Warrior's Journal (My POIS Protocol)

[Warrior]

Correct me if I'm wrong but according to Nanna1's theory, your animal-based approach should not improve your POIS (Arachidonic acid).

Yes that’s correct.

From what I’ve read from Nanna1 I do not believe he had the same degree of food sensitivities that I do, rather he had exercise intolerance (from my memory). Who knows tho - I doubt he would have ever tried a diet that is so low in plant foods. He did abide by a gluten-free vegan diet though.

My animal-based diet without a doubt improved my POIS dramatically because of removing the plant foods that I am sensitive to (as part of my POIS condition.)

The arachidonic acid (AA) part is super interesting, but I’m not sure if he got the entire picture of the EPA/AA part. When I first began his method, it was extremely effective and I was still eating adequate amounts of animal foods - lots of beef, eggs, and dairy and therefore high amounts of AA. This was all off the back of many months being on an animal-based diet as well. I believe that the reason the method worked very effectively initially is because I kept my omega-6 consumption pretty much close to zero for many months before beginning his method. My Omega-3 would have been at a very solid level. Then I began eating foods higher in omega-6 and this seems to correspond with the method becoming less effective. I could be wrong though, this is just my bro science theory.

For clarification during my animal-based diet - I ate strictly red meat from Australia which is predominantly grass fed (which should in theory contain higher Omega-3) and sardines (high in Omega-3). I also ate a lot of dairy (I believe most dairy in Australia is mostly grass-fed). I also ate regular free-range eggs, which would have contained a bit of omega-6. All these foods contain decent amounts of the omega-6 AA Nanna1 talks about being very inflammatory in the context of his POIS theory.

From my imperfect memory of scrolling through a lot of his messages and theories, his understanding of EPA/AA seemed to be a developing learning. He later on introduced the CLA and believed that allowed him to not require as much EPA for the method.

[Warrior]

I have discovered why Nanna1's method stopped working for me: vitamin D3

I went from taking 14,000iu/d (2x 7000iu per capsule LifeExtension) to virtually zero: 2000iu/d (2x SuperNutrition 1000iu per capsule). The LifeExtension brand contains extra virgin olive oil, I assume to increase the absorption of D3 if you don't take it with a fatty meal. The SuperNutrition contains no fat, meaning you must take it with a fatty meal for absorption. 90% of the time I was taking it on an empty stomach. So my D3 levels plummeted significantly. I also now work in a warehouse and live in the city, so don't get much sunlight compared to a year ago where I was working outside and lived in a more urban environment. As soon as I began supplementing the D3, I noticed a significant improvement in mood and the effectiveness of the method. I am smashing between 20,000-30,000iu/d. Will taper to 3000-10,000iu/d eventually. 25mcg K2/1000 D3.

This slipped completely under the radar! Glad I found the issue.

What's interesting is that, this final ingredient of D3 is essentially clearing up my POIS food sensitivities (as per Nanna1s method). It must be working in synergy with the other Nanna1 supplements as when I was on my animal-based method, my D3 was very high (I even got it tested - I was out in the sun all day everyday) CHECK EDIT. My D3 was actually in hindsight looking at my bloodwork from this time period, D3 was actually relatively low. Check edit below.

My original B complex is also working again (the one where they reduced certain ingredients). Low D3 was clearly making it unpleasant.

Edit: I should say the method is working again, but is still a bit patchy. Sometimes I will experience waves of anxiety and anhedonia. A bit difficult to describe, but it's certainly working 80-90%... Hopefully it will improve as my D3 levels improve.

EDIT 14/05/24 - My D3 back then actually wasn't very high, but was in what would be considered ok/normal range. But I would not consider it optimal range, no where near 'high' range. It was 79 nmol/L (22 ng/mL)... very much on the lower end, which would be completely ill advised against for someone with immune inflammatory issues you would think.

[Muon]

Vitamin D resistance?

Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol: https://www.frontiersin.org/articles/10.3389/fimmu.2021.655739/full

[Warrior]

Vitamin D resistance?

Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol: https://www.frontiersin.org/articles/10.3389/fimmu.2021.655739/full

Interesting, thanks for sharing

[Thomas]

Glad you found the issue with the stack. Just be careful with high dose of vitamin D, it can leads to hypercalcemia and kidney stones : https://www.healthline.com/health-news/too-much-vitamin-d-can-lead-to-kidney-failure

I believe the solution is to take k2 vitamin in synergy, but i'm not 100% sure and I don't know the dosage.

[Warrior]

I have identified a 2nd major reason why Nanna1s method stopped working for me: SAM-e quality/dosage/tolerance

For context, adding back the D3 improved the method to around 80-90%, but still wasn't perfect until I made the following adjustment:

I just started taking another brand of SAM-e as my old Jarrows brand ran out. Upon taking this new brand, I felt an immediate improvement in symptoms. It's supposedly the same dose as the Jarrow's I was taking (200mg active from 400mg total per pill). The brand is NutraLife, and is a high quality reputable brand. After taking 1 pill from this new brand, I felt exactly how I felt in that first month of the method working. Sensitivities went away like magic.

I also distinctively remember the pills in the Jarrows box sticking to the plastic, which is probably indicative of melting/heat exposure, which is known to degrade SAM-e. So it's possible the quality from this batch had been diminished from heat exposure. Either that or, it's possible I'm absorbing this new brand better and getting a slightly higher amount of SAM-e. This morning when I took the SAM-e on an empty stomach (along with B complex and choline) I felt like I still could have used more SAM-e. This afternoon I decided to take 2x 200mg active SAM-e, but 30 minutes spaced apart so I could observe the effects of each dosage. And sure enough, after the first dose, which was my 2nd total for the day, again felt like I could use another. So I dosed the 3rd and sure enough felt incredible again. So more than likely a tolerance is building to the SAM-e. This is the first time I've gone over 400mg of active SAM-e per day. Some people dose as high as 1600mg/day.

From reading through Nanna1s messages, he cycled the SAM-e/POIS Cascade stack. For me, this isnt preferable as the SAM-e (POIS Cascade Stack) takes away my food sensitivities as well as POIS. He does say in his theory that each one of us, given our unique genetic breakdown, will have a different mixture of symptoms alongside POIS. Sounds like he probably didn't have too many food sensitivities like I do, and yet, our cure/root cause appears to be extremely similar as per his theory. From memory, he had exercise intolerance, which I do not. Given that he most likely cycled the SAM-e, this would have broken up any tolerance that built for him, allowing him to keep his dosage relatively low (200mg active twice a day).

Hi Nas,

  That's awesome you are seeing results. Keep listening to your body to see what works best for you. I take around 1800mg omega-3 EPA and 2000IU of D3 per day and on orgasms days I usually take 2 x 200mg of SAM-e (400mg). To save money, I have started taking alphaGPC, SAM-e and B1 only on orgasm days. Cutting the stack when you don't need it sounds like a useful strategy to guard against any tolerance that might develop to SAM-e. Thanks for sharing that part  . B6 should also help prevent tolerance to SAM-e.

  I'm cautious about pausing and resuming omega-3 and D3 since they take days to fully build up in the body. So for me, I always take those two supplements.

  In a new development on my side, I have started experimenting with tocotrienols which are rare forms of vitamin E. I did a post about it. It just came in two days ago and subjectively today have noticed more creativity and quickness in my thoughts. And also I feel more resilient to stress. Not much worries me. I'm not entirely sure this is due to the tocotrienols since it has only been two days, but my ultimate goal is to replace/eliminate/reduce the three most expensive parts of the stack (SAM-e/alphaGPC/omega-3). This is not something I would suggest others do. I'm more curious to see if I can reduce the number of pills I take (and save some money).

Heres some tolerance information from PsychonautWiki on SAM-e:

Tolerance and addiction potential
SAM-e is not habit-forming with a low potential for abuse. It does not seem to be capable of causing psychological or physiological dependence among users.

Tolerance to many of the effects of S-adenosyl methionine develops over several weeks of prolonged and repeated use. This results in users having to administer increasingly larger doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption).

Moving forward I am going to continue to investigate the SAM-e component of the method, specifically tolerance, bioavailability/absorption on empty stomach & whether this is effected by orange juice versus water, SAMe brand quality, and tolerance cycling. It may be that I need to cycle Nanna1s method (specifically the SAM-e) with my animal-based method for the SAM-e to work long-term. I.e., take SAM-e for month straight, enjoy normal diet, then take 2 week tolerance break & jump back on animal-based while tolerance resets, etc.

With all this being said, I dont believe the Omega-3 to Omega-6 ratio has impacted the effectiveness of the method, like I initially thought. So far I havent seen or felt any evidence of that. I still try to keep my ratio in Omega-3 balance regardless. The one thing I'm learning with this method is attention to details is important lol

[Frank]

Hi Warrior.

SAM-e is temperature sensitive as you've already discovered. Fortunately in Australia we have a brand available to us that uses refrigeration for transport and storage of some medicines, including SAM-e.

BioCeuticals NuroSAMe Plus Tablets

You can get it from some Chemist Warehouses and will need to ask a pharmacist to get it out of the fridge. It's not the most cost friendly option, but to have a bit more of a guarantee of efficacy is what swayed me.

I will use this until I dive deeper into the other methylation problems which seems a lot cheaper to manage than the more direct SAM-e route.

[Warrior]

Update on Nanna1s protocol:

I still haven't been able to get Nanna1s POIS Cascade working like it was in that initial month. Supplementing D3 & Omega3, and higher doses of SAM-e has certainly helped, but isn't working at 100% like it was. I think more than likely its a tolerance to SAM-e. I am going to continue the protocol alongside my animal-based diet & original method, and then in about 25 days time, reintroduce some non animal-based foods and see if there is a reaction. If I get a reaction, this will prove to me that more than likely its a tolerance to SAM-e, as by that time my Omega-3 and D3 levels (which are fat soluable & take time to build up) should be well and truly at solid levels again by then. I will then take a break from the SAM-e (at least 2 weeks) and see if its effective again. Perhaps it must be used exclusively for releasing days to prevent tolerance.

Regardless, it’s a huge breakthrough, and I am going to be bringing this fresh information to my functional medicine specialist at my next appointment. I am going to get him to read through Nanna1s theory.

In addition to all of this, I have begun Nanna1’s immune therapy competence. Specifically the immune activation part. I believe this, at the very least some variation of this process, targeting the immune system & viral/bacteria/infection element is key to curing this bitch.

[Hopeoneday]

Yes, according to nana1, he was "premanently cured" by
immune stimulating protocoll. Who knows, maybe this will work for you
to, if you dont try you will newer know.

About sam-e, what about creatine use insted of sam-e?
Some poisers talked here that is better..?

It is intresting how sam-e worked for you, i quest my self what
sam-e "unlock" for you? Antiinflamatory? Detox pethways?

[Hopeoneday]

Quck google..
SAMe plays a role in the immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. It works with vitamin B12 and folate (vitamin B9). Being deficient in either vitamin B12 or folate may reduce levels of SAMe in your body.
How does SAM-e affect hormones?
SAM-e (S-adenosylmethionine) Benefits, Dosage and Side ...
Basically, SAM-e is involved in many metabolic processes throughout the body, and it plays a role in the formation, activation and breakdown of many chemicals, including hormones and proteins. SAM-e increases the turnover of serotonin and may increase levels of dopamine and norepinephrine.15. maj 2023.

S-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver.

[Hopeoneday]

Me personaly had to give up on sam-e after 1 day because of side
effects, high iritability(now food brand).

[Warrior]

Hi Warrior.

SAM-e is temperature sensitive as you've already discovered. Fortunately in Australia we have a brand available to us that uses refrigeration for transport and storage of some medicines, including SAM-e.

BioCeuticals NuroSAMe Plus Tablets

You can get it from some Chemist Warehouses and will need to ask a pharmacist to get it out of the fridge. It's not the most cost friendly option, but to have a bit more of a guarantee of efficacy is what swayed me.

I will use this until I dive deeper into the other methylation problems which seems a lot cheaper to manage than the more direct SAM-e route.

Thanks. I just went out and purchased a pack yesterday while I have more in the mail. Expensive stuff, cost me $70 for the packet.

Yes, according to nana1, he was "premanently cured" by
immune stimulating protocoll. Who knows, maybe this will work for you
to, if you dont try you will newer know.

About sam-e, what about creatine use insted of sam-e?
Some poisers talked here that is better..?

It is intresting how sam-e worked for you, i quest my self what
sam-e "unlock" for you? Antiinflamatory? Detox pethways?

Creatine is on my todo try list, given that I've responded so well to B vitmains & methylation supplements (SAM-e, choline/alphaGPC).

[Warrior]

Pretty sure monolaurin is improving my symptoms. Bit early to tell, but I’ve been taking monolaurin and propolis in addition to Nanna1’s immune therapy (zinc, beta-glucans, AHCC, etc) and am noticing an actual immediate improvement from taking the monolaurin. I know another user Going Less Crazy had a positive response to monolaurin as well, who also has food sensitivities.

It could be another supplement in the immune stack (my 2nd guess would be AHCC), but from observing my feelings after each supplement, it appears to be the monolaurin. Will update again in the future.

It’s reported that some of the viruses that have been inactivated, at least partially, by monolaurin include:

HIV
measles
herpes simplex-1
vesicular stomatitis
visna virus
cytomegalovirus

HHV-5: Cytomegalovirus (CMV): Epithelial mucosa

Beta herpesvirus dependent POIS
"Furthermore, angioplasty-induced injury to the vessel wall and reperfusion after balloon angioplasty produce ROS8 and cytokines. The resulting activation of NF-kB can in turn stimulate the MIEP present in latently infected cells and thereby contribute to reactivation of latent CMV...Recent studies have shown that CMV infection of human cells leads to stimulation of arachidonic acid (AA) release." -Aspirin Attenuates Cytomegalovirus Infectivity and Gene Expression Mediated by Cyclooxygenase-2 in Coronary Artery Smooth Muscle Cells (1998)

  Cytomegalovirus (CMV, HHV-5) and HHV-6 are Betaherpesvirinae that primarily latently infect endothelial cells such as blood vessels and epithelial mucosa such as intestinal epithelia (Ref). This is unlike alpha-herpes viruses (HSV-1, HSV-2, VZV) which primarily latently infect neurons. Within minutes of infecting endothelial cells CMV upregulates reactive oxygen species (H2O2), NF-kB, COX-2 and cytokines (RefSE). These Betaherpesvirinae maintain this inflammatory environment while latent.

Garlic & HHV-5/CMV/HCMV anti-viral: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434784/

I am currently getting tested for HHV-1 to HHV-6 (I forgot to get HHV-7). HHV-5 and HHV-6 are most important to test according to Nanna1's theory.

[Warrior]

Continuing to have some pretty profound results from Monolaurin. I am surprised this hasn't been spoken about more on here or at the subreddit.

It is a potent anti-viral, is relatively cheap and fairly safe (you still need to use it responsibly). I am eating normal food and it's wiping away my sensitivities. It's still very early, but extremely promising results thus far and would recommend others give it a go.

My approach now is very focused on anti-viral/anti-bacterial, infection related. Still taking many Nanna1 and immune supplements (cycling many).

Monolaurin dosage guide: https://www.monolaurinandmore.com/monolaurin-dosage

How does Monolaurin work?
Monolaurin research suggests it is able to inactivate lipid-coated viruses such as herpes, cytomegalovirus, influenza, and various pathogenic bacteria and protozoa in lab settings [Ref #1, 2, 3, 11, 12].

Monolaurin purportedly works by binding to the lipid-protein envelope of the virus, thereby preventing it from attaching and entering host cells, making infection and replication impossible [Ref #2]. Other studies suggest that monolaurin disintegrates the protective viral envelope, killing the virus [Ref #13].

Monolaurin has Generally Recognized As Safe (GRAS) status and is considered to be nontoxic. It is effective against
many microorganisms and can be taken on a daily basis, given
that evidence suggests it does not create antiviral or antibacterial resistance.
The general recommended adult dose of monolaurin is 1–3 g.
Higher amounts can be used to achieve desired results if necessary. It is safe for children (ages 3–10) with the recommended
dose being smaller—30 mg, one to three times per day. Monolaurin is available as minipellets that should be swallowed and not
chewed.19

[Quantum]

Continuing to have some pretty profound results from Monolaurin. I am surprised this hasn't been spoken about more on here or at the subreddit.

It is a potent anti-viral, is relatively cheap and fairly safe (you still need to use it responsibly). I am eating normal food and it's wiping away my sensitivities. It's still very early, but extremely promising results thus far and would recommend others give it a go.

My approach now is very focused on anti-viral/anti-bacterial, infection related. Still taking many Nanna1 and immune supplements (cycling many).

Monolaurin dosage guide: https://www.monolaurinandmore.com/monolaurin-dosage

How does Monolaurin work?
Monolaurin research suggests it is able to inactivate lipid-coated viruses such as herpes, cytomegalovirus, influenza, and various pathogenic bacteria and protozoa in lab settings [Ref #1, 2, 3, 11, 12].

Monolaurin purportedly works by binding to the lipid-protein envelope of the virus, thereby preventing it from attaching and entering host cells, making infection and replication impossible [Ref #2]. Other studies suggest that monolaurin disintegrates the protective viral envelope, killing the virus [Ref #13].

Interesting, Warrior !

Do you have any idea how many grams of organic coconut oil will equal a 600mg capsule of monolaurin ?

[Warrior]

Continuing to have some pretty profound results from Monolaurin. I am surprised this hasn't been spoken about more on here or at the subreddit.

It is a potent anti-viral, is relatively cheap and fairly safe (you still need to use it responsibly). I am eating normal food and it's wiping away my sensitivities. It's still very early, but extremely promising results thus far and would recommend others give it a go.

My approach now is very focused on anti-viral/anti-bacterial, infection related. Still taking many Nanna1 and immune supplements (cycling many).

Monolaurin dosage guide: https://www.monolaurinandmore.com/monolaurin-dosage

How does Monolaurin work?
Monolaurin research suggests it is able to inactivate lipid-coated viruses such as herpes, cytomegalovirus, influenza, and various pathogenic bacteria and protozoa in lab settings [Ref #1, 2, 3, 11, 12].

Monolaurin purportedly works by binding to the lipid-protein envelope of the virus, thereby preventing it from attaching and entering host cells, making infection and replication impossible [Ref #2]. Other studies suggest that monolaurin disintegrates the protective viral envelope, killing the virus [Ref #13].

Interesting, Warrior !

Do you have any idea how many grams of organic coconut oil will equal a 600mg capsule of monolaurin ?

I read somewhere you need to drink 100-300mL of coconut oil daily or something ridiculous to get a therapeutic dose. Getting Monolaurin from coconut oil just isn’t realistic, even though that’s where it’s found. You need to take actual Monolaurin through supplement form.

Lauric acid can be ingested in coconut oil and your body will convert it into monolaurin, but researchers are unsure of the conversion rates. Because of this, it's impossible to say how much coconut oil you would need to ingest to receive a therapeutic dose of monolaurin.

[Quantum]

Thanks for this comprehensive answer, Warrior !
I see that a site that I order from, Vitacost, has introduced a new monolaurin preparation in its brand line.   They have put some inosine in it as well. I took a look to see the utility, and inosine is supposed to also have antiviral activity, and inosine also reduces the level of some pro-inflammatory cytokines like IL-6, which are causing many symptoms in viral infections like influenza.
Would have been very useful to me 25 years ago, when I had mononucleosis/EPV - been very very sick for 6 weeks.

[Warrior]

Thanks for this comprehensive answer, Warrior !
I see that a site that I order from, Vitacost, has introduced a new monolaurin preparation in its brand line.   They have put some inosine in it as well. I took a look to see the utility, and inosine is supposed to also have antiviral activity, and inosine also reduces the level of some pro-inflammatory cytokines like IL-6, which are causing many symptoms in viral infections like influenza.
Would have been very useful to me 25 years ago, when I had mononucleosis/EPV - been very very sick for 6 weeks.

Ah yes, my current supplement is just monolaurin and calcium, but they've added calcium as a filler, so I also have another supplement in the mail for 100% monolaurin. Do you suspect any kind of viral or infection element behind your POIS? I know Nanna1 was big on this theory when he was active on the forum.

[Thomas]

3) Some trouble with Omega-3 supplementation has slowed me down. Gave me anxiety, brain fog, and irritability, so I had to stop everything and figure out what was causing it. Initially I was worried that the effectiveness of Nanna1s POIS Cascade stack was dwindling. Nope, turned out to be an Omega-3 supplement I had recently begun taking for the POIS Cascade stack. Now I just eat regular sardines with extra virgin olive oil in some apple cider vinegar frequently for the Omega-3. And back to feeling amazing, POIS free.

I might be experiencing the same symptoms as you with omega-3 supplements. I'm struggling to find information about this on the internet. Do you have any clue about what causes these symptoms and why it's different with regular fish ?

[Quantum]

Thanks for this comprehensive answer, Warrior !
I see that a site that I order from, Vitacost, has introduced a new monolaurin preparation in its brand line.   They have put some inosine in it as well. I took a look to see the utility, and inosine is supposed to also have antiviral activity, and inosine also reduces the level of some pro-inflammatory cytokines like IL-6, which are causing many symptoms in viral infections like influenza.
Would have been very useful to me 25 years ago, when I had mononucleosis/EPV - been very very sick for 6 weeks.

Ah yes, my current supplement is just monolaurin and calcium, but they've added calcium as a filler, so I also have another supplement in the mail for 100% monolaurin. Do you suspect any kind of viral or infection element behind your POIS? I know Nanna1 was big on this theory when he was active on the forum.

No, I do not think that a viral infection in particular is an essential factor in my POIS.  There is no Lyme around here ( too cold, just appeared a few years ago in the southern part of Quebec province, and I am North).  I had EBV ( mononucleosis) in my 30s but already had POIS for over 15 years ( since puberty).  I had lots of colds, flus, allergies, and respiratory tract infections as a child - I was always sick, all year round.  I had dozens of antibiotic treatments.  So, probably my overall poor health is an important factor, but it would be hard to pinpoint one infection out of the hundreds I had.  My immune system was surely not functioning normally. But when I got older and did what I had to do to improve my health, I stopped to have all those viral and bacterial infections, but POIS stayed, even if my immune system got better.