Author Topic: Case series: expanding diagnostic markers in postorgasmic illness syndrome  (Read 809 times)


Progecitor

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This is quite a blow to your mast cell activation theory, isn't it?

In addition, the serum tryptase level was not elevated postorgasm in 3 of our cases, suggesting there was no mast cell activation, a key feature of IgE-mediated allergic reactions.
The cause is probably the senescence of sexual organs and resultant inducible SASP, which also acts as a kind of non-diabetic metabolic syndrome.

Quantum

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Excellent article, well written.  It combines a literature review with some case reports so that it can expand a little bit about what has been already written. 

They play it very safe, but they do deserve a mention for their effort in bringing new data. I appreciate that they did not fall into the pure "allergy to semen" trap, and are conscious that POIS is much more complex than that.

I am also glad that they agree with my view that there are many subtypes of POIS:
"It is likely that the diagnosis of POIS captures a variety of conditions with different mechanisms, and we advocate for treatment targeting both physical and psychological substrates, paying attention to individual variations in symptom profiles when choosing treatment."
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

demografx

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10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Muon

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I wonder if we will see more papers testing for the same set of parameters. Choosing random and untested parameters is a better option than going for the same stuff again IMO.

They mention central sensitization, which is something that is on my radar as well.

This is quite a blow to your mast cell activation theory, isn't it?

In addition, the serum tryptase level was not elevated postorgasm in 3 of our cases, suggesting there was no mast cell activation, a key feature of IgE-mediated allergic reactions.
I wish it was. This measurement does not suggest anything. Try test tryptase in a group of patients with proven IgE mediated allergic reactions and tell me how many of them show elevations. Result of the amount with elevated tryptase will likely to be very low and the same suggestion can be made.
« Last Edit: March 08, 2023, 10:57:45 AM by Muon »

Muon

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Central sensitization syndrome thread:
https://poiscenter.com/forums/index.php?topic=4213.0

Hopeoneday

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Case series: expanding diagnostic markers in postorgasmic illness syndrome

Discussion thread about this paper.

This is intresting to me:
Allergies (environmental/food/drug)           +    +    +    +    + 
« Last Edit: March 16, 2023, 09:28:57 AM by Hopeoneday »
Dr-pois.

Muon

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Nice table of patient history but what I would like to know, in addition to that, is what other triggers induce symptoms in them.