I have had a lot of tests, I will just post what is abnormal and relevant. Everything worsened a lot after taking an antibiotic called Ciprofloxacin so I guess it is related to gut bacteria. See my thread here for more information:
http://poiscenter.com/forums/index.php?topic=2775.0Amyloidosis (No indication of this disease)Serum Free Kappa Light Chains 14.1 mg/l (3.3 -19.4)
Serum Free Lambda Light Chain 13.4 mg/l (5.71 - 26.3)
Serum Free Kappa/Lamda Ratio 1.05 (0.26 - 1.65) Please note in patients with low GFR (<15) the K:L ratio normal range changes to 0.37 - 3.1
Thyroid (My results indicate subclinical hypothyroidism that does not require treatment):THYROID STIMULATING HORMONE * 5.83 mIU/L 0.27 - 4.2
FREE THYROXINE 18.0 pmol/l 12.0 - 22.0
FREE T3 3.2 pmol/L 3.1 - 6.8
Antibodies were negative for autoimmune thyroid disease.
Antioxidant Profile from Biolab (Elevated Superoxide Dismutase):Alpha Carotene 0.46 umol/L 0.30 - 1.50
Beta Carotene 15.40 umol/L 0.40 - 3.00 (This is elevated because I eat tons of sweet potatoes every day)
Alpha Tocopherol [Vitamin E] 33 umol/L 25 - 60
Gamma Tocopherol [Vitamin E] 0.29 umol/L 2.0 - 8.5
Antioxidant Activity [serum total] 1.36 mmol/L 1.32 - 1.58
Antioxidant Activity [nutritional] 600 umol/L 450 - 800
~
Ceruloplasmin [serum - trace] 16.4 mg/dl 18 - 34
Copper [plasma] 13.3 umol/L 12.5 - 25.0
GSHPx-1 [red cell] 33 IU/gm Hb 25 - 50
GSHPx-3 [plamsa] 241 IU/L 115 - 400
Paraoxonase [serum] 85 IU/L 150 - 1000
Superoxide Dismutase [red cell] * 1987 U/gHb 1102 - 1601
Vitamins/MineralsTested most vitamins and all found to be within range.
Homocysteine was tested twice, first was 15.10 umol/L and then a week later was 13.70 umol/L (ref <15), suggests B12 is bit low.
Whole blood tests for minerals were within range except Manganese was a bit low.
Bone Tests:Osteocalcin * 48.7 ug/L 9.0 - 40.0
Beta-CTx (Crosslaps-Serum DPD) * 1.21 ng/ml < 0.58
Sex hormones (High SHBG):D.H.E.A. Sulphate 10.5 umol/L 0.44 - 13.4
FOLLICLE STIM. HORMONE 4.0 IU/L 1.5 - 12.4
LUTEINISING HORMONE 3.2 IU/L 1.7 - 8.6
TESTOSTERONE 12.7 nmol/L 7.6 - 31.4
Reference Ranges apply to adults
SEX HORMONE BINDING GLOB * 84 nmol/L 16 - 55
Testosterone/SHBG Ratio * 15.1 24 - 104
Cholesterol (Lipids are very high and I'm not overweight):TRIGLYCERIDES 1.23 mmol/L 0.00 - 2.30
CHOLESTEROL *5.79 mmol/L 0.00 - 4.99
HDL CHOLESTEROL *1.66 mmol/L 0.90 - 1.50
LDL CHOLESTEROL *3.57 mmol/L 0.00 - 3.00
NON-HDL CHOLESTEROL *4.13 mmol/L 0.00 - 3.89
Steroid hormones during a flare:CORTISOL *688.000 nmol/l 133.00 - 537.00
Aldosterone SERUM/PLASMA * 2210 pmol/l 61 - 970
16S Microbiome test from Atlas Biomed (I don't have any printout of results, they are visible in a webpage with diagrams, so I can't post all of it)- I am missing a number of important butyrate-producing bacteria such as faecalibacterium, roseburia, coprococcus, akkermansia. I also have very low eubacterium.
- I am also missing a non-butyrate bacteria called Lactobacillus.
- Bifidobacteria is about 2.4%.
Butyrate maintains the gut lining, it also produces regulatory immune cells that prevent autoimmune disease. People with Celiac disease and IBS have been found to have low butyrate bacteria. I think when we orgasm, oxidative stress rises and our butyrate bacteria cannot produce enough butyrate to suppress it so we get damage to the body.
ImmuneLymphocytes CD3, CD4, CD8 all normal.
Interleukins 1B, 2, 6, 8, 10, TNF, CRP, ESR all normal.
Viruses/BacteriaSyphilis - Neg
HIV - Neg
Hep B - Neg
Hep C - Neg
HSV 1 - Neg
HSV 2 - Neg
Enterovirus IGM - Neg
Toxoplasma IGM/IGG - Neg
Lyme ELISA - Neg
Cytomegalovirus - Neg
Mycoplasma pneumoniae IgG/IgM - Neg
Psittacosis/L.G.V. Antibodies - Neg
Adenovirus C.F.T - Neg
EBV IGG/IGM - Neg
HHV6 - Possibly latent past infection or negative, the lab couldn't decide. Very low titre.
VZV - IGM is negative, I have had chicken pox as a child so would assume IGG shows latent virus.
Hair AnalysisVery high Aluminium and Zirconium levels - Report suggested that deodorant caused this.
MitochondrialLactate - Normal
Total carnitine 28 umol/l 30 – 70
Free carnitine 18 umol/l 20 – 55
Aminos Acids (No GABA detected and low in GABA precursors like Leucine, Glutamine, Valine, Serine)_URINE AMINO ACIDS QUANTITATION_
Ref Range:
AMINO ACID Result (uM/mM Crea) Reference Range (uM/mM Crea)
~
Phosphoserine 4 Not Detected
Taurine 58 16-180
Phosphoethanolamine 3 Not Detected
Aspartic Acid 2 2-7
Hydroxyproline 1 <13
Threonine *6 7-29
Serine *16 21-50
Asparagine 4 <23
Glutamic Acid 1 <12
Glutamine 20 20-76
Sarcosine 0 Not Detected
Alpha Aminoadipic acid 1 Not Detected
Proline 0 <9
Glycine 46 43-173
Alanine 21 16-68
Citrulline 1 <4
Alpha Aminobutyric 0 <4
Valine 3 3-13
Cystine 3 3-17
Methionine *1 2-16
Isoleucine 1 <4
Leucine *1 2-11
Tyrosine 3 2-23
Phenylalanine 3 2-19
Beta Alanine 2 Not Detected
Beta Aminoisobutyric 2 <91
GABA 0 Not Detected
Ethanolamine 17 Not Detected
Tryptophan 0 Not Detected
Hydroxylysine 0 Not Detected
Ornithine 2 <5
Lysine 7 7-58
1-Methylhistidine 59 Not Detected
Histidine *25 26-153
3-Methylhistidine *14 19-47
Anserine 1 Not Detected
Carnosine 5 Not Detected
Arginine 1 <5
-
Creatinine 1469 mg/l
Lab Interpretation:
Aminoacids (U): Essentially normal urinary excretion of
physiological aminoacids. Excluded are cystinuria, Hartnup
disease, and lysinuric protein intolerance. No generalised
hyperaminoaciduria.
Sex Hormones August 2019 (All normal except very high Prolactin but this test was 12 hours after an O)Albumin 42.1 g/L (Range: 35 - 50)
SHBG 25.4 nmol/L (Range: 18.3 - 54.1)
FSH 4.19 IU/L (Range: 1.5 - 12.4)
LH 4.7 IU/L (Range: 1.7 - 8.6)
Oestradiol 61.5 pmol/L (Range: 41 - 159)
Testosterone 11 nmol/L (Range: 8.64 - 29)
Free Testosterone - Calc. 0.255 nmol/L (Range: 0.2 - 0.62)
Free Androgen Index 43.31 Ratio (Range: 24 - 104)
Prolactin 638 mU/L (Range: 86 - 324)
DHEA Sulphate 5.180 umol/L (Range: 4.34 - 12.2)
Vitamins/Minerals (These tests were taken at a time when I was very sick and could only eat Sweet potato with chicken everyday, hence the high Beta-Carotene and maybe it also explains the elevated B6Vitamin A (Retinol) 2.46 umol/l 1.05 - 3.84 Deficiency: < 0.66 Toxic: > 4.87 (according to WHO guideline)
Beta-Carotene * 13.3 umol/L 0.28 - 2.33
Vitamin B1 (Thiamine) 27.5 ug/l 15 - 70
Vitamin B2 79.6 ug/l 40 - 140
Vitamin B3 (Nicotinamide) 9.7 ug/l 8 - 100
Vitamin B5 (Panthothenic acid) 53.9 ug/l 25 - 80
Vitamin B6 (pyridoxine) * 40.4 ug/l 8.7 - 27.2
Biotin (Vitamin H) 250 pg/ml > 250
Active Vitamin B12 68 pmol/L 25.1 – 165.0
Vitamin C 57.9 umol/L > 11.4
25 OH Vitamin D 59 nmol/L 50 - 200 Interpretation of results: Deficient: <25 nmol/L Insufficient: 25 - 49 nmol/L
Normal Range: 50 - 200 nmol/L Consider reducing dose: >200 nmol/L
Vitamin E (alpha Tocopherol) 27.9 umol/l 11.6 - 46.4
Red cell folate 449 nmol/L 285.4 - 1474.7 <150 nmol/L is associated with folate deficiency
Whole Blood Chromium <1.0 ug/l < 1
Whole Blood Potassium 1850 mg/l 1450 - 2100
Whole Blood Calcium 63.0 mg/l 48 - 65
Whole Blood Copper 1.03 mg/l 0.8 - 1.65
Whole Blood Magnesium 39.0 mg/l 29 - 42
Whole Blood Manganese *5.1 ug/l 7 - 11
Whole Blood Zinc 6.9 mg/l 4.0 - 7.6
Whole Blood Selenium 103 ug/l 85 - 200
Mast Cell Activation / Histamine intoleranceSerum Tryptase 4.7 ug/l Up to 11
Diamine Oxidase Activity * 6.5 U/ml < 3 : Histamine intolerance indicated
3 - 10 : Histamine intolerance probable
> 10 : Histamine intolerance improbable
What has possibly helpedIt's difficult to pinpoint things when you gradually improve over time.
- I've taken many single-strain probiotics, Lactobacillus species seem most helpful. Plantarum 299v, Lindens Pro Bio Live Max, BioGaia. I don't find probiotics reliable though, they only work sometimes.
- Sovereign Labs Colostrum LD (Vanilla flavour) may have helped.
- Allicin Max (The one with the UK flag on the front)
- Thorne Molybdenum Glycinate
- Maybe some standard B6 (not the active P5P form)
- Now L-Lysine powder (not the capsules but the pure powder)
- Doctor's Best Sam-e (Avoid the Jarrow brand, it seems to damage my digestive system)
CommentMitochondrial dysfunction? Gut Dysbiosis? Shame the medical profession have no interest in helping me, this illness has completely ruined my life.