Dear friends,
I think that in time POIS will be found to be a subset of CFS...They only differ on trigger and symptoms duration.
I have known several peolple that have both. Or actually relized they have CFS with O trigget. As opposed to just CFS.
I even wonder if CFS in men is mostly found as POIS. Hence why men are underrepresented in CFS.
Can people with only POIS exercise extrenously for two consecutive days while under severe symptoms and if so what happens afterwards?
I understand that when with no symptoms POIS -only patients could feel almost normal. But how about while under the awful effects of O? I am referring to after extrenous aerobic exercise during a POIS episode, not just movement.
The POIS is very secondary to me now. The big issue is my long term CFS, which along with POIS, are just symptoms
of the hormones being in various states of deficiency. I'm so glad to be on the right track--finally. It only took 31
years.
It's worth noting that observations regarding POIS in / and / or MECFS go back (at least) some 25 years. Noted ME specialist Dr. Jay Goldstein in his 1996 Betrayal by the Brain (https://me-pedia.org/wiki/Betrayal_by_the_Brain):Ref (https://forums.phoenixrising.me/threads/postorgasmic-illness-syndrome-pois.81982/)
"Several of my male patients have complained that they feel exhausted for several days after ejaculating. Although little is known about the central neurochemistry of orgasm, it appears that NE [norepinephrine] facilitates it, and that NE is depleted after ejaculation. If a male neurosomatic patient were deficient in NE prior to sexual activity, ejaculation could thereby worsen his symptoms" (Goldstein 1996: 63).
Norepinephrine is synthesised from dopamine. Goldstein postulates a "dopaminergic hypofunction" in MECFS.
I wonder which are the earliest records out there clearly talking about someone reporting fatigue/brainfog/physical/etc. symptoms after orgasms is there any such data from let's say the 70s or 80s? The earliest POIS appearance I read about was from a Reddit user named /u/c-rockett88 who got it in the 70s and has relief from it by taking DAO, C vitamin, D vitamin and some other supplements and he believes it's excess Histamine causing POIS for him but I wonder if there are more POISers who got it around that time or even earlier unfortunately ones that might have had it earlier would be harder to find because they could be less likely to use the Internet or might not know POIS is a thing and so on etc.Quote from: J.GIt's worth noting that observations regarding POIS in / and / or MECFS go back (at least) some 25 years. Noted ME specialist Dr. Jay Goldstein in his 1996 Betrayal by the Brain (https://me-pedia.org/wiki/Betrayal_by_the_Brain):Ref (https://forums.phoenixrising.me/threads/postorgasmic-illness-syndrome-pois.81982/)
"Several of my male patients have complained that they feel exhausted for several days after ejaculating. Although little is known about the central neurochemistry of orgasm, it appears that NE [norepinephrine] facilitates it, and that NE is depleted after ejaculation. If a male neurosomatic patient were deficient in NE prior to sexual activity, ejaculation could thereby worsen his symptoms" (Goldstein 1996: 63).
Norepinephrine is synthesised from dopamine. Goldstein postulates a "dopaminergic hypofunction" in MECFS.(https://me-pedia.org/images/f/fc/Betrayal_by_the_brain.jpg)
I remember someone on this forum posted about symptoms appearing back in 80s. This person said it developed after antibiotic use.I wonder which are the earliest records out there clearly talking about someone reporting fatigue/brainfog/physical/etc. symptoms after orgasms is there any such data from let's say the 70s or 80s? The earliest POIS appearance I read about was from a Reddit user named /u/c-rockett88 who got it in the 70s and has relief from it by taking DAO, C vitamin, D vitamin and some other supplements and he believes it's excess Histamine causing POIS for him but I wonder if there are more POISers who got it around that time or even earlier unfortunately ones that might have had it earlier would be harder to find because they could be less likely to use the Internet or might not know POIS is a thing and so on etc.Quote from: J.GIt's worth noting that observations regarding POIS in / and / or MECFS go back (at least) some 25 years. Noted ME specialist Dr. Jay Goldstein in his 1996 Betrayal by the Brain (https://me-pedia.org/wiki/Betrayal_by_the_Brain):Ref (https://forums.phoenixrising.me/threads/postorgasmic-illness-syndrome-pois.81982/)
"Several of my male patients have complained that they feel exhausted for several days after ejaculating. Although little is known about the central neurochemistry of orgasm, it appears that NE [norepinephrine] facilitates it, and that NE is depleted after ejaculation. If a male neurosomatic patient were deficient in NE prior to sexual activity, ejaculation could thereby worsen his symptoms" (Goldstein 1996: 63).
Norepinephrine is synthesised from dopamine. Goldstein postulates a "dopaminergic hypofunction" in MECFS.(https://me-pedia.org/images/f/fc/Betrayal_by_the_brain.jpg)
I remember someone on this forum posted about symptoms appearing back in 80s. This person said it developed after antibiotic use.
All explained mepedia:Interesting there seems to be alot of data showing that ME/CFS/POIS could have actual physical reasons for them how do you think what is the very root cause that started the rest of the dysfunction cascade in those disorders?
https://me-pedia.org/wiki/Myalgic_encephalomyelitis
All explained mepedia:Interesting there seems to be alot of data showing that ME/CFS/POIS could have actual physical reasons for them how do you think what is the very root cause that started the rest of the dysfunction cascade in those disorders?
https://me-pedia.org/wiki/Myalgic_encephalomyelitis
Second, many people do not understand that the first response our body mounts against a viral, bacterial, or any kind of infection is metabolic. Yes, our chemistry is our first line of defense. Our chemistry reflects our instantaneous state of health. Innate immunity is coordinated...
In CFS, is there a phase with complete recovery, during which the patient feels perfectly healthy? If yes, then sure, I would vote that POIS is a type of CFS, with specific trigger.
Yesterday and the day before, I was feeling great and strong. So I pushed myself on physical exercise yesterday (cardio). Only to activate my POIS and to get the brain fog and usual fatigue today.
Although Goldstein knew the conditions were related somehow more than 25 years ago, I am just starting to see greater interest from some POISERs and CFSers on looking at what light one condition might share on the other.
I saw that someone mentioned that this started when they got CFS and that is exactly what happend to me. When I was 25 I got MONO and that turned to CFS so they say anyway I was bedridden for two years, I'm now 29 and almost back to my old self but this POIS has been going on for two years. I never had the orgasm problems before getting ill so it must be linked.https://www.thenakedscientists.com/forum/index.php?topic=14697.msg344849#msg344849
https://forums.phoenixrising.me/threads/you-probably-have-an-autoimmune-disease.82395/page-5#post-2316670I think antibodies to adrenergic receptors is a very probable cause of POIS.
Alpha-1 Adrenergic receptor (a1AR) autoantibody at #1. What about POISers? And what about autoantibodies against opioid receptors?
I think antibodies to adrenergic receptors is a very probable cause of POIS.
I think antibodies to adrenergic receptors is a very probable cause of POIS.
Wow.
Very strong statement!
I tested for adrenal cortex antibody and was negative not sure if it's the same thing as you're speaking about.It's not. It's completely different.
Dr Theoharides suggested checking folate auto antibodies for me considering I react to all forms of folate and have a folate deficiencyWhat lab provides this test?
What lab provides this test?
Dr Theoharides suggested checking folate auto antibodies for me considering I react to all forms of folate and have a folate deficiency
My POIS disappeared during the duration of being sick with the cold in the 2020 February despite not abstaining during that time and the moment it healed and I trigerred the POIS it came back full with symptoms but when I did not have it I had even less brain fog and symptoms in general and felt better than I feel even on many weeks of abstinence in terms of cognitive clarity and such however due to the cold itself I did not feel that well physically however cognitively I had almost zero brain fog and this weird mental processing speed slowdown I seem to always have even when on a long streak of abstinence had fully disappeared while I was sick with that cold in the 2020 February
I think antibodies to adrenergic receptors is a very probable cause of POIS.
Wow.
Very strong statement!
I'm a layman, so take this with a huge grain of salt. I just think autoimmunity would explain why people find help with strategies that manipulate the gut (diet, probiotics, antibiotics, etc), various supplementa, etc. Alternatively, there could be many other explanations, but autoimmunity, HPA axis dysfunction is where it is, IMO. This is pure speculation on my part.
My POIS disappeared during the duration of being sick with the cold in the 2020 February despite not abstaining during that time and the moment it healed
My POIS disappeared during the duration of being sick with the cold in the 2020 February despite not abstaining during that time and the moment it healed and I trigerred the POIS it came back full with symptoms but when I did not have it I had even less brain fog and symptoms in general and felt better than I feel even on many weeks of abstinence in terms of cognitive clarity and such however due to the cold itself I did not feel that well physically however cognitively I had almost zero brain fog and this weird mental processing speed slowdown I seem to always have even when on a long streak of abstinence had fully disappeared while I was sick with that cold in the 2020 February
I think antibodies to adrenergic receptors is a very probable cause of POIS.
Wow.
Very strong statement!
I'm a layman, so take this with a huge grain of salt. I just think autoimmunity would explain why people find help with strategies that manipulate the gut (diet, probiotics, antibiotics, etc), various supplementa, etc. Alternatively, there could be many other explanations, but autoimmunity, HPA axis dysfunction is where it is, IMO. This is pure speculation on my part.
I wonder what is the root cause of this immune engagement? John21 POIS disappeared for some months after taking antibiotics and then returned. That could mean perhaps there is some pathogen that is chronically in the organisms of those with those rare chronic multisymptoms disorders and they either are attacked directly and thus the inflammation formed affects other and nearby tissues as well or they mimick healthy tissue which then the immunity system interprets as the pathogen because of their similarities and therefore causes those symptoms. Therefore the question should be what is the root cause of those symptoms and what to do to permanently fix and cure it? If John21 had POIS disappear for some months after taking those antibiotics and probiotics and then it returned it could mean for some reason those potential possible pathogens tend to return therefore the question should be why they returned in John21 POIS case? And what to do to ensure the organism is permanently free from those underlying imbalances or pathogens that then cause those symptoms. It could besome other imbalance that makes it harder for the body to naturally fight against them or some foods or environmental factors might contain them and the POISers are more prone to having those pathogens accumulate or some genetical reasons could make it easier for those pathogens to accumulateMy POIS disappeared during the duration of being sick with the cold in the 2020 February despite not abstaining during that time and the moment it healed and I trigerred the POIS it came back full with symptoms but when I did not have it I had even less brain fog and symptoms in general and felt better than I feel even on many weeks of abstinence in terms of cognitive clarity and such however due to the cold itself I did not feel that well physically however cognitively I had almost zero brain fog and this weird mental processing speed slowdown I seem to always have even when on a long streak of abstinence had fully disappeared while I was sick with that cold in the 2020 February
I think antibodies to adrenergic receptors is a very probable cause of POIS.
Wow.
Very strong statement!
I'm a layman, so take this with a huge grain of salt. I just think autoimmunity would explain why people find help with strategies that manipulate the gut (diet, probiotics, antibiotics, etc), various supplementa, etc. Alternatively, there could be many other explanations, but autoimmunity, HPA axis dysfunction is where it is, IMO. This is pure speculation on my part.
One more argument for POIS being related to CFS, because this is not uncommon in CFS community to have symptoms improve or disappear when sick. I've also had this experience. Some say it's because immune system shifts the focus away from something that's causing symptoms (maybe pathogen or autoimmunity) and directs it where ir is most needed, fighting the virus.
I'm a layman, so take this with a huge grain of salt...
I wonder what is the root cause of this immune engagement? John21 POIS disappeared for some months after taking antibiotics and then returned. That could mean perhaps there is some pathogen that is chronically in the organisms of those with those rare chronic multisymptoms disorders and they either are attacked directly and thus the inflammation formed affects other and nearby tissues as well or they mimick healthy tissue which then the immunity system interprets as the pathogen because of their similarities and therefore causes those symptoms. Therefore the question should be what is the root cause of those symptoms and what to do to permanently fix and cure it? If John21 had POIS disappear for some months after taking those antibiotics and probiotics and then it returned it could mean for some reason those potential possible pathogens tend to return therefore the question should be why they returned in John21 POIS case? And what to do to ensure the organism is permanently free from those underlying imbalances or pathogens that then cause those symptoms. It could besome other imbalance that makes it harder for the body to naturally fight against them or some foods or environmental factors might contain them and the POISers are more prone to having those pathogens accumulate or some genetical reasons could make it easier for those pathogens to accumulateMy POIS disappeared during the duration of being sick with the cold in the 2020 February despite not abstaining during that time and the moment it healed and I trigerred the POIS it came back full with symptoms but when I did not have it I had even less brain fog and symptoms in general and felt better than I feel even on many weeks of abstinence in terms of cognitive clarity and such however due to the cold itself I did not feel that well physically however cognitively I had almost zero brain fog and this weird mental processing speed slowdown I seem to always have even when on a long streak of abstinence had fully disappeared while I was sick with that cold in the 2020 February
I think antibodies to adrenergic receptors is a very probable cause of POIS.
Wow.
Very strong statement!
I'm a layman, so take this with a huge grain of salt. I just think autoimmunity would explain why people find help with strategies that manipulate the gut (diet, probiotics, antibiotics, etc), various supplementa, etc. Alternatively, there could be many other explanations, but autoimmunity, HPA axis dysfunction is where it is, IMO. This is pure speculation on my part.
One more argument for POIS being related to CFS, because this is not uncommon in CFS community to have symptoms improve or disappear when sick. I've also had this experience. Some say it's because immune system shifts the focus away from something that's causing symptoms (maybe pathogen or autoimmunity) and directs it where ir is most needed, fighting the virus.
Also my gf has terrible POIS too, and by terrible I mean really for like 2-3 days if she orgasms twice in a day...
These symptoms started for my guy when he was 15 years old. But I don?t know when these really started for me. My guy was the one who found that I also have this thing. Before, we thought only he has this shit. (We called it ?Over?). Then we started to notice my symptoms too. We did search internet and I found you tube video about POIS and then I saw this forum link in the comments section.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back! (https://www.mdpi.com/2218-273X/11/2/185/htm)
Furthermore, it was demonstrated that EBV dUTPase is secreted in exosomes from chemically induced Raji cells at sufficient levels to induce NF-?B activation and cytokine secretion in hDCs and PBMCs through a TLR 2-dependent mechanism [72]. Exosomes are produced by numerous cell types, have been implicated in numerous diseases, including ME/CFS [84], and are capable of trafficking to various organs within the body, including the brain, where they function as intercellular messengers.
Virus changing exosome content?
Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions (https://academic.oup.com/nar/article/42/11/7290/1440924?login=true)
Extracellular vesicles in human semen modulate antigen-presenting cell function and decrease downstream antiviral T cell responses (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223901)
(https://www.mdpi.com/biomolecules/biomolecules-11-00185/article_deploy/html/images/biomolecules-11-00185-g003.png)
A downregulated DBH can be problematic when you need a burst of norepi during orgasm via DBH.
Checking in. I've been on Abilify (aripiprazole) 0.2mg for ~6 weeks. I'm happy to report that it reduces the severity and intensity of my ME symptoms across the board, including very noticeably those of POIS. It's the first drug to ever work for my ME.
As I wrote earlier in this thread, the POIS became more prominent over the years as I declined from moderate to severe (98% bedbound). The inverse now also appears true: an improvement to ME symptoms eases the POIS.
Some form of neurotransmitter imbalance appears to tie the two together, in my case of secondary POIS, at least.
Brainstem Abnormalities in ME/CFS: A Scoping Review and Evaluation of Magnetic Resonance Imaging Findings (https://forums.phoenixrising.me/threads/brainstem-abnormalities-in-me-cfs-a-scoping-review-and-evaluation-of-magnetic-resonance-imaging-findings-nelson-et-al-2021.86604/)
(https://www.frontiersin.org/files/Articles/769511/fneur-12-769511-HTML-r1/image_m/fneur-12-769511-g003.jpg)
POIS/CFS/POTS could be brainstem pathologies as in overlap of affected areas within the brainstem.https://poiscenter.com/forums/index.php?topic=2683.msg23766#msg23766
And now this amazing article that explains why amino acids, vasodilators, immune mediators help both POIS and CFS. It is an irrigation issue!
https://www.healthrising.org/blog/2021/12/08/energy-chronic-fatigue-syndrome-immunometabolic-disease/
I find it really intriguing that so many aphrodisiacs are effective in my case. Mastic gum is no exception as it is a traditionally known aphrodisiac. It is however not clear if all of these supplements' aphrodisiac properties are only due to an increase in testosterone. I can only guess there is a convergence between aphrodisiacs and the mechanisms of anti-inflammatory pathways. Of course I have no clear proof of this, but one still has to wonder about the coincidence.
Amazing Muon :)It actually makes me sad when I think about how much time I have spent on this forum. :(
You're still doing a fantastic job after so many years :)
Quote from: J.GIt's worth noting that observations regarding POIS in / and / or MECFS go back (at least) some 25 years. Noted ME specialist Dr. Jay Goldstein in his 1996 Betrayal by the Brain (https://me-pedia.org/wiki/Betrayal_by_the_Brain):Ref (https://forums.phoenixrising.me/threads/postorgasmic-illness-syndrome-pois.81982/)
"Several of my male patients have complained that they feel exhausted for several days after ejaculating. Although little is known about the central neurochemistry of orgasm, it appears that NE [norepinephrine] facilitates it, and that NE is depleted after ejaculation. If a male neurosomatic patient were deficient in NE prior to sexual activity, ejaculation could thereby worsen his symptoms" (Goldstein 1996: 63).
Norepinephrine is synthesised from dopamine. Goldstein postulates a "dopaminergic hypofunction" in MECFS.(https://me-pedia.org/images/f/fc/Betrayal_by_the_brain.jpg)
Quote from: J.GIt's worth noting that observations regarding POIS in / and / or MECFS go back (at least) some 25 years. Noted ME specialist Dr. Jay Goldstein in his 1996 Betrayal by the Brain (https://me-pedia.org/wiki/Betrayal_by_the_Brain):Ref (https://forums.phoenixrising.me/threads/postorgasmic-illness-syndrome-pois.81982/)
"Several of my male patients have complained that they feel exhausted for several days after ejaculating. Although little is known about the central neurochemistry of orgasm, it appears that NE [norepinephrine] facilitates it, and that NE is depleted after ejaculation. If a male neurosomatic patient were deficient in NE prior to sexual activity, ejaculation could thereby worsen his symptoms" (Goldstein 1996: 63).
Norepinephrine is synthesised from dopamine. Goldstein postulates a "dopaminergic hypofunction" in MECFS.(https://me-pedia.org/images/f/fc/Betrayal_by_the_brain.jpg)
Book download links: https://annas-archive.org/search?q=betrayal+by+the+brain
It's on page 63.
Treatment protocol for neurosomatic patients can be found on page 16.
I actually flew to LA to see Dr. Jay Golgstein circa 1990. Such a nice guy. I had read his book. Maybe it was not fully published then.
as if my brain isn't getting enough juice.
Apparently there is no blood circulation in the front of my frontal lobe!
why were the brain cells of the ME/CFS-like long-COVID patients eating up so much oxygen? (Oxygen is the substance that generates ATP (energy) for the brain). A reduction in blood flows to the brain could do it.
I've regularly been following poiscenter since it's very beginnings and was also on the previous NSF forum…
I've regularly been following poiscenter since it's very beginnings and was also on the previous NSF forum…
less_fogged, thank you for being with us all the way back - - from the beginning NSF years!
POISCenter’s predecessor NSF days began in….2007!
I've regularly been following poiscenter since it's very beginnings and was also on the previous NSF forum. Been living with POIS for over 36 years now. Like most of you it's had a pretty big impact on the quality of my life. I remind you all again, I've experienced all known symptoms of POIS, sometimes changing in severity in different stages of my life. My approach over the years with trial and error was making me either better or worse. I've had endless examinations and tests done on me and they never found something significant. The fact that a diagnosis for POIS still not exists always felt like a dead end. But now I've been diagnosed with ME/CFS. I'm stunned as I've always considered myself a pretty fit person! Just feel like huffing and puffing while in POIS!
I was diagnosed after a CT scan for the brain together with Neurospect.
I suppose I must have POIS and ME/CFS overlapping each other, or is it a version of ME/CFS!?
I'm sure there must be more POIS members that are in the unknown about this. I really did not know what to expect for the outcome of results after the test. I did not expect anything as I was pretty used to the idea of not finding anything significant! I don't think it would influence my test results but just in case; I had 3 ejaculations in the 2 days before the scan test. Apparently there is no blood circulation in the front of my frontal lobe!
By the way have you ever tried ginkgo biloba?
Brainstem perfusion is impaired in chronic fatigue syndrome
https://academic.oup.com/qjmed/article-abstract/88/11/767/1569403
it's latent Hsv virus bro, I'm positive for hsv1 and ghsv2 ,
even Aciclovir helps in daily brainfog that I get from morning erection, Also monolaurin helps immensely
@Progecitor
I find it difficult to follow your posts. Sorry about that!
Your latest post here consists of lots of quotes of scientific text using specialised medical terms that I think very few people would understand unless they have a very specialised medical background. Perhaps you yourself have a specialised medical background?
Your post seems to have a theme of the condition hypoxia. That's one term that I could guess the meaning of :)
I have a feeling that you might be making an interesting point but it's hidden amongst all the medical jargon. Are you able to summarise how you think pois might be connected with hypoxia in one short sentence of let's say about 20 words, readable to those of us on the forum who do not have a science/medical background?
@Progecitor
I find it difficult to follow your posts. Sorry about that!
Your latest post here consists of lots of quotes of scientific text using specialised medical terms that I think very few people would understand unless they have a very specialised medical background. Perhaps you yourself have a specialised medical background?
Your post seems to have a theme of the condition hypoxia. That's one term that I could guess the meaning of :)
I have a feeling that you might be making an interesting point but it's hidden amongst all the medical jargon. Are you able to summarise how you think pois might be connected with hypoxia in one short sentence of let's say about 20 words, readable to those of us on the forum who do not have a science/medical background?
@Progecitor
I find it difficult to follow your posts.
If I could tell you in one sentence I would have done so…
Hi Progecitor. Thanks for your response. I'm afraid, perhaps due to all the medical jargon you've used again, I don't understand your summary of your post either! It's way over my head ???.Could you write a short summary of your summary? Or maybe you feel the content has been simplified as much as possible already?
• PINK1
• HIF-1alpha factors
• ME/CFS
• mitophagy
• mitochondria
• glycolytic metabolism
• hypoxia
• oxidative stress
• PEM induction
Latest post from Progec is ok, it is connected to a mater and wery
well summarized.
Enyone who want to understand what he is wroted, can easly learn
on google, yust can ask what it is.
As I stated yesterday:
technical jargon can alienate readers
As I stated yesterday:
technical jargon can alienate readers
Alright! I won’t post about scientific matters in the future! It took away much of my time and I have more important things to do anyway. Hopefully our researchers are going to fully figure out POIS soon!
As I stated yesterday:
technical jargon can alienate readers
Alright! I won’t post about scientific matters in the future! It took away much of my time and I have more important things to do anyway. Hopefully our researchers are going to fully figure out POIS soon!
I can appreciat the effort you put into your posts, but this is a sulky attitude. In my everyday technical writing I also tend to overcomplicate things and go down endless rabbit holes of derivations. But most often brevity trumps endless elaborations, if you want to get a point across in scientific matters. As suggested earlier, in the future, you could restrict your posts to the key messages and put your intermediate reasonings into a text file attachment. This allows forum members to follow your arguments in-depth, if they wish.
If I could tell you in one sentence I would have done so, but you have to see the whole process to understand how it all comes together. I am not exactly sure how much hypoxia is involved, but ROS is a certain culprit and there is clearly a glycolytic shift in our metabolism partly due to mitochondrial dysfunction. Mitochondrial dysfunction itself may come about due to a variety of reasons (e.g. sepsis, senescence, autoimmunity, etc). If we consider the treatments that we, ME/CFS and long covid patients have used with some degree of success, then it is easy to see that HIF-1a regulation is majorly involved in disease control. It is especially interesting to see that post-exertional malaise (PEM) in long covid patients last for about a week, similarly to a POIS episode, when there is a back shift towards oxidative phosphorylation. However the tricarboxylic acid (TCA) cycle remains impaired with somewhat elevated glycolytic metabolites even at baseline. This is quite relevant from my point of view as I have POIS/CFS and this exactly could explain the difference between my acute (dominated by POIS) and chronic phases (dominated by CFS).
The condition involves problems with how the body produces energy, often due to issues with the mitochondria. Some treatments for ME/CFS and long COVID focus on a protein called HIF-1a, which seems important for managing symptoms. The way energy shifts in the body during these conditions may explain the similarities between long COVID and POIS.
FYI I took this post:and pasted it into ChatGPT and asked it to dumb it down into easier language and summarize it to 3 sentences (twice):
If I could tell you in one sentence I would have done so, but you have to see the whole process to understand how it all comes together. I am not exactly sure how much hypoxia is involved, but ROS is a certain culprit and there is clearly a glycolytic shift in our metabolism partly due to mitochondrial dysfunction. Mitochondrial dysfunction itself may come about due to a variety of reasons (e.g. sepsis, senescence, autoimmunity, etc). If we consider the treatments that we, ME/CFS and long covid patients have used with some degree of success, then it is easy to see that HIF-1a regulation is majorly involved in disease control. It is especially interesting to see that post-exertional malaise (PEM) in long covid patients last for about a week, similarly to a POIS episode, when there is a back shift towards oxidative phosphorylation. However the tricarboxylic acid (TCA) cycle remains impaired with somewhat elevated glycolytic metabolites even at baseline. This is quite relevant from my point of view as I have POIS/CFS and this exactly could explain the difference between my acute (dominated by POIS) and chronic phases (dominated by CFS).Quote from: ChatGPTMaybe it's an option you put a tl;dr in front of your posts that contain an AI summary?
The condition involves problems with how the body produces energy, often due to issues with the mitochondria. Some treatments for ME/CFS and long COVID focus on a protein called HIF-1a, which seems important for managing symptoms. The way energy shifts in the body during these conditions may explain the similarities between long COVID and POIS.
1.Berlin, I used tl;dr in front of this AI below twice…
Maybe it's an option you [Progecitor] put a tl;dr in front of your posts that contain an AI summary?
Brilliant, Berlin!!