Vitamin D, and Fatigue and Inflammation

[Quantum]

It has been shared by many members that vitamin D has been beneficial in reducing their POIS symptoms, even if it does not seem to be a complete solution on its own.
A very recent study in Italy was trying to identify the mechanism by which vitamin D reduces fatigue.  They came up with the conclusion that is it linked to vitamin D reducing oxidative stress and reduces also the production of pro-inflammatory cytokines.   A role in the control of the neurotransmitters dopamine and serotonin has also been demonstrated: an imbalance in the relationship between these two neurotransmitters is linked to the genesis of fatigue. Furthermore, vitamin D is implicated in the control of voltage-gated calcium and chloride channels.  Interesting article to dig, in my opinion:

https://www.mdpi.com/2072-6643/16/2/221

[Warrior]

I'm currently learning a tonne of interesting stuff from Chris Masterjohn Phd. In one of his masterclasses on nutrition and immunity, he talks about the importance of not only Vitamin D but also Vitamin A in immune function.

"Vitamins A and D are used up for differentiation of immune cells during infections; without them, T cells are suppressed."

Taken from Nanna1's Immune Suppresion/Immune Tolerance model of POIS:

Since, most POISers recover from POIS in the 5 to 7-day range. The time kinetics of NK, T, B cells seems to suggest that, in the absence of an immunocompetent NK response, POIS recovery is correlated with the time-dependent expansion of non-memory CD8+ T cells.

This time-dependent increase in CD8 T cells occurs during sleep (How Sleep Fights Infection: Snoozing Makes Killer Immune Cells More Sticky). So, the sooner sleep occurs following orgasm, the sooner CD8 T cells can start replacing the function of NK cells in the immune response. Moreover, sleep deprivation has been shown to suppress NK cells in humans (Ref1, Ref2, Ref3). So good sleep is vital for immune function and recovery from POIS.

Now I'm not a scientist, but connecting these two bits of information on T cells: Both Vitamin A and D are important for POIS recovery, as without them, T cells which POISers rely on according to Nanna1's theory, may be repressed.

Other quotes from his masterclass:

"Every “immune event” taxes vitamins A and D."
"Vitamin A and D are depleted during Covid."

[Muon]

Chapter 13:

THE CONCEPT OF VITAMIN D DEFICIENCY IS FLAWED: LOW BLOOD CONCENTRATIONS OF 25-D LIKELY RESULT FROM THE INFLAMMATORY DISEASE PROCESS

If true, what inflammatory mechanism is involved?

(We already have multiple Vit D threads running, I don't see why we need another one)

[quiteQuiet]

I always noticed that in the summer a pois episode was often not as long provided I force myself to go outside, take a walk/stand in direct sunlight every day for atleast 20 minutes. It has such a good effect on me - sometimes people are wondering why I'm chasing the sunshine.
I never knew why that is. So thanks for the post!