Author Topic: Uncovering the Role of Mast Cell Dysfunction in the Pathophysiology of POIS  (Read 914 times)


demografx

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10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Progecitor

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I have just tried Houttuynia cordata a few days ago and it was quite useful for my symptoms. One needs to be careful though as it can be hepatotoxic when used in a higher amount for a longer time.

Interstitial cystitis/bladder pain syndrome (IC/BPS), accompanied by bladder inflammation and elevated number of activating mast cells in bladder tissues, is another condition that could benefit from treatment with H. cordata extracts.
Urinary frequency, nociceptive behaviors, cystometry, bladder weight, histological changes, and cytokine (IL-6, IL-8, TNF-a) concentration were selected as parameters for measurement of anti-inflammatory effects, and it was found that the group treated with H. cordata extract had reduced number of mast cells, decreased concentration of cytokines, in addition to longer intercontraction interval, bigger bladder capacity and higher nociceptive threshold. The study demonstrated the inhibitive efficacy of H. cordata on inflammation via inhibition of mast cell proliferation and regulation of proinflammatory cytokine levels.

https://www.sciencedirect.com/science/article/pii/S2405844022016747

Regulation by ERB of PTEN, NFkB, and TGFB suggests wide-spread effects of this receptor in cells in which it is expressed. ERB is not ubiquitously expressed. In addition to the prostate epithelium and stroma, ERB is expressed in several organs where it has profound physiological effects: to name a few, the immune system, the sympathetic nervous system, in blood vessels where its loss leads to hypertension, the urinary bladder where its loss leads to interstitial cystitis, and in the lung where its loss leads to general hypoxia because of a decrease in elasticity.
https://www.pnas.org/doi/full/10.1073/pnas.1702211114

Houttuynia cordata also shows a phytoestrogenic activity. (Table 1.)
https://sci-hub.st/https://www.sciencedirect.com/science/article/abs/pii/S0308814607002609
The cause is probably the senescence of sexual organs and resultant inducible SASP, which also acts as a kind of non-diabetic metabolic syndrome.