Testosterone

[demografx]

Great to hear, joelawerence!

[demografx]

There is also a bit of Chicken and Egg scenario here. Is the Low Testosterone causing POIS or is POIS causing Testosterone to become low 

Interesting, joelawerence!

Never thought of it that way.

Demo

[demografx]

With my newfound 30-day supply of TRT patches, I continue my old POIS treatment regimen.

It’s still working for me: today is POIS Day Zero (POIS symptom onset began this morning).

For details, read my recent posts at this Testosterone thread. I have been using this protocol (TRT + Benadryl - note: a Benadryl side effect for me is nightmares for the last 10 years.

Can it work for you? That’s for you and your doctor to explore. We are all different.

This continues to work for me. But...I slept 17 hours - Benadryl-aided - since last night, plus “rested” the rest of today. Sleep for me is extremely effective, but I’m retired, so everyone can’t easily do this. I’m lucky in that respect. But not so lucky in my decades of working!

• I do not exceed Benadryl’s published dose guidelines.

But you should be aware of some risks, e.g.,
Benadryl’s increased dementia risk
in this Harvard Medical School article:

https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-201501287667

• I work closely under my endocrinologist’s supervision. I recently asked for - and received - an increase in TRT dosage. But only after a new blood test which confirmed my still-low T.

• After many failed attempts, it was only the guidance of this forum’s predecessor, Naked Science Forum/POIS thread, that led me to a successful treatment.

[demografx]

One doctor’s opinion:

Unpacking the Dangers of TRT
(Testosterone Replacement Therapy)

Before approaching testosterone replacement therapy, I also strongly believe men should look into natural ways to increase their testosterone. This begins and ends with losing weight, as we already mentioned, but here are a few more methods to consider.

By Dr. David Samadi 152, Contributor
HuffPost [blog]
https://tinyurl.com/86t9mhuv

[demografx]

My feeling of the ups & downs of being...

IN-POIS vs. OUT-OF-POIS
IN-POIS vs. OUT-OF-POIS
IN-POIS vs. OUT-OF-POIS
Repeat above year after year in-and-out-of-POIS...since you were a teenager!

[demografx]

2 cortisone shots to my feet yesterday (pain from metatarsal stress).

Today: shots seem to have helped my POIS?!?!

Could be placebo effect. Will update this when I feel I “know” more.

[demografx]

Sleep study last night. As expected (this was my 2nd study), I showed severe sleep apnea

Improved POIS symptom relief (took regular dose of 6mg testosterone & Tylenol PM - - includes 50mg Benadryl - - right before study)

Slept better than in YEARS. Mood lifted. Chronic fatigue lifted as well.

Resisted mask wearing for years. Now ready to wear it!!

[amstro]

Hi,

I'm trying to find an endocrinologist who would like to take me (the one I saw basically gave up on the second appointment asking me to see a sexologist and didn't charge me).
I got normal levels of "free testosterone" but didn't get the serum testosterone tested.

I wonder if some of us suffer from POIS not because of a lack of testosterone but because of an issue with androgen receptors.
A study in rats (study and sci-hub unlocked version) showed that sexual activity decreased "androgen receptor density (ARd) in the medial preoptic area (MPOA) and in the ventromedial hypothalamic nucleus (VMH), but not in the bed nucleus of the stria terminalis (BST)".

So the theory would be that POIS can be the result of two different mechanisms:
A) Patient has a low testosterone level, but still high enough not to provoke symptoms. However, after ejaculation, the androgen receptor density decreases. Low testosterone * low receptor density -> POIS

B) Patient has normal testosterone level but ejaculation decreases the androgen receptor density more than usual. Normal testosterone * very low receptor density -> POIS

Type A) and B) POIS could both be cured by increasing testosterone level (Normal testosterone * low receptor density -> still OK / High testosterone * very low receptor density -> still OK).

[Muon]

Sleep study last night. As expected (this was my 2nd study), I showed severe sleep apnea

Improved POIS symptom relief (took regular dose of 6mg testosterone & Tylenol PM - - includes 50mg Benadryl - - right before study)

Slept better than in YEARS. Mood lifted. Chronic fatigue lifted as well.

Resisted mask wearing for years. Now ready to wear it!!

You should compile this info in a personal thread/summary. People are unable to get a proper overview of your case. you could copy and dump it in that thread.

[demografx]

You should compile this info in a personal thread/summary. People are unable to get a proper overview of your case. you could copy and dump it in that thread.

This testosterone thread basically tells my story. People have been fine with the overview, simply by skimming it.

Thanks.

[demografx]

My most recent testosterone results (last week)

Component   Value   Reference Range & Units   Status

Sex Hormone Binding Globulin   25   11 - 80 nmol/L   Final

REFERENCE INTERVAL: Sex Hormone Binding Globulin


Testosterone, LC-MS/MS   187   300 - 720 ng/dL   Final

REFERENCE INTERVAL: Testosterone, LC-MS/MS


Testosterone, Free LC-MS/MS   35.6   47.0 - 244.0 pg/mL   Final

To convert to pmol/L, multiply pg/mL by 3.47

Note from my old endocrinologist’s office
(who has moved to another city)

Dear Demografx,

I am covering for [the endocrinologist who has left my city] since she is no longer with [our Medical Group]. Your testosterone levels are still low with the increase in dose of the patches [to 6mg/day Androderm]. You might need to change the type of testosterone you are using or increase the dose further. You can discuss this in your upcoming appointment with [my new endocrinologist].

Let me know if any questions.
Sincerely,

Dr. XYZ

 

[demografx]

I'm trying to find an endocrinologist who would like to take me…

I found this once by accident, can’t vouch for it, haven’t tried it but it seems very intriguing and worthwhile to explore (just my opinion)

To chat with an endocrinologist online, their ad states, “Unlimited chats – $5 one-week trial membership. Cancel anytime”
I just went to the endocrinologist site shown below and it lists
Dr. David, MD
Endocrinologist-Chief Resident at NYU
Pearl Wilson, Endocrinologist's Assistant seems to be the one who you begin with
https://tinyurl.com/j23z9jkc





*My only question/concern is that I could not google-find a “Dr David at NYU”. Maybe this service only uses his first name? I would ask Pearl Wilson, the first person who responds, about that if you decide to try it. Let me know if you do!

[Aladin]

The title is a bit misleading: interesting read about new findings about the link between sunlight and testosterone levels

https://www.technologynetworks.com/neuroscience/news/sex-and-sunlight-exposure-to-suns-uv-rays-enhances-romantic-passion-353062

[demografx]

Case of post-orgasmic illness syndrome associated with hypogonadism
https://onlinelibrary.wiley.com/doi/full/10.1002/iju5.12184

Thanks for the article, etcosp!

For the last 10 years I’ve been treated for “POIS” with TRT (testosterone replacement therapy).

However, my endocrinologist diagnosis says “hypogonadism”.

After 10 years, I’m still confused: which is which???

My POIS, like most POISers, lasted 3,4 days (prior to TRT).

As far as I know, hypogonadism is a 24/7/365 days/year condition, and is not connected specifically to orgasm in any way.

Maybe a forum expert like Quantum, Limejuice or Berlin can help me understand this better?

[Quantum]

Case of post-orgasmic illness syndrome associated with hypogonadism
https://onlinelibrary.wiley.com/doi/full/10.1002/iju5.12184

Thanks for the article, etcosp!

For the last 10 years I’ve been treated for “POIS” with TRT (testosterone replacement therapy).

However, my endocrinologist diagnosis says “hypogonadism”.

After 10 years, I’m still confused: which is which???

My POIS, like most POISers, lasted 3,4 days (prior to TRT).

As far as I know, hypogonadism is a 24/7/365 days/year condition, and is not connected specifically to orgasm in any way.

Maybe a forum expert like Quantum, Limejuice or Berlin can help me understand this better?

Demo, I cannot answer your question, since the causes of POIS are not scientifically known for now.  All I can say is that there is the possibility that there is a type of POIS related to hypogonadism, but not all men with hypogonadism have POIS, so there would be something else at play.  It is that 'something else' that research has to identify.

[aswinpras06]

Dear Demo

Just my finding.  I do not know  whether it is correct or not.

Testosterone reduces autoimmune diseases and allergic diseases caused by mast cells.
May be its the reason for the relief of your Pois.  Research is still going on  for using it exclusively for allergic asthma.

https://arstechnica.com/science/2018/02/testosterone-may-protect-men-from-autoimmune-diseases/

https://www.jaci-inpractice.org/article/S2213-2198(20)30514-6/fulltext


Most of the pois treatment prepacks work  largely by blocking the mast cell activaton or histamine release.

Niacin
http://getwellstaywellathome.com/blog/2015/06/seasonal-allergies-and-the-niacin-flush/

Taurine
https://www.ncbi.nlm.nih.gov/pubmed/28694089


Relief with Antihistamines, flavanoids in fenugreek&garlic, oral corticosteroids ,methylation support,pre-pack with  IDO/TDO/NMDAr blockers+ anti-oxidants and gluten free diet etc  all point to mast cell activation disorder.

Most of our members get relief with one of the above mentioned ways which also fits with MCAD where everyone has individual triggers and get relief with personalised treatment.

So POIS  is most likely to be MCAD triggered by mast cells present in the urinary tract and causing systemic inflammation which many a time crosses blood brain barrier and results in neural inflammation.

[demografx]

After 10 years, I’m still confused: which is which??? [hypogonadism vs POIS]

Demo, I cannot answer your question, since the causes of POIS are not scientifically known for now.  All I can say is that there is the possibility that there is a type of POIS related to hypogonadism, but not all men with hypogonadism have POIS, so there would be something else at play.  It is that 'something else' that research has to identify.

Thanks, Quantum! I feel better now (less foolish) about my confusion.

[demografx]

Dear Demo

Just my finding.  I do not know  whether it is correct or not.

Testosterone reduces autoimmune diseases and allergic diseases caused by mast cells.
May be its the reason for the relief of your Pois.  Research is still going on  for using it exclusively for allergic asthma.

Many thanks, aswinpras06!

[berlin1984]

Obstructive Sleep Apnea Is Associated With Low Testosterone Levels in Severely Obese Men
(Body Mass Index (BMI) > 35 kg/m2)
low free and total testosterone
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350060/
https://news.ycombinator.com/item?id=28254252

Not sure if this would also apply with lower BMI maybe in lower grade?

[demografx]

Obstructive Sleep Apnea Is Associated With Low Testosterone Levels in Severely Obese Men
(Body Mass Index (BMI) > 35 kg/m2)
low free and total testosterone
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350060/
https://news.ycombinator.com/item?id=28254252

Not sure if this would also apply with lower BMI maybe in lower grade?

Berlin, very interesting!

Thanks!