Author Topic: a1-adrenergic antagonists act as 6-nitrodopamine receptor antagonists in vas def  (Read 1973 times)

Muon

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Not a POIS article but it gives a better insight into how this medicine works. The blocking of ejaculation by Silodosin itself probably prevents POIS in individuals instead of the way/mechanism of blocking, but the new info might be helpful, you never know.

Alpha1-adrenergic antagonists act as 6-nitrodopamine receptor antagonists in the human vas deferens (2023)

"Discussion and conclusion: The results indicate that 6-ND plays a major role in the human vas deferens contractility and doxazosin, tamsulosin, prazosin and silodosin cause ejaculation disorders in man by blocking the 6-ND receptor rather than a1-adrenoceptors."

Muon

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Post orgasmic illness syndrome: a review (Odusanya, 2024)



Alpha blockers I think are based on Silodosin. The 6-nitrodopamine receptor is responsible for blocking ejaculate according to the latest research.

demografx

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Muon, thanks for adding the nature.com graphics for the POIS Review.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business