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71
Hormonal Causes and Treatments / Re: Mast Cell Activation Syndrome
« Last post by Muon on April 04, 2025, 08:12:24 AM »
Topical Lidocaine
https://www.reddit.com/r/POIS/comments/1jqagge/lidocaine_use_for_pois_symptom_relief/
”…overuse can even cause death”, per above reddit poster - Demo

Effect of lidocaine on histamine release and Ca2+ mobilization from mast cells and basophils
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-6576.1996.tb05577.x

Quote
Our results indicate that lidocaine directly inhibits histamine release from both rodent mast cells and human basophils
no great evidence that mast cells do or do not play a role in POIS - - demografx



***Forum Administrator (demografx) note:***


AI Overview

Lidocaine, while a useful local anesthetic, poses several hazards, including potential for allergic reactions, cardiovascular complications like arrhythmias and hypotension, and central nervous system effects like seizures and coma, especially with overdose or misuse.
72
Hormonal Causes and Treatments / Re: Traumatic brain injury, thyroid, liver and adrenal problems
« Last post by solomon on April 03, 2025, 08:19:35 AM »
Though difficult to respond to very long stayed post, I believe that your problem is quite similar with me mainly in related to POIS and hyperthyroidism problem however your hypothesis of brain damage require a scientific proof. My hyperthyroidism is the outcome of autoimmune response. I didn't have any accident or trauma before but I primely developed POIS and hypothyroidism followed. I believe that  either mast cell activation by O or any other triggering factors could be the culprit. How is your condition now? how did you manage it?
73
POIS Research / Re: Great News - POIS Lab is Almost Ready for the Study !
« Last post by Quantum on April 02, 2025, 11:52:32 AM »
Quote from: Pointpleasant88 on April 01, 2025, 02:36:08 PM
Anyone knows about the progress of this study?
The lastest news we had is that the pilot study (testing all the settings and procedures with a few non-POISers test subjects) is about to begin in the coming weeks.  Just some supplies are missing, and some last minutes details with computers, sensors, equipments and else.   Stay tuned !
74
What is POIS / Re: Is POIS a version of CFS?
« Last post by Pointpleasant88 on April 02, 2025, 11:09:48 AM »
When is the study finished did I hear correctly she said recruiting at the end of the year ?
75
General POIS Discussions / Re: Dopamine’s role in male ejaculation
« Last post by demografx on April 02, 2025, 12:48:14 AM »
Quote from: Aladin on April 01, 2025, 09:32:29 PM
https://neurosciencenews.com/dopamine-male-sexual-behavior-28519/?fbclid=IwZXh0bgNhZW0CMTEAAR2tMmV_yJQ-HeO9zw3ELOZ6vLuMpj1iz5_l9rtcuBdh5qMs5KgIDnxpqIY_aem_qLt0WXCCXm56ilNS3Lu8OA

Wouldn’t this be worth transferring to the NORD researchers?

Sent, thank you.
76
General POIS Discussions / Dopamine’s role in male ejaculation
« Last post by Aladin on April 01, 2025, 09:32:29 PM »
https://neurosciencenews.com/dopamine-male-sexual-behavior-28519/?fbclid=IwZXh0bgNhZW0CMTEAAR2tMmV_yJQ-HeO9zw3ELOZ6vLuMpj1iz5_l9rtcuBdh5qMs5KgIDnxpqIY_aem_qLt0WXCCXm56ilNS3Lu8OA

Wouldn’t this be worth transferring to the NORD researchers?
77
POIS Research / Re: Great News - POIS Lab is Almost Ready for the Study !
« Last post by demografx on April 01, 2025, 04:45:08 PM »
Quote from: Pointpleasant88 on April 01, 2025, 02:36:08 PM

Anyone knows about the progress of this study?


https://poiscenter.com/forums/index.php?action=recent
78
POIS Research / Re: Great News - POIS Lab is Almost Ready for the Study !
« Last post by Pointpleasant88 on April 01, 2025, 02:36:08 PM »
Anyone knows about the progress of this study?
79
General Alternative Causes and Treatments of POIS / Re: Possible Cure for Pois. Pois Free for a Month
« Last post by b_jim on March 31, 2025, 01:40:44 AM »
Mine is normal. If you drink a lot of water it's normal.
Your first urine after waking up must be colored. If not you need to check your kidneys with the doctor.
80
General Alternative Causes and Treatments of POIS / Re: Possible Cure for Pois. Pois Free for a Month
« Last post by picasso1122 on March 30, 2025, 11:33:07 PM »
Quote from: b_jim on March 29, 2025, 03:01:47 AM
I vote for nitric oxide.

A little watermelon cure this summer is something worth trying.  8)
Symptoms targeted : feel cold just after ejaculation, disturbed blood circulation...

excuse me sir.  i have the same problem but also colorless urine. what about you?
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