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61

General POIS Discussions / Re: Has anyone consulted doctors is Boston, MA?

« Last post by pois_nc on November 23, 2023, 04:40:21 PM »

Thanks!

62

General Alternative Causes and Treatments of POIS / Re: Chart of POIS Types and Their Possible Relief Methods (ongoing project)

« Last post by Harrie on November 23, 2023, 04:41:54 AM »

Hi Harrie, and welcome to poiscenter  

Thanks for taking the time to share your positive experience with forskolin and zinc.
There are some preliminary scientific data showing that forskolin may increase testosterone level ( see https://www.greatgreenwall.org/supplements/forskolin-increase-testosterone/ ) .   Zinc is well known to be positive for the prostate.
This method of control of POIS symptoms could be in the same family as TRT ( Testosterone Replacement Therapy), but with probably fewer potential side effects, if forskolin does not have too many side effects, and does not have the cardiovascular side effects of testosterone itself, as well as its effect on fertility.  Since forskolin is not very well known up to now, it is hard to say.
If your method is still consistently effective 3 months from now, let me know - I would be happy to add it to my "POIS Types chart and their possible control methods", found at the beginning of this thread

What were your other symptoms, apart from brain fog?  How long did your POIS attacks usually last, with no inc and forskolin?
And, about your control method, do you take Forskolin and zinc every day, or only after orgasm?  Did you ever tried taking it 20 to 60 minutes before orgasm, to see if it would be more effective still?

Thanks for your reply. Although I have had these symptoms for over two decades, I never thought to connect them to having orgasms. As a result I am almost embarrased to say that I had them regularly (almost daily) during this period and I can't remember having periods of not having orgasms for longer than three, maybe four days.. This might explain why I experienced my symptoms lighter than some of the members here, but also in a more continuous, constant state. Its only after I withheld myself from having orgasms a couple of months ago, that I experienced the severe negative benefits right after having one again.

My most frequent symptoms are brainfog combined with headaches, memory problems and concentration issues (difficult to focus). In addition I also feel very tired afterwards (I notice this now, although I also tend to sleep too little) and I have a chronic nose cold (not sure if this is related). I have been seeing doctors about this since 2004 and I've done MRI's, memory tests, have been treated for conditions like a slow Thyroid, a B12 defficiency, etc, and tried a boat load of supplements, but non of it helped.

Since I started to link my symptoms to orgasms, I did try to limit them as much as possible which comes down to basically once a week. I now experience the symptoms for approx 3 days afterwards, of which the first day is by far the most severe. One thing that I additionally notice now is that I become easily overstimulated (I always had this too some degree, I can't wear regular jeans for instance) and get extremely short tempered and angry when this happens (which isn't usefull in a household with three small kids).

I found this forum several months ago and tried some of the proposed solutions in this topic, e.g vitamin D / vitamin B3 / Macca Tea that didn't help. I also read in one of the topics about anti-allergy pills and because I already used Centrizine, I started to take 2 10mg pills 10 minutes before an orgasm. This brought some relief for the physical symptoms, but did not help with being over stimulated and hot tempered. Now that I have tried the Forskolin + Zinc combination, I feel much more relaxed and (as far as I can tell) completely symptom free.

I use Forskolin + Zin only right after or approx. an hour after having an orgasm (I prefer to take it when I go to bed, because I might get a bit nauseous). I haven't tried taking it before (I will try that next time), so I can't judge on that. I also didn't do follow up dosseses, although I have to admit that I had a 5 day period with daily orgasms, so I took it 5 days in a row. I could try to use it daily, but I now had my last orgasm two days ago, so I took it then and now still feel fine.  In the beginning I combined Forskolin + Zinc with the centrizine, but soon started to take only the Forskolin + Zinc with similar results.

 I am definitly not a health expert, so I don't know why it works as it does, but I did feel so positive about it that I wanted to share.  I hope this helps to provide some additional explanation and hopefully some others (for instance who are still searching for a solution) decide to try it and experience positive effects as well.

63

Lifestyle Diary and POIS Summaries / Re: Warrior's Journal (My POIS Solution, Experiments, & Theories)

« Last post by Warrior on November 22, 2023, 07:32:55 PM »

Correct me if I'm wrong but according to Nanna1's theory, your animal-based approach should not improve your POIS (Arachidonic acid).

Yes that’s correct.

From what I’ve read from Nanna1 I do not believe he had the same degree of food sensitivities that I do, rather he had exercise intolerance (from my memory). Who knows tho - I doubt he would have ever tried a diet that is so low in plant foods. He did abide by a gluten-free vegan diet though.

My animal-based diet without a doubt improved my POIS dramatically because of removing the plant foods that I am sensitive to (as part of my POIS condition.)

The arachidonic acid (AA) part is super interesting, but I’m not sure if he got the entire picture of the EPA/AA part. When I first began his method, it was extremely effective and I was still eating adequate amounts of animal foods - lots of beef, eggs, and dairy and therefore high amounts of AA. This was all off the back of many months being on an animal-based diet as well. I believe that the reason the method worked very effectively initially is because I kept my omega-6 consumption pretty much close to zero for many months before beginning his method. My Omega-3 would have been at a very solid level. Then I began eating foods higher in omega-6 and this seems to correspond with the method becoming less effective. I could be wrong though, this is just my bro science theory.

For clarification during my animal-based diet - I ate strictly red meat from Australia which is predominantly grass fed (which should in theory contain higher Omega-3) and sardines (high in Omega-3). I also ate a lot of dairy (I believe most dairy in Australia is mostly grass-fed). I also ate regular free-range eggs, which would have contained a bit of omega-6. All these foods contain decent amounts of the omega-6 AA Nanna1 talks about being very inflammatory in the context of his POIS theory.

From my imperfect memory of scrolling through a lot of his messages and theories, his understanding of EPA/AA seemed to be a developing learning. He later on introduced the CLA and believed that allowed him to not require as much EPA for the method.

64

Lifestyle Diary and POIS Summaries / Re: Warrior's Journal (My POIS Solution, Experiments, & Theories)

« Last post by Muon on November 22, 2023, 06:34:37 PM »

Correct me if I'm wrong but according to Nanna1's theory, your animal-based approach should not improve your POIS (Arachidonic acid).

65

General POIS Discussions / Re: Has anyone consulted doctors is Boston, MA?

« Last post by demografx on November 22, 2023, 05:15:39 PM »

I am moving to Boston soon, so I was wondering if anyone has consulted doctors in this area

Quantum has a list of POIS doctors here you can search. Geographic location included. So if not in Boston, someone in reasonable proximity may be found.

Meanwhile, I found this, pois_nc. It’s an old post, but perhaps you can track Dr Aidan Long and/or see if Massachusetts General Hospital may perhaps have some legacy interests in POIS.

Also Hoping, a longtime member might possibly assist?

Hey everyone,
I'm a current student at Harvard, and have been working with a team of doctors here to try and map out a treatment. I recently sat down with my allergist and discussed Waldinger's papers and the allergy theory. He was really excited about it and very receptive to the idea (always a plus to get some positive feedback in the medical community!). He's been in touch with a number of his colleagues about the condition. He's interested in exploring the allergy theory but also doing some hormonal testing, blood work, etc. to rule out other options. He's referred me to Dr. Aidan Long, an allergist at Massachusetts General Hospital, who will be conducting the testing. I haven't met with Dr. Long yet, but I hope to in the next week or so.

I just wanted to spread the word. It's helpful to know that we're getting somewhere, and Harvard isn't a bad place to start!

Is anyone in the Boston area and interested in also visiting with Dr. Long? Please let me know. I may ask him if he's interested in doing a case study of a group of us. I can't promise anything, but it's definitely something I'll propose to him.


Keep fighting the good fight everyone!

Hi Hoping!

How terrific!!!!! POIS is now known in what may be the most famous university in the world!!

If Dr. Long and his colleagues are interested in doing some type of case study -- they may be able to accept specimens from those of you from other states in the US -- and even from overseas. So everyone -- there's a chance of your specimens being included if this comes to pass.

What better motivation could there be for you all to support your research grant??? Whether it's the ivory towers of Harvard or the local junior college -- funds will be needed to do an in-depth study.

Wonderful news, Hoping!  You've brought some realistic optimism to your POIS comrades!! 

Your name fits you perfectly. :-)

Stef





 

66

General Alternative Causes and Treatments of POIS / Re: Chart of POIS Types and Their Possible Relief Methods (ongoing project)

« Last post by demografx on November 22, 2023, 05:05:28 PM »

Hi everyone,

I am new to the forum, but I have been reading up for a while (and tried several potential solutions). I am almost 40 years old and only recently discovered that there was a name for my condition, POIS. I don't think that I have it as severe as some of you here, but I have always had the feeling that something was wrong. I experienced an almost continuous state of brain fog and found it difficult to concentrate and memorize important information. I have done every test there is, including MRI's & memory tests in the hospital. I never once realized it could be orgasm related until a couple of months ago when I read up about the (potential) positive effects of not having an orgasm. I decided to out for a week and instead of the benefits noticed the very negative effects as soon as I had an orgasm again (not only the brain fog, but also becoming over stimulated very easily and very short tempered towards my loved ones).

Anyway, enough for the introduction let's get to the reason why I decided to create an account. two weeks ago I've found this topic on Reddit (https://www.reddit.com/r/POIS/comments/17l4z5k/potential_pois_treatment_for_symptoms_too_much/?rdt=37968) where the TS links POIS to a AcetylCholine/Choline Dominance. As a potential remedy he combined Forskolin (a weight loss supplement) with Zinc and had great results with the reducing effects of POIS ("Within 5-10 minutes it's like the lights came on in my brain and my brain fog was gone!").

Based on his review I decided to give it a go and ordered 1000mg of Forskolin and 30mg of Zinc supplements to try it for myself and I am very happy that I did. I have tried it approx. 6 times now where I took both supplements directly or some time after an orgasm (or multiple ones) and I feel so much better than I did before. My brainfog is completely gone and I feel much more relaxed than I used to (not as short tempered as I normally would in the days after an orgasm). In the meantime another user (lanonimoose) replied in the same topic who tried it and experienced much milder symptoms that lasted much shorter than he normally had. That makes three positive experiences, which is why I wanted to share it here on this forum as well (I couldn't find anything on Forskolin here). Perhaps this can be a solution for others as well.

Please note that I am not a doctor, just a guy searching for a cure. I did experience one side-effect, which is that sometimes I experience a short period of nausea which might also be caused by the fact that I took it on an empty stomach. Nothing too bad tho and it quickly faded, so it definitely is worth it.

I hope this info is helpfull to some of you. If you have any questions, then let me know.

Take care!

PS, I also wanted to share my experience on Reddit, but apparently your account has to be 15 days old before you can post in the POIS section there 

Hi Harrie, and welcome to poiscenter  

Thanks for taking the time to share your positive experience with forskolin and zinc.
There are some preliminary scientific data showing that forskolin may increase testosterone level ( see https://www.greatgreenwall.org/supplements/forskolin-increase-testosterone/ ) .   Zinc is well known to be positive for the prostate.
This method of control of POIS symptoms could be in the same family as TRT ( Testosterone Replacement Therapy), but with probably fewer potential side effects, if forskolin does not have too many side effects, and does not have the cardiovascular side effects of testosterone itself, as well as its effect on fertility.  Since forskolin is not very well known up to now, it is hard to say.
If your method is still consistently effective 3 months from now, let me know - I would be happy to add it to my "POIS Types chart and their possible control methods", found at the beginning of this thread

What were your other symptoms, apart from brain fog?  How long did your POIS attacks usually last, with no inc and forskolin?
And, about your control method, do you take Forskolin and zinc every day, or only after orgasm?  Did you ever tried taking it 20 to 60 minutes before orgasm, to see if it would be more effective still?

Welcome to POISCenter, Harrie.

As a lifetime testosterone fan, I appreciate this discussion, Harrie & Quantum.


Thank you!

67

General Alternative Causes and Treatments of POIS / Re: Chart of POIS Types and Their Possible Relief Methods (ongoing project)

« Last post by Muon on November 22, 2023, 12:20:09 PM »

https://www.reddit.com/r/POIS/comments/17l4z5k/potential_pois_treatment_for_symptoms_too_much/

Forskolin plus zinc (long term?)

https://en.wikipedia.org/wiki/Forskolin#Mechanism_of_action

Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP

68

General Alternative Causes and Treatments of POIS / Re: Chart of POIS Types and Their Possible Relief Methods (ongoing project)

« Last post by Quantum on November 22, 2023, 11:52:02 AM »

Hi everyone,

I am new to the forum, but I have been reading up for a while (and tried several potential solutions). I am almost 40 years old and only recently discovered that there was a name for my condition, POIS. I don't think that I have it as severe as some of you here, but I have always had the feeling that something was wrong. I experienced an almost continuous state of brain fog and found it difficult to concentrate and memorize important information. I have done every test there is, including MRI's & memory tests in the hospital. I never once realized it could be orgasm related until a couple of months ago when I read up about the (potential) positive effects of not having an orgasm. I decided to out for a week and instead of the benefits noticed the very negative effects as soon as I had an orgasm again (not only the brain fog, but also becoming over stimulated very easily and very short tempered towards my loved ones).

Anyway, enough for the introduction let's get to the reason why I decided to create an account. two weeks ago I've found this topic on Reddit (https://www.reddit.com/r/POIS/comments/17l4z5k/potential_pois_treatment_for_symptoms_too_much/?rdt=37968) where the TS links POIS to a AcetylCholine/Choline Dominance. As a potential remedy he combined Forskolin (a weight loss supplement) with Zinc and had great results with the reducing effects of POIS ("Within 5-10 minutes it's like the lights came on in my brain and my brain fog was gone!").

Based on his review I decided to give it a go and ordered 1000mg of Forskolin and 30mg of Zinc supplements to try it for myself and I am very happy that I did. I have tried it approx. 6 times now where I took both supplements directly or some time after an orgasm (or multiple ones) and I feel so much better than I did before. My brainfog is completely gone and I feel much more relaxed than I used to (not as short tempered as I normally would in the days after an orgasm). In the meantime another user (lanonimoose) replied in the same topic who tried it and experienced much milder symptoms that lasted much shorter than he normally had. That makes three positive experiences, which is why I wanted to share it here on this forum as well (I couldn't find anything on Forskolin here). Perhaps this can be a solution for others as well.

Please note that I am not a doctor, just a guy searching for a cure. I did experience one side-effect, which is that sometimes I experience a short period of nausea which might also be caused by the fact that I took it on an empty stomach. Nothing too bad tho and it quickly faded, so it definitely is worth it.

I hope this info is helpfull to some of you. If you have any questions, then let me know.

Take care!

PS, I also wanted to share my experience on Reddit, but apparently your account has to be 15 days old before you can post in the POIS section there 

Hi Harrie, and welcome to poiscenter  

Thanks for taking the time to share your positive experience with forskolin and zinc.
There are some preliminary scientific data showing that forskolin may increase testosterone level ( see https://www.greatgreenwall.org/supplements/forskolin-increase-testosterone/ ) .   Zinc is well known to be positive for the prostate.
This method of control of POIS symptoms could be in the same family as TRT ( Testosterone Replacement Therapy), but with probably fewer potential side effects, if forskolin does not have too many side effects, and does not have the cardiovascular side effects of testosterone itself, as well as its effect on fertility.  Since forskolin is not very well known up to now, it is hard to say.
If your method is still consistently effective 3 months from now, let me know - I would be happy to add it to my "POIS Types chart and their possible control methods", found at the beginning of this thread

What were your other symptoms, apart from brain fog?  How long did your POIS attacks usually last, with no inc and forskolin?
And, about your control method, do you take Forskolin and zinc every day, or only after orgasm?  Did you ever tried taking it 20 to 60 minutes before orgasm, to see if it would be more effective still?

69

General Alternative Causes and Treatments of POIS / Re: Brain Fog

« Last post by Muon on November 22, 2023, 10:28:23 AM »

Based on his review I decided to give it a go and ordered 1000mg of Forskolin and 30mg of Zinc supplements to try it for myself and I am very happy that I did. I have tried it approx. 6 times now where I took both supplements directly or some time after an orgasm (or multiple ones) and I feel so much better than I did before. My brainfog is completely gone and I feel much more relaxed than I used to (not as short tempered as I normally would in the days after an orgasm). In the meantime another user (lanonimoose) replied in the same topic who tried it and experienced much milder symptoms that lasted much shorter than he normally had. That makes three positive experiences, which is why I wanted to share it here on this forum as well (I couldn't find anything on Forskolin here). Perhaps this can be a solution for others as well.

70

Articles, References and Links / Re: POIS paper treatment summary

« Last post by Muon on November 22, 2023, 10:26:13 AM »

Based on his review I decided to give it a go and ordered 1000mg of Forskolin and 30mg of Zinc supplements to try it for myself and I am very happy that I did. I have tried it approx. 6 times now where I took both supplements directly or some time after an orgasm (or multiple ones) and I feel so much better than I did before. My brainfog is completely gone and I feel much more relaxed than I used to (not as short tempered as I normally would in the days after an orgasm). In the meantime another user (lanonimoose) replied in the same topic who tried it and experienced much milder symptoms that lasted much shorter than he normally had. That makes three positive experiences, which is why I wanted to share it here on this forum as well (I couldn't find anything on Forskolin here). Perhaps this can be a solution for others as well.