Niacin vs. Niacinamide

[b_jim]

I found this on a forum :

One way you can test your histamine levels is to buy some nicotinic acid (the niacin that causes the flush) in 50 mg. dose. If you have high histamine levels then you will experience a flush from only 50 mg. dose.
 If it takes 100 mg. to cause you to flush then you have normal (or balanced) histamine levels.
If it takes from 150 mg. to 250 mg. dose of niacin to flush then you have low histamine levels.

I like this idea and this test but it's probably too easy to be true.

[Vincent M]

Also I don't think that histamine test accounts for whether you take the niacin on an empty stomach or not.

[Bulls eye]

flushing isnt because of histamine release

the major cause for flushing when taking niacin is direct specefic activation of a G coupled protien receptor called NIACR1   which in turn activates the langerhans cells in the skin to release prostaglandin d2 which causes vasodilation and thus the flushing effect

[Daveman]

flushing isnt because of histamine release

the major cause for flushing when taking niacin is direct specefic activation of a G coupled protien receptor called NIACR1   which in turn activates the langerhans cells in the skin to release prostaglandin d2 which causes vasodilation and thus the flushing effect

Yes, it's subtle, but the vasodilation then incentivates histamine release. The increased bloodflow to each cell stimulates the release of toxins, which in turn generates a histamine cycle.

But, these subtle differences are very important. The whole reaction with prostaglandin d2 as it relates to POIS is very complex. The question remains, "why does niacin help so dramatically (in some) with POIS?"

It has also been noted that the flush DOESN'T seem to be the critical factor in POIS symptom relief although it is the best "indicator" that the body has received enough niacin.

What is the role of prostaglandins d2 in the production of dopamine and serotonin?

[Nightingale]

But, these subtle differences are very important. The whole reaction with prostaglandin d2 as it relates to POIS is very complex. The question remains, "why does niacin help so dramatically (in some) with POIS?"

I've been thinking lately, what if (assuming flushing is actually required for POIS relief) the prostoglandin d2 gets used/depleted by a large flush.  During this depletion we "O," and perhaps there is no prostoglandin d2 available to get those mast cells to produce the immune response things that they do?

Also, i just read an article that claims that serotonin is also responsible for the niacin flush:

http://www.ncbi.nlm.nih.gov/pubmed/18784348

[vetrofragile79]

Ok guys, niacin reduces brain fog, other symptoms such as fatigue and tiredness as a cure?

[b_jim]

Niacin may improve my cognitive symptoms only.

[vetrofragile79]

Niacin may improve my cognitive symptoms only.

me too...only brain fog slide away

[Bulls eye]

I've been thinking lately, what if (assuming flushing is actually required for POIS relief) the prostoglandin d2 gets used/depleted by a large flush.  During this depletion we "O," and perhaps there is no prostoglandin d2 available to get those mast cells to produce the immune response things that they do?

Also, i just read an article that claims that serotonin is also responsible for the niacin flush:

http://www.ncbi.nlm.nih.gov/pubmed/18784348

interesting theory , what ever nictotinic acid does , it only works when taken before orgasm not after , i just had an O during sleeping and am having a very bad pois right now specially cognitively i took niacin when i woke up but didnt seem to work at all after O

[vetrofragile79]

after which month of treatment with niacin can say that the only side effect is leg cramps that last for a couple of days, cramping the tibia annoying ... happens to someone?

[Suppertime]

I bought Niacin but it's Inositol Heanicotinate. Is that not the same one you guys are using?

[Daveman]

No, that's the non-flush type. Not very effective at all. I don't know anyone who has had success with it.

[demografx]

Does anyone know if there are any similarities between testosterone (my cure) and niacin? They both have had success for POIS and I wonder if studying the 2 together would lead to any more clues?

[Daveman]

I saw something over at the "other place" a while back that clicked as a tie in between the two.

I can't find it now though, don't even remember who it was that posted it.

But aside from the other effects that testosterone have, they interact as well with this  catecholamine system,
where I think we have some common problem.

The other thing about the nature of the failure of this system, is that important neurotransmitters are left depleted, and it takes time
to reestablish them. This also gives the impression that the body is struggling to replace something, and the sooner it does it
the sooner we feel better. So this ties in very well with your perception that it has to do with sperm regeneration, except in this case it's
the catecholamine precursors.

I want to set up a couple of threads to investigate some of this stuff in more detail.

One to dig into and even test remedies based on the catecholamine "theory", and another would be this, the tie in
between testosterone and niacin as relates to this theory,

It might have to wait till after the Indiegogo campaign gets going and a couple of site mods get put in till I have time.

[Suppertime]

Where can I buy Niacin? The one I found at my local shoppers drug mart was a phony.

[Daveman]

Where can I buy Niacin? The one I found at my local shoppers drug mart was a phony.

It’s easiest to find in health supplies rather than drug stores. If a drugstore has it they usually only have it in combination with other vitamins and in low doses.

The health supply stores have herbs, and natural remedies, including all kinds of different vitamin combinations.

If you still can’t find it, there are a lot of on-line outlets. Look for Nature’s Way Niacin, bottle of 100 capsules of 100mg. That can be found at EBay, or a number of other on-line outlets.

[Suppertime]

Thanks. I just purchased it from iherb.

[demografx]

 Please Click H E R E

[vetrofragile79]

What are the risks compared to niacinamide to niacin?
Have you ever examination your  liver?

[Suppertime]

Thanks. I just purchased it from iherb.

Quoting myself. I purchased it and received it a few days ago. I took a pill after masturbating and ejaculating. I felt reduced sickness, but definitely was still tired and felt a little hungover (I don't drink). But I think I was still socially sane, rather than the awkward self. I took masturbated the following day and took another pill, symptoms are at least 85% gone. I don't feel the hangover but I do feel a slight "burning" in my chest that I usually get from POIS. It's not as severe but this is definitely a good start.

While it isn't a cure, it definitely is a compromise.

Thank you POIS center.