Case series: expanding diagnostic markers in postorgasmic illness syndrome

[Muon]

Case series: expanding diagnostic markers in postorgasmic illness syndrome

Discussion thread about this paper.

[Progecitor]

This is quite a blow to your mast cell activation theory, isn't it?

In addition, the serum tryptase level was not elevated postorgasm in 3 of our cases, suggesting there was no mast cell activation, a key feature of IgE-mediated allergic reactions.

[Quantum]

Excellent article, well written.  It combines a literature review with some case reports so that it can expand a little bit about what has been already written. 

They play it very safe, but they do deserve a mention for their effort in bringing new data. I appreciate that they did not fall into the pure "allergy to semen" trap, and are conscious that POIS is much more complex than that.

I am also glad that they agree with my view that there are many subtypes of POIS:
"It is likely that the diagnosis of POIS captures a variety of conditions with different mechanisms, and we advocate for treatment targeting both physical and psychological substrates, paying attention to individual variations in symptom profiles when choosing treatment."

[demografx]

Case series: expanding diagnostic markers in postorgasmic illness syndrome

Discussion thread about this paper.

Sent to POIS Research Study Team. Thank you.

[Muon]

I wonder if we will see more papers testing for the same set of parameters. Choosing random and untested parameters is a better option than going for the same stuff again IMO.

They mention central sensitization, which is something that is on my radar as well.

This is quite a blow to your mast cell activation theory, isn't it?

In addition, the serum tryptase level was not elevated postorgasm in 3 of our cases, suggesting there was no mast cell activation, a key feature of IgE-mediated allergic reactions.

I wish it was. This measurement does not suggest anything. Try test tryptase in a group of patients with proven IgE mediated allergic reactions and tell me how many of them show elevations. Result of the amount with elevated tryptase will likely to be very low and the same suggestion can be made.

[Muon]

Central sensitization syndrome thread:
https://poiscenter.com/forums/index.php?topic=4213.0

[Hopeoneday]

Case series: expanding diagnostic markers in postorgasmic illness syndrome

Discussion thread about this paper.

This is intresting to me:
Allergies (environmental/food/drug)           +    +    +    +    + 

[Muon]

Nice table of patient history but what I would like to know, in addition to that, is what other triggers induce symptoms in them.