Author Topic: How to increase testosterone naturally  (Read 7903 times)


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Re: How to increase testosterone naturally
« Reply #20 on: March 23, 2023, 03:18:08 AM »
Shilajit / Mumijo sounds very interesting.

Anyone want to try? ;-) Progecitor?

Link to studies:

Yeah, I heard about it, but I wasn’t that interested. After checking some facts, it appears more interesting though. However I practically swore to myself not to buy any more new supplements as I have too many as it is and I just want to get over them before attempting to cure myself.

RemarkableNeck had no luck with Shilajit, but it is true that he also did not improve on maca or tribulus either, so only some of us may benefit from testosterone boosters.

Some other mechanisms of its action also need to be mentioned:

Following subacute (5days) treatment, there was decrease in 5-hydroxytryptamine and 5-hydroxyindole acetic acid concentrations and an increase in the levels of dopamine, homovanillic acid and 3.4-dihydroxyphenyl-acetic acid concentrations, with insignificant effects on noradrenaline and 3-methoxy-4- hydroxyphenylethylene glycol levels. The observed neurochemical effects induced by Shilajit, indicating a decrease in rat brain 5-hydroxytryptamine turnover, associated with an increase in dopaminergic activity, helps to explain the observed nootropic and anxiolytic effects of the drug.
Shilajit, apart from being used in diverse clinical conditions in Ayurveda, has been proposed to arrest aging and induce rejuvenation, and to improve memory.
It has now been shown to contain significant quantities of organic compounds, including the bioactive oxygenated dibenzo-alpha-pyrones, tirucallane triterpenes, phenolic lipids and small tannoids.

I have recently managed to test Shilajit, but I could only afford a one day trial. I had a positive initial reaction, but only gut issues appeared noticeably better in this time frame. This may not mean much as most benefits should show up after at least 5-7 days of usage.

Nevertheless I found some additional research that could justify some long-term benefit. There are two other bioactive compounds in Shilajit that should be mentioned. These are fulvic/humic acid and urolithin.

1. Fulvic/humic acid

Another bioactive compound is the Indian Shilajit, commonly used on traditional indian ayurvedic medicine. This plant, found at high altitudes, among its main components have fulvic acid and humic substances. Administration of Shilajit extract for 7 days to winstar rats downregulates the acetyl-cholinesterase activity and enhanced muscarine 1 (M1) receptor binding. The latter suggest that the memory enhance associated with Shilajit is related to the Cholinergic, but not GABAergic or Glutamatergic pathways, as none of them was affected when Shilajit was administrated.'s_Disease_and_Other_Chronic_Disorders/links/5c273fc6299bf12be3a050c8/The-Emergency-of-Nutraceutical-Compounds-in-the-Preventive-Medicine-Scenario-Potential-for-Treatment-of-Alzheimers-Disease-and-Other-Chronic-Disorders.pdf

A few members reported some benefit with fulvic/humic acid:
- yesyesyes
- xeon
- Progecitor (me)
(Huminiqum) - It may have some mixed effects on gut issues though.
I had no such problems with Shilajit at least, but it was also less useful acutely.

One of us had a negative experience:
- swell

2. Urolithins

Urolithin is accumulated in the prostate and as an ERbeta agonist it has a potential anti-inflammatory and anti-cancer activity. Many of us also had success with several urolithin sources.

Urolithins are also relevant constituents of shilajit, a soil-derived medicinal product used in Ayurvedic medicine. The occurrence of low concentrations or urolithin metabolites in mouse prostate gland after pomegranate ellagitannins intake and in human prostate after the intake of pomegranate juice and walnuts has been reported. This last study is the only one available on the evaluation of the occurrence of ellagitannin metabolites in human tissues (prostate biopsies), and the occurrence of urolithin A glucuronide (2 ng/g tissue) and traces of urolithin B glucuronide and ellagic acid dimethyl ether was reported.
The same behavior is observed in humans after the intake of pomegranates, walnuts, tea, muscadine grapes, strawberries, raspberries, blackberries, cloudberries, oak acorns, and oak-aged red wine. Urolithins will also be eventually produced after the intake of all ellagitannin-containing foods and medicinal plants as is the case of camu camu (Myrciaria dubia), arctic bramble, rose hip, sea buckthorn, cranberry, Geranium, and oak-aged spirits (whisky, etc.).
Urolithin A bound more effectively than urolithin B, and that the affinity was higher for the ERa than for the ERB receptor. Using a proliferation assay with cells sensitive to estrogens (E-screen) urolithins A and B exhibited estrogenic activity (in the absence of estradiol) and antiestrogenic activity (in the presence of estradiol) in a similar fashion to other known phytoestrogens.
The human prostate gland is one of the organs where urolithins can be detected after the consumption of pomegranate juice and walnuts. In prostate cancer cells, urolithins (A, B, C, and D) inhibited CYP1B1 activity (a target in prostate cancer chemoprevention) in a dose ranging from 1.15 uM (urolithin A) to 137 uM (urolithin D) whereas higher concentrations were needed for CYP1A1 activity inhibition (12.4–2,907 uM).
It should be noted that among the changes detected, some important tumor suppressors such as p53 and Rb1 were upregulated whereas the antiapoptotic genes BclXL and Akt were downregulated by urolithin A.
Our group also reported for the first time the in vivo prebiotic effect of pomegranate extract and urolithin A.

We examined 17 black raspberry constituents and metabolites (10 uM or 10 ug/mL, 48 h) for their ability to prevent endometrial cancer cells from proliferating. Urolithin A (UA) was most able to suppress proliferation in a time- and dose-dependent manner. It arrested the G2/M phase of the cell cycle by upregulating cyclin-B1, cyclin-E2, p21, phospho-cdc2, and CDC25B. UA also acted as an estrogen agonist by modulating estrogen receptor-a (ERa) dependent gene expression in ER-positive endometrial cancer cells. UA enhanced the expression of ERB, PGR, pS2, GREB1 while inhibiting the expression of ERa and GRIP1.

Triphala-derived polyphenols such as chebulinic acid are transformed by the human gut microbiota into metabolites such as urolithins, which have the potential to prevent oxidative damage. The authors speculate that the bioactivity of Triphala is elicited by the gut microbiome to generate a widened spectrum and abundance of anti-inflammatory compounds.
« Last Edit: March 23, 2023, 03:21:10 AM by Progecitor »
The cause is probably the senescence of sexual organs and resultant inducible SASP, which also acts as a kind of non-diabetic metabolic syndrome.


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Re: How to increase testosterone naturally
« Reply #21 on: May 31, 2023, 03:37:56 PM »
Acteoside could be another potentially great compound in the management of POIS. Its best source is probably Cistanche, which has been already mentioned on the site as a testosterone booster. Unfortunately nobody has yet reported about it, which could be the cause of low interest.
Acteoside (Cistanche) appears to be one of the slower acting compounds that need some time to begin to work well. At least it appears to have a smoother effect with fewer side-effects compared to some of the more potent testosterone boosters like tongkat ali.
If one finds Cistanche too expensive or unavailable, then as an alternative solution a combination of some other herbs with the same constituent could be tried. Echinacea is a source of echinacosides, while acteoside which is also called verbascoside or kusagin can be found in a number of commercially available herbs: mullein, common verbena, lemon verbena, white dead-nettle (not stinging nettle!), ribwort plantain and Rehmannia. Of course this means that these herbs could be considered as testosterone boosters as well.

According to the Chinese Comprehensive Pharmaceutical Dictionary, it supplements renal function, increases sexual power, and smoothes the intestines.
Sinphar Pharmaceutical Co., Ltd. and Peking University have also discovered that the extract has activities to improve brain functions, prevent aging or fatigue, and boost immune strength from test data accumulated in their long-term study. The main effective ingredients of Cistanche Tubulosa extract are phenylethanoid glycosides, especially echinacoside and acteoside. Although echinacoside is known as the main component of the herb Echinacea, Cistanche Tubulosa contains a higher amount of echinacoside than any other plant. Acteoside (a type of polyphenols) has an extremely strong antioxidative property which is reported to be 15 times stronger than resveratrol (polyphenols contained in grapes) and 5 times stronger than vitamin C. In recent study, new compounds (kankanoside and others) have been isolated and vasorelaxing activity has been reported as a pharmacological action of the new compounds, echinacoside, and acteoside.
Cistanche salsa extract (fraction where phenylethanoid glycosides are the main components) and its components echinacoside and acteoside have been reported to have an activity to improve sexual ability. Cistanche Tubulosa is expected to perform a similar activity because it belongs to the same family as Cistanche salsa and contains larger amounts of effective components.
In the specimen from the Cistanche Tubulosa extract administration group, the expression of 3B-hydroxysteroid dehydrogenase (3B-HSD), which is involved in testosterone, was enhanced by 1.5 times. The expression of the genes of steroid 5a-reductase 2 and aldo-keto reductase, which the synthesis of dihydrotestosterone, doubled.
« Last Edit: May 31, 2023, 03:40:21 PM by Progecitor »
The cause is probably the senescence of sexual organs and resultant inducible SASP, which also acts as a kind of non-diabetic metabolic syndrome.