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a1-adrenergic antagonists act as 6-nitrodopamine receptor antagonists in vas def
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Topic: a1-adrenergic antagonists act as 6-nitrodopamine receptor antagonists in vas def (Read 2514 times)
Muon
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Posts: 3084
a1-adrenergic antagonists act as 6-nitrodopamine receptor antagonists in vas def
«
on:
October 13, 2023, 02:33:49 PM »
Not a POIS article but it gives a better insight into how this medicine works. The blocking of ejaculation by Silodosin itself probably prevents POIS in individuals instead of the way/mechanism of blocking, but the new info might be helpful, you never know.
Alpha1-adrenergic antagonists act as 6-nitrodopamine receptor antagonists in the human vas deferens
(2023)
"
Discussion and conclusion
: The results indicate that 6-ND plays a major role in the human vas deferens contractility and doxazosin, tamsulosin, prazosin and silodosin cause ejaculation disorders in man
by blocking the 6-ND receptor rather than a1-adrenoceptors.
"
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Muon
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Posts: 3084
Re: a1-adrenergic antagonists act as 6-nitrodopamine receptor antagonists in vas def
«
Reply #1 on:
March 15, 2024, 12:09:00 PM »
Post orgasmic illness syndrome: a review
(Odusanya, 2024)
Alpha blockers I think are based on Silodosin. The 6-nitrodopamine receptor is responsible for blocking ejaculate according to the latest research.
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demografx
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All of us working together to defeat POIS!
Re: a1-adrenergic antagonists act as 6-nitrodopamine receptor antagonists in vas def
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Reply #2 on:
March 15, 2024, 01:32:54 PM »
Muon, thanks for adding the nature.com graphics for the POIS Review.
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10 years of significant POIS-reduction, treatment consisting of weekly (52 weeks/year) testosterone self-injections.
TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.
40+ years of severe 4-days-POIS, married, raised a family, started/ran a business.
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a1-adrenergic antagonists act as 6-nitrodopamine receptor antagonists in vas def