A few years ago I also had bad experience with complex B vitamins, but taking into account the positive experiences of other POISers I recently have started to experiment with separate vitamin B types and soon realized that some of them are actually good (B3 and B12), while biotin (B7) makes me even more ill. Unfortunately at this point it is really a trial and error situation. If you are worried about possible adverse effects you could break a pill into tiny bits and only slowly increase the dosage.
Although your case at first glance seems quite remote from mine, I still found some detail that may be in common.
At one post you mentioned that sometimes in acute POIS you have swollen nodules in your breasts. Although I am a man I often have this problem, still the cause may be different. I checked your blood tests, but I don't see if they have ever checked your estrogen level. A high level of estrogen may also cause similar problems.
https://en.wikipedia.org/wiki/High-dose_estrogenIn my early POIS I was also prone to diarrhea and feverishness, but sometime along the years this changed. Nowadays I usually have a hypothermic sensation most of the time.
Sometimes I also wake for tachycardia in the middle of the night, but for me it is not very serious (about 100 bpm at most). In my case urination and fresh air can surely help to reduce this issue.
You mentioned you don't have mind fog, but rather irritability. Actually in POIS I am quite relaxed and dull and I just can't really care about anything happening. It is true however that when I have a serious POIS I also can't enjoy anything even if it was something that I love to do otherwise.
I also tend to lose weight in acute POIS or at least I need to eat a lot to be able to maintain it. It is also interesting that I develop an unsatiable appetite at POIS onset while you completely lose it.
Although in an other post you mentioned that you are always hungry and skinny.
It may be important to point out that some of your blood tests are actually the opposite of mine. I always have a high urine specific gravity while yours is low. The absolute values are within range, but the lymphocyte/neutrophil ratio is somewhat high for me. In your case this is reversed and also shows in the absolute values. This may also mean that some of the medication I use could be detrimental for you, so be careful if you try those.
Your experience with bleach intrigued me as it may have a connection with PPAR reprogramming. I couldn't find exact proof for this, however I still found an article that seems highly interesting in regard of your case:
https://sci-hub.se/https://www.sciencedirect.com/science/article/pii/S1561541309602441Some of your blood tests also showed a low serum iron level.
Increased production of O2– leads to H2O2, and nondetoxified H2O2 reacts with Fe++ in a process known as the Fenton reaction to produce toxic ROS. Active neutrophils show high myeloperoxidase (MPO) activity in cardiac tissue, which indicates an inflammatory response. In our study, cardiac MPO activity was increased in both hyperlipidemic and non-hyperlipidemic ischemia/reperfusion (I/R) groups.It also implicates hypochlorous acid in relation to activated neutrophils.
Neutrophils are major cells involved in ROS production, and they play a role in oxidative injury via the action of NADPH oxidase or the MPO system. Neutrophils produce O2?, which is a ROS. On the other hand, hypochlorous acid (HOCl) is produced largely from stimulated neutrophils via MPO, which catalyses the production of HOCl. HOCl oxidizes cellular molecules including proteins, amino acids, carbohydrates, nucleic acids, and lipids, increasing cardiac damage.
In conclusion, renal I/R injury caused cardiac damage via oxidative stress and inflammatory processes in hyperlipidemic and non-hyperlipidemic rats. Our results showed that fenofibrate treatment prevented cardiac damage induced by renal I/R in hyperlipidemic and non-hyperlipidemic rats by decreasing lipid peroxidation and protein oxidation, and increasing antioxidant enzyme activity.This is interesting as you tend to have a low urea level, although your creatinine level looks to be alright.
Patel et al demonstrated that the levels of lipid peroxidation and myeloperoxidation, which were increased in renal I/R injury, were reduced to within normal ranges by fenofibrate. They found high creatinine and urea levels in the I/R group compared to the control group.Fenofibrate is mainly used to reduce cholesterol, but your level is already low, which probably doesn't make it beneficial.
Even though a high level of cholesterol is a risk factor in cardiovascular diseases, however cholesterol is also a precursor for vitamin D and hormones so a low level can be detrimental as well.
Even though fenofibrate seems to be a promising drug no POISer seems to have tested it before, so nothing is really known about its effectiveness.
Just so you know fenofibrate and niacinamide are both PPARA agonists, so their effect may be somewhat similar. Of course they also have other effects as well and this is only a theory of mine so far. Recently I have tested chia seeds and they proved to be somewhat beneficial for me. Chia seeds also have a PPARA agonist activity, so it may be a safer approach to test PPARA agonists, rather than to go with niacinamide right away.
A high monocyte count was also implicated in your case. This may also explain how your Helicobacter Pylori problem got resolved.
In the human organism, HOCl is formed in the reaction of H2O2 with chloride (Cl?) catalyzed by myeloperoxidase (MPO) from phagocytic cells, viz., neutrophils and monocytes. HOCl, being a powerful oxidant, plays a key role in the elimination of pathogenic microorganisms. By virtue of its high reactivity, HOCl comes into contact with many biologically important molecules and thus exerts cytotoxic effects by provoking the development of many severe conditions associated with inflammation.
Activated neutrophils are able to generate in vitro up to 100?uM HOCl. However, the local level of HOCl in vivo can be significantly higher. Indeed, the local concentration of HOCl in the inflammatory focus, calculated on the basis of the data given in, can reach 25-50?mM. Taking into account the potential for the formation of such high local concentrations of hypochlorous acid during a respiratory explosion, it can be assumed that even a large number of HOCl interceptors present in the blood plasma do not guarantee complete protection of RBC from HOCl-induced hemolysis.
Indeed, similar to ascorbate and Trolox, vitamin E, taurine, flavonoids exert pronounced antioxidant effect by virtue of their ability to prevent RBC lysis in oxidative stress. The mechanism of this effect consists in inhibition of lipid peroxidation and protection of SH-groups of RBC proteins from oxidation.https://www.hindawi.com/journals/omcl/2019/2798154/Another study further suggested that oxidative stress and inflammation are interrelated as oxidative stress resulting from high ROS can precipitate the formation of inflammation by increasing the gene expression coding for inflammatory proteins, including NF-kB, peroxisome proliferator activator receptor gamma (PPARG), and activator protein 1 (AP-1). Consequently, inflammatory chemokines and cytokines are produced to induce inflammation. On the other hand, inflammation can increase ROS production via several signaling cascades. Polymorphonuclear neutrophils (PMN) is an immune cell that is largely involved in inflammatory processes. During inflammation, they congregate the gp91-phox, which is a catalytic subunit of NADPH oxidase 2 (NOX) and generate more ROS, including hydroxyl radical, superoxide anion, and hypochlorous acid, thereby enhance inflammation through mitogen-activated protein kinase (MAPK), protein kinase C (PKC), and c-Jun-N-terminal kinase (JNK) pathways. Activation of these signaling cascades lead to production of more inflammatory chemokines and cytokines. Therefore, this forms a vicious cycle leading to chronic inflammation and eventually a range of medical conditions, including cardiovascular diseases, neurodegenerative diseases, and cancers.https://www.mdpi.com/2079-7737/10/4/287/htmYou could also try some potent antioxidants as they are ROS scavengers. Some POISers had success with Sulforaphan, NAC and glutathione.
I am not sure if an iron supplement would be beneficial for you as it could increase ROS production according to the Fenton reaction.
My personal recommendation would be saffron tea as it has many health benefits (e.g. antioxidant). Even though you don't have the mind fog symptom, it may still help you.
Saffron also down-regulates myeloperoxidase (MPO):
In addition, saffron down-regulates the key pro-inflammatory enzymes such as myeloperoxidase (MPO), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), phospholipase A2, and prostanoids.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535192/If you are worried about any adverse reaction, you could start with as few as one stigma and slowly raise the number of pieces. About 10-30 stigmas should show a benefit, otherwise it may be not effective for you.
In one of your laboratory tests they actually measured myeloperoxidase, which proved to be negative. You were also feeling very well at the time, which may mean that the measurement was not representative for your POIS state. If saffron proved to be effective this may still worth further consideration.
