a1-adrenergic antagonists act as 6-nitrodopamine receptor antagonists in vas def

[Muon]

Not a POIS article but it gives a better insight into how this medicine works. The blocking of ejaculation by Silodosin itself probably prevents POIS in individuals instead of the way/mechanism of blocking, but the new info might be helpful, you never know.

Alpha1-adrenergic antagonists act as 6-nitrodopamine receptor antagonists in the human vas deferens (2023)

"Discussion and conclusion: The results indicate that 6-ND plays a major role in the human vas deferens contractility and doxazosin, tamsulosin, prazosin and silodosin cause ejaculation disorders in man by blocking the 6-ND receptor rather than a1-adrenoceptors."

[Muon]

Post orgasmic illness syndrome: a review (Odusanya, 2024)



Alpha blockers I think are based on Silodosin. The 6-nitrodopamine receptor is responsible for blocking ejaculate according to the latest research.

[demografx]

Muon, thanks for adding the nature.com graphics for the POIS Review.