This is great. I did contact Dr. Natale with some of my own discoveries/testing/diagnoses/treatment which have resulted in me feeling 80% better. See below w/ test results/attachments:
<<<<Hello Dr. Natale,
I heard about your research on one of the POIS forums. I'm sure you're inundated, so let me be quick.
I have had these POIS symptoms for the past 30+ years, but worst over the past 7. (Irritability, excessive urination, excessive sweating, complete social withdrawal, anhedonia, dark circles under eyes, skin hyperpigmentation (black stuff coming out of skin in shower/bath-mostly post orgasm). At it's worst, I'd sleep at least 12 hours after orgasm.
I am certain that there is a low acetylcholinesterase component which can lead to cholinergic crisis (post orgasm) as well as failure to break down acetylcholine (a problem in high protein diets) and organophosphate buildup. I have test results to show this). Additionally, low aldosterone/renin levels (adrenal insufficiency) low 4 point cortisol saliva test, at least in my case, is also a contributing factor. Gastric testing shows high H Pylori, streptococcus and enteroccocus levels and potentially low stomach acid. Hypothyroidism as well. I would recommend including this in your research. I did a semen allergy test (blood test) and it came back negative, but perhaps it could be an intolerance. Haven't tested for that yet. High levels of mycotoxins (urine testing has appeared as well). Reactivated Epstein Barr Virus "may" also be relevant.
I am doing much better with treatment (Adderall is essential) and am convinced that there are some overlapping conditions that most of us POIS sufferers share that can be treated. I believe that the GI Map test should be done by all of us. Adrenal testing and stomach acid testing as well.
Nootropics like piracetam and centrophenoxine have been super helpful as well as alpha lipoic acid. I still take robinul/ditropan in moderation. I'm 80% better than I was 7 years ago when I was nearing autism spectrum type of behavior (always feeling toxic). I hope that this is helpful. There are some HUGE discoveries here. Most of these tests can be ordered directly using sites like ultalabtests.com, walkinlab.com, requestatest.com etc. For the GI Map (Diagnostic Solutions), I needed my doctor to order.
