I can masturbate relatively symptom free, especially when I am not aroused, but whenever some lubricating fluid or precum comes out I can see a sudden deterioration of symptoms like a sudden onset of bloodshot eyes. Sexual desire and arousal greatly increases the incidence of precum even without masturbation and this was a frequent problem when I was younger. I can mostly rebound from these effects to baseline within a day. Of course if ejaculation also happens then comes the avalanche with it. Nevertheless it is interesting that recently I had success with some compounds that are regarded as constituents of the seminal plasma. This may mean that supplementing these compounds could be actually useful.
Earlier I was a bit conflicted about zinc, but I tested two products (zinc citrate and zinc picolinate) in a greater dose (50-60 mg) and I found them to have a significant benefit. I am less sure about citric acid, but magnesium citrate was the only magnesium form that showed a noticeable benefit so far. I took L-Dopa regularly a few months ago and it had a generally positive effect with some anti-depression as well. It is hard to say what the exact truth about norepinephrine, but I certainly saw great improvement on yohimbine/rauwolscine and naphazoline and had some with venlafaxine as well in the past. However bupropion hadn’t done anything in four months, so I stopped taking it a few days ago. A low dose of spermidine doesn’t seem to do anything even if taken for a longer time (3 months), but a higher dose gives some noticeable improvement the same day.
I can share some experience regarding amino acids as well, which is the original topic.
I took a full box of L-serine, but I could not see any particular improvement. Phosphatidylserine was quite beneficial, but its efficacy dropped after a few days. I could not see any particular benefit of L-threonine either, even after a whole box. D,L-Phenylalanine produced a little anti-depressive effect in the beginning, but with continuous taking this was lost. After that box was over I switched to L-Phenylalanine powder that I have been taking for months now without seeing any particular improvement. I am almost over a big bag of L-lysine powder as well, that I have been taking for several months now without any striking benefit either. L-arginine surely gives me erections, but it also induces some heart ache. Otherwise it only helps minimally with POIS. L-citrulline noticeably reduced the POIS inflammation in the beginning, however after a few days it didn’t do much anymore. I took a box of Aspartic acid (DAA) which seemed to help a little in the beginning, but nothing noticeable later. I took a bag of essential amino acids (EAA) powder over months without seeing much benefit. L-methionine seemed to help noticeably on the first try, but not so much afterwards. As methionine may accelerate aging I am not too much in its favor, though it may help SAM-e production. L-Valine seemed to provide some benefit when first taken, but not afterwards even though I took a whole bag of it. L-theanine wasn’t of much use in a smaller dose, but a larger dose was surely useful. Unfortunately by continuous usage the shine was lost. L-tryptophan was also evidently useful, however it also induced POIS in some ways. At least sexual endurance was greatly improved, which may help avoid ejaculation. A smaller dose hardly produced any anti-depressive effect, while a larger dose did. However the side-effects (e.g. intensification of the burning pain) occurred even at a low dose when it was taken continuously and thus the harm-benefit ratio is not so much in its favor unless there are no alternative choices. I haven’t tested L-glutamine much, but it may help a little with gut issues, though L-citrulline was better short term. Taurine seems to often induce bloodshot eyes and on gut issues it seems to have a mixed effect, which does not make this my favorite choice. L-Tyrosine did not help with depression. At first I thought that it may induce bloodshot eyes, but it is probably not the case. When continuously taken it may possibly cause some urinary tract irritation, though I still have to confirm this. I haven’t tested L-ornithine much, but it seems to help a little, while also causing some side-effects. L-Glycine appears to be beneficial especially if I haven’t taken it for a while, but continuous taking kills the benefit. NAC helps a little generally, but its effect also vanes over time and an increased dose may lead to some bad side-effect, though I still need to confirm this as I have mostly taken a lower dose, but at least I did so for quite a few months by now. I took beta-alanine regularly a few years ago. It did not help much with POIS, but I was also working quite a lot at that time and I was quite fit as I recall, so retrospectively it may have helped building my physique. As a side-effect it caused a bad itchiness at the peak of its effect, but it was only an inconvenience. I haven’t tested L-histidine much, but on the days I took it my POIS seemed a bit worse, though this may have been only a coincidence and I need to test it more. At least in combination with beta-alanine histidine is a precursor of carnosine, which helped me a lot, so I plan take the two together to see if they are useful in that way.
Some seminal fluid components that seem to be beneficial:
The prostate, an accessory male reproductive organ comprising 70% glandular tissue and 30% fibromuscular tissue, secretes prostatic fluid, which plays a role in optimising conditions for sperm motility and viability. It accounts for 15%–30% of semen, including zinc, citric acid and enzymes such as prostate-specific antigen.https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Commonality+and+heterogeneity+of+pacemaker+mechanisms+in+the+male+reproductive+organs&btnG=The old link is dead. Use this instead:
https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1439-0272.2001.00461.x
High concentration of catecholamines is present in sperm :
http://www.blackwell-synergy.com/doi/abs/10.1046/j.1439-0272.2001.00461.x
"In conclusion, noradrenaline and DOPA are present in human semen at concentrations that are much higher than maximal normal values in plasma."
Noradrenaline : 19 times more than concentration in plasma
Dopa : 2 times
Lactoferrin is one of the components of the immune system of the body; it has antimicrobial activity (bacteriocide, fungicide) and is part of the innate defense, mainly at mucoses. It is constantly produced and released into saliva, tears, as well as seminal and vaginal fluid.
https://en.wikipedia.org/wiki/Lactoferrin
