Author Topic: The Role of BDNF in Etiology of Premature Ejaculation  (Read 962 times)

Muon

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The Role of BDNF in Etiology of Premature Ejaculation
« on: April 07, 2019, 06:24:16 PM »
The Role of Brain Derived Neurotrophic Factor in Etiology of Premature Ejaculation

If PE is related to POIS and low serum level of BDNF to PE, then BDNF could play a role in POIS.
My brother's BDNF serum level

Hypothesis: Serum level of BDNF is lower in patients with POIS when compared to controls.
« Last Edit: April 07, 2019, 06:32:10 PM by Muon »

Nas

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #1 on: April 07, 2019, 06:33:48 PM »
Testing BDNF, then if low, getting it within normal range could be an investigative method.
There are no viable methods to increase BDNF directly, however some supplements are found to encourage BDNF production. Effectiveness of these supplements could be tested after a period of consistent supplementation, these are as follows:
-ashwagandha
-Asian ginseng
-bacopa
-cordyceps
-gotu kola
-Magnolia officinalis
-Rhodiola rosea
-coffee fruit extract
-curcumin
-olive leaf extract
-quercetin
-resveratrol
-omega-3 essential fatty acids, especially DHA (docosahexaenoic acid)
-l-theanine
-niacin
-magnesium, especially magnesium l-threonate
-taurine
-zinc (note that too much zinc can reduce BDNF)[Ref]

One study found that 100mg of whole coffee fruit concentrate increases BDNF by an astounding 143%[Ref]
« Last Edit: April 07, 2019, 06:47:25 PM by Nas »

demografx

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #2 on: April 08, 2019, 04:10:22 AM »
Third Point: PE also seems odd but perhaps relevant towards discerning the mysterious mechanism of POIS.
If PE is related to POIS...
It’s not. Flawed studies have mixed up PE and POIS. Not discussing publicly.
« Last Edit: April 08, 2019, 04:16:58 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Nas

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #3 on: April 08, 2019, 05:41:34 AM »
That's not fair demo, the majority of POISers have PE, you're telling me that's not actually related by a way or an other to POIS?

demografx

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #4 on: April 08, 2019, 09:01:04 AM »
Poll the forum.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

fernab

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #5 on: April 08, 2019, 09:27:51 AM »
In my case I don't have PE.
« Last Edit: April 08, 2019, 10:22:25 AM by demografx »

Nas

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #6 on: April 08, 2019, 09:43:48 AM »
Let's do a proper poll on this, I do have severe PE which causes me to last less that 10 seconds.

demografx

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #7 on: April 08, 2019, 09:50:35 AM »
Go ahead.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #8 on: April 08, 2019, 11:03:34 AM »
Vandemolen, I removed your post. We discussed this before: you
cannot combine PE and NE! You cannot combine apples & pears.
« Last Edit: April 08, 2019, 11:07:13 AM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #9 on: April 08, 2019, 11:07:55 AM »

In my case I don't have PE.
me neither - Demo
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #10 on: June 06, 2019, 02:12:00 PM »
''On the other hand, testosterone administration was shown to increase BDNF protein levels in castrated male rats. Another group also indicated that BDNF mediates the effects of testosterone on neuronal survival. It is also possible that BDNF contributes to testosterone function in the brain.''.
Functional interactions between steroid hormones and neurotrophin BDNF

''Therefore, we conclude that intact BDNF in the peripheral circulation crosses the BBB by a high-capacity, saturable transport system.''
Transport of brain-derived neurotrophic factor across the blood-brain barrier.


Nas

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #11 on: June 06, 2019, 02:23:25 PM »
I've been thinking a lot lately and perhaps what links PE, smoking induced POIS and POIS itself, is a dysfunction in dopamine. Perhaps there is a issue of over excitability that causes some sort of neuronal exitotoxicity. For me I never had any problem of getting an
*erection* and I always can
*ejaculate*in like 5 seconds if I over stimulate my self. Maybe the issue is related there.

Ban Warning: edited for profanity
« Last Edit: June 07, 2019, 09:39:18 PM by demografx »

Muon

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #12 on: June 06, 2019, 02:53:24 PM »
Sometimes there is minor friction between my clothing and glans penis while riding my bicycle. I had a few times that I had to stop riding the bicycle because my penis became extremely sensitive to the slightest friction (This is without any erection or sexual thought, it's just limp). This example sounds like over stimulation aside from my PE.

I've read there is a correlation between stress hormones and BDNF. Thus high stress hormones and low BDNF. Since there are some folks here with elevated stress hormones, they might have low BDNF levels. PE is also correlated with low BDNF. Testosterone administration, which seem to be beneficial to some members, can upregulate BDNF implying low levels in these men. There are a couple of members who feel better when doing certain strength exercises, this also upregulates BDNF. BDNF also seem to play a role in mediating neurotransmission but haven't read anything about that yet, just saw some titles of papers discussing this.
« Last Edit: June 06, 2019, 03:00:07 PM by Muon »

Guts

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #13 on: August 02, 2019, 07:49:40 AM »
Testing BDNF, then if low, getting it within normal range could be an investigative method.
There are no viable methods to increase BDNF directly, however some supplements are found to encourage BDNF production. Effectiveness of these supplements could be tested after a period of consistent supplementation, these are as follows:
-ashwagandha
-Asian ginseng
-bacopa
-cordyceps
-gotu kola
-Magnolia officinalis
-Rhodiola rosea
-coffee fruit extract
-curcumin
-olive leaf extract
-quercetin
-resveratrol
-omega-3 essential fatty acids, especially DHA (docosahexaenoic acid)
-l-theanine
-niacin
-magnesium, especially magnesium l-threonate
-taurine
-zinc (note that too much zinc can reduce BDNF)[Ref]

One study found that 100mg of whole coffee fruit concentrate increases BDNF by an astounding 143%[Ref]

Only thing that kinda worked is extreme high dosages of zinc..the other ones are lifting symptoms to varying degrees. Don't get me wrong here..i like the effects of taurine, honokiol, quercetin   magnesium etc all combined, problem is i need to take extreme amounts and in the end the $$$$ isn't worth the relief. Might as well stay celibate as long as you can and save some health and $.

Try dabbling into low dosages of mescaline, you will be surprised..its like iboprufen, diclofenac, anti histamine and anti depressant in one package. its also cheaper. You can grow your own trichocereus cacti. Psychoactive tryptamines used for migraines and epilepsy are extremely effective, but few can handle the side effects and psychoactive effects. (Causes brainfog)

I seem to get narcolepsy / epilepsy symptoms from pois so its pretty obvious why it helps.

5-meo-mipt  was an extreme one ... i tripped my balls off but my pois symptoms were way less.. i simply do not like to repeat it, the body load and psychoactive effects are insane. Its also extremely easy to overdose because a normal dose is 3mg to 5mg...1/2 mg too much and you are going through hell / overdose.  Also long term i can see stuff like this ruining your personality especially when taken daily in much lower amounts.

Non psychoactive tryptamines barely help and they have similar side effects to psychoactive ones. Usually anti epileptic drugs help pois even milder medications like gabapentin, fasoracetam and extreme high dosages of taurine. Anti depressants like duloxetine and other neuroprotective SNRI helped long term with heat intolerance and vasospasms, eyesight and tingly feelings, brainfog, however the insomnia it causes is horrible and it does change your personality when you take it long term. Also withdrawals of duloxetine are the worst of all SNRI/SSRI. Some Heroin addicts say its harder to withdraw from high dosages of duloxetine than heroin.

All other drugs only made pois worse or created a temporary bandaid. I liked citalopram because it helped the most with anxiety and didn't had adverse effect on other drugs neither did it change my personality. Iboprufen, diclofenac (nsaids) , anti histamine all help with itch, inflammation and histamine related effects. Kratom helped with pain. And benzodiazapines helped with spinal nerve pain and reduced motor function in muscles.

Psychedelic mushrooms made pois worse long term. Same for MDMA , 6-apb, cathinones, 2C-X drug classes, phenylphentamines and other synthetic shit. Almost all of these synthetic drugs have extremely potent anti histamine/anti inflammatory effects (similar to 120 mg cetirizin or higher ) but long term i think they probably make pois worse. 4-FMP  was also good  but it simply **** language  up your kidneys with local vasoconstriction.

Most promising is mescaline (especially derived from trichocereus bridgessi) and 5-meo-mipt with the latter being shitty because of side effects ( even for me), but i do have to admit it kinda works. Ketamine and phenidines were the best for neuropathy and overall depression (even used once every 2 weeks) but didn't do much for pois itself. If you have depression of pois do ketamine therapy if its legal in your country.

 Tried all syntethic drugs out there..only ones i avoided are obvious ones like meth, heroin , mdpv, pcp etc.  I recommend not taking drugs at all, the cost is not worth  the risk and there are purity issues. I always had suppliers who provided me pharmceutical quality. What lead me to do it was desperation and exploration because i know how neurobiochemistry works and pois clearly (to me)  is related to neurochemistry. I also know about receptor affinity of substances and that kinda stuff. Most of the times i knew what i was doing and sometimes i made mistakes. Drugs target way more receptors than research papers show alot of them alter substance P and many other exotic systems, they all cause nerve growth (not always the right kind, be aware) and almost all target BDNF.

Drugs you absolutely have to stay away from all together is magic mushrooms , MDMA, cathinones (3-mmc, 4-mmc etc cathinones simply too addictive even with one dose). They all make pois worse i even believe they probably could cause pois if you abuse them. I can see people using magic mushrooms when their pois headache  is bad, i would defo not take this daily or weekly.

Benzofurans like 5-apb , 6-apb, 6-mapb all have therapeutic effects on depression and psychological trauma ( yes it really does, especially 6-mapb and 5- mapb etc) but don't do anything for pois. 5-apb was really enjoyable and had absolutely no side effects it wasn't psychedelic..i usually fell asleep on 5-apb and felt extremely good afterwards (mentally) this is also kinda addicting, to the point where you consider using it as an escape from pois and reality.

2C drug classes have extremely long halve lives and are ridden with side effects  like increasing blood sugar and body load (feels like your body weights 4x more).

Many new drugs appear on the market legally and illegal but are all in similar classes like for example benzofuran class,when you tried one in a class usually the other ones have similar effects. If it doesn't help pois or give information then there is no need to use a newer drug of that class in the same category.

All drugs create a false sense of wellbeing (some are authentic tho) and usually create a bandaid on pois but do zero for the underlaying mechanism of pois. Someone who never had MDMA and try it for the first time think they cured pois but in fact making it worse long term.

Also im really experienced ..i had many bad trips and can brush them off and survive while staying sane. Someone who uses tryptamines and take 1mg too much can easily lose his mind. Its not for the faint hearted or minded, also they can worsen emotions caused by pois like depression, isolation etc. Alot of drugs also boost libido, if you stay celibate for 2 months and use drugs one could be compelled to seek release , this could also be an issue. Drugs change your behaviour short term this is guaranteed, this also relates to self control and discipline..

DMT im not sure about ...sometimes it seems to help pois and other times it makes it worse. Even tho it is natural it doesn't always means its good for you. Cannabis is hit and  miss, helps long term with inflammation but is more of a bandaid when it comes to pois. At a certain point cannabis made my chronic fatigue worse and made me emotionally blunt..i tried well over 30 strains inc. Cbd strains vaped, eaten and smoked. CBD is an anti psychotic and lowers % neurotransmitters transmitted, it is marketed as anti depressant but in fact is an depressant like all other anti psychotics. I stopped using it because it made depression worse long term, it sedates you so you think it feels better...again another bandaid.

CBD marketed in general is largely controlled by companies who control other giant companies...nothing revolutionary about it. The whole drug war is a scam anyway..make drugs illegal, slip them into the market yourself to make $$$ then arrest people and make more cash...this is what goverments do...there is no drug war, goverments themselfs smuggle huge amount of hashish/drugs into their own country. USA army goes to afganisthan to control the opium industry, then poison their own population with oxycodone / vicodin etc.

Smart drugs / nootropics like noopept and racetams all have beneficial effects on bdnf and nerve protection/ growth. Noopept worked wonders  for cognitive recovery but can drop blood sugar or deplete acetylcholine. Sublingual fasoracetam worked really well. I 100% recommend people trying these 2 nootropics, they work wonders on pois brainfog, depression and anxiety. Best 2 things i have tried next to mescaline and tryptamines.

« Last Edit: August 04, 2019, 06:34:59 PM by certainlypois2 »

drop247

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Re: The Role of BDNF in Etiology of Premature Ejaculation
« Reply #14 on: October 29, 2019, 09:45:05 PM »
Testing BDNF, then if low, getting it within normal range could be an investigative method.
There are no viable methods to increase BDNF directly, however some supplements are found to encourage BDNF production. Effectiveness of these supplements could be tested after a period of consistent supplementation, these are as follows:
-ashwagandha
-Asian ginseng
-bacopa
-cordyceps
-gotu kola
-Magnolia officinalis
-Rhodiola rosea
-coffee fruit extract
-curcumin
-olive leaf extract
-quercetin
-resveratrol
-omega-3 essential fatty acids, especially DHA (docosahexaenoic acid)
-l-theanine
-niacin
-magnesium, especially magnesium l-threonate
-taurine
-zinc (note that too much zinc can reduce BDNF)[Ref]

One study found that 100mg of whole coffee fruit concentrate increases BDNF by an astounding 143%[Ref]

This is like a list of things that help POIS acutely for me. Intersting.