Hi Fernando,
Yes perhaps plasma leaks through walls and causes low blood pressure. The body could compensate for this effect by raising heart rate (POTS?). I wonder if this can lead to hypovolemia which can also be seen in POTS patients. I have the same low muscle mass.
So Ang-1 could inhibit IL-8 production, that is what the first link I have posted states. So my IL-8 is elevated and could make a case for getting this substance. I don't know if there is a medicine containing Ang-1 or indirect releases it in the body. I'm tired at the moment, if someone could look into this matter and search what receptors are at play here and what medicine can simulate the effect of Ang-1 in the first paper then please post it in this thread, It's late I'm going to bed.
Very interesting Nanna,(1) is a genetic autoimmune mechanism for POIS. My test results suggest that I do not have genetic autoimmunity (see "Autoimmunity blood test: (http://poiscenter.com/forums/index.php?topic=2683.msg24039#msg24039)" section). So for me, (1) would not be the cause of my POIS symptoms. My immune system does not attack healthy cells in my body. However, semen is generally high in prostaglandins (prostate-gland-in, in the prostate gland). Also, you might find this article interesting (Seminal plasma components stimulate interleukin-8 and interleukin-10 release (https://www.ncbi.nlm.nih.gov/pubmed/10333355)).
I wonder though what would be the cause of H1-histamine activity in the blood ? According to your theory it could be the dormant virus' activity. But what I suggest is that in a case of a dysfunctional Endothelium, the ejaculation process can cause a diffusion of Semen components through the testicles blood barrier which initiates the immune response. Here, there could be two possible cases: 1) The immune system attacks the Semen component increasing the levels of histamine in the blood causing the dysfunction in the Endothelium.
2) We have a general Endothelial dysfunction that makes these Semen components not only get passed the Testicles Blood Barrier but also get passed the BBB.In my test results, I posted the doctors notes from my MRI angiogram (MRA). The doctor found what he believed to be a small bulge (aneurysm) in a blood vessel in my brain on the left side (see "Brain scan: (http://poiscenter.com/forums/index.php?topic=2683.msg24039#msg24039)" section). In the doctor's notes, he says "There is no evidence for vessel irregularity, stenosis or other aneurysm formation." In other words, the angiogram did not find anything generally wrong with my blood vessels. They only found a blood vessel abnormality in this small location in the left hemisphere of my brain. However, MRAs are not detailed enough to diagnose endothelial dysfunction. And like others here, I also have relatively low blood pressure (110/70). So you could be right about this blood vessel dysfunction. But what would be the cause of Generalized Endothelial Dysfunction?
Although I would like to note that I already tryed different anti-histamines including cetrizine but they didn't do much unfortunately.I'm not trying to suggest endothelial dysfunction is the cause of POIS. I was just suggesting that Zyrtec is a way of testing the theory of endothelial dysfunction. If cetirizine does not work, that may be evidence that the source of the problem is not mast cells opening the BBB. However, it takes a while for an injured or inflamed blood vessel to heal, similar to if you have a skin cut. It could take a week or more of consistent use to heal the injury. There are receptors other than H1 that can release arachidonic acid. So a better test might be using a general phospholipase inhibitor like the corticosteroid you suggested, Dexamethasone.
I know sometimes you refer to the herpes virus theory of POIS as my theory, but many people on this forum have suggested herpes as the cause of POIS even before I became a member. So I don't consider it my theory. Most of what I have been doing recently is summarizing the many ideas surrounding immunity and infection so that it is easy for us see the common points of agreements. Thanks for challenging the ideas and offering new ideas. We all beat POIS together! ;)
This article suggests: "Dexamethasone in doses of 8 to 40 mg per day upregulates angiopoietin 1 to stabilize the blood-brain barrier and downregulates VEGF" . What do you think? I'm not explicitly thrilled at trying a chorticosteriod but maybe worth a try?Thanks for bringing this up Nas. It goes on my things to try list. I have no idea whether it may be worth it, I don't have the medical background to say anything useful about it in general. In my case however it could be of interest if the IL-8 production is of EC origin. At the end of the day it's a matter of experimentation. VEGF is by the way an interesting parameter to test in this context, there could be an overexpression of it. If you are going to use it Nas be careful not to suddenly abort intake schedules, ask your doctor.
I currently believe that the aneurysm in my brain is caused by white blood cell (lymphocyte, neutrophil) chemotaxis.Now to think of it, I had a conversation with Disaster about Sjogren's syndrome and IgG antibodies. He said he had an focus score of 1.0 which is a borderline criteria for lymphocyte infiltration near salivary glands in sjogren's. There could be chemotaxis at work here.
Just to add to this discussion, I would like to point out the role of cartilage/collagen in vascular integrity.Good point. There are also indications of a link between mast cell disorders and cartilage/collagen disorders.
In my own case, I clearly have a defect in collagen/cartilage genetic, as shown by a rib cage birth defect linked to a cartilage malformation.You mean like this: http://pectusexcavatumfix.com/wp-content/uploads/2015/06/My-Flared-Ribs-Case.jpg
Thanks Muon for sharing, I think my autoimmune test (http://poiscenter.com/forums/index.php?topic=2683.msg24039#msg24039) rule out Sjogren's syndrome for me. But I am thinking of getting more blood test. So it has been interesting to read about those immunoglobulins.Quote from: nanna1I currently believe that the aneurysm in my brain is caused by white blood cell (lymphocyte, neutrophil) chemotaxis.Now to think of it, I had a conversation with Disaster about Sjogren's syndrome and IgG antibodies. He said he had an focus score of 1.0 which is a borderline criteria for lymphocyte infiltration near salivary glands in sjogren's. There could be chemotaxis at work here.
http://poiscenter.com/forums/index.php?topic=305.15
Hi Nas, and Nanni,That's interesting Quantum! I heard about UC-II collagen (https://www.amazon.com/s/?ie=UTF8&keywords=uc-ii+collagen&tag=googhydr-20&index=aps&hvadid=153722604928&hvpos=1t2&hvnetw=g&hvrand=5264449278886249167&hvpone=&hvptwo=&hvqmt=e&hvdev=c&hvdvcmdl=&hvlocint=&hvlocphy=9027891&hvtargid=kwd-3146389657&ref=pd_sl_4jb3kzhtej_e) and I was thinking of trying it for my bad knees. Also, I used to have arthritis in graduate school. I think B vitamins and vitamin D3 fixed the arthritis. Not sure if that has anything to do with collagen defects.
Just to add to this discussion, I would like to point out the role of cartilage/collagen in vascular integrity. When there is a genetic problem with collagen quality/collagen metabolism in the body, veins are one of the structures that can be affected, because a blood vessel need a good and elastic wall in order to undergo dilatation, and than be able to contract back. Varicose veins, as you may know, are veins in which the venous wall has been chronically enlarged and twisted, their wall have lost elasticity, and they do not go back to original size, leading to many physiological problems ( https://en.wikipedia.org/wiki/Varicose_veins). However, I do not know if varicose veins can worsen endothelial dysfunction, but I figure out that it would. The endothelium is lining the interior of the venous wall, so if the later is dilated, it automatically stretches the endothelium. I suppose that stretching the endothelium can have a worsening effect on permeability problems.
Quote from: QuantumJust to add to this discussion, I would like to point out the role of cartilage/collagen in vascular integrity.Good point. There are also indications of a link between mast cell disorders and cartilage/collagen disorders.Quote from: QuantumIn my own case, I clearly have a defect in collagen/cartilage genetic, as shown by a rib cage birth defect linked to a cartilage malformation.You mean like this: http://pectusexcavatumfix.com/wp-content/uploads/2015/06/My-Flared-Ribs-Case.jpg
My brother has this malformation, do you have something similar like this?
Hey guys,
So after about 5 days of trying 1mg dexamethason, I'm terminating this method.
So here is my conclusion:
1- The medication really accelerates your recovery from POIS, I was more social, clear headed, motivated and focused in three days of dexamethason after orgasm than an entire week of normal POIS recovery.
2- Unfortunately, Dexamethason comes with side effects, which unfortunately bit my ass on the fifth day. As someone who deals with pure OCD and depression as a POIS symptom, at first dexamethason seemed great for those two until yesterday I was watching a video on YouTube, then suddenly I started experiencing soul crushing pure OCD thoughts that put me in a state of panic and anxiety; I couldn't even sleep that day and until right now I'm feeling some of the effects of OCD. So definitely I do not recommend Dexamethason if you suffer from psychological issues.
Yet I also would like to remind everybody, that for someone who tried so many of the treatments that have been tested on this forum and got a 30% improvement max. This was still a great experience. Dexamethason definitely works for me but It's not a safe method of treatment at all.
When it comes to the theory of Endothelial dysfunction this is still not a proof that Dexamethason healed my Endothelium, because there is an equal chance that Dexamethason healed my brain inflammation that I suffer from. I never usually find success with NSAID's nor with Histamine blockers though so I'm not sure about that.
Thus, to properly test weather the vascular permeability factor is the driving reason for POIS symptoms I need to use much safer methods and treatments for Endothelial Dysfunction. There are many methods that I found articles about, but most of them focus on Endothelial function when it comes to elevated blood pressure related illnesses. Hence the blood pressure lowering treatment methods suggested by many articles. So I wonder is it a good idea to try ACE inhibitors or Beta blockers even though POIS causes us lower blood pressure? Looking forward for your suggestions.
Hi guys,
So I stumbled upon an online article about repairing a leaky Blood Brain Barrier:https://www.optimallivingdynamics.com/blog/how-to-repair-a-leaky-blood-brain-barrier-ways-heal-fix-supplements-mental-health-neuroinflammation-treatments-causes-gaba-injury-hyperpermeability (https://www.optimallivingdynamics.com/blog/how-to-repair-a-leaky-blood-brain-barrier-ways-heal-fix-supplements-mental-health-neuroinflammation-treatments-causes-gaba-injury-hyperpermeability)
What's interesting is that this article suggests ?in his book Why Isn?t My Brain Working, Dr. Datis Kharrazian explains that the blood-brain barrier can break down and become ?leaky?. This allows harmful substances to enter your brain, contributing to brain inflammation, which has been shown to cause cognitive problems and mental illness"
And many of the treatment methods have been discussed in this forum such as: Omega-3, gluten free diet, healing the gut, B-vitamines, Curcumin, Vitamin D-3, etc.
If pois related to an endothelial dysfunction this could be an easy test. It has Glisodin, SOD molecules protected through GI degradation and other compounds for endothelium regulation?
http://www.lifeextension.com/Vitamins-Supplements/item01997/Endothelial-Defense-with-Full-Spectrum-Pomegranate-and-Cordiart
Perhaps we should map all the layers of tissue making up the 'walls' within the entire Genitourinary system first. Like what is the order of layers or cells within walls of the https://en.wikipedia.org/wiki/Seminal_vesicle or https://en.wikipedia.org/wiki/Urethra . I still don't have a clear picture in front of me.
If you categorize and divide the Genitourinary system into two parts, organs where organic material is being stored/produced and transport tubes. I think POIS reactions take place on the inside of transport tubes. I do get symptoms when pre-ejaculate is dripping out so that's why I suspect tissue which transport fluids.
Now if you compare storage tissue with transport tissue you may find differences in their structure and this will eliminate layers which are the same for both. You may focus on what they do not have in common.
I do get reactions from food as well upon contact with the oral cavity. I suspect there is something wrong with mucous membranes in general.
Also does this supplement support a leaky Endothelium? Because many products can actually increase permeability for cases of hypertension for example.If pois related to an endothelial dysfunction this could be an easy test. It has Glisodin, SOD molecules protected through GI degradation and other compounds for endothelium regulation?
http://www.lifeextension.com/Vitamins-Supplements/item01997/Endothelial-Defense-with-Full-Spectrum-Pomegranate-and-Cordiart
Hmmm, I wonder if that Endothelial protection would be useful at all in our case, maybe should order it and see what.
But pre-ejaculate comes free before ejaculation/orgasm and it also lacks sperm. Some men produce pre-ejaculate with sperm but the presence of sperm in this fluid is very low. Symptoms only seem to arise when fluids are moving around (transported). Anyway, everyone has a theory but where do we go from here?The point that I am trying to make is how to pinpoint the Enndothlial leak that causes the immune system to attack. I do not think that it is in the BTB rather in the transport tube, possibly the utethra.
I wish I had expertise when it comes to this matter, I think with the help of a sexologist we can test for the place of the leak, or let's say the place where the immune system becomes active.Yes that's the issue for this forum, the complete absence of any specialist that will join the discussion and share their expertise.
https://en.wikipedia.org/wiki/Endothelial_dysfunction#Nitric_oxideHmmmm, can't believe all I had to do is look into a Wikipedia page haha.
Testing diagnosis etc.
https://en.wikipedia.org/wiki/Endothelial_dysfunction#Nitric_oxideThank you Dr. POIS!
But pre-ejaculate comes free before ejaculation/orgasm and it also lacks sperm. Some men produce pre-ejaculate with sperm but the presence of sperm in this fluid is very low. Symptoms only seem to arise when fluids are moving around (transported). Anyway, everyone has a theory but where do we go from here?The point that I am trying to make is how to pinpoint the Enndothlial leak that causes the immune system to attack. I do not think that it is in the BTB rather in the transport tube, possibly the utethra.
For me it seems that sperms are the most logical component in the semen as a suspect for being attacked by the immune system.
The way to move forward is to do tests and possible treatments for this problem.
I wish I had expertise when it comes to this matter, I think with the help of a sexologist we can test for the place of the leak, or let's say the place where the immune system becomes active.
I get POIS only on ejaculation and have absolute 0 POIS on pre-ejaculate fluid. I read that pre-ejaculate fluid composition is similar to the ejaculation composition EXCEPT the following:
1. pre-ejaculate has absence of: Gamma-glutamyltransferase
2. is highly alkaline to neutralize acidic environment of urethra (to protect the passage of live sperm later)
3. for some males, it can include dead sperm.
The ejaculation fluid, is comprised of following properties:
Property Per 100mL In average volume (3.4 mL)
Calcium (mg) 27.6 0.938
Chloride (mg) 142 4.83
Citrate (mg) 528 18.0
Fructose (mg) 272 9.25
Glucose (mg) 102 3.47
Lactic acid (mg) 62 2.11
Magnesium (mg) 11 0.374
Potassium (mg) 109 3.71
Protein (g) 5.04 0.171
Sodium (mg) 300 10.2
Urea (mg) 45 1.53
Zinc (mg) 16.5 0.561
Buffering capacity (β) 25
Osmolarity (mOsm) 354
pH 7.7
Viscosity (cP) 3?7
Volume (mL) 3.4
Ref: Wikipedia, search 'semen'
This brings to: what is Gamma-glutamyltransferase (GGT)
GGT is present in the cell membranes of many tissues, including the kidneys, bile duct, pancreas, gallbladder, spleen, heart, brain, and seminal vesicles.[7] It is involved in the transfer of amino acids across the cellular membrane[8] and leukotriene metabolism.[9] It is also involved in glutathione metabolism by transferring the glutamyl moiety to a variety of acceptor molecules including water, certain L-amino acids, and peptides, leaving the cysteine product to preserve intracellular homeostasis of oxidative stress.
GGT is predominantly used as a diagnostic marker for liver disease. Latent elevations in GGT are typically seen in patients with chronic viral hepatitis infections often taking 12 months or more to present.
Ref: Wikipedia, search 'Gamma-glutamyltransferase'
Could possibly GGT be the culprit?But pre-ejaculate comes free before ejaculation/orgasm and it also lacks sperm. Some men produce pre-ejaculate with sperm but the presence of sperm in this fluid is very low. Symptoms only seem to arise when fluids are moving around (transported). Anyway, everyone has a theory but where do we go from here?The point that I am trying to make is how to pinpoint the Enndothlial leak that causes the immune system to attack. I do not think that it is in the BTB rather in the transport tube, possibly the utethra.
For me it seems that sperms are the most logical component in the semen as a suspect for being attacked by the immune system.
The way to move forward is to do tests and possible treatments for this problem.
I wish I had expertise when it comes to this matter, I think with the help of a sexologist we can test for the place of the leak, or let's say the place where the immune system becomes active.
My GGT blood test is normal, well below the level = 16.
But I have endothelial dysfunction. Whenever I take a weak stroke I already have a huge purple spot (black bruise) and I have a vascular problem. I already had 2 surgeries to remove varicose veins and I have low blood pressure, always 10/6.
I think my microcirculation is problematic. I have astigmatism and myopia, muscular tension, and in the cerebral part I have problems to easily forget things.
In my case what improves a lot is the physical activity, mainly running and swimming.
NASFernando it's not about anti-inflammatory or analgesics. It's the vasoconstrictor property of this stack; by constricting vascular walls we can increase integrity and thus reduce vascular wall's permeability.
Propranolol as a daily medicine may be a good option.
But I do not agree with the idea of ??taking analgesics or anti-inflammatories every time it's going to have an orgasm. Relieves the symptom but does not address the cause of the problem.
Hi guys,
So I previously mentioned in this thread that Vasoconstrictor drugs could possibly decrease Endothelial permeability by increasing vascular walls' integrity.
So I did by the suggestion of Nanna on his thread: http://poiscenter.com/forums/index.php?topic=2502.msg24507#msg24507
Where he mentioned:
"Taken 45 minutes prior to sexual activity (prepack):
Vasoconstrictors:
---Excedrin (acetaminophen 250mg, aspirin 250mg, caffeine 65mg)"
"The below supplements were not taken in the above trial, but can be stacked. However, consult your doctor before stacking multiple vasoconstricting agents as they can increase the risk of heart attack or stroke.
Enhancements:
---Trimethylglycine/TMG (methyl-donor) (2g)
---Indomethacin (COX inhibitor/antioxidant) (75mg)
---propranolol (beta2-blocker, blocks PGE2 induced vasodilation) (see personal doctor for details)"
So I did try a vasoconstrictor based on his suggestion yesterday, and after consulting a doctor, he suggested taking: Propanolol 10mg, Indomethacin 25mg, Paracetamol 250mg and Aspirin 100mg, all before orgasm.
The results were positive, I noticed a clear reduction in many of the Cognitive POIS symptoms I usually suffered from; there were still some symptoms that I felt, like social anxiety, brain fog and fatigue. But overall dare I say that I had about 80% success rate?. I even masturbated two more times after the first session, after about an hour, and I still was able to talk to people after that! That's an insane result for some one who suffers from POIS.
So this trial and the Dexamethasone trial both gave good results, so I can not dismiss the effect these medications had on the Enndothlium and thus I can not disprove the role of the Endothelium and Epithelium on POIS.
I highly advise you people to try one of these suggested treatments after consulting a doctor to prove a consistency in results. And perhaps be able to look more accurately for suitable tests and predict more accurate theories for the future.
Ok so I have tried a second round of Vasoconstrictor stack with an increase in some of the doses; I've taken 50mg Indomthacin, 20mg propanolol, 100mg Aspirin and 250 paracetamol, waited 45 minutes as usual and had an O. The result was different, in that while I believe there was a reduction, I'd say about 40%, I still suffered from usual symptoms like brain fog and speech issues. There were less fatigue and pain in the urethra and the genitals region and slightly clearer mind. Still, I was still annoyed from POIS symptoms so I decided to take another 25mg Indomethacin pill to see if it can clear my head a bit more, and it did, but at the same time it caused a huge decrease in blood pressure. I tested it and it was about 116/61 with a 55 heart beat rate, I took it on an empty stomach which is probably why there was a huge decrease in blood pressure. I stabilized my self later after breakfast and drinking salt water.
Overall I'd say that it still caused me POIS, with decreased symptoms.
Do you have tension in the jaw (clenching/bruxism)? I'm getting some good results in the speech/articulation department by simply keeping my jaw relaxed during the day. (I say "simply", but it's not that simple actually, and really requires and effort. But for me the effect is remarkable.)No, and probably it's not that simple in my case lol.
Do you have tension in the jaw (clenching/bruxism)? I'm getting some good results in the speech/articulation department by simply keeping my jaw relaxed during the day. (I say "simply", but it's not that simple actually, and really requires and effort. But for me the effect is remarkable.)
Ok so I have tried a second round of Vasoconstrictor stack with an increase in some of the doses; I've taken 50mg Indomthacin, 20mg propanolol, 100mg Aspirin and 250 paracetamol, waited 45 minutes as usual and had an O. The result was different, in that while I believe there was a reduction, I'd say about 40%, I still suffered from usual symptoms like brain fog and speech issues. There were less fatigue and pain in the urethra and the genitals region and slightly clearer mind. Still, I was still annoyed from POIS symptoms so I decided to take another 25mg Indomethacin pill to see if it can clear my head a bit more, and it did, but at the same time it caused a huge decrease in blood pressure. I tested it and it was about 116/61 with a 55 heart beat rate, I took it on an empty stomach which is probably why there was a huge decrease in blood pressure. I stabilized my self later after breakfast and drinking salt water.
Overall I'd say that it still caused me POIS, with decreased symptoms.
Ok so I have tried a second round of Vasoconstrictor stack with an increase in some of the doses; I've taken 50mg Indomthacin, 20mg propanolol, 100mg Aspirin and 250 paracetamol, waited 45 minutes as usual and had an O. The result was different, in that while I believe there was a reduction, I'd say about 40%, I still suffered from usual symptoms like brain fog and speech issues. There were less fatigue and pain in the urethra and the genitals region and slightly clearer mind. Still, I was still annoyed from POIS symptoms so I decided to take another 25mg Indomethacin pill to see if it can clear my head a bit more, and it did, but at the same time it caused a huge decrease in blood pressure. I tested it and it was about 116/61 with a 55 heart beat rate, I took it on an empty stomach which is probably why there was a huge decrease in blood pressure. I stabilized my self later after breakfast and drinking salt water.
Overall I'd say that it still caused me POIS, with decreased symptoms.
Hi Nas,
20mg of propranolol is a high a dose for someone who has a normal blood pressure and normal heart rate to begin with, and therefore, hypotension and bradychardia are quite possible outcome to watch for. Two of the main effects of propranolol is that it lowers blood pressure, and, it slows down the heart rate ( it his an antihypertensive drug, as well as a beta-blocker, which all slow down the heart rhythm in a very significant way).
With prescription drugs, more is not necessarily better. The usual aim is to find the lower efficient dosage.
Hi Nas,Ok so I have tried a second round of Vasoconstrictor stack with an increase in some of the doses; I've taken 50mg Indomthacin, 20mg propanolol, 100mg Aspirin and 250 paracetamol, waited 45 minutes as usual and had an O. The result was different, in that while I believe there was a reduction, I'd say about 40%, I still suffered from usual symptoms like brain fog and speech issues. There were less fatigue and pain in the urethra and the genitals region and slightly clearer mind. Still, I was still annoyed from POIS symptoms so I decided to take another 25mg Indomethacin pill to see if it can clear my head a bit more, and it did, but at the same time it caused a huge decrease in blood pressure. I tested it and it was about 116/61 with a 55 heart beat rate, I took it on an empty stomach which is probably why there was a huge decrease in blood pressure. I stabilized my self later after breakfast and drinking salt water.
Overall I'd say that it still caused me POIS, with decreased symptoms.
I will try to give a more accurate prescription of symptoms using Muon's symptoms from his Muon's case post: http://poiscenter.com/forums/index.php?topic=2545.msg24545#msg24545
1= positive result ( had relief )
0= negative result ( did not have relief )
%= about 50% decrease
X= Do not suffer from this symptom
- Extreme fatigue = 1
- Muscle ache = 1
- Joint pain = X
- Exercise/motion intolerance = %
- Heavy body = 1
- Feeling cold/warm, feeling cold happens far more often than warm = 1
- Decreased endurance, especially with the duration of standing and sitting straight = 1
- Sensitive teeth = X
- Stinging pain at liver area = X
- Yellowing of facial skin = X
- Pale skin and facial skin becomes like a babyskin = X
- Decreased vocabulary = 0
- Articulation problems = %
- Poor concentration = %
- Grammar problems (constructing sentences suddenly becomes a puzzle) = 1
- Short term memory loss (temporary) = %
- Motivation in general is being lowered and often completely wiped out = %
- I become someone without personality = %
- Accelerated Bowel movement, loose stools and sometimes diarrhea = X
- It amplifies my food intolerance/sensitivity = X
- Decreased digestion = X
- A sense of being full (digestion) = X
- Fasciculations = X
- Itching = X
- Soar Throat = X
- Decreased accuracy of handwriting ,also problems with controlling videogames like aiming in FPS = 1
- Faster spreading of local fungal skin infection at feet in POIS = X
So there are two points that are interesting here:
1- It seems that I do not suffer from Physical symptoms, or let's say that they are not really that extreme, possible explanation? Perhaps endothelial leaks vary from person to person?
2- I still suffer from cognitive symptoms, which can mean that this treatment is not enough to reduce Endothelial permeability enough so that an inflammatory response doesn't happen in the brain. Any suggestions for better cognitive relief? Also what do you guys think of all of this?
I have no idea, haven't looked into it though. Try to google it. But the first step should be to check if HPV plays a role. Someone should explore this option to rule out HPV involvement.
Brilliant. But why the delay ? I feel 50% muscular energy loss on day 2, not just after orgasm. Is choline loss with semen causing Ach defiency 24h later ?I don't know man, this illness is so confusing and nothing works for me and I just keep theorizing but reaching nothing, I so feel done with this crap.
I don't know man, this illness is so confusing and nothing works for me and I just keep theorizing but reaching nothing, I so feel done with this crap.
QuoteI don't know man, this illness is so confusing and nothing works for me and I just keep theorizing but reaching nothing, I so feel done with this crap.
I've been theorizing about my own situation, and perhaps there is a connection with (sex/porn) addiction, where the urge is delayed until day 2, because that's sort of when libido fully restores. The urge may cause the muscle problems. (?)
Not sure how that would be explained in terms of biochemistry though.
Brilliant. But why the delay ? I feel 50% muscular energy loss on day 2, not just after orgasm. Is choline loss with semen causing Ach defiency 24h later ?
My problems also show at right about the 24th hour. Its creepy why the heck symptoms dont begin right away. My 7th day will be tomorrow I am already celebrating for tomorrow to come. So much relief is on the way.Brilliant. But why the delay ? I feel 50% muscular energy loss on day 2, not just after orgasm. Is choline loss with semen causing Ach defiency 24h later ?
I have a small cyst near my testicles. My theory was that after ejaculation a small amount of semen stays there and that’s the cause of my UTI or/and my POIS. But my urologist doesn’t think so. He said the cyst is small.
Low Testosterone Level Is an Independent Determinant of Endothelial Dysfunction in Men (https://www.nature.com/articles/hr2007144)Could NO dysfunction = weak pelvic muscles, thus = PE ?
''In conclusion, a low plasma testosterone level was associated with endothelial dysfunction in men independent of other risk factors, suggesting a protective effect of endogenous testosterone on the endothelium.''
Since we have a bunch of members with low testosterone, there is a chance they could have an endothelial dysfunction as well.
People using TRT could be modulating their endothelial function. If this is the case and POIS symptoms improve then could POIS be related to an endothelial dysfunction? More food for thought.
Could NO dysfunction = weak pelvic muscles, thus = PE ?NO dysfunction could be responsible for hyperexcitatory disturbances of ejaculation (premature ejaculation). Here is a paper my POIS doctor gave me a long time ago: https://www.ncbi.nlm.nih.gov/pubmed/12597985 These kind of drugs may have an effect on PE.
Nitric-oxide donating drugs could be a good way of testing the role of NO on POIS. My deduction of its role, is probably related to our PE problems, the question is whether it is a fundamental issue in POIS, or just another symptom of the hyperactive immune-response in POIS.Could NO dysfunction = weak pelvic muscles, thus = PE ?NO dysfunction could be responsible for hyperexcitatory disturbances of ejaculation (premature ejaculation). Here is a paper my POIS doctor gave me a long time ago: https://www.ncbi.nlm.nih.gov/pubmed/12597985 These kind of drugs may have an effect on PE.
Endothelial dysfunction could indicate problems relating to NO/acetylcholine cycles. We need FMD testing and if these are positive then this could be an indication to look further into NO and/or acetylcholine.
The question is why some POIS-patients have PE and others do not. I can last for hours. One time more than 4 hours. And is PE connected to POIS? We think so because the majority of the POIS-patients in the first Waldinger-paper have PE. When I came to this forum and before on the Naked Scientist Forum I discovered there are a lot of other men who do not have PE. The same for prostate/bladder problems. I have that problem. So I thought it was connected with POIS. But a lot of members here do not have those problems.Nitric-oxide donating drugs could be a good way of testing the role of NO on POIS. My deduction of its role, is probably related to our PE problems, the question is whether it is a fundamental issue in POIS, or just another symptom of the hyperactive immune-response in POIS.Could NO dysfunction = weak pelvic muscles, thus = PE ?NO dysfunction could be responsible for hyperexcitatory disturbances of ejaculation (premature ejaculation). Here is a paper my POIS doctor gave me a long time ago: https://www.ncbi.nlm.nih.gov/pubmed/12597985 These kind of drugs may have an effect on PE.
Endothelial dysfunction could indicate problems relating to NO/acetylcholine cycles. We need FMD testing and if these are positive then this could be an indication to look further into NO and/or acetylcholine.
Guys, the bottom line is; We will need testing/research, these will give us answers. Without research, we will continue to speculate in circles for years here on this forum.I'm getting NO supplements soon, that'll be my part.
I have read something about it that it's not known whether taking them in supplement form can also have an impact on NO synthesis. The drugs stated in the paper are different than the 'NO' supplements which you can buy in store.Guys, the bottom line is; We will need testing/research, these will give us answers. Without research, we will continue to speculate in circles for years here on this forum.I'm getting NO supplements soon, that'll be my part.
Nebivolol: The Somewhat-Different β-Adrenergic Receptor Blocker (https://www.sciencedirect.com/science/article/pii/S0735109709024310?via%3Dihub)Again, I'm not really sure about this, wouldn't lowering the blood pressure be bad for POTS? If not it would also be bad for inflammation? Since more vasodilation means more penetration?
Comparison of Beta blockers on endothelial function (https://www.sciencedirect.com/science/article/pii/S0735109709024310?via%3Dihub#tbl2)
''In conclusion, nebivolol has beneficial effects on endothelial function mainly by increasing NO bioavailability.''
Nebivolol and Endothelial Dysfunction in Patients With Essential Hypertension: A Reputation Saver of β‐Blockers? (https://onlinelibrary.wiley.com/doi/full/10.1111/jch.12856)
Again, I'm not really sure about this, wouldn't lowering the blood pressure be bad for POTS? If not it would also be bad for inflammation? Since more vasodilation means more penetration?
Good point, I might give it a try.Again, I'm not really sure about this, wouldn't lowering the blood pressure be bad for POTS? If not it would also be bad for inflammation? Since more vasodilation means more penetration?
Nebivolol has beneficial effects on endothelial function so I will place this here. There are always side effects involved with medicine. The point is whether these benefits are outweighing the negative side effects. This might be useful for people who want to increase NO bioavailability as well.
I am still annoyed that this has not been tested on me. NO defects can play a role in POTS and premature ejaculation. I got both but this has never been tested. Endothelial dysfunction can be an indication for NO related issues. Nothing is being done.Can't you do tests your self?
Can't find any labs that offer these kind of FMD tests.I am still annoyed that this has not been tested on me. NO defects can play a role in POTS and premature ejaculation. I got both but this has never been tested. Endothelial dysfunction can be an indication for NO related issues. Nothing is being done.Can't you do tests your self?
Nebivolol: The Somewhat-Different ?-Adrenergic Receptor Blocker (https://www.sciencedirect.com/science/article/pii/S0735109709024310?via%3Dihub)
Comparison of Beta blockers on endothelial function (https://www.sciencedirect.com/science/article/pii/S0735109709024310?via%3Dihub#tbl2)
''In conclusion, nebivolol has beneficial effects on endothelial function mainly by increasing NO bioavailability.''
Nebivolol and Endothelial Dysfunction in Patients With Essential Hypertension: A Reputation Saver of ??Blockers? (https://onlinelibrary.wiley.com/doi/full/10.1111/jch.12856)