Intravenous Immunoglobulin Therapy (IVIG) for POIS?

[Muon]

https://en.wikipedia.org/wiki/Immunoglobulin_therapy

I haven't seen a discussion about this. Has there been a POISer who has tried this therapy?

[Muon]

I guess not. IVIG is something that could be explored regarding autoimmune theory.

[Muon]

Yes I got Neuropathy doses of IVIG back in 2015, I thought it was helping me but after a few months I got a very mysterious symptom and had to stop getting it. Unfortunately the symptom persisted long after so I never could restart it. It was a pain to get Insurance to cover it

[Huser]

I have pois which develops into something like gulliane barre sindrom, every few years. Simptomes last one or two years. Symptoms feel like pois symptomes, but 10 times stronger. Pois is like weak gullian barre syndrome. Medication for gulliane barre is immunoglobulin. So this could probably help pois. But i think immunoglobulin just helps to stop atack of the immune system quicker as if you would wait the natural way. That means immunoglobulin would just make pois attack quicker to heal and not prevent it. If it would work. I think...

[Progecitor]

Interestingly the opposite of immunoglobulin infusions may also help. Immunoadsorption or immunoapheresis is a technique to selectively remove specific pathogenic autoantibodies.
In this manner immunoapheresis is supposed to be a more specific form of plasmapheresis. There are a few places around here that have been doing plasmapheresis for a long time now. There were a few times in the past when I considered donating plasma or blood. However I was extremely worried about unintentionally transmitting POIS to someone else, so I have never done it. People actually receive a small amount of money for the service, as the plasma has a good price. This lead many poor people to do it very frequently that deteriorated their health and it is said that a few of them even died due to this.
Nevertheless if the pharmacological treatment of POIS does not work out, than I may give this a chance later.

Some long-covid patients could benefit from experimental immunoadsorption therapy.
https://www.reddit.com/r/LongCovid/comments/1ha7lmv/new_research_results_in_the_netherlands_pem_and/

Similarly some ME/CFS patients also found it useful.
https://www.reddit.com/r/cfs/comments/1hg8oso/efficacy_of_repeated_immunoadsorption_in_patients/

This thread is also noteworthy in this regard:
https://poiscenter.com/forums/index.php?topic=2175.msg17520#msg17520

Additional information:
https://en.m.wikipedia.org/wiki/Immunoadsorption
https://www.sciencedirect.com/topics/medicine-and-dentistry/immunoabsorption
https://en.wikipedia.org/wiki/Plasmapheresis

Of course lipid peroxidation connects autoimmune diseases.

Lipid peroxidation may not simply be an associated side effect of disease progression but a possible etiology of SLE and other autoimmune diseases.
Moreover, since all of these patients had an active disease and some patients receiving no steroids had high anti-HNE levels, the increased anti-HNE antibodies may reflect some form of manifestation of SLE. Therefore, the HNE-specific epitopes may be used as the antigenic probe for detecting specific autoantibodies that can serve as reliable biomarkers for the practical evaluation of the disease activity in a subpopulation of SLE patients.
https://www.jbc.org/article/S0021-9258(20)74652-1/fulltext