So here I am. I've been suffering with CFS and POIS for more than 5 years with little hope in sight. I always knew about the FMT as an option, but I think I'm gonna finally pull the trigger. I believe that for those of us like me, who feel that gut is their primary cause, it could potentially be a cure. There are a lot of unknowns in the FMT world and it's a risky procedure. It can sometimes result in serious side effects and very rarely death, so nobody should undergo this without serious consideration, but I don't have much to loose anymore so I think I'm gonna do it.
I feel very clearly that whatever helps my gut, helps with general CFS symptoms, POIS and PE and vice versa. If I do something to upset my gut, POIS symptoms will be SO much worse. It's interesting that I get more easily aroused and my PE is worsened if I eat anything that upsets the gut, but it makes sense. I think the problem (at least for me) lies in the compromised gut barrier (aka leaky gut), and vagus nerve irritation, which I'm pretty sure is an underlying cause of PE, ectopic heart beats, brain fog, etc.
As to how the POIS symptoms are caused, I don't know. Obviously, nobody does. My guess is it's either autonomic/vasomotor dysfunction (judging by improvement with acetylcholinesterase inhibitors by some members or that some only get symptoms with masturbation, but not sex) or some other neuroimmune dysregulation due to antibodies to receptors or whatnot. Keep in mind, what is thought of as autoimmune diseases may be something different. E.g., there are reports of "transmission" of autoimmune diseases like rheumatoid arthritis, or immune thrombocytopenia by fecal transplant. There are also reports of these same illnesses being cured by FMT. So the theory of body just randomly attacking its tissues or receptors for no apparent reason is likely incorrect and the so called autoimmune diseases may be caused by dysregulation of gut microbiota and/or by pathogens/pathobionts in the gut either through molecular mimicry (body is attacking microbes, but is also attacking a cell that's similar to that microbe), or some other type of immune activation.
Alternatively, POIS symptoms could be caused by afferent vagus nerve sensing inflammation in the gut (or somewhere else in ghe body), sending signals to the brain, which induces microglia activation and maybe causes some kind of neuro-hormonal dysregulation, etc which may only manifest in the extremes of autonomic function (like ejaculation).
All in all, it's not necessary to know how exactly it all works if you're trying to address the underlying issue, which in my case is the gut. I have done a lot of research over the years and this the only thing that makes sense to me. I'm not saying that everyone has the same problems. Obviously, only a minority here have CFS. That being said, I doubt that there's anyone here who is 100% healthy and that the only problem that they have is POIS. Maybe I'm wrong, but that's how I see it.
Has anyone here tried FMT?
