Post Orgasmic Illness Syndrome (P.O.I.S.)
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: dk12
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+  Post Orgasmic Illness Syndrome (P.O.I.S.)
|-+  POIS Cause/Treatment Discussions
| |-+  Hormonal Causes and Treatments
| | |-+  Mast Cells Activation Syndrome
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: Mast Cells Activation Syndrome  ( 10917 )
Nas
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« #15 : May 23, 2019, 01:11:37 PM »


Hi Nas

As per  a recent article from American Academy of Allergy, Asthma & Immunology.  mast cell diseases can only be partially  treated with current medications.
Hence your failure with therapy for MCAS may not rule out whether you have the disease or not unless you meet a immunologist for confirmation.
 
https://www.aaaai.org/global/latest-research-summaries/New-Research-from-JACI-In-Practice/mast-cells
Yes well I wasn't even partially treated; I wasn't treated at all. I think my research on MCAS and the methodology I used all conform that MCAS is not involved in my case.
Muon
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« #16 : June 29, 2019, 05:20:42 PM »

''These unique tissue immune cells are critical for allergic reactions triggered by immunoglobulin E (IgE), but are also stimulated (not activated) by immune, drug, environmental, food, infectious, and stress triggers, leading to secretion of multiple mediators often without histamine and tryptase.''

Recent advances in our understanding of mast cell activation ? or should it be mast cell mediator disorders?

''MC-hippocampal neuron interaction affects neuronal [Ca2+]i and exocytosis signaling through a NMDAR-dependent mechanism.''

Proteoglycans involved in bidirectional communication between mast cells and hippocampal neurons

Don't know where to place this but I found this one interesting as well:
''Importantly, this is the first evidence that the CAIP has a role in modulating type 2 mediated immune disorders, as it was previously only investigated in disorders characterized by innate an Th1/Th17 immune responses, therefore expanding the applicability of VNS as a therapeutic tool to an even wider range of immune disorders.''

The cholinergic tone as a modulator of Food Allergy
Nas
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« #17 : June 29, 2019, 10:03:49 PM »

I personally lean towards the hypothesis that the flu like/allergy symptoms of POIS are not based on semen auto-immunity, rather on a dysfunction in the limbic system causing a plethora of physical manifestations.
The vagus nerve is incredibly close to the limbic system.
Muon
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« #18 : June 30, 2019, 05:29:36 AM »

Here you can find publications from Dr. Theoharides which are free:

https://www.mastcellmaster.com/publications.php
Muon
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« #19 : June 30, 2019, 10:30:09 AM »

I wondered whether we could overcome the problem of bioavailability by vaporising some of the substances. Camomile, fennel and other natural herbs could be consumed this way. For example does this post (https://medium.com/cbd-origin/what-is-cbd-bioavailability-and-why-does-it-matter-69d9a2e37e6c) compare the bioavailability of CBD through digestion (4-20%), sublingual (12-35%) and vaporising (34-46%). Camomile and fennel teas already have a significant influence on my symptoms, even when taken a post medication.

I might do a trail just by inhaling both.

Does anyone have experience with vaporising substances?
https://en.wikipedia.org/wiki/Chamomile#Research

Go to the research section of that page. I'm not surprised, the main compounds are natural mast cell stabilizers.

Apigenin is a mast cell stabilizer, crosses the BBB and is abudant in Chamomile flowers:
https://en.wikipedia.org/wiki/Apigenin#Sources_in_nature

I wonder if these flowers can be vaporized and inhaled without serious side effects.
''Apigenin readily crosses the blood-brain barrier and has not demonstrated toxicity at high doses.[17] It could thus prevent amyloid beta deposition and tau phosphorylation due to neuroinflammation, which are associated with Alzheimer's disease.[17]

Are you thinking about vaporizing these flowers Jacob?
« : June 30, 2019, 10:38:37 AM Muon »
Muon
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« #20 : August 05, 2019, 12:02:18 PM »

Mast Cells in Gut and Brain and Their Potential Role as an Emerging Therapeutic Target for Neural Diseases

Describes gut-brain axis dysfunction. Introducing tryptophan producing microbiotica could be a therapeutic tool.
OpiesDad
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« #21 : August 16, 2019, 07:19:27 PM »

Guys this is it.  I would bet $100k bucks my POIS is a MAST cell activation related disorder.  I am booked to see a specialist next week.  As an aside, that linked presentation was brilliant.
Nas
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« #22 : August 16, 2019, 07:32:25 PM »

Guys this is it.  I would bet $100k bucks my POIS is a MAST cell activation related disorder.  I am booked to see a specialist next week.  As an aside, that linked presentation was brilliant.
Bet me, I'd use some of that 100k myself.
I bet you 100k it's not MCAS.
OpiesDad
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« #23 : August 16, 2019, 09:25:50 PM »

I'd need to see your proof of funds, and we'd put both in escrow, but yeah I'd bet.  :)
aswinpras06
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« #24 : August 17, 2019, 02:51:18 AM »

Hi OpiesDad

Even I am 100% sure it is mast cell activation disorder.  Only drawback is it is very complex problem only a few specialists understand and each one of us require individualised treatment.  Current biologic therapies for mast cell are promising and may soon reach mainstream medicine.  Once they are approved we can get rid of this monster.
Nas
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« #25 : August 17, 2019, 03:50:57 AM »

I'd need to see your proof of funds, and we'd put both in escrow, but yeah I'd bet.  :)
I don't have that much. Honestly if I had this amount I'd spend it on research for POIS. So if you actually have this amount why not help with research funding?
OpiesDad
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« #26 : August 18, 2019, 10:39:11 PM »

Nas, I promise when we have another research oppty I'm pitching in $$$.  In any event, I am meeting with a well regarded immunologist in LA this week who has background in mast cell conditions.  Let's pray for all of us that he takes an interest in the case and has a novel approach.....
Nas
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« #27 : August 19, 2019, 08:25:11 AM »

Nas, I promise when we have another research oppty I'm pitching in $$$.  In any event, I am meeting with a well regarded immunologist in LA this week who has background in mast cell conditions.  Let's pray for all of us that he takes an interest in the case and has a novel approach.....
An advise from me would be to spend money studying your brain chemistry. Study your brain pathways and neurotransmitters during POIS. That's in my opinion money well spent. You will need to gain access to PT/MRI for that, which will showcase changes in brain chemistry during POIS. It serves the purpose of knowing the mechanism through which POIS causes us the brain symptoms. PT/MRI is expensive so if you have money you'd do us a great service if you undertook one.
demografx
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All of us working together to defeat POIS!


« #28 : August 20, 2019, 10:48:04 AM »


...when we have another research oppty I'm pitching in $$$. 


Hello OpiesDad,

Wonderful to hear.

T H A N K   Y O U!

Demo
(on behalf of the entire Forum
and for POISers everywhere!)



« : August 21, 2019, 01:54:16 PM demografx »

10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business
aswinpras06
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« #29 : September 03, 2019, 10:14:57 PM »

Hi Nas

You've always said any mast cell medicine never worked for you,  but only Corticosteroids such as dexamethasone. Do you know that 

Corticosteroids such as dexamethasone are effective inhibitors of mast cell activation and a proven treatment for mast cell-associated diseases . In fact, it is recently found that dexamethasone inhibits not only IgE- but also IL-33-mediated mast cell function.

https://www.frontiersin.org/articles/10.3389/fimmu.2018.00868/full
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