maybe some POIS was caused by repeated Coronavirus infection during childhood?

[romies]

This may sound far-fetched right now, but hear me out.

1. 4 strains of common coronavrius (HCoV-OC43, HCoV-HKU1, HCoV-229E, and HCoV-NL63) have been around for decades, mostly affecting kids/teens until they build up immunity

2. From COVID19, we know that immune response to coronavirus vary by orders of magnitude. and a minority have lingering complications.

3. Those who had long-term complications are similar to Mast-cell activation syndrome.
An example here: https://www.statnews.com/2020/07/08/my-covid-19-symptoms-lasted-100-plus-days/

So maybe just maybe, some POIS were acquired as a result of the other common coronavirus infection in early childhood: our immune system being set into a hypersensitive state to PGE2/histamine generated by an O, and also our nervous system being ultrasensitive to cytokines/histamines etc.

I have no way to prove or disprove this right now. but if there is a sudden increase in POIS patients in the next 5 years. This hypothesis is worth considering

The silver lining is that with more people reporting POIS, we might finally get more understanding and potentially a cure out of this.

[romies]

to be clear, I was thinking about the neurological symptoms of convalescent COVID19 patients, CFS like symptoms. brain fogs. etc.

[Journey]

Can be. I had colds, stomach viruses till puberty when my immunity strengthened. At 4/5 years had near-pneumonia, temp went almost to 40 celsius, was given antibiotics, got cured. Maybe the antibiotic at that age did something but neither I or parents recall its name so might need to ask GP.

[swell]

Immune system study is immature currently.  Doctors are afraid to make conjecture statements, while scientists have a narrow study of specific areas, but no one really has a sound end-to-end grasp of it.  Big Pharma has little interest to fill the gaps, since solving immune puzzle obsoletes all medicines maybe except anti-biotics

You are not wrong in your assessment, POIS'ers are indeed hyper-sensitive.  That said, I dont think there are enough interest groups in favor of resolving diseases like POIS that are systemic, vague, not life threatening. 

[Journey]

I got a memory that at 2016? winter I had a bad cold for 2 weeks, my whole throat was so sore, each time I ate food  it hurt, drank lot of tea/warm water, slept in thick clothes, etc. felt odd, achy, stiff overall and I think when I Oed I recall feeling even worse, when I healed, I still felt the nausea I had while sick, even though I wasn't physically sick for a few days after I felt as I still was, it disappeared as I forgot about it, around that time is when I recall feeling bad after PMO, even if O without P and every time I did it, I thought how I must stop it (but might've had POIS before but I never was aware/paid attention to brainfog so don't recall when symptoms appeared) then I felt bit off post-O, but never abstained longer than a few days so didn't see connection till end of 2018/start of 2019 year when I had 1st big abstinence streak that I noticed post-O/WD I had symptoms, then I made the connection and read about POIS later.

[romies]

I still think we are going to see a surge of POIS sufferers after COVID19 sweeps through the northern hemisphere this winter.

But it will take them years to discover this forum.