Last night I had an normal ejaculation with NO POIS symptoms. I reduced manganese intake, thank Gbolduev for letting me know it increased Ach, I used to ignore that, and I used androstenedione (testosterone precursor) in the morning and glutamic acid supplementation (for GABA). I think magnesium also plays a role, I have so much energy after adding it I now suffer from insomnia, plus modifying the supplementation for anti Ach ratios. The problem is I still consume 7.5mg of manganese a day because it is included on multivitamin, but I take 75mg of zinc with the manganese. I think testosterone effect on depressing immune system (reducing natural killers and cytokines like TNFa wich studies show disregulation of TNF disrupts adrenals) not only reduces inflammation, but it aids/ optimizes cortisol production. I still had so much energy after ejaculation I slept poorly. Maybe I am finally producing decent amounts of cortisol, that happen to keep me awake and cause my insomnia possibly. Low Testosterone and reduced cortisol production are a huge factor in disregulated inflammation in POIS