Allergy or neurological

[Quantum]

Good info Quantum, concurring with BluesBrother, thanks for sharing the insight! Enjoy reading & learning from those detailed postings, ty.

Thank you, Prancer, and thanks to Bluesbrother too. 

I will make some follow up posts eventually, for example about excitotoxicity and the role of NMDA receptors, and how this ties to what I have already shared.  It would explain, for example, why, for years, I have been having relief with magnesium, because magnesium is a NMDA blocker.

[Nightingale]

To further clarify my position concerning cluster 3 and cluster 4 symptoms origin, I want to say that for me, ejaculation, not orgasm, is the trigger of the immune reaction. I believe that the neurological/brain imbalance in the brain in POIS has nothing to do with the neurotransmitters frenzy of orgasm itself, and has everything to do with ejaculation, has a trigger of the hypersensitivity reactions.  Those hypersensitivity reactions will not only produce allergy and flu-like symptoms, but also cause some specific changes in the body functioning at the metabolic level, leading to cognitive and emotional symptoms.  I have at least 2 arguments for this.  First, many POIS sufferers will get some POIS symptoms after a semen leak caused by a bowel movement, or also by pre-ejaculation emissions, as in edging.  You will agree that no O has occurred in those situations, but POIS did.  Also, you can have POIS even in the case of ejaculatory anhedonia, that means an ejaculation with no pleasure felt or anything happening in the brain during ejaculation - again, no O, but POIS symptoms. Also, POIS symptoms seems minimal in case of a "dry orgasm", that is, an O without ejaculation ( although in this last case, this is not a common occurrence, so data are few).

I feel this an important paragraph to highlight. I believe like you that ejaculation is the true trigger, and anything that builds towards that can cause a POIS symptom of varying intensity. And speaking of POIS, I actually think PEIS would be more accurate!

[G-man]

To further clarify my position concerning cluster 3 and cluster 4 symptoms origin, I want to say that for me, ejaculation, not orgasm, is the trigger of the immune reaction. I believe that the neurological/brain imbalance in the brain in POIS has nothing to do with the neurotransmitters frenzy of orgasm itself, and has everything to do with ejaculation, has a trigger of the hypersensitivity reactions.  Those hypersensitivity reactions will not only produce allergy and flu-like symptoms, but also cause some specific changes in the body functioning at the metabolic level, leading to cognitive and emotional symptoms.  I have at least 2 arguments for this.  First, many POIS sufferers will get some POIS symptoms after a semen leak caused by a bowel movement, or also by pre-ejaculation emissions, as in edging.  You will agree that no O has occurred in those situations, but POIS did.  Also, you can have POIS even in the case of ejaculatory anhedonia, that means an ejaculation with no pleasure felt or anything happening in the brain during ejaculation - again, no O, but POIS symptoms. Also, POIS symptoms seems minimal in case of a "dry orgasm", that is, an O without ejaculation ( although in this last case, this is not a common occurrence, so data are few).

I feel this an important paragraph to highlight. I believe like you that ejaculation is the true trigger, and anything that builds towards that can cause a POIS symptom of varying intensity. And speaking of POIS, I actually think PEIS would be more accurate!

I agree with what is said above. POIS seems to be a hypersensitivity reaction that correlates with ejaculation.

I am happy to report that my symptoms are continuing to improve with my gut supplement regiment. I also feel much better now when not in the POIS state than I did before I started the regiment. I'm still sick so I will wait until I am better before giving a full update.

I had two orgasms within an hour Thursday night, and one Friday afternoon. I noticed with the first O, the burning feeling in my urethra was completely gone. I was surprised by the difference in how it felt. My prostate felt itchy after the first O. The second O I had a barely noticeable burning sensation the last couple seconds at the end of the O. My prostate became really itchy by the time I had the third O on Friday, which was normal for me. The third O I had the barely noticeable burning sensation, but the itchiness in my prostate has been nearly nonexistent since then.

Since my supplements are working the question then becomes why are they working. I started reading about organisms that live in the G.I. tract. One startling fact is that there are ten times more individual organisms living in our gut than cells in our body. I also read that certain types of fungi in the gut can be the cause of hypersensitivity reactions. So while POIS is a hypersensitivity reaction, the organisms making up our G.I. tract could very well be causing the hypersensitivity reaction. More research is needed.

Edit: I forgot to mention that I know my absorption of nutrients has improved because my adderall dosage, which has been the same for a couple years, is now waaaaaaay too strong.

[G-man]

What I'm saying is that POIS is likely a part of something bigger. Many of us have other immune problems such as eczema, asthma, seasonal allergies, food sensitivities, etc. Something could be causing all of our immune problems.

I appreciate all the work Quantum has put into the four clusters. All of us could have any combination of the different clusters, just like all of us have a different combination of immune problems.

[poiseidon]

I agree with you...What if changing the way our body absorbs nutrients changes the chemistry of the semen thus making it more acceptable by our body?

[G-man]

I went to see my doctor yesterday, and now I am more unsure of why the supplements are working. He said it is because they are healing my leaky gut, and that is the first step in treating an autoimmune disease. I'll check in every few weeks and let you guys know where I'm at in terms of progress.

[demografx]

My body has just gone wild with diverticulitis > major surgery, plus fighting pneumonia. Also had in recent years quintuple bypass, cardiac disease. Urinary frequency probs. wondering if this plus POIS says something about my autoimmune system.

[Colm]

My body has just gone wild with diverticulitis > major surgery, plus fighting pneumonia. Also had in recent years quintuple bypass, cardiac disease. Urinary frequency probs. wondering if this plus POIS says something about my autoimmune system.

Demo,

You are a truly amazing character to have given all you have contributed to this forum and NSF previously, keeping folks motivated over the years toward the study and engaging people to post here.

If anyone is in any doubt, here's the first NSF posts from 2007, with Demo, B_Jim, Mellivora and others having a banter 8 years ago about the joy of POIS http://www.thenakedscientists.com/forum/?topic=6576.0

Around in circles as Daveman says, for 8 years, but closing in, no doubts about that !

All the while you have been unwell yourself with autoimmune and inflammatory related chronic sickness. As many others do struggle, I am sure they do very much appreciate what you, DM and others gave here. They mighn't say it often enough, but I'm sure they think it. 

It is only when someone isn't around for a while, as you haven't been though illness, that you realize what they give to the cause.

Keep looking after yourself, build your immune system strong and I for one am looking forward to seeing the fancy graphics and comments on the site here soon, but only when you are well enough. 

Colm

[demografx]

Colm, thank you greatly.

I am at a loss for more words than that!





Best wishes,
Demo

[demografx]

My body has just gone wild with diverticulitis > major surgery, plus fighting pneumonia. Also had in recent years quintuple bypass, cardiac disease. Urinary frequency probs. wondering if this plus POIS says something about my autoimmune system.

edit - will also need 2nd surgery (elective) in 2-3 months...as soon as I heal from #1 -- so guys, please keep sending those Health Signals!

[Outsider]

Hi, everybody
I have an allergy to the sun
In french we call that Leucite
I have spot and excema on my hands
I take loratadine or cetirizine
For that
So i don t have the symptoms
But my pois still the same

[Nightingale]

Hi, everybody
I have an allergy to the sun
In french we call that Leucite
I have spot and excema on my hands
I take loratadine or cetirizine
For that
So i don t have the symptoms
But my pois still the same

Do you take antihistamines? Lowering your histamine response could help. Also, you might have a mast cell problem because the sun may be irritating them to release histamine. Look up DAO enzyme and histamine intolerance diet. This may help.

[Outsider]

Hi, everybody
I have an allergy to the sun
In french we call that Leucite
I have spot and excema on my hands
I take loratadine or cetirizine
For that
So i don t have the symptoms
But my pois still the same

Yes, i take anti histaminic, loratadine or cetirizine
it works pretty good, but it doesn't help me against my pois
this allergy is linked with my pois like a side effect

Do you take antihistamines? Lowering your histamine response could help. Also, you might have a mast cell problem because the sun may be irritating them to release histamine. Look up DAO enzyme and histamine intolerance diet. This may help.

[b_jim]

Can I vote "Both WITH relation to each other " ?

I'm reading and tanslating  this long and difficult document :
http://journal.frontiersin.org/article/10.3389/fimmu.2014.00117/full

I imagine after ejaculation dopamine crash and triggers immune reaction in the intestine.

[Colm]

Hi, everybody
I have an allergy to the sun
In french we call that Leucite
I have spot and excema on my hands
I take loratadine or cetirizine
For that
So i don t have the symptoms
But my pois still the same

Hi Outsider,

I also have a severe allergy to any exposure to the Sun's UV rays.  Affects me psychologically and physically through dermatitis on the face and scalp that inflames with exposure.

I think it is part of an Autoimmune and Inflammatory problem, part of or associated to the POIS condition. A lupus lookalike condition.

I assume your alergy affects your eczema also?

All the best,
Colm

[Colm]

Can I vote "Both WITH relation to each other " ?

I'm reading and tanslating  this long and difficult document :
http://journal.frontiersin.org/article/10.3389/fimmu.2014.00117/full

I imagine after ejaculation dopamine crash and triggers immune reaction in the intestine.

Really excellent detailed article B_Jim. Difficult to understand it all but seems to be of the same family of thinking that Quantum speaks of quite often here.

I would assume the researchers are keeping in touch with these great contributions on the forum here, and bringing the newest thinking into their analysis.

[b_jim]

I have thinking about this today... Something is wrong. In fact I think the digestive speed is linked to the severity of symptoms. Food with high digestive speed will cause more symptoms and food with low digestive speed less symptoms.

I have the feeling and I sincerly think I'm right, that the phenomenon happens just after stomac (pancreas / dudodenum).
For Parkinson disease, there is a cure called dopamine pump. With a pump, dopamine is injected in the duodenum of the sufferer.

[demografx]

...I would assume the researchers are keeping in touch with these great contributions on the forum here, and bringing the newest thinking into their analysis...

I encourage you, Colm, and all,  to send an email to Barry or Dr Nan, expressing your (Colm's) sentiments above. I think it's critical for at least a Rutgers staffer to read/study/convey to all the POIS-Rutgers Team.

Thanks.

[demografx]

Timing is good since we are now collaborating on meaningful member characteristics. Your postings analysis may prove an interesting part of the study. Agree?

[b_jim]

I sincerely hope that searchers use our posts. There is more chance if a large number of cases have the same observations.
For example whan we had 15... 20 and more Poisers improving symptoms  with niacin.