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71
Hormonal Causes and Treatments / Re: Mast Cell Activation Syndrome
« Last post by Muon on April 04, 2025, 08:12:24 AM »
Topical Lidocaine
https://www.reddit.com/r/POIS/comments/1jqagge/lidocaine_use_for_pois_symptom_relief/
”…overuse can even cause death”, per above reddit poster - Demo

Effect of lidocaine on histamine release and Ca2+ mobilization from mast cells and basophils
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-6576.1996.tb05577.x

Quote
Our results indicate that lidocaine directly inhibits histamine release from both rodent mast cells and human basophils
no great evidence that mast cells do or do not play a role in POIS - - demografx



***Forum Administrator (demografx) note:***


AI Overview

Lidocaine, while a useful local anesthetic, poses several hazards, including potential for allergic reactions, cardiovascular complications like arrhythmias and hypotension, and central nervous system effects like seizures and coma, especially with overdose or misuse.
72
Though difficult to respond to very long stayed post, I believe that your problem is quite similar with me mainly in related to POIS and hyperthyroidism problem however your hypothesis of brain damage require a scientific proof. My hyperthyroidism is the outcome of autoimmune response. I didn't have any accident or trauma before but I primely developed POIS and hypothyroidism followed. I believe that  either mast cell activation by O or any other triggering factors could be the culprit. How is your condition now? how did you manage it?
73
POIS Research / Re: Great News - POIS Lab is Almost Ready for the Study !
« Last post by Quantum on April 02, 2025, 11:52:32 AM »
Anyone knows about the progress of this study?
The lastest news we had is that the pilot study (testing all the settings and procedures with a few non-POISers test subjects) is about to begin in the coming weeks.  Just some supplies are missing, and some last minutes details with computers, sensors, equipments and else.   Stay tuned !
74
What is POIS / Re: Is POIS a version of CFS?
« Last post by Pointpleasant88 on April 02, 2025, 11:09:48 AM »
When is the study finished did I hear correctly she said recruiting at the end of the year ?
78
POIS Research / Re: Great News - POIS Lab is Almost Ready for the Study !
« Last post by Pointpleasant88 on April 01, 2025, 02:36:08 PM »
Anyone knows about the progress of this study?
79
Mine is normal. If you drink a lot of water it's normal.
Your first urine after waking up must be colored. If not you need to check your kidneys with the doctor.
80
I vote for nitric oxide.

A little watermelon cure this summer is something worth trying.  8)
Symptoms targeted : feel cold just after ejaculation, disturbed blood circulation...

excuse me sir.  i have the same problem but also colorless urine. what about you?
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