POIS treatment: theory & supplement stack

[Rinat]

  1.thanks for your answer, Quantum. I used to take benfotiamine with thiamine, and there were no such symptoms. In addition, another symptom was pain in the upper back, around the neck. But gradually the symptoms go away. The main symptom is pain in the heart, a quick pulse, it scares me, because I think it's dangerous.
    2.I feel good after Sam (good brain work and good mood) .I take it while in a day (so that there is no overdose). But I took it in the evening on the same day with benfotiaminom (Maybe it influenced).The first time I took it without vitamins b, and felt fragility in the bones. But then with vitamin b it was better.
   3.  Also, omega-3 is good for me. My acne almost go away with it, and better mood. But it's expensive for me, so I stopped taking it.
   4.Tmg seemed first good for me. (better ability to talk) But then there was pain in the bones, dull hair and weight loss.
   5. I still take Vitamin d3, it seems good
   What can you advise from acne?)

[Rinat]

Will vitamin E help with acne?(if omega helped)?

[swell]

Hello everyone, very interested to know what works for others here am going to read through here.  I try various vitamins to treat my pois, going to list below as you may can tell me what may causing me issue.  Recently I notice my face puffing up, skin on cheeks hardening up, and just something inside trapped within skin and surface showing some uneven patches.  Like even when I move my fingers across face I can tell there is even different sensation to skin and it feels wood like, though wife says it not too obvious.  Yesterday I stop L-Citrulline to see if it may be causing it though still cannot figure out. You think my current symptom is allergy?     
Benfotiamine 150mg, Alpha Lipoic Acid 300mg, Asgwaghandha Root powder 1200mg with 5mg Black Pepper, L-Citrulline 750mg, L-Lysine 500mg

[Vandemolen]

Will vitamin E help with acne?(if omega helped)?

I don’t think mature POIS-patients have acne. I think we have Pityrosporum folliculitis. Chevk this topic:
http://poiscenter.com/forums/index.php?topic=2612.msg22755#msg22755

[Quantum]

Hello everyone, very interested to know what works for others here am going to read through here.  I try various vitamins to treat my pois, going to list below as you may can tell me what may causing me issue.  Recently I notice my face puffing up, skin on cheeks hardening up, and just something inside trapped within skin and surface showing some uneven patches.  Like even when I move my fingers across face I can tell there is even different sensation to skin and it feels wood like, though wife says it not too obvious.  Yesterday I stop L-Citrulline to see if it may be causing it though still cannot figure out. You think my current symptom is allergy?     
Benfotiamine 150mg, Alpha Lipoic Acid 300mg, Asgwaghandha Root powder 1200mg with 5mg Black Pepper, L-Citrulline 750mg, L-Lysine 500mg

Hi Swell, and welcome on the forum.

I cannot tell which one of your supplements is causing this skin reaction, but if try to eliminate them one at a time, you should be able to identify which one is the culprit.

[demografx]

Hi, swell, welcome to POISCenter!

[Rinat]

Hi all!
Yesterday I tried to use SAM-e and vitamins b. In general, the condition was good, but there was a pain in the heart. Then I decided to use TMG, and it seems the pain is gone. Today I again used vitamin B, only without SAM-e, in the morning I still felt a pain in my heart, I again took 500 mg of TMG and it seems better Now I plan to take bi-daily SAM-E(200 vu), every day vitamin B (3 mg b6, 2.5 mg thiamine, 4.5 mg b12, 300 mg glycine), and TMG (500 mg).(Also vitamin D3 and omega-3, (EPA-250 mg,because it's expensive:)).
. I plan to use  Quantum's pre-pack befor the O.. I also limit sugar.

[romies]

Will vitamin E help with acne?(if omega helped)?

I don’t think mature POIS-patients have acne. I think we have Pityrosporum folliculitis. Chevk this topic:
http://poiscenter.com/forums/index.php?topic=2612.msg22755#msg22755

As you mentioned in the other post, Pityrosporum folliculitis can be treated with Nizoral Shampoo.

[swell]

Thank you quantum.   I stopped L-cit and Asgwagh. and think now swelling to be gone.   Will soon re add Asgwagh. to see if it was L-cit for my trouble as I suspect that to be.

Hello everyone, very interested to know what works for others here am going to read through here.  I try various vitamins to treat my pois, going to list below as you may can tell me what may causing me issue.  Recently I notice my face puffing up, skin on cheeks hardening up, and just something inside trapped within skin and surface showing some uneven patches.  Like even when I move my fingers across face I can tell there is even different sensation to skin and it feels wood like, though wife says it not too obvious.  Yesterday I stop L-Citrulline to see if it may be causing it though still cannot figure out. You think my current symptom is allergy?     
Benfotiamine 150mg, Alpha Lipoic Acid 300mg, Asgwaghandha Root powder 1200mg with 5mg Black Pepper, L-Citrulline 750mg, L-Lysine 500mg

Hi Swell, and welcome on the forum.

I cannot tell which one of your supplements is causing this skin reaction, but if try to eliminate them one at a time, you should be able to identify which one is the culprit.

[swell]

Thank you demografx.  Lots good material here.

Hi, swell, welcome to POISCenter!

[nanna1]

This post is about theory. Below is a diagram showing the central role that NF-kB (NF-kappaBeta) plays in inflammation. Don't worry about trying to understand all the complicated arrows.

• Region 1 (above the top dashed-line) shows initiators of inflammation (TNF, IL-1, bacterial antigen, virus, etc...).
• Region 2 (below the top dashed-line) shows the NF-kB activator (IKK-alpha, IKK-beta, IKK-gamma) (3 red rectangles).
• Region 3 shows a bunch of biochemistry with activated NF-kB.
• Region 4 (below the bottom dotted-line) shows the genetic up-regulation of Oxidative enzymes (COX, LOX, TDO, IDO, KMO, iNOS, etc...) by NF-kB.

Oxidative enzymes are responsible for inflammation (oxidative stress, allergy, depression, DNA damage, asthma, aging, and other inflammatory diseases). The oxidative enzymes are not shown in the below image.

In the above diagram (Region 1), IL-1 is just representative of the inflammatory class of cytokines (IL-6, IL-8, etc...). All of the inflammatory cytokines activate NF-kB. The anti-inflammatory cytokines (i.e. IL-10) inhibit NF-kB. This discussion fits into the POIS Cascade model in the following way:

[Quantum]

Hi Nanna,

Oregano, Coffee, Thyme, Clove, and Walnuts seems to Inhibit NF-?B , at cellular level  ( ref:  http://cancerpreventionresearch.aacrjournals.org/content/3/5/653 )

However, it is not clear how using these would translate in term of POIS symptoms relief.

 

[Michael218]

Nanna's stack did not seem to help me... I upped my fish oil dosage to about 10 capsules a day for over a month. (EPA 1800 mg total). SAMe. B1 (Bennfetiomine), Vitamin b's. Lecithin. Etc.
The first week using SAMe my POIS was a bit worse... oh well. Nice try.

[rakeshbaasu]

Hi Nanna,

I asked a doctor here to translate the medicines you mentioned to a prescription and below is what I got. Do you think below will give desired result

https://www.1mg.com/otc/shelcal-500-tablet-otc137210
https://www.1mg.com/otc/tetrafol-plus-tablet-otc149386
https://www.1mg.com/otc/multivite-fm-omega-capsule-otc67645

[Nas]

Hi Michael
For me, I have not committed high doses like two pills a day. But I can tell you that the pills worked as symptoms reducers rather than POIS preventers. Which is kinda disappointing given the heavy price we pay. And it also proves that no one have yet to find a universal solution.

[Vandemolen]

Nanna's stack did not seem to help me... I upped my fish oil dosage to about 10 capsules a day for over a month. (EPA 1800 mg total). SAMe. B1 (Bennfetiomine), Vitamin b's. Lecithin. Etc.
The first week using SAMe my POIS was a bit worse... oh well. Nice try.

So untill now Nanna is the only one who finds relief from Nanna’s stack? I bought all the medicines, but first I want to empty my taurine bottle. Because of an attack on my immune system I was too sick to have sexual activity, so I didn’t find out if taurine helps me. If not, I will try Nanna’s stack about a few weeks.

[Michael218]

Nope, Nanna's stack didn't seem to help at all in my case. Everyone's body and diet differ and this makes a huge difference. I believe this forum is helpful in the sense that everybody lists what helps them personally and so it leaves you in a position to try every single option and see what works for you...

There are ingredients within Nanna's stack that I am sure reduce my POIS significantly, being Vitamin B6, B1 and 12. It seems to me that most people are benefiting from high dose Vitamin B's.

Even Quantum, who does not include vitamin B's in his prepack, mentioned that Vitamin Bs helped reduce his POIS greatly from memory - correct me if wrong Q. So it seems that there are certain ingredients that are more universally helpful than others. I have no idea if fish oil is helping at all... anyway I don't eat fish so I take them happily for the omega 3. The first time I got nearly full relief from POIS I had not taken any fish oil on a daily basis, I only took it the once with prepack. So I have no idea what role if any that plays for me personally.

Quantum's prepack didn't work for me. Nanna's didn't. Yet all of us somehow benefit from Vitamin B's...

Not sure if I have any point at all or am just rambling on...

[Hopeoneday]

Hi Michael218. For me taking only 200mg SAMe lead me in horible state.
That mean this is not for me.
B vit not helping me at all, but I didnt try active b vitamines because cant get them in my country. I am ordered them to test because( kurtosis teory of genetics mutations).

My main problem is evan in apstineting period NERVE OVERSENSIBILITY, that mening evan touching and masaging lover back erea (wright up prostate erea) couse me heatrt palpilation, pelvis floar muscule cramps , asopagus muscule cramps... that afect my quality of life a lot(sewere breathing probl). This all X10 after eyaculation I barly surwive.
When I eksplane this to eny doctor, nowbody bolive me.
Only thing that help me to save my life in hard atacs are small dose of benzos.
All that lead me to i myabe hawe STIFF MAN SINDROME because good reaction on bezos. Stress and wory are bigg NO to our condition, bat that for me is imposible to manage, because i must earn mony for living.

[Quantum]

Even Quantum, who does not include vitamin B's in his prepack, mentioned that Vitamin Bs helped reduce his POIS greatly from memory - correct me if wrong Q. So it seems that there are certain ingredients that are more universally helpful than others.

....

Quantum's prepack didn't work for me. Nanna's didn't. Yet all of us somehow benefit from Vitamin B's...

Hi Michael,

I do not use B complex very often, but they are good for my energy level, if I do not take them on a regular basis.  Otherwise, the effect fades after a week or so.   I cannot comment about memory problems, since POIS does not cause me memory problems, or other cognitive problem ( but a lot of emotional problems, as well as extreme fatigue, and hypotension).

For about 2 to 3 months, you had great results with you modified pre-pack version, last year.  I have even included you in my POIS chart as reference member in the type responding to pre-pack ( around 2017-07, see http://poiscenter.com/forums/index.php?topic=2338.msg21433#msg21433).  Does it mean that, sadly, you no longer have symptoms reduction with your personal pre-pack? Or that % of relief is not at 70 anymore?  If so, anything special happened, or it just slowly has lost its effectiveness ?

[Michael218]

Hi there. Quantum, i recall you writing that B vitamins reduced your POIS a lot before you came up with your own prepack.

Fortunately my "prepack" is still very effective. It varies. But usually about 70% effective which is a huge leap. Crucially, my POIS used to be 2 days of hell. The second day was the worst. Absolute hell. Now, I basically have no second day of POIS. So there is a significant reduction on the first day, and I can count on second day being relatively normal and not distuptive to life. Huge leap.

HOPEONEDAY, it is important to mention, B vitamins only appear to be effective IF YOU TAKE THEM IRREGULARLY, NOT EVERY DAY. I wrote that in caps to stress this point. From what I conclude based on other users experience and my own, B vitamins become useless if you use them every day. No idea why, I guess immunity builds up.