Poll

Do you get the impression that POIS impairs/reduces blood flow?

Yes
6 (42.9%)
Yes, however POIS does more things to my circulatory system
4 (28.6%)
No, but POIS does something else to my circulatory system
0 (0%)
No
1 (7.1%)
I don't know
3 (21.4%)

Total Members Voted: 14

Author Topic: Circulatory changes  (Read 847 times)

Muon

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    • MCAD Thread
Circulatory changes
« on: August 02, 2020, 02:20:38 PM »
Edit: potential related polls: https://poiscenter.com/forums/index.php?topic=3147.0

https://poiscenter.com/forums/index.php?topic=3611.0

It could be that POIS ---> hypovolemia ---> SNS activation ---> vasoconstriction ---> increased peripheral resistance
Or POIS ---> inflammation --> increased blood plasma viscosity --> alterations in blood flow.
Or POIS ---> blood pressure alterations ---> changes in blood flow
Or POIS --> mast cell activation --> cardiovascular problems
Low-flow POTS?

von Willebrand factor, fibrinogen and other plasma proteins as determinants of plasma viscosity

Direct relationship between blood pressure and blood viscosity in normal and hypertensive subjects: Role of fibrinogen and concentration

Plasma viscosity: A forgotten variable

Hormone changes ---> hypovolemia.
Altered adrenergic states ----> bloodflow changes.

AVP constricts arterioles, which increases peripheral vascular resistance. https://en.m.wikipedia.org/wiki/Vasopressin

Smooth muscle NO/calcium signaling leading to altered peristaltic pumping of blood?

Decreased intracellular calcium stimulates renin release via calcium-inhibitable adenylyl cyclase
« Last Edit: June 13, 2021, 09:32:45 AM by Muon »

Clues

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Weird vascular symptom. Vasoconstriction?
« Reply #1 on: June 02, 2021, 09:13:50 AM »
I have a symptom whereby it feels like my blood flow is somehow impaired, especially in my arms and legs. It correlates with POIS, but doesn't quite go away even when abstinent for long periods. It's especially severe in cold weather.

It seems to fit the description of vasoconstriction. Anyone else have this? Any known treatment that works specifically for this issue? Any ideas why it happens?