest, hearing from Demo this morning, really made my day. Because I realized what a huge Win this was in overcoming it... so it really made my day, that I could follow up with the community.

[Nas]

Hi everyone,
I heard the group was curious about a follow-up from my "Animus solution" haha. from 2009. 
Demo, and Quantum, you guys are doing a great job on here. and I really like the quality of dialogue.
Thanks to Demo for making this happen!
I just re-watched that video from 10 years ago, and that date at the end with the girl, they told me to tell her everything about my illness... so it's a little embarrassing to watch that. Because I would not say things in the same manner again.!.. haha.
I think 10 years on, I am looking back, and I am truly grateful that my troubles are over.
To be honest, hearing from Demo this morning, really made my day. Because I realized what a huge Win this was in overcoming it... so it really made my day, that I could follow up with the community.  POIS is like a brotherhood among us, that we all know.

Congratulations, I wish you the best and thank you for letting us know that the method worked for you.

Just a tiny question Animus, you only removed the testicles right?

[Animus]

I think Quantum summed up my background very well.  Very accurately and scientifically.

I apologize, but won't be able to take part on this thread on a daily basis, as my business is very busy right now.

But briefly, Yes,
The surgeries removed both Testicles. Removed the Seminal Vesicles. Surgically reduced the Prostate, but left it in.  Cowper's gland was also left in on recommendation of my Doctor. Because the amount of semen the Cowper's produces is very fractional, small.. and he felt it would be also good just to have some lubrication of the urethra. 

I started on a weekly dose of Testosterone replacement.  Because of many things, but mainly because one can get depressed, lose muscle mass, etc. when you are low T... And I also still wanted to have sex every now and then.

Other than that- I take Avodart to further reduce my Prostate.
I think I did a "pie-chart" once for the group, showing the different components of Semen
(which includes Sperm from the Testicles, and  other ejaculatory fluids from the Seminal Vesicles, Prostate, Cowper's...
Now, this is a Pie chart that I made through my own research at the time... so please don't cite it as any official chart.!

[demografx]

Animus...you’re here!!!

Yay!!!!!!

[Nas]

Thank you Animus.
Unfortunately that doesn't let us pinpoint which part of the genitourinary tract is the auto-immunogenic substance producer. But overall it confirms the role of Ejaculation, rather than Orgasm, as the cause of your POIS.
Further investigation built on your finding can be fruitful to combat POIS.

[demografx]

To be honest, hearing from Demo this morning, really made my day.

Animus, it was most definitely mutual!

[Animus]

Yes, I am actually wondering on your reply, there, Nas... because you reference the auto-immunologic theory, which was proposed first by Dr. Waldinger., I think?  Yes, I'm familiar with that.  I heard that theory has many problems though... so I would not assume it's the correct one!.. I know, I for one, never really felt right about that theory.
Because I have Allergies, and POIS never ever felt like an Allergy to me. Also his skin prick tests were inconclusive. ( no allergic reaction).
So to start- I'd reconsider that line of investigation.

My "Theory" I guess you could say...
was just very centered on fluid loss. I felt that the cause of POIS had to do with Semen loss.  I found that it generally takes 7 days to reproduce the semen that is ejaculated during sex.  And my POIS would last about 7 days. 
I surmised that the body reaction to semen loss is to go into semen production again.. and it was perhaps the semen production that Threw my Body into a terrible state, into a sort of Shock, and Depletion of energy.

So I sought to totally eliminate Semen production, and achieve a dry-ejaculation.  And that required the surgical removal of those organs.  Now orgasm is just as sexually fulfilling, actually, but without the POIS after.

[demografx]

Demo, and Quantum, you guys are doing a great job on here. and I really like the quality of dialogue.

Thanks to Demo for making this happen!

Thank you so very much, Animus!

Your incredibly brave contributions to the community will be a major hallmark when  The History Of POIS is finally written!

[Nas]

Very interesting theory Animus, never heard of it, might deserve an investigation.

So about your criticism of Waldinger's theory, you're 100% right, he needed to do more to have a concrete proof of auto-immunity, instead we only ended up with a theory with little facts.
Note however that auto-immunity is not allergy, these two are different.
Speaking of my case, auto-immunity strikes me as very likely, because of many facts about my POIS. One: Each time I have Ejaculation I get my whole groin region on fire, and my urethra becomes incredibly inflamed. Two: Dexamethasone; an immuno-supressant; is the only thing that helps me with relief from POIS. Based on these I think auto-immunity is highly likely.

Thanks again for your time Animus, glad we heard from you.