Recent Posts

91

What is POIS / Re: Is POIS a version of CFS?

« Last post by Hopeoneday on February 24, 2025, 12:29:16 PM »

Latest post from Progec is ok, it is connected to a mater and wery
well summarized.
Enyone who want to understand what he is wroted, can easly learn
on google, yust can ask what it is.

92

What is POIS / Re: Is POIS a version of CFS?

« Last post by demografx on February 24, 2025, 10:10:57 AM »

• PINK1

• HIF-1alpha factors

• ME/CFS

• mitophagy

• mitochondria

• glycolytic metabolism

• hypoxia

• oxidative stress

• PEM induction

PROGECITOR:

• These are not terms understood by the majority of our non-technical POISCenter forum members

• This is not good forum communication

• This is poor forum etiquette

• Please *E D I T*  & speak “English”!


As I stated yesterday:
technical jargon can alienate readers

93

What is POIS / Re: Is POIS a version of CFS?

« Last post by Progecitor on February 24, 2025, 09:41:03 AM »

I repost this for the curious. I hope this way it won’t offend anyone!

Recently the PINK1 and HIF-1alpha factors have been found to be increased in ME/CFS and long covid (LC) patients and there is no reason to believe that this would be any different in the case of POIS.
PINK1 induces mitophagy to eliminate damaged mitochondria, while HIF-1alpha induces glycolytic metabolism due to hypoxia and oxidative stress as a protective mechanism. In long covid patients there is a down shift in the glycolytic metabolism within a week after PEM induction, which makes it very reminiscent of a POIS episode.

94

What is POIS / Re: Is POIS a version of CFS?

« Last post by demografx on February 23, 2025, 12:08:00 PM »

Hi Progecitor. Thanks for your response. I'm afraid, perhaps due to all the medical jargon you've used again, I don't understand your summary of your post either! It's way over my head  .Could you write a short summary of your summary? Or maybe you feel the content has been simplified as much as possible already?

Once again, a forum etiquette issue!

Internet forum etiquette discourages the use of technical jargon, especially in forums with a non-technical member base.

95

What is POIS / Re: Is POIS a version of CFS?

« Last post by demografx on February 23, 2025, 11:39:26 AM »

@Progecitor

I find it difficult to follow your posts.

If I could tell you in one sentence I would have done so…

Rude reply!

I removed Progecitor’s post from: Today at 05:06:09 AM for his re-submission for length, clarity & technical jargon.

96

What is POIS / Re: Is POIS a version of CFS?

« Last post by Sisyphus on February 23, 2025, 08:16:16 AM »

Hi Progecitor. Thanks for your response. I'm afraid, perhaps due to all the medical jargon you've used again, I don't understand your summary of your post either! It's way over my head  .  Could you write a short summary of your summary? Or maybe you feel the content has been simplified as much as possible already?

97

What is POIS / Re: Is POIS a version of CFS?

« Last post by Progecitor on February 23, 2025, 07:55:56 AM »

@Progecitor

I find it difficult to follow your posts. Sorry about that!

Your latest post here consists of lots of quotes of scientific text using specialised medical terms that I think very few people would understand unless they have a very specialised medical background. Perhaps you yourself have a specialised medical background?

Your post seems to have a theme of the condition hypoxia. That's one term that I could guess the meaning of   
I have a feeling that you might be making an interesting point but it's hidden amongst all the medical jargon. Are you able to summarise how you think pois might be connected with hypoxia in one short sentence of let's say about 20 words, readable to those of us on the forum who do not have a science/medical background?

If I could tell you in one sentence I would have done so, but you have to see the whole process to understand how it all comes together. I am not exactly sure how much hypoxia is involved, but ROS is a certain culprit and there is clearly a glycolytic shift in our metabolism partly due to mitochondrial dysfunction. Mitochondrial dysfunction itself may come about due to a variety of reasons (e.g. sepsis, senescence, autoimmunity, etc). If we consider the treatments that we, ME/CFS and long covid patients have used with some degree of success, then it is easy to see that HIF-1a regulation is majorly involved in disease control. It is especially interesting to see that post-exertional malaise (PEM) in long covid patients last for about a week, similarly to a POIS episode, when there is a back shift towards oxidative phosphorylation. However the tricarboxylic acid (TCA) cycle remains impaired with somewhat elevated glycolytic metabolites even at baseline. This is quite relevant from my point of view as I have POIS/CFS and this exactly could explain the difference between my acute (dominated by POIS) and chronic phases (dominated by CFS).

98

General Alternative Causes and Treatments of POIS / Re: Got Cured

« Last post by Sisyphus on February 23, 2025, 06:59:38 AM »

@lw

Congratulations on finding a cure for your pois. That must feel great!
It would be great if you could summarise your history, what your pois systems were, any interesting medical results/diagnoses, the steps you took to get rid of pois, what your treatment was and how you are doing today?

99

What is POIS / Re: Is POIS a version of CFS?

« Last post by demografx on February 23, 2025, 06:57:29 AM »

@Progecitor

I find it difficult to follow your posts. Sorry about that!

Your latest post here consists of lots of quotes of scientific text using specialised medical terms that I think very few people would understand unless they have a very specialised medical background. Perhaps you yourself have a specialised medical background?

Your post seems to have a theme of the condition hypoxia. That's one term that I could guess the meaning of   
I have a feeling that you might be making an interesting point but it's hidden amongst all the medical jargon. Are you able to summarise how you think pois might be connected with hypoxia in one short sentence of let's say about 20 words, readable to those of us on the forum who do not have a science/medical background?

Thank you, Sisyphus.

100

General Alternative Causes and Treatments of POIS / Re: Got Cured

« Last post by lw on February 23, 2025, 06:44:49 AM »

It's been a while. I still believe I've completely figured out POIS -I really do. There were still times when it came back during periods of nervousness, and I'm practically certain it's a nervous system disorder linked to anxiety and a specific stress response. I'm also convinced that POIS is intensified when a person orgasms while under stress.

I genuinely want to help you all, even those who don?t believe me. I?ve endured five brutal days of POIS.