Author Topic: List of Natural Mast Cells Stabilizers  (Read 23359 times)

Quantum

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List of Natural Mast Cells Stabilizers
« on: October 21, 2016, 11:28:43 AM »
Short version :  Natural Mast Cells Stabilizers like quercetin, luteolin, apigenin, curcumin, pine bark extract and others are good candidates at becoming part of a pre-pack taken before release in order to lower duration and severity of POIS symptoms.



Longer version :     ;-)   

I have already written about the fact that I see a link between many POIS symptoms and symptoms that are seen in Mast Cells Activation Disorder ( MACD).  This clearly goes toward the auto-immune hypothesis of POIS cause.  Allergic and flu-like symptoms are not hard to link to a immune response, and I have already explained my view on how cognitive and emotional symptoms may be also linked to immune response, via TDO and IDO upregulating, shunting the tryptophan metabolism from niacin and serotonin production to kynurenine production and its toxic by-products, quinolinic acid and kynuretic acid.

Recently, Romies have shared his success with a pre-pack containing celecoxib, quercetin/bromelain, curcumin ( see his post at http://poiscenter.com/forums/index.php?topic=2090.msg19833#msg19833 )  He also, as myself, have symptoms similar to POIS after exercise ( sport, training), but milder than a POIS attack, and successfully uses the same pre-pack to prevent these exercise-induced symptoms, for him being fatigue and brain fog ( see at http://poiscenter.com/forums/index.php?topic=2090.msg19834#msg19834 ).  The three component f his pre-pack have mast cells stabilizing properties, and that was part of the reason he came with this combo.

I had myself included mast cells stabilizers in my pre-pack, and have success with them.  So, I though it would be useful to expand a little bit on the subject of natural mast cells stabilizers ( I prefer natural supplements over prescription drugs, as you may have noticed, because they are relatively safer, and easier to obtain, without the need to see a doctor).   I truly believe that mast cells stabilizers are useful for POIS relief, in particular when taken before release.

The interest of mast cells stabilizers is that they act one step earlier than antihistamines.   They block degranulation, that is, the release of histamine and other pro-inflammatory messengers by activated mast cells.  Antihistamine block the histamine receptors, so are used to lower the effects of histamine that has already been release in the tissues,and of course, they work only against histamine, and not the other immune messengers that are released by mast cells and that cause inflammation and symptoms in the body and brain (pro-inflammatory cytokines, etc) .  Natural mast cells stabilizers have usually less side effects than anti-histamine, if you use safe doses  ( antihistamine have usually a drowsiness side effect, in particular for first generation antihistamine like diphenydramine)

For a great start about natural mast cells stabilizers, here is a excellent article titled "Twenty-first century mast cell stabilizers", listing natural mast cells stabilizers, and providing scientific references for them : http://onlinelibrary.wiley.com/doi/10.1111/bph.12138/full .  The text is very informative, and I never saw a so extensive list of natural mast cells stabilizers elsewhere.

In Table 1 there is an extensive list of naturally occurring mast cells stabilizers.  Many of them I already uses, like quercetin and luteolin, and this article learned me about interesting others I didn't came across so far, like apigenin.

Reading table one, you may not recognize some of the names, but may know about the plants and supplements that are a source of them.  Here are those that I find the most interesting, and their possible sources:

Quercetin:  yes, my favorite.  I use a supplement of quercetin with bromelain, the later raising the absorption of quercetin.  Quercetin supplements are not expensive.  However, better look for a preparation that enhance the low absorption of quercetin.  Food containing quercetin include red kidney beans and capers, and many other fruits and vegetables.  For more info and other food sources, see https://en.wikipedia.org/wiki/Quercetin

Luteolin: very interesting flavonoid.  If you have brain fog, you should read this article: https://www.ncbi.nlm.nih.gov/pubmed/26190965 .  It states that luteolin is effective against brain fog and other cognitive symptoms.  Luteolin is contained in  parsley, artichoke leaves, celery, peppers, olive oil, rosemary, lemons, peppermint, sage, thyme and other foods.  My favorite sources are artichoke supplement and rosemary essential oils.  Olive leaf extract also contains luteolin.


Apigenin:  according to the article, it is very potent.  Best source is chamomile flower tops.   Chamomile tea or supplements are fairly cheap and are safe if used in standard doses.  As a bonus, chamomile also contains at least two other mast cells stabilizers:  luteolin and chrysin.  And, being calming, chamomile is good for anxiety symptoms.  I didn't try it so far, but may do so in the following months, even if I already have good anti-POIS supplements ( I am open to find better ones if they are safe to use).

L-theanine:  I already use it in my pre-pack.  Is contained in green tea, but also available in standalone supplement.   Has also a calming effect.


In table one of the article, you may note silymarin, contained in Milk Thistle, EGCG from green tea, Ginkgetin from Ginkgo, curcumin from turmeric, resveratrol , and other substances I have already used and talked about, some being part of my current relief method.

Note that most mast cells stabilizers can be also recognized as anti-inflammatory, COX-2 inhibitors, or antioxidants - those notions tends to overlap.   If you block mast cells degranulation, you avoid the manifestation of more inflammation symptoms, and so on.


P.S.( 2017-08) I would like to add that Pine Bark extract/pycnogenol is also an excellent antioxidant that has good mast cells stabilizer properties  ( see Nanna1 reference at http://poiscenter.com/forums/index.php?topic=2505.msg21603#msg21603 ).  I have been using it for a long time, and like its antioxidant effects and beneficial use in POIS, but didn't know it was also a mast cell stabilizer too.





« Last Edit: June 26, 2020, 10:47:18 AM by Quantum »
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

demografx

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Re: List of Natural Mast Cells Stabilizers
« Reply #1 on: October 21, 2016, 03:14:53 PM »
I take quercetin for insomnia.
Does that fit?
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

Quantum

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Re: List of Natural Mast Cells Stabilizers
« Reply #2 on: October 22, 2016, 11:13:22 AM »
I take quercetin for insomnia.
Does that fit?


Hi Demo,

Sure it does if it is efficient for you.  It this not the most usual indication for quercetin, but it has been tested for anxiety, depression and insomnia. But like for many natural products, there are not a lot of studies to draw conclusions from.

Quercetin surely fits for me as part of my relief method for POIS, and it is also helping me with exercise induced fatigue. Both these symptoms are somehow related or additive, because if I exercise too much before or after ejaculation, I worsen my "POIS attack".
You are 100% responsible for what you do with anything I post on this forum and of any consequence it could have for you.  Forum rule: ""Do not use POISCenter as a substitute for, or to give, medical advice" Read the remaining part at http://poiscenter.com/forums/index.php?topic=1.msg10259#msg10259

15yrsAndCounting

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Re: List of Natural Mast Cells Stabilizers
« Reply #3 on: September 25, 2020, 12:07:46 PM »
What quantities are safe quantities specifically for quercetin & luteolin

Muon

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Re: List of Natural Mast Cells Stabilizers
« Reply #4 on: September 25, 2020, 12:15:00 PM »
What quantities are safe quantities specifically for quercetin & luteolin

"NOTE: The total amount of all/any combined bioflavonoids (including but not limited to Algonot products) consumed should not exceed 1500 mg per day, without consulting with your health professional, especially if the individual is found to have decreased liver metabolic enzyme activity."

https://algonot.com/neuroprotek/

15yrsAndCounting

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Re: List of Natural Mast Cells Stabilizers
« Reply #5 on: September 25, 2020, 01:57:32 PM »
Thanks Muon, do you take it daily now ? or before O ?
Or as and when you see symptoms.

Muon

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Re: List of Natural Mast Cells Stabilizers
« Reply #6 on: September 25, 2020, 02:36:47 PM »
Thanks Muon, do you take it daily now ? or before O ?
Or as and when you see symptoms.

I don't take it yet because I'm thinking about spending money on a MRI of the spine first (plus a DXA scan). I will try the product after that. They are using it in MCAS and neuroinflammation where mast cells are involved for at least a few months daily. It's about long term stabilization getting those cells 'calm' instead of short term effects. The dose I hear and read about is 2 capsules in the morning and 2 at night or higher as in 1 capsule per 10 kg of body weight spread over the day, like morning, midday, night. They build it up towards that dose. Some people are phenolic and can't tolerate these products, that's why there is a low phenol version. Algonot got two independent laboratories that test the quality.

Here is an example, they are using brain gain: Post-Lyme Syndrome‚ÄďAssociated Polyneuropathy Treated With Immune Immunoglobulin and a Luteolin-Containing Formulation

Mushnikk

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Re: List of Natural Mast Cells Stabilizers
« Reply #7 on: September 28, 2020, 05:02:02 AM »
How much do you take of these supplements (Quercetin, L-Theanine, ...)?

EnriqueM075

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Re: List of Natural Mast Cells Stabilizers
« Reply #8 on: December 18, 2020, 08:07:56 AM »
Ginger is from the same family as turmeric, I think it should work, I was recently taking ginger with chamomile for cold symptoms that seemed to be associated with POIS and I get better a lot, in this article they recommend it


https://eldia.com.do/remedios-naturales-que-ayudan-a-prevenir-y-calmar-las-alergias/