All, I wanted to update this thread. I believe I have cured or controlled my POIS, I call it a 'solution' to my POIS problems; to the extent that I am now able to ejaculate without the torture of POIS. My journey has been tumultuous. I am inherently cautious, so I dont want to blindly credit Thyroid as this solution. Over last 10 years I aggressively tried to improve my health through supplements but nothing ever worked for me. The last 3 months however have been a game changer. Today, for some reasons, when I take anything, I noticeably feels its effect. E.g. Vitamin C, this thing never ever worked for me. I was so frustrated by vitamins, because they always produced the opposite effect
Vitamin C instead of helping a sore throat used to make it worse, and so on. Detox could be important, but the various detox supplements never did a dime for me.
I am not a medical professional so I'll use plain language. I feel my body was plugged/clogged to the extreme maybe that is why nothing worked except the aggressive pharmaceuticals (which while curing the specific symptom, leave many other trails of destruction in your body). When I ejaculated I used to smell chemicals coming out of skin pores and producing uticaria, hyperpigmentation, skin texture/roughness, coupled with brainfog, anger, speech lethargy, extreme irritability.
My first tiny break-through occurred with Glutathione stack and Sam-E. But it was not sufficient. While I have always eaten reasonably healthy, however in last 3 months, I did a 360 degree switch. I started eating lot of healthy "fats", raw/uncooked - Olive oil (cholesterol metabolism), Wheat germ oil (for growth factors), Bile acids with a sprinkle of Taurine (for fat metabolism, bile production), protolytic enzymes (for food digestion) including Trypsin and Chymotrypsin.
I reduced proteins, I still eat them, and I drastically cut down carbohydrates. At same time, I started using natural dissected Thyroid (from bovine sources for T3, T4). For first time in my life, I noticed a significant change happening to my body and mind. I became scared later from Thyroid so reduced dosage, today I open a capsule and sprinkle a small amount in a class of water and take it, the effects have been holding since. Its been few months. I used to be swelled on face and ankles all the time. Not only that disappeared but also with that POIS.
I feel much much calmer, relaxed, more social. My skin has no longer those smelly oily chemicals come out after ejaculation and I no longer have the uticaria etc. I am not 100% certain if Thyroid hormones OR Fats have been the solution, but I'll say they have been a catalyst. Over last 3 months, I have had 100+ ejaculations with sperm (I did not ever experience POIS with orgasm so differentiating it), so I'm reasonably confident today but humbly cautious.
All in all, I think its Growth Factors and Testosterone insufficiency or imbalance that produces the "allergic response" to semen or sperm cells - inflammation / mast cell activation and what not at least in my POIS. Healthy 'fats' are precursor to Testosterone. Thyroid hormones are the governance mechanism over Testosterone as well Growth Factors. I think when we ejaculate, our levels for Growth factors including Testosterone plummet, sending our body into a 7 day 'freeze mode' - the mast cells, uticaria, brain slowing to a halt, extreme irritation etc.
Just a quick thanks to the forum and all of you. Dont give up. I'll be less active but still check this forum from time to time, hopefully my solution will stay effective. And hopefully someday a gene or something will get identified that will help all understand POIS better.
