Apparently testosterone exerts an inhibitory effect on mast cells, thus TRT could act as a mast cell stabilizer. See table 1 in 'The neuroendocrinology of mast cells'
Didn't we have a few poisers who were using Progesterone with succes? Take a look at the table again, it's capable of exerting an inhibitory effect on mast cells as well.
Ok now, go to the supplementary data etable1:
https://www.smoa.jsexmed.org/article/S2050-1161(18)30019-9/fulltextLook at the hormone balance. Estradiol is high which is a mast cell stimulant at the same time Testosterone is low which is an inhibitor.
The net effect favors mast cell stimulation according to table 1 and figure 1 in
'The neuroendocrinology of mast cells'.
You might generalize this by every other imbalance in the body like dysbiosis(TLR) and other immune parameters which favors mast cell stimulation. Some people tend to be more sensitive to stimuli than other people. These people have less locks to unlock before getting triggered. Now these imbalances already unlock a few locks, the stronger the imbalance, the more locks will open up thus increasing the tendency for mast cells to react on stimuli and making you more sensitive.
Mast cells support autocrine actions. They can grow receptors on themselves by their own actions. Some imbalance in the body might grow receptors on genitourinary mast cells which let them act on molecules in seminal fluid.
The long lasting POIS reaction (days to weeks) could be explained by the autocrine actions which keeps positive feedback loops or self perpetuating loops intact.
Now to think of it this might explain my short lived dampening of arousal/precum exposure symptoms by strong orgasm before hell breaks loose after ejaculation as time goes by. Each hormone might have a different concentration vs time curves, the inhibitory ones might have the upper hand at the start of orgasm interfering with genitourinary mast cell activation by ejaculation. My POIS is heavier when orgasm is weak. There is a competition going on between orgasm and ejaculation while orgasm itself could be a double edged sword.
It could all lead to the same cell type but there could be hundreds of ways.
