TRT Success Story

[quotz]

I am in my early 20s, you could see my past posts regarding POIS and brain fog.

It took me 3 years jumping from one doctor to another and nobody knew anything about it. I was even referred to a neurologist and a psychiatrist which then got me diagnosed as anxious and depressed. I even considered dropping out of college.

I knew there was nothing wrong with me mentally. I got things into my own hands and examined every single blood test and scan I did in the past few years. I googled every single measurement, until I found out on reddit that it is completely out of the ordinary to have a 300 ng/dl Total Testosterone, for any age not just early 20s. I did a bunch of other scans, same result. I went to a bunch of doctors who refused to prescribe TRT, until I found another one who did prescribe me TRT but she had no idea what she was doing, so I just used to prescription to make my own protocol.

I celebrated last month 2 years of starting TRT. I've never felt better, POIS is gone 90%. I put my dad on TRT (60y/o) for health reasons. The more I orgasm the less POIS I get, and if I do not orgasm in a while the POIS gets worse once I do. Not just POIS though, I no longer have brain fog!

Recently I started 300mcg B6 after orgasm, worked like a charm, I felt ZERO POIS. I am also thinking of getting cabergoline just to experiment a bit.

But point of the post is, get on TRT ASAP. The subreddit /r/testosterone will guide you on how to to it properly if you dont have a good doctor. Some people quit TRT before getting their protocol adjusted and they dont feel the effects, but if that happens to you dont feel discouraged, its just that you would need to adjust the protocol to better suit you.

GOOD LUCK!

[drop247]

How long did it take for you to get to the 90% mark? What's your protocol and what are your hormone levels now? Thanks

[demografx]

Just a reminder - - for those who might not be aware - - that we also have a large TRT thread at:
https://poiscenter.com/forums/index.php?topic=17.0

[drop247]

300mcg of B6 seems like a very small dose. Though 300mg is very high. Did you really mean 300mcg?

[quotz]

300mcg of B6 seems like a very small dose. Though 300mg is very high. Did you really mean 300mcg?

I meant 3mg sorry about that. 1mg didnt do the trick, 3mg did. But I understand this isnt scalable since if I make love to my gf ever day I would be overdosing in just a few weeks or months. Thats why I wanna obtain cabergoline and see how that will work. But when I took 3mg I literally didnt feel any POIS, zero. Also pre-TRT I would feel POIS for like 2-3 days, now I feel it for like 6-8 hrs, so generally I avoid orgasming during day and leave it for the evening. Also my gf has terrible POIS too, and by terrible I mean really for like 2-3 days if she orgasms twice in a day... Soo POIS to some extent is natural, but generally minimizing it is optimal. I think if pharma companies see POIS as a problem they could make cabergoline studies and submit to FDA, but they have to have a bigger market in mind, more of like a sexual optimization pill, like birth control I assume to some extent

How long did it take for you to get to the 90% mark? What's your protocol and what are your hormone levels now? Thanks

Started off 50mg Testosterone Enanthate Every 3 Days (E3D), like recommended, that ended up bumping my levels to Total T 600ng/dl which is super low. Then did 75mg E3D and then 100mg E3D which resulted in ~1200ng/dl = optimal. All blood tests  are taken during trough, meaning when Total T should be super low, just before injection. I also took AI but super miniscule amounts, something like 0.050 mg half a day after injection or whenever I feel like the E2 goes bad. Then I added 300iu HCG E3D.

But generally I guide my protocol with how I feel, lately Ive started drinking a lot of coffee which spiked my insulin and lowered my SHBG drastically, and this completely ruined my protocol so I've been injecting 100mg Test. Enanthate each morning and evening, along with HCG. I tried using metformin and cutting back on coffee which improves it a bit, but still gonna take some time until I bump SHBG back into normalcy. There is nothing worse for your protocol than SHBG being low, do everything it takes to keep it up. If you have lower than 20-30 its quite bad, average is 40 and thats okay, but basically SHBG uses up your Test. super fast and I started growing hair like crazy and not feeling injections at all, was waking up with anxiety again just like preTRT, so now I inject huge amounts of T to make up for it, at least until I get the SHBG back in control by cutting on coffee completely, and by taking metformin, and if these two dont work I will start the keto diet.

But generally go to the subreddit and find all the guidance there and how to optimize your protocol, and most importantly get a few doctors on this so that they wouldnt be guiding your protocol but rather you yourself will. I am going to the best doc in NYC (Dr Michael Rotman) and he still knows less than all the knowledge you can find on the subreddit.

[Journey]

300mcg of B6 seems like a very small dose. Though 300mg is very high. Did you really mean 300mcg?

I meant 3mg sorry about that. 1mg didnt do the trick, 3mg did. But I understand this isnt scalable since if I make love to my gf ever day I would be overdosing in just a few weeks or months. Thats why I wanna obtain cabergoline and see how that will work. But when I took 3mg I literally didnt feel any POIS, zero. Also pre-TRT I would feel POIS for like 2-3 days, now I feel it for like 6-8 hrs, so generally I avoid orgasming during day and leave it for the evening. Also my gf has terrible POIS too, and by terrible I mean really for like 2-3 days if she orgasms twice in a day... Soo POIS to some extent is natural, but generally minimizing it is optimal. I think if pharma companies see POIS as a problem they could make cabergoline studies and submit to FDA, but they have to have a bigger market in mind, more of like a sexual optimization pill, like birth control I assume to some extent

How long did it take for you to get to the 90% mark? What's your protocol and what are your hormone levels now? Thanks

Started off 50mg Testosterone Enanthate Every 3 Days (E3D), like recommended, that ended up bumping my levels to Total T 600ng/dl which is super low. Then did 75mg E3D and then 100mg E3D which resulted in ~1200ng/dl = optimal. All blood tests  are taken during trough, meaning when Total T should be super low, just before injection. I also took AI but super miniscule amounts, something like 0.050 mg half a day after injection or whenever I feel like the E2 goes bad. Then I added 300iu HCG E3D.

But generally I guide my protocol with how I feel, lately Ive started drinking a lot of coffee which spiked my insulin and lowered my SHBG drastically, and this completely ruined my protocol so I've been injecting 100mg Test. Enanthate each morning and evening, along with HCG. I tried using metformin and cutting back on coffee which improves it a bit, but still gonna take some time until I bump SHBG back into normalcy. There is nothing worse for your protocol than SHBG being low, do everything it takes to keep it up. If you have lower than 20-30 its quite bad, average is 40 and thats okay, but basically SHBG uses up your Test. super fast and I started growing hair like crazy and not feeling injections at all, was waking up with anxiety again just like preTRT, so now I inject huge amounts of T to make up for it, at least until I get the SHBG back in control by cutting on coffee completely, and by taking metformin, and if these two dont work I will start the keto diet.

But generally go to the subreddit and find all the guidance there and how to optimize your protocol, and most importantly get a few doctors on this so that they wouldnt be guiding your protocol but rather you yourself will. I am going to the best doc in NYC (Dr Michael Rotman) and he still knows less than all the knowledge you can find on the subreddit.

In 2019 January my Total Testosterone was measured to be 475ng/dl

[Iwillbeatthis]

Also my gf has terrible POIS too, and by terrible I mean really for like 2-3 days if she orgasms twice in a day...

Did she have POIS before you were together? Or did one of you guy's POIS start when you started dating?

[drop247]

Sorry why do you want higher SHBG if it uses up Test? Wouldn't this effectively lower your free Test?

[Muon]

Also my gf has terrible POIS too, and by terrible I mean really for like 2-3 days if she orgasms twice in a day...

Did she have POIS before you were together? Or did one of you guy's POIS start when you started dating?

Relevant questions from IWBT. In addition to that...what's wrong with your father?

These symptoms started for my guy when he was 15 years old. But I don?t know when these really started for me. My guy was the one who found that I also have this thing. Before, we thought only he has this shit. (We called it ?Over?). Then we started to notice my symptoms too. We did search internet and I found you tube video about POIS and then I saw this forum link in the comments section.

I have read about a couple on nakedscientists where the wife started to get symptoms after sex (husband has POIS).

[quotz]

She had it forever yeah, shes prone to depression, the females from her mom side of the family all diagnosed with clinical depression. I suppose POS has to do a lot with depression.

Higher SHBG means u wont have free test, but with low SHBG I am injecting a lot of T because its all getting used up super quickly. When I had higher SHBG I was feeling way better than now. I think the golden number is around 40-50 for SHBG, which I had a year ago pre-coffee.

Also 475ng/dl is not great at all. Get yourself a few nice doctors to put you on TRT, but most importantly educate yourself with the subreddit so you dont rely too much on the doctors as they dont know much anyway. Your life will change 180 degrees, if there was Testosterone stocks I will invest in it with all my savings

[Jean23]

Do you have any physical or psychological markers that could lead you to believe that you lacked testosterone? (Low libido, soft voice, face shape etc)

[quotz]

I didnt realize I had it, but some old friends when they saw me said "what happened with ur voice" Which I thought nothing of it. Also libido was fine, but I didnt have any comparable example to see that it wasnt fine at all, I couldve actively sought to have sex every 3-4 days, but now its like every day. Also I had ED issues which I always attributed to something else (say alcohol or lack of sleep). I never thought I would be low T because I was an incredible womanizer in high school and college, but blood levels say otherwise haha. Also my muscle mass wasnt too great either. I am 86kg now, 180cm tall, and have 15% body fat, my muscle phisique is huge, back then preTRT I was 75kg, and I had around 15-20% body fat, so yeah huge difference. But at that time I still had no idea because my biggest problem would be not being able to focus on my studies, I had a girlfriend and sex life was fine, I hit the gym 3 times a week, all was generally okay for my age which was 21 y/o

[Muon]

She had it forever yeah, shes prone to depression, the females from her mom side of the family all diagnosed with clinical depression. I suppose POS has to do a lot with depression.

Does she suffer from some kind of female premature orgasm? And when did you notice your POIS, after dating her?

[Journey]

Also my gf has terrible POIS too, and by terrible I mean really for like 2-3 days if she orgasms twice in a day...

Did she have POIS before you were together? Or did one of you guy's POIS start when you started dating?

Relevant questions from IWBT. In addition to that...what's wrong with your father?

These symptoms started for my guy when he was 15 years old. But I don?t know when these really started for me. My guy was the one who found that I also have this thing. Before, we thought only he has this shit. (We called it ?Over?). Then we started to notice my symptoms too. We did search internet and I found you tube video about POIS and then I saw this forum link in the comments section.

I have read about a couple on nakedscientists where the wife started to get symptoms after sex (husband has POIS).

Could there be some microbes in POISers that could get transferred to other people through close contact like through sexual intercourse and then they could maybe activate MCAS or SIBO or molecular mimicry of the autoimmunity process thus giving POIS to somebody as well?

[Journey]

She had it forever yeah, shes prone to depression, the females from her mom side of the family all diagnosed with clinical depression. I suppose POS has to do a lot with depression.

Higher SHBG means u wont have free test, but with low SHBG I am injecting a lot of T because its all getting used up super quickly. When I had higher SHBG I was feeling way better than now. I think the golden number is around 40-50 for SHBG, which I had a year ago pre-coffee.

Also 475ng/dl is not great at all. Get yourself a few nice doctors to put you on TRT, but most importantly educate yourself with the subreddit so you dont rely too much on the doctors as they dont know much anyway. Your life will change 180 degrees, if there was Testosterone stocks I will invest in it with all my savings

Do you know though what could be the root cause of not high enough Testosterone production? I have read a lot about how hormones production occurs like the Pregnenolone conversion with the usage of Thyroid hormones by the body and how Pregnenolone is made from the Cholesterol and how all nutrition must be good so that there are resources for the full steroidogenesis to occur and how good sleep ensures the LH is able to be generated so that then it can activate the Leydig cells for them to convert the Pregnenolone into Testosterone using the Thyroid hormones and how other anti-androgenic factors and hormones like Cortisol, Estrogens, Prolactin and etc. can decrease both the production of Testosterone through impairment of GnRH/LH/FSH/'steroidogenesis and by directly lowering it but if one does not have optimal hormones then that means there is something else wrong with their body because if one has enough nutrition, base hormone production factors, proper enzyme and body system functioning then why would they have any hormonal issues?

A full blood test of LH, FSH, Prolactin, Cortisol, Estrogen, VitaminD, Total Testosterone, SHBG, Albumin, all immune and inflammatory factors and markers, all of the Thyroid markers and hormones could show me a full picture of the state of my body and health and also explain if there are any other imbalances that might not be letting my body to fully optimally properly produce the hormones.

[quotz]

She had it forever yeah, shes prone to depression, the females from her mom side of the family all diagnosed with clinical depression. I suppose POS has to do a lot with depression.

Does she suffer from some kind of female premature orgasm? And when did you notice your POIS, after dating her?

I had POIS before dating her. She does not suffer from female premature orgasm.

Could there be some microbes in POISers that could get transferred to other people through close contact like through sexual intercourse and then they could maybe activate MCAS or SIBO or molecular mimicry of the autoimmunity process thus giving POIS to somebody as well?

Yeah I dont think so. After orgasming its quite normal to feel a bit sad, but in the POIS case its more extreme than usual. After orgasm prolactin gets released, which is a dopamine antagonist, which basically makes us unable to focus and feel like crap. B6 is a dopamine agonist and a prolactine suppresant, and it does the job of treating POIS after orgasming for me. If somebody mails me cabergoline or other alternatives I will happily experiment for you.

She had it forever yeah, shes prone to depression, the females from her mom side of the family all diagnosed with clinical depression. I suppose POS has to do a lot with depression.

Higher SHBG means u wont have free test, but with low SHBG I am injecting a lot of T because its all getting used up super quickly. When I had higher SHBG I was feeling way better than now. I think the golden number is around 40-50 for SHBG, which I had a year ago pre-coffee.

Also 475ng/dl is not great at all. Get yourself a few nice doctors to put you on TRT, but most importantly educate yourself with the subreddit so you dont rely too much on the doctors as they dont know much anyway. Your life will change 180 degrees, if there was Testosterone stocks I will invest in it with all my savings

Do you know though what could be the root cause of not high enough Testosterone production? I have read a lot about how hormones production occurs like the Pregnenolone conversion with the usage of Thyroid hormones by the body and how Pregnenolone is made from the Cholesterol and how all nutrition must be good so that there are resources for the full steroidogenesis to occur and how good sleep ensures the LH is able to be generated so that then it can activate the Leydig cells for them to convert the Pregnenolone into Testosterone using the Thyroid hormones and how other anti-androgenic factors and hormones like Cortisol, Estrogens, Prolactin and etc. can decrease both the production of Testosterone through impairment of GnRH/LH/FSH/'steroidogenesis and by directly lowering it but if one does not have optimal hormones then that means there is something else wrong with their body because if one has enough nutrition, base hormone production factors, proper enzyme and body system functioning then why would they have any hormonal issues?

A full blood test of LH, FSH, Prolactin, Cortisol, Estrogen, VitaminD, Total Testosterone, SHBG, Albumin, all immune and inflammatory factors and markers, all of the Thyroid markers and hormones could show me a full picture of the state of my body and health and also explain if there are any other imbalances that might not be letting my body to fully optimally properly produce the hormones.

Go on mayoclinic and search for Hypogonadism causes. Theres 2 types, primary (your testicles not producing enough T), and secondary (your brain/pituitary gland not producing enough hormones that tell the testicles to produce T). As of now, they dont know exactly why the secondary cause exists, but primary can be caused from injuries or even mumps when you were a kid, but generally its quite of a black hole thing and nobody knows why. Docs check for Vit D and if its low you will get supplements to see if your T will go up, Cortisol also suppresses T but you could easily do a 24hr Cortisol urine test, or even the normal blood test, and check that out. If you go to a mens health clinic they will test all these things you mentioned and have a rough idea of whats going wrong, but its still just scratching the surface, and if ur T is low then you will get TRT anyway, theres no other fix.

[resilient]

Hi mate. Congrats on your treatment success.

I have a couple of questions.

Would you say you experienced progressive improvement in your symptoms as your Total T levels kept going up with your therapy?

Also you said earlier that Total T of 600 ng/ml was too low.

So at what Total T levels would you say you started feeling pretty significant improvement in your pois symptoms? Thanks.

[Journey]

She had it forever yeah, shes prone to depression, the females from her mom side of the family all diagnosed with clinical depression. I suppose POS has to do a lot with depression.

Does she suffer from some kind of female premature orgasm? And when did you notice your POIS, after dating her?

I had POIS before dating her. She does not suffer from female premature orgasm.

Could there be some microbes in POISers that could get transferred to other people through close contact like through sexual intercourse and then they could maybe activate MCAS or SIBO or molecular mimicry of the autoimmunity process thus giving POIS to somebody as well?

Yeah I dont think so. After orgasming its quite normal to feel a bit sad, but in the POIS case its more extreme than usual. After orgasm prolactin gets released, which is a dopamine antagonist, which basically makes us unable to focus and feel like crap. B6 is a dopamine agonist and a prolactine suppresant, and it does the job of treating POIS after orgasming for me. If somebody mails me cabergoline or other alternatives I will happily experiment for you.

She had it forever yeah, shes prone to depression, the females from her mom side of the family all diagnosed with clinical depression. I suppose POS has to do a lot with depression.

Higher SHBG means u wont have free test, but with low SHBG I am injecting a lot of T because its all getting used up super quickly. When I had higher SHBG I was feeling way better than now. I think the golden number is around 40-50 for SHBG, which I had a year ago pre-coffee.

Also 475ng/dl is not great at all. Get yourself a few nice doctors to put you on TRT, but most importantly educate yourself with the subreddit so you dont rely too much on the doctors as they dont know much anyway. Your life will change 180 degrees, if there was Testosterone stocks I will invest in it with all my savings

Do you know though what could be the root cause of not high enough Testosterone production? I have read a lot about how hormones production occurs like the Pregnenolone conversion with the usage of Thyroid hormones by the body and how Pregnenolone is made from the Cholesterol and how all nutrition must be good so that there are resources for the full steroidogenesis to occur and how good sleep ensures the LH is able to be generated so that then it can activate the Leydig cells for them to convert the Pregnenolone into Testosterone using the Thyroid hormones and how other anti-androgenic factors and hormones like Cortisol, Estrogens, Prolactin and etc. can decrease both the production of Testosterone through impairment of GnRH/LH/FSH/'steroidogenesis and by directly lowering it but if one does not have optimal hormones then that means there is something else wrong with their body because if one has enough nutrition, base hormone production factors, proper enzyme and body system functioning then why would they have any hormonal issues?

A full blood test of LH, FSH, Prolactin, Cortisol, Estrogen, VitaminD, Total Testosterone, SHBG, Albumin, all immune and inflammatory factors and markers, all of the Thyroid markers and hormones could show me a full picture of the state of my body and health and also explain if there are any other imbalances that might not be letting my body to fully optimally properly produce the hormones.

Go on mayoclinic and search for Hypogonadism causes. Theres 2 types, primary (your testicles not producing enough T), and secondary (your brain/pituitary gland not producing enough hormones that tell the testicles to produce T). As of now, they dont know exactly why the secondary cause exists, but primary can be caused from injuries or even mumps when you were a kid, but generally its quite of a black hole thing and nobody knows why. Docs check for Vit D and if its low you will get supplements to see if your T will go up, Cortisol also suppresses T but you could easily do a 24hr Cortisol urine test, or even the normal blood test, and check that out. If you go to a mens health clinic they will test all these things you mentioned and have a rough idea of whats going wrong, but its still just scratching the surface, and if ur T is low then you will get TRT anyway, theres no other fix.

How do mumps suppress the Testosterone production?

[BoneBroth]

Yeah, testosterone deficiency might be what is biochemically causing the POIS symptoms, and adding testosterone might block the symptoms. However the underlying cause is still there causing other health issues in the long run, and when you stop using testosteone the symptoms will come back, probably even worse. I believe the underlying cause  are related to gut problems - fix the gut, eat for the good gut bacteria and fix the stress that causes the gut issues. Then the body might correct testosterine deficiencies by itself.

[quotz]

Hi mate. Congrats on your treatment success.

I have a couple of questions.

Would you say you experienced progressive improvement in your symptoms as your Total T levels kept going up with your therapy?

Also you said earlier that Total T of 600 ng/ml was too low.

So at what Total T levels would you say you started feeling pretty significant improvement in your pois symptoms? Thanks.

Men should have a total T of 1200 ng/dl if not even more, theres research stating men used to have higher levels back in the days 50-80 years ago google it, with SHBG being 40-60, and albumin being in the correct levels too. Yes TRT totally fixed everything. Either get a good doc, or do self-therapy, dont risk it by going to bs docs, save some $$ and get urself an amazing doc its worth it if u dont have the time to read the reddit stuff.

Yeah, testosterone deficiency might be what is biochemically causing the POIS symptoms, and adding testosterone might block the symptoms. However the underlying cause is still there causing other health issues in the long run, and when you stop using testosteone the symptoms will come back, probably even worse. I believe the underlying cause  are related to gut problems - fix the gut, eat for the good gut bacteria and fix the stress that causes the gut issues. Then the body might correct testosterine deficiencies by itself.

Your way of thinking is dangerous and its bro-science. If you go to Mayo Clinic or Cleveland Clinic they wont say "fix your gut" or whatever. If you want good gut bacteria go do a fecal transplant of someone that has normal T levels and check if your levels will improve, quite of a simple experiment actually. You wont find a doctor that will diagnose you with "gut problems" for hypogonadism, ever, so youre gonna have to make a fecal transplant yourself, which you can easily find resources online about it but theres some risks involved so research well and choose a great poop donor. Eating good food is of course very important, but its pseudoscience for saying it will treat hypogonadism. Good food is preventative medicine, not treatment in most cases. Please stop spreading fake news. Hypogonadism is a chronic condition btw, I will have to be on TRT forever, if I stop TRT of course I will get the symptoms back. Also, TRT doesnt treat symptoms, it treats the cause, being not enough T. Treating symptoms would be like taking Acetaminophen for a headache, when the headaches are caused by a condition such as hypothyroid or whatever. Please do your research and dont post these things, or if you do make sure its either backed by research or youve experimented yourself