Glutamate

[Nightingale]

A major trend in psychiatric medicine, and other areas of medicine is the importance or glutamate in proper mental and physical function.  I felt we should start a topic on this so we can categorize our findings on this neurotransmitter.

To start things off: http://www.ncbi.nlm.nih.gov/pubmed/21827775

"Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders."

"A wealth of data from animal models have shown that different types of environmental stress enhance glutamate release/transmission in limbic/cortical areas and exert powerful structural effects, inducing dendritic remodeling, reduction of synapses and possibly volumetric reductions resembling those observed in depressed patients. Because a vast majority of neurons and synapses in these areas and circuits use glutamate as neurotransmitter, it would be limiting to maintain that glutamate is in some way 'involved' in mood/anxiety disorders; rather it should be recognized that the glutamatergic system is a primary mediator of psychiatric pathology and, potentially, also a final common pathway for the therapeutic action of antidepressant agents."

Also, I was caught by the line regarding a potential "malfunction in the mechanisms regulating clearance and metabolism of glutamate" as a contributor to dysfunction.  Given our successes in supplementation, what can we do to ensure a healthy glutamatergic system?

Supplements I've seen so far include glutamine (precursor of glutamate), tryptophan and 5-htp (b6)

I don't totally understand the glutamine/glutamate metabolism or breakdown, but perhaps it's worth looking into.

Again, I think this is worth having it's own thread, so I made it

[b_jim]

There is a new study very very interesting 
https://www.cell.com/cell/abstract/S0092-8674(18)30520-8

1 Ketogenic diet blocks seizure
2 The effects is caused by increased GABA and decreased GLUTAMATE
3 It only works if gut microbiota is good

Considering :
My Pois has muscle tremors as main symptom
Low carb diet reduces symptoms
Taurine (=Gaba like amino acid) reduces my symptoms
I have gut activity inPOIS especially diarheas if i take sugar,

I suspect my gut microbiota to be very bad

[Hopeoneday]

Intresting B, yes gut, is is proven on this forum that some people hawe ralefe from pois whith diet and from repaing guts.
I think that i hawe sibo , constant bloating whotewer i eat .
I went to my gastro to test, he didnt want to ewan look at me, he sez- goo
outside fond some girls , dont yocking with me, what "sibo"
The only medicine who helps me to survive is benzos-gaba.

[notmythirdaccount]

There is a new study very very interesting 
https://www.cell.com/cell/abstract/S0092-8674(18)30520-8

1 Ketogenic diet blocks seizure
2 The effects is caused by increased GABA and decreased GLUTAMATE
3 It only works if gut microbiota is good

Considering :
My Pois has muscle tremors as main symptom
Low carb diet reduces symptoms
Taurine (=Gaba like amino acid) reduces my symptoms
I have gut activity inPOIS especially diarheas if i take sugar,

I suspect my gut microbiota to be very bad

Hey, b_jim,

It's interesting you point out muscle tremors and bowel issues as I also have these symptoms (essential tremor., I've also suspected Acetylcholine overload), but it's way worse during pois. My bowels are also screwed after an O for at least 1 day during recovery.

I've recently found success with NAC (N-Acetyl-Cysteine), which is known to reduce Glutamate and is a pre-cursor to Glutathione and Gaba, if I recall.

NAC seems to significantly reduce my tremors and practically all of my mental pois symptoms, and I have smoother bowels after dosing. I take roughly 1200mg daily.

As I posted in a recent response, I can replicate my improvements with taking NAC. I suspect that excess Glutamate is to blame in our case.

If you're up to it, I think you should give it a shot and see if it helps you. I plan on working up to 1g doses here soon, and incorporate more flods that contain NAC.

[b_jim]

Next time i take a bottle of NAC with my bottle of taurine.
Glutamate rich food seems not to increase my pois symptoms anyway.