"Permanent" POIS

[Quack]

I abstained from masturbation for a period of approximately five months in 2020 because I was frightened after I ejaculated for the first time and did not want to deal with cleaning seminal fluid after every masturbation session. Before my first ejaculation, I was extremely carefree, joyful, and happy. While I still masturbated back then, I did not ejaculate semen because I was not able to produce it yet. Of course, there were times in which I felt as sad as I do now, but they did not last very long. After my first ejaculation, my mood completely reversed; I was irritable, depressed, and unmotivated. Nothing was able to cheer me up. Not even more than five months without ejaculation cured me.

Ever since I broke the five-month-long streak, with each orgasm, my symptoms seemed to gradually worsen. The POIS symptoms that I felt in 2020 are nothing compared to those that I feel now. I can barely function. I sleep or am inactive for most of the day. In 2023, I abstained from masturbation for 6 days, which made me more energetic but did not cure the other symptoms. I sometimes wonder if POIS has somehow caused permanent damage, rendering abstinence of any duration ineffective.

Does anyone have "permanent POIS"?

[Aladin]

i have major depressive disorder since 6 months: anxiety mixed with depressive feelings all day long.; No idea if POIS was the original trigger or just the political and meteorological climate

[CureHunter]

i have major depressive disorder since 6 months: anxiety mixed with depressive feelings all day long.; No idea if POIS was the original trigger or just the political and meteorological climate

If you have MDD, it makes eligible to take levomilnacprin or milnacipran. Ask your doctor about it.

[Poisick]

Have you tried anything to relieve the issues? Mine also started in puberty when I first started to ejaculate and much of my life after that was like a combination of not knowing what POIS was with compounding trauma and likely genetic defects leading to a vulnerability to neuro-immune conditions and general abnormalities feeding into everything else in an endless loop I didn't know enough about to pick apart (nor did I have the resources money or information wise, this was when the internet was still in it's dial-up days). I don't have any issues with sexual fluid itself mentally, I just take a shower after. Was essentially stuck in a perpetual state state of neurological agony and horrible situation with no way out and only began to start trying supplements and chipping away at things in my 20's.

In the research section of the site there is a noradrenaline topic that I'm currently looking into in regards to the entire catecholamine conversion system. My initial thoughts were that we have a problem where noradrenaline or adrenaline itself is getting stuck on high and feeding into a broken loop that is very difficult to get out of and will cause long term multi-system problems in the body downstream like contribute to immune dysfunction which many of us are also likely prone to which has ties to the nervous system in many ways anyways. I have some things in mind that I want to try that I'm brainstorming based on my years already of trying to dissect this condition. But I'm trying to take it easy because excitement also makes me more prone to POIS and alone if extreme enough can mimic POIS anyways and this effect will amplify in POIS states where excitement will make all symptoms worse and the symptoms will make the reaction worse in a feedback loop. Right now it's under control but I found since I started working a lot today on this that the fast paced work and excitement itself is making symptoms push through which is really interesting though under current conditions in a much more controlled fashion due to what I'm currently trying. It doesn't help that I need to work at my job anyways where often during the week I'm really only able to take notes and try things in very controlled bursts but I'm on break this week so a lot that I have on hold when it comes to really digging into this general bubble of topics gets crammed into a small window of time where it feels like it becomes my job and triggers the problems itself. lol   

[freuemich]

I also feel like it permanently changed the way my brain processes life. It is almost impossible to make me laugh nowadays. Almost nothing makes me excited and it is very hard to engage in any activity. My cognitive abilities suck too. I used to be very sharp and had a great memory. Not anymore.


I will post catecholamines test results and some others here.

[Quack]

Have you tried anything to relieve the issues?

Not really. I do not have any access to supplements.

Mine also started in puberty when I first started to ejaculate

Did you masturbate at all before your first ejaculation with semen? If so, for how many years before? I suspect that excessive masturbation at an abnormally young age may be the cause of POIS for some people.

But I'm trying to take it easy because excitement also makes me more prone to POIS and alone if extreme enough can mimic POIS anyways

It is strange that all forms of excitement, regardless of whether they are connected to sex or romance or not, cause POIS symptoms in you. That sounds like Mast Cell Activation Syndrome(MCAS), which many users on this forum have claimed is the main cause of POIS. POIS symptoms are only triggered in me whenever I feel an emotion connected to sex; even slight romantic feelings are enough to trigger a mild form of POIS. Generally, the severity of the POIS symptoms that a feeling connected to sex that I have triggers is proportional to the feeling's intensity.

[Quack]

i have major depressive disorder since 6 months: anxiety mixed with depressive feelings all day long.; No idea if POIS was the original trigger or just the political and meteorological climate

It could be unrelated; however, some POIS symptoms strongly resemble those of depression.

[Quack]

I also feel like it permanently changed the way my brain processes life. It is almost impossible to make me laugh nowadays. Almost nothing makes me excited and it is very hard to engage in any activity. My cognitive abilities suck too. I used to be very sharp and had a great memory. Not anymore.


I will post catecholamines test results and some others here.

This is also true for me. I rarely feel genuine joy, if at all. It may have ruined my life. Do all your negative symptoms go away after a few days of abstaining from masturbating, or are some of them permanent?

[Warrior]

Have you tried to see if you have additional sensitivities tied into your POIS that you are unconsciously triggering and therefore experiencing the POIS symptoms 24/7? This was the case for me with food.

[Aladin]

which food sensitivities did you have, Warrior?

[Warrior]

which food sensitivities did you have, Warrior?

Severe sensitivity to starch. White rice, oats, bread, etc. If I ate these in every meal, my entire reality would quickly become consumed with 24/7 POIS symptoms, like it did many years ago. Not all starches are the same though, sweet potato appears to be the most benign but still far from optimal.

I am also sensitive to vegetables, but these dissappear when I am under a ketogenic diet. I can tolerate vegetables like normal when eating keto.