Xanthiol Nicotinate - Benefits, Risks and Function in POIS

[jivetalk]

Niacin Pills Report #4:

Okay Guys for this little experiment, I tried to do something which would normally have had me in VERY VERY POIS, cowering in a corner somewhere, shutting myself away from the world - completely unmotivated, lethargic, full of brain Fog and likely depressed. I have tried to O twice in two days - both times using Niacin (Nicotinic Acid Pills).

Monday Night:
Dosage: 3 x 100mg Nicotinic Acid Pills about 40 Minutes prior to O.

Straight after O, absoloutely no Brain Fog which is my main symptom straight after O. Was able to sleep fine - It seems that the Niacin Side Effects that I initially had are starting to wear off.

Tuesday Morning:
Woke up the next morning, was again absolutely amazed that I was NOT lethargic, and had Zero Brain Fog. It really is a DIFFERENT feeling waking up the next morning - expecting POIS but having NONE. Throughout the day, I maybe had 5-10% of Brain Fog - but it's hard to tell if this was due to brain fog or something else/stress/headache etc...

Tuesday Night:
Dosage: 3 x 100mg Nicotinic Acid Pills about 40 Minutes prior to O.

Same Scenario as previous night - No problems sleeping or overheating at all.

Wednesday Morning:
I woke up this morning, really really expecting POIS - some of Lethargy or brain fog at least. To my great suprise I had absotley NOTHING. It is currently about 3.21pm here - and I have had absolutely Zero symptoms all Day. I feel absolutely fantastic today - This is probably a combination of it being a Sunny day here AND the fact I have no POIS today, and are very excited by this little experiment.


Notes:
- I am VERY VERY excited by this test, I wanted to do something that would have for SURE put me in POIS previously.
- I did this test to prove to myself that this is NOT a PLACEBO effect.
- I made SURE that I took the Pills at least 30 mins Prior to O, and that I felt the FLUSH effect completely - and let it pass before O. I feel this is a critical component.
- I think that if you do not do the above, the damage would have already been done if you O - and these pills would only have little effect (although they still will have some).
- I will try to reduce my dosage soon, but at this stage am reluctant, as I am getting such good results.
- Please Keep posting our Results - GOOD or BAD.


If you will now excuse me, I am going to make some 'I LOVE B3' Tshirts to wear around. I think some of you here also made some promises about putting up posters of a certain Guy and his CAT    

[Habibou]

Here is the pharmacokinetics of an oral pill and the optimal effect in the body :
(it can fluctuate, regarding the pills, but this is an average) Our next step is to know it for the Niacin/XN.

[Starsky]

Slow release pills DONT WORK. You must have this quick strong flush, otherwise you will get POIS.

[Daveman]

jivetalk!!

Great news, lets hope that others can get the same results.

Make those T-Shirts and lets sell then to raise funds for our research.

We are so close with this that the research should be able to devise a definitve cure much more easily. Something that doesn;t damage the stomach and liver and something that doesn't cause the flush.

But in the meantime..EXTATIC

[victor.kons]

Niacin Acid Tablets Report #5.

Yesterday I've tried to experiment with the dose of Niacin Acid used by jivetalk. I took 300mg in Niacin Acid tablets. And I had a very good experience.

Last time I'm working pretty hard - 15 hours a day, and last days I felt pretty bad, my heart started going down because of tiredness. After taking 300mg Niacin Tablets I felt rise of my strength, my heart started working good again and I finished important milestone yesterday in my work after having an O. Also I had pleasant feeling in my head. This time there were not any negative feelings from stomach or liver. So maybe I have started to adapt to Niacin Acid tablets somehow.

After taking 300mg of Niacin Acid I felt flush in 5 minutes and in an hour the flush was pretty strong, but this time it was even pleasant. My face was red, but I didn't feel any discomfort. I had an O in an hour after taking the tablets. I didn't feel any POIS symptoms neither yesterday, nor today in the morning. So, this time niacin acid tablets was as good as XN injections for me.

I'm going to continue taking niacin acid tablets several times more to check whether this result will be stable.

Victor

[jivetalk]

jivetalk!!

Great news, lets hope that others can get the same results.

Make those T-Shirts and lets sell then to raise funds for our research.

We are so close with this that the research should be able to devise a definitve cure much more easily. Something that doesn;t damage the stomach and liver and something that doesn't cause the flush.

But in the meantime..EXTATIC

Daveman,

Was really joking about the T-Shirts - I'm not sure if I'd be game enough to walk around and have people ask me 'Why do you love B3 ?' - And I'm not sure how many of us would want to either. Unfortunately POIS is one of those 'embarrassing' disorders which we don't really want to talk about much out in the open, sometimes even with our own doctors.

I do sincerely hope that others get similar results to myself and Victor for the Niacin Tablets. I am very much looking forward to hearing about peoples experiences.
I hope people do allow Niacin the right 'chance', i.e, by taking it properly  (about an hour prior to O).

JT

[B_Daniel]

I took 3 Xan-Pro tablets (450mg of XN) last night and after a mild flush for 20 mins I had an O.  My POIS today is sub 20% for sure!  Success!  I woke up this morning at 6:30am and had trouble going back to sleep until 8am.  On a POIS day, I wouldve slept til 1pm no problem.  I'll write a follow-up post later to let ya'll know if my pois symptoms creep back later today or not.

edit: i don't think I faced any additional POIS later on in the day.  that's a somewhat difficult thing for me to accurately gauge though.

[B_Daniel]

.....

Make those T-Shirts and lets sell then to raise funds for our research.

We are so close with this that the research should be able to devise a definitve cure much more easily. Something that doesn;t damage the stomach and liver and something that doesn't cause the flush.

But in the meantime..EXTATIC

I completely agree that research will be SOOO valuable at this point!  And we do need to find a way to boost donations.  haha I don't think it's an I heart B3 t shirts, but I LIKE the thought process, daveman.  Maybe Dr. Waldinger would sign a copy of his Jan 2011 Published Study, that we could mail to anyone making a donation of $100 and up?  I'm gonna put this idea on the NORD Fundraising thread...

[Vincent M]

Can someone post a link to where I can buy Niacin pills(the fast releasing kind)?

Perhaps jivetalk and guthrie since you've had good results with niacin pills could you give me the link to where you bought yours?

I wanna give 'em a test run, but I want to make sure I'm getting the right stuff.

[Daveman]

As far as I know, Niacin pills are available over the counter just about anywhere. That's the beauty of it.

Any place that sells vitamins should have them.

[jivetalk]

As far as I know, Niacin pills are available over the counter just about anywhere. That's the beauty of it.

Any place that sells vitamins should have them.

Correct Daveman. I literally went into the First Health/Vitamin Store and Asked for some Nicotinic Acid/Niacin Pillls.

The tablets i used are made by Thompsons who are An australian and new zealand company. Depending on where u r in the world will determine if you can get this brand. However, any brand which is 'nicotonic acid' will be exactly the same. Just make sure it is not a variant like niacidimide or something like that. I've added a link below of the brand i use.

http://www.completehealth.com.au/Products/Vitamin_B3_Niacin_~_Nicotinic_Acid_100mg__100_tablets.aspx

Some others have tried Xan-pro from anti aging systems and seem to have similar results too.

A couple of things if u r going to try this...
1. Check with your dr to ensure its okay for you to take 300mg or more of niacin, as it can interfere with other meds, and can cause liver damage.
2. Take the niacin well in advance of the O. Ensure that you get the flush and it has passed before u O. This varies depending on if you have eaten etc...but is for me usually between 30 mins and 60 mins. Taking niacin After the o seems to have little effect.

Please let us all know your results - Good or Bad.

Good Luck!

[Vincent M]

Thanks guys. I'll let you know how it works out for me.

[Daveman]

I should be picking up Niacin tomorrow. I'm in day 2 so I'll very likely wait until I'm "free".

This will give me a bit of time to test the dosage (for flush and reaction), maybe up to two tests depending how the first one goes. I'm going to start with 100mg, being as I'm not sure how I'll react.

[jivetalk]

I should be picking up Niacin tomorrow. I'm in day 2 so I'll very likely wait until I'm "free".

This will give me a bit of time to test the dosage (for flush and reaction), maybe up to two tests depending how the first one goes. I'm going to start with 100mg, being as I'm not sure how I'll react.

Awesome Daveman! Can't wait to see if it works for you as well as it has for me!

[victor.kons]

Hi All,

I continue experiments with Niacin Acid tablets. Seems the effect is stable for me, e.g. no POIS symptoms if tablets are taken 1 hour before "O" in dosage of 150 mg. I've tried this trick 3 times so far, and every time - no POIS.

Victor

[Daveman]

Thanks Victor, great news, and a reasonable dose!

I hope to start soon. I made the mistake of sending my wife out to look for the Niacin, and she came back empty handed.    The pharmacist was completely stupid and my wife didn't have enough information to set her straight. They're so focused in selling brand names, they don't know how to sell by ingredient... Anyways it would have been better to go to a health store or herbal place...

I'll just have to go myself. I live in the country so will need to wait till the next time I go into town. The trip costs as much as the Niacin!

[JRD]

http://www.ncbi.nlm.nih.gov/pubmed/676925

The vasomotor response of dopamine and dopaminergic agonists was studies on feline isolated middle cerebral arteries in vitro and pial arterioles in situ following microapplication. The action of various inhibitors was tested to define the receptors involved. The contractile response could be blocked by alpha-receptor as well as serotonin receptor antagonists. The mode of inhibition suggested that serotonin receptors rather than alpha-adrenoceptors mediated the dopamine-induced contraction. A dose-dependent dilation could be evoked by the dopaminergic agonists on actively contracting pial arteries in vitro and by apomorphine in situ. The relative potency for the agonists together with blocking experiments indicated that the vasodilation was mediated by specific dopamine receptors.

[victor.kons]

Btw, forgot to say. I tried having 2 - 3 O's after taking 150mg in Niacin Acid tablets and had no POIS after that. Seems effect of niacin lasts for many hours.

Victor

[Daveman]

http://www.ncbi.nlm.nih.gov/pubmed/676925

The vasomotor response of dopamine and dopaminergic agonists was studies on feline isolated middle cerebral arteries in vitro and pial arterioles in situ following microapplication. The action of various inhibitors was tested to define the receptors involved. The contractile response could be blocked by alpha-receptor as well as serotonin receptor antagonists. The mode of inhibition suggested that serotonin receptors rather than alpha-adrenoceptors mediated the dopamine-induced contraction. A dose-dependent dilation could be evoked by the dopaminergic agonists on actively contracting pial arteries in vitro and by apomorphine in situ. The relative potency for the agonists together with blocking experiments indicated that the vasodilation was mediated by specific dopamine receptors.

OK, let's talk about this. First of all clarify what all of this means, and what the implication might be in the identification of an abnormal condition particularly as what might be exposed by the positive responses in taking XN and or Niacin.

[Observer]

Btw, forgot to say. I tried having 2 - 3 O's after taking 150mg in Niacin Acid tablets and had no POIS after that. Seems effect of niacin lasts for many hours.

Victor

Victor, would you mind to answer me some questions, they are very important for me.

Have you changed your diet since you know you have POIS?

Do you feel a worsening of POIS symptoms when you take foods with high glycemic index(Sugars, red meat, creams, desserts...)?

If the answer is yes; if you take foods like this(with high levels) before taking Niacin and having an Orgasm, do you develop symptoms? I ask you that because i have noted that if i have eaten a big salad, fruits, and then i took fenugreek prior having an orgasm, i will develop less POIS symptoms than if i take meat, desserts and then fenugreek...

The last question: You take your nicotinic acid pills, you have the flush, and you have the orgasm 1-2-3 hours later. It doesn´t matter if you eat a lot of desserts after that, that you´re going to not have POS because you have fully eliminated the symptoms?

Thank you very much!