Is POIS a version of CFS?

[less_fogged]

May 12th was chosen as ME/CFS Awareness Day!

I'm would not be surprised that some POISers don't realize they actually have a degree of ME/CFS or that ME/CFS is actually there problem.

It's estimated that only 25% of ME/CFS victims are bedbound.

From a research article: people with ME/CFS had higher resting heart rates, markers of a drawn-out and overstimulated immune response that exhausts T cells, and less diverse gut bacteria than controls.

The ME/CFS group showed no signs of muscle fatigue, and performed normally on cognitive tests, despite reporting greater cognitive symptoms.

And yet the immune and gut microbiome changes clearly impacted the central nervous system in several ways. People with ME/CFS had lower levels of chemicals called catechols, which help regulate the nervous system, in their cerebrospinal fluid and less activity in a brain region called the temporal-parietal junction (TPJ) during motor tasks.

[Muon]

Brainstem perfusion is impaired in chronic fatigue syndrome
https://academic.oup.com/qjmed/article-abstract/88/11/767/1569403

[Crying24/7]

it's latent Hsv virus bro, I'm positive for hsv1 and ghsv2 ,
even Aciclovir helps in daily brainfog that I get from morning erection, Also monolaurin helps immensely

[Hopeoneday]

I learned that herpes virus theory is wrong!
That is only a conequence of imunity compromised.
Why is our imunity compromised?...

[Crying24/7]

if we have immune compromised than pois symptoms may lasts too long but we had only 3-4,7 days issues,
I think sexual hormones leads hidden virus to reactivation, as i have positive PCR for Hsv 1 and 2, btw I'd done sexual activity with someone who'd given it to me, Aciclovir everytime release headache and neck stiffness if I take 200mg 3 times a day

[Hopeoneday]

A bilions of people hawe hsv1, hsv2 etc...
Problems ocure only if you are imunocompromised.

[less_fogged]

Brainstem perfusion is impaired in chronic fatigue syndrome
https://academic.oup.com/qjmed/article-abstract/88/11/767/1569403

Thanks for highlighting this article!

[Muon]

Polling CFS patients. This does not tell you anything about the type of symptoms.
https://www.reddit.com/r/cfs/comments/1ggmu29/do_you_have_triggers_related_to_sexual_activity/

[sartre02]

it's latent Hsv virus bro, I'm positive for hsv1 and ghsv2 ,
even Aciclovir helps in daily brainfog that I get from morning erection, Also monolaurin helps immensely

do you combine it with celecoxib??

[Progecitor]

Some ME/CFS members also experience PEM loops due to sexual activity that is similar to the POIS loops we have.
https://www.reddit.com/r/cfs/comments/1ht8o1s/masturbation_causing_pem_how_to_decrease_libido/

[Sisyphus]

@Progecitor

I find it difficult to follow your posts. Sorry about that!

Your latest post here consists of lots of quotes of scientific text using specialised medical terms that I think very few people would understand unless they have a very specialised medical background. Perhaps you yourself have a specialised medical background?

Your post seems to have a theme of the condition hypoxia. That's one term that I could guess the meaning of   
I have a feeling that you might be making an interesting point but it's hidden amongst all the medical jargon. Are you able to summarise how you think pois might be connected with hypoxia in one short sentence of let's say about 20 words, readable to those of us on the forum who do not have a science/medical background?

[demografx]

@Progecitor

I find it difficult to follow your posts. Sorry about that!

Your latest post here consists of lots of quotes of scientific text using specialised medical terms that I think very few people would understand unless they have a very specialised medical background. Perhaps you yourself have a specialised medical background?

Your post seems to have a theme of the condition hypoxia. That's one term that I could guess the meaning of   
I have a feeling that you might be making an interesting point but it's hidden amongst all the medical jargon. Are you able to summarise how you think pois might be connected with hypoxia in one short sentence of let's say about 20 words, readable to those of us on the forum who do not have a science/medical background?

Thank you, Sisyphus.

[Progecitor]

@Progecitor

I find it difficult to follow your posts. Sorry about that!

Your latest post here consists of lots of quotes of scientific text using specialised medical terms that I think very few people would understand unless they have a very specialised medical background. Perhaps you yourself have a specialised medical background?

Your post seems to have a theme of the condition hypoxia. That's one term that I could guess the meaning of   
I have a feeling that you might be making an interesting point but it's hidden amongst all the medical jargon. Are you able to summarise how you think pois might be connected with hypoxia in one short sentence of let's say about 20 words, readable to those of us on the forum who do not have a science/medical background?

If I could tell you in one sentence I would have done so, but you have to see the whole process to understand how it all comes together. I am not exactly sure how much hypoxia is involved, but ROS is a certain culprit and there is clearly a glycolytic shift in our metabolism partly due to mitochondrial dysfunction. Mitochondrial dysfunction itself may come about due to a variety of reasons (e.g. sepsis, senescence, autoimmunity, etc). If we consider the treatments that we, ME/CFS and long covid patients have used with some degree of success, then it is easy to see that HIF-1a regulation is majorly involved in disease control. It is especially interesting to see that post-exertional malaise (PEM) in long covid patients last for about a week, similarly to a POIS episode, when there is a back shift towards oxidative phosphorylation. However the tricarboxylic acid (TCA) cycle remains impaired with somewhat elevated glycolytic metabolites even at baseline. This is quite relevant from my point of view as I have POIS/CFS and this exactly could explain the difference between my acute (dominated by POIS) and chronic phases (dominated by CFS).

[Sisyphus]

Hi Progecitor. Thanks for your response. I'm afraid, perhaps due to all the medical jargon you've used again, I don't understand your summary of your post either! It's way over my head  .  Could you write a short summary of your summary? Or maybe you feel the content has been simplified as much as possible already?

[demografx]

@Progecitor

I find it difficult to follow your posts.

If I could tell you in one sentence I would have done so…

Rude reply!

I removed Progecitor’s post from: Today at 05:06:09 AM for his re-submission for length, clarity & technical jargon.

[demografx]

Hi Progecitor. Thanks for your response. I'm afraid, perhaps due to all the medical jargon you've used again, I don't understand your summary of your post either! It's way over my head  .Could you write a short summary of your summary? Or maybe you feel the content has been simplified as much as possible already?

Once again, a forum etiquette issue!

Internet forum etiquette discourages the use of technical jargon, especially in forums with a non-technical member base.

[Progecitor]

I repost this for the curious. I hope this way it won’t offend anyone!

Recently the PINK1 and HIF-1alpha factors have been found to be increased in ME/CFS and long covid (LC) patients and there is no reason to believe that this would be any different in the case of POIS.
PINK1 induces mitophagy to eliminate damaged mitochondria, while HIF-1alpha induces glycolytic metabolism due to hypoxia and oxidative stress as a protective mechanism. In long covid patients there is a down shift in the glycolytic metabolism within a week after PEM induction, which makes it very reminiscent of a POIS episode.

[demografx]

• PINK1

• HIF-1alpha factors

• ME/CFS

• mitophagy

• mitochondria

• glycolytic metabolism

• hypoxia

• oxidative stress

• PEM induction

PROGECITOR:

• These are not terms understood by the majority of our non-technical POISCenter forum members

• This is not good forum communication

• This is poor forum etiquette

• Please *E D I T*  & speak “English”!


As I stated yesterday:
technical jargon can alienate readers

[Hopeoneday]

Latest post from Progec is ok, it is connected to a mater and wery
well summarized.
Enyone who want to understand what he is wroted, can easly learn
on google, yust can ask what it is.

[demografx]

Latest post from Progec is ok, it is connected to a mater and wery
well summarized.
Enyone who want to understand what he is wroted, can easly learn
on google, yust can ask what it is.

• mater?

• wroted?

• wery?

• enyone?

• easly?

• yust?

THAT’s good forum communication?


Poor spelling and grammar is poor forum etiquette for several reasons:
   1.   Clarity: Proper spelling and grammar help ensure that your message is clear and easy to understand. When posts are filled with errors, it can be difficult for others to grasp your intended meaning.
   2.   Professionalism: Using proper language can convey respect for the community and the topic being discussed. It shows that you are taking the time to communicate effectively.
   3.   Engagement: Well-written posts are more likely to engage readers and encourage meaningful responses. Poorly written posts might deter others from participating in the conversation.
   4.   Respect for Readers: Taking the time to proofread your posts demonstrates respect for the people who will be reading them. It shows that you value their time and are willing to make an effort to communicate clearly.

If you’re concerned about your spelling and grammar, using tools like spell checkers or grammar checkers can be helpful. Additionally, taking a moment to review your post before submitting it can make a big difference.