Author Topic: Amino Acid Megathread  (Read 1781 times)

Muon

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Amino Acid Megathread
« on: February 13, 2024, 11:59:52 AM »
Has anyone tried amino acids isolated at relatively high dosage? This thread is meant to post your experiences with them. What have you tried? (Yes there are a few threads running but these are about certain selections of amino acids)

Example:

Glycine: The Smallest Anti-Inflammatory Micronutrient

In this review, we emphasize that glycine exerts its anti-inflammatory effects throughout the modulation of the expression of nuclear factor kappa B (NF-?B) in many cells
« Last Edit: May 11, 2024, 11:07:07 AM by Muon »

Prospero

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Re: Supplementing Isolated Amino Acids Megathread
« Reply #1 on: February 22, 2024, 04:32:05 PM »
I tried Glycine for a few days some years ago, not at a very high dosage but not ridiculous (can't remember). It felt bad, mood worsened, heavy legs, more difficult breathing... I stopped.

I also tried Aspartic Acid for a few days and stopped. It didn't feel right, although I might try anew. Can't remember what was going on precisely.
« Last Edit: February 22, 2024, 05:35:58 PM by Prospero »

Warrior

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Re: Supplementing Isolated Amino Acids Megathread
« Reply #2 on: February 23, 2024, 05:01:54 AM »
I tried Glycine for a few days some years ago, not at a very high dosage but not ridiculous (can't remember). It felt bad, mood worsened, heavy legs, more difficult breathing... I stopped.

I also tried Aspartic Acid for a few days and stopped. It didn't feel right, although I might try anew. Can't remember what was going on precisely.

Glycine actually works to buffer excess methyl groups. When you are deficient in folate, this buffer system does not know when to turn off, buffering all methyl groups (including the ones you need) and in turn making you under methylated. This would make you feel worse.

The above is exactly what happened to me when I first introduced glycine as a methyl buffer for SAM-e, but I did not know that I was deficient in folate at the time. It essentially inhibited my methylation stack from working at all. Full blown POIS symptoms began pouring in, even as I was taking 400mg of SAM-e twice a day. It wasn't until I increased my folate that I could tolerate glycine properly, where it would "know" when to turn off the methyl buffering.

I believe that POIS depletes methyl groups, which would in theory deplete folate levels, as folate is a co-factor nutrient for SAM-e, and a very important methyl donor for the methylation cycle in general.

Source: Info learnt from Chris Masterjohn who has a Phd in Nutritional Science. You can learn more about this buffer system here, which is a reddit post outlining information directly from the Masterjohn video.
« Last Edit: February 23, 2024, 05:04:43 AM by Warrior »
Nothing I say is medical advice. Always do your own research. Follow anything I say at your own discretion.
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Muon

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Re: Amino Acid Megathread
« Reply #3 on: May 11, 2024, 11:04:57 AM »
Anyone tried high dose Lysine (antiviral)?
« Last Edit: May 11, 2024, 11:07:27 AM by Muon »