Few members have reported their experiments with alpha blockers in this forum. Most of them (including myself) could not tolerate the side effects of Silodosin and gave it up because of that.
Dosage and timing mentioned in this paper: 8 mg, 2 hrs before the O.
All 14 patients started treatment with on-demand Silodosin 8 mg in which eight (57.1%) of them, although they complained about the need for planning, were satisfied with the results, with no ejaculation and without postorgasmic complaints. One patient was suffering from a Silodosin side effect (dizziness) and discontinued with Silodosin. Seven patients (six unresponsive and one with side-effects of Silodosin) received Ibuprofen 400 mg with an improvement of their complaints in two of them (28.5%).
Four of the five unresponsive patients to Ibuprofen (80%) who received Prednisone (third-line treatment) saw an improvement in their symptoms. One patient without improvement received supportive therapy.
The 2019 paper ( Pierce et al., Scandinavian Journal of Urology) tried Alfuzosin/Terazosin on a single patient:
...we suspected his symptoms could be in part secondary to an increased autonomic response, and he was started on a trial of terazosin, followed by several months of alfuzosin. He reported significant improvement of all symptoms on both alpha-blockers.... Despite these beneficial effects, he decided to discontinue alpha-blockers due to dizziness and significant erectile dysfunction which he attributed to the medications...
