Female with POIS new here, possible POIS also triggered by stress and exercise

[takedrugstoletgo]

Hi all,

I recently came across POIS. I have has issues with depression and anxiety for a long time which only happen after orgasm or stress (including exercise). My symptoms are: generalized pain, poor stamina and sluggishness after orgasm, muscle weakness, flu like symptoms (runny nose/headache) night sweats, bad mood/temper, general depression and sadness after sex, hair loss.

I first managed it with Dextroamphetamine which is used for ADHD but now not even that helps and i will feel like crap for up to 10 days after sex or stressful days and exercise. I also have severe heat sensitivity after sex and feel like crap for a long time after with very little motivation. I tend to get severe sugar cravings alcohol cravings in POIS and feel extremely tired and weak. I also look awful, very puffy and my face looks kind of deformed and have cold hands and feet. I get diarrhea sometimes too during POIS.

Just came up with a new plan to try and heal myself which include water fasting, cold showers, low intensity exercise (walking mainly) and i stopped eating carbs. My doctor prescribed propranolol (beta blocker) and Xanax. I also stopped caffeine but that hasn?t helped much yet.

Hoping to learn more here and wish everyone good look with trying to cure POIS. Will be active on forum as much as i can. I have a week off of work now and plan on water fasting all week.

[Muon]

Welcome to the forum and thanks for sharing. I've copied your story to the 'Women with Post Orgasmic Illness Syndrome' thread:
https://poiscenter.com/forums/index.php?topic=2755.msg37400#msg37400

[demografx]

takedrugstoletgo, welcome to the forum!

[pert]

Hello takedrugstoletgo,

I've been reading about a supplement stack from nanna1, who has similar triggers to you. I think you should check it out: https://poiscenter.com/forums/index.php?topic=2502.0

[Muon]

I first managed it with Dextroamphetamine which is used for ADHD but now not even that helps and i will feel like crap for up to 10 days after sex or stressful days and exercise.

From the book Tuning the brain:

"Amphetamine salts (Adderall) are superior to dextroamphetamine and need only be administered twice a day."

"Guanfacine has been found to be as effective as dextroamphetamine in the treatment of ADHD in adults (Taylor FB, Russo JR, 2001). It is a specific agonist at the alpha2AR, which is particularly abundant in the PFC and LC."

"Arousal can be augmented by dextroamphetamine, which also increases DA, particularly in the NAc. Lesions of the MPOA in animals decrease sexual behavior. Sexual arousal, causing increased DA secretion, can cause relapse."

"The first plausible explanation about the mode of action of amphetamine in ADHD is that inhibition of DA firing and activation of negative feedback mechanisms increases DA release by stimulating NE release. Alpha1 heteroceptors on DA neurons stimulateDArelease (Zametkin AJ, LiuttaW, 1998). D1 and D2 antagonists do not affect amphetamine-induced stimulation, nor do alpha2 antagonists or beta blockers (ShiWXet al., 2000). Alpha1 antagonists block amphetamine-induced burst responses and diminish increase in firing rate. I should be able to administer the alpha1 agonist midodrine to a patient and see the same response as I do with dextroamphetamine. My patients who have obtained the NE-reuptake inhibitor reboxetine should also have a similar effect, but they do not."

[Muon]

What duration of stimulation does it take to reach orgasm?

[Muon]

Hey all,

I was thinking about this just now. I notice that i get POIS symptoms from other things than sex/orgasm too which include too much stress, lack of sleep, caffeine, too much exercise.

I got a new symptoms today and i?m wondering if anyone else has this (only happens after orgasm): my body will hurt all over, like i have been working out like crazy all day or something. All my muscles hurt and my skin gets extremely sensitive/irritable.

Can anyone relate to the skin sensitivity issue? I also have ADHD so it might just be that but it can?t be a coincidence IMO. Prolactin/Dopamine related maybe?

Yep. It gets even worse the more often i have sex. I?m 5?9/5?10 or so (female) and weigh 120-125 pounds, no appetite most of the time and food doesn?t really taste that good anymore unfortunately. Even stuff i really used to enjoy i can?t eat anymore.

Im a female so my progesterone naturally fluctates, but i notice during the 2 weeks that my progesterone rises i feel almost constant POIS with flu-like symptoms and fatigue. When my period starts and the 2 weeks before ovulation i feel pretty much normal with no flu symptoms and energy is pretty good most of the time.

Does anyone here know their progesterone levels? Are they high aswell?

+1 here for the low muscle mass despite working out a lot. Never been able to build much if any muscle, just skin and bones mainly.

Kind of a story about my POIS, wonder if anyone can relate to anything (i think most here can..)


I noticed this lately. My POIS gets triggered by more and more things including exercise, fatigue, cold weather (heat too though, any extremes), excitement (when very happy or when emotional), stress.. Also the slightest bit of sexual excitement triggers POIS even if its just texting or hinting at anything sexual.

I was texting with a girl last night (i?m female & bisexual) and there was some sexual tension, nothing extreme but today i woke up feeling hungover in POIS state. I could already feel POIS symptoms while texting. My mood got bad out of nowhere and i suddenly felt like going to sleep and ignored the girl for the rest of the night.

Anything that stimulates me triggers POIS symptoms i think. My main symptoms are bad mood, sweating, heart palpitations, neck pain and i feel extremely cold despite normal temperature and my bowels get very bad during POIS. Also start feeling anxious/panic for no reason and get extreme insomnia despite being very tired i can?t sleep no matter how tired i am.. I haven?t slept for more than 4-5 hrs for weeks, some nights only an hour or i dont sleep at all..

I feel very irritable during POIS and want to be alone most of the time. I get short tempered and just generally annoyed very easily whereas outside of POIS im usually calm and can control myself well.

I have always been very thin but ever since POIS started i went from thin to underweight unable to gain weight. I am skin & bones at this point.. I used to lift weights a lot and play a lot of sports but my muscles are so weak now and my endurance is very bad ever since POIS too and it doesn?t improve with working out.. It?s so weird.

Also only during POIS i have allergies and histamine intolerance, runny nose and congestion/sinusitis, swollen lymph nodes. Out of POIS i have no allergies or congestion.

I have no advice but i have the same problem with exercise intolerance. Usually intense exercise triggers POIS for me and i feel extremely tired for days after exercising with tachycardia & flu like symptoms. It sounds like PEM (post exertional malaise) which is also common in CFS, dysautonomia etc.

@prospero

About the bisexuality, i too notice that during POIS i lean more towards dating a girl (aka same sex) and be the leader/dominant one whereas in my ?normal? state i lean more towards dating a guy (thus opposite sex) & enjoy feeling more feminine. Its very weird.

Curious about this. My cortisol is low.

DAE have these symptoms? After orgasm i immidiately get a headache and fever. Then next day i sweat way more than usual and my stamina is very bad too.
I also get tachycardia episodes during/after orgasm for up to a week. I feel very cold also most of the time which only happens after orgasm too.

I notice my muscles are getting more and more tight during POIS. Mainly legs and back/neck. Sometimes they are so tight it hurts when sitting down.

Anyone else? Or any way to reduce tightness? I tried heat but heat makes my POIS worse still.