Xanthiol Nicotinate - Benefits, Risks and Function in POIS

[Daveman]

I take 260mg niacinammide daily as part of my B-Complex, I wonder is that contributes to niacin "tolerance" in some way...
I guess the next way to try is on morning as I wake-up, as I already did with the old brand, unfortunately with similar effects.
I caught a cold (guess how?) now and must wait.
Ironically, I don't drink alcohol and pork meat and very sparingly deep fried food, so it could be very easy for me to flush ;-)
What I usually do eat on evening are fresh (goat) cheeses, I wonder if the high content in fats and proteins has an influence. In other words, if niacin would work better after a carbs, protein or fats meal.

It´s possible that the niacinamide lowers the niacin threshold. It is niacin after all, just a different form.

People who take niacin regularly can take over 2 gr. without getting flush.

I always flush HARD in the morning, with just 100 mg. My first time was in the morning with about 70mg and I
got a good flush.

You could try stopping the niacinamide for a while too.

[asdfdoc]

oh wow...

i didn't believe in niacin. I was looking for other possible answers with serotonin, dopamin and all, which caused me to try different ssris/adhd medications without so much success..

I tried inositol hexanicotinate 500mg about a year ago without any success. I gave up on niacin. I read a few more threads a few weeks ago and I bought Doctor's best REAL niacin timed release 500mg. You guys are right. This thing works. My physical and mental fatigue is noticeably reduced after O. I did have some flush and itchiness first 10 minutes after taking it. Otherwise, this is godsend. Really interesting stuff. I even had O twice and I feel fine. This is weird.

[victor.kons]

Herman has posted a link on a very interesting article about Niacin on Russian forum. I would like to share it here as well, very interesting stuff:

http://www.reboundhealth.com/cms/images/pdf/rdid129niacintoflushornottoflush.pdf

Victor

[b_jim]

I have a question : what is the form of niacin in food ? Maybe this form is more easily absorbed ?
(compared to suplements)

[ssquall]

Does anyone still have success with Xanathiol Nicotinate???

[Daveman]

Most have just been using regular Flush type Niacin instead of Xanthiol Nicotinate.

Works great

[Jmari]

Has anyone considered using something called Picamilon(a fusion of Niacin and GABA)

[mevsp]

I don't know if this is the 'official' Niacin experiment thread or if there is another one. I see no one posted in the last 120 days.

I tried Niacin for the first time yesterday. After reading a lot about it I decided to test it out and see for myself. I bought the flush type 100mg. I had not eaten for four hours before taking it. Took the pill at 5:30 pm and felt nothing till 6pm so I decided to take another one. Within 5 minutes my body started to tingle and after 15  minutes my face was as red like a tomato. I don't know if this was the effect of the first or second pill but it was definitely working. At around 6:35 pm I had an orgasm. At first I didn't know if this was too soon since it was about 20 minutes after the flush really started but I could feel the flush going away and my face was still a bit red when I orgasmed. Next time I try to be a bit more patient and orgasm 45 minutes after the flush.

Anyways, immediately after the orgasm I noticed that I wasn't sleepy like I normal am after an orgasm. I just got up and cleaned myself. I didn't really feel a drop in energy as well like is normally the case.
So almost no difference before and after orgasm. One thing I did notice was that I was very tired very soon in the evening. Went to sleep at 9:30 pm already and slept for ten hours.

The flush was really strong so maybe that took a lot of energy from my body? I felt very energized the first two hours after taking the Niacine but then became tired.

Today I don't feel the symptoms as strong as I would without Niacine. It's hard to measure but I would say the symptoms reduced 60 to 70%. It's still early so I don't know what the rest of the day will bring, also day 2 is normally my worst day after an orgasm so we have to see how that goes. But until now I would describe my experience with Niacin as positive

[b_jim]

I wonder if the flush effect is not to create a release of endorphins to counter a possible drop of endorphins after ejaculation. Eating pepper causes an endorphins rush.

[Nightingale]

Today I don't feel the symptoms as strong as I would without Niacine. It's hard to measure but I would say the symptoms reduced 60 to 70%. It's still early so I don't know what the rest of the day will bring, also day 2 is normally my worst day after an orgasm so we have to see how that goes. But until now I would describe my experience with Niacin as positive

Congrats

[b_jim]

I think hypothalamus may be the center of gravity of Pois.
The fluctuations of hormones and neurotransmitters after ejaculations cause an activity in hypothalamus cells.
Niacin flush might work as a vaccine.

There is a difference between "dry flushing" (eg: nicin flush) and "wet flushing" (eg : menopause).
http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/endocrinology/flushing/Default.htm

It may explains too different cure are possible.

Increase of catecholamines cause hotflashes.
Increase of opioids cause decrease of catecholamines.
Decrease of sexual hormones cause decrease of opioids.


When sexual hormones are low, it cause hot flashes :

http://www.hindawi.com/journals/isrn/2013/240108/
The symptom of hot flashes is among the most common and early described side effects of ADT as it was reported by Huggins and Hodges in 1941 in 9 of the first 21 prostate cancer patients ever to undergo ADT. Hot flashes are caused by inappropriate stimulation of thermoregulatory centers in the hypothalamus, resulting in peripheral vasodilatation [11]. Hot flushes are described by patients as the perception of intense warmth and subsequent cooling, flushing of the skin, perspiration, and chills in the upper part of the body, usually the neck and face. Associated symptoms may include anxiety and palpitations. Hot flashes usually last from a few seconds to several minutes but can persist for up to 20?min.

* Androgen deprivation therapy (ADT)

[Vanker]

 I have been a silent reader for 3 years. I have tried Niacin it prevents my physical symptoms of POIS. But my cognitive functions doesn't improves or sometimes worse.

[Raj]

It's an old thread, but I want to ask a question. I stopped using niacin as it was not giving me flush. But today morning, I took 3 niacin pills (100 mg each), not because I wanted to masturbate. It was lying around and I thought of giving it a try. Maybe it would work that time. And oh my goodness, it actually worked giving me a strong so called "flush"! Man, I was on fire! And, I loved that feeling too. Anyways, I just masturbated after 40-50 mins and haven't got any symptom so far. Hopefully, I will not be getting any until next orgasm. Anyways, my question is - can I masturbate multiple times during that flush period? It's a dull question, I know. But it makes sense for me.. Somehow... Also can anyone explain why I wasn't flushing before? Thanq!

[FloppyBanana]

harder to flush on full stomach

[b_jim]

It seems niacine supplementation might work as a light benzodiazepine, muscle relaxant or might increase Gaba synthesis.