Author Topic: Oxytocine effect on male adult rodents that experienced childhood trauma  (Read 1512 times)


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How is this related to POIS? As far as I know people release oxytocine and prolactine after O, and it's level can be retain bigger for a while after it...

So to the point:
I once saw a scientific article describing study, that concluded that inducing higher oxytocine levels in male rodents that experienced childhood trauma caused them to be more socially anxious. It sounded very convincing and was hyperlinked to me via a legit source. But I wasn't able to find it since.

My POIS symptoms are mainly psychological, and social-anxiousness, and lower self-confidence are the biggest of them. So I thought that might be the direction to look into.

Has anyone seen simillar studies? or maybe someone more experienced in medical field browsing could take a look if is able to find it?

Any help is appreciated. That idea has been going after me for a while now.
« Last Edit: April 11, 2020, 06:47:57 AM by whateverestest »


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Oxytocin is actually supposed to have the opposite effect. Oxytocin is supposed to stimulate the release of GABA, an inhibitory neurotransmitter.

Oxytocin is the hormone the allows a mother to bond with her baby,  and also to produce milk. It's also the hormone that enables "pair bonding" between two mates after sex, increasing the changes they bond and stay together (evolutionary adaptive monogamy). Oxytocin is also elevated in those who take MDMA / Ecstasy, thus the "love" everyone experiences for each other when taking the drug.

Are you able to find that article and provide a link?

Generally, the anxiety after orgasm is the stimulation of the sympathetic fight-of-flight response which is part of the overall POIS series of symptoms.

There is a great thread on this forum about the "POIS Cascade" and the science behind it seems to be an over-binding of norepinephrine to the alpha 1 receptors (which are part of the sympathetic nervous system, hence the cascade).

From everything I read on this forum and beyond, the overall reaction (and continued negative feedback loop)  is likely due to the continued rise in adrenaline / norepinephrine from arousal / orgasm, and subsequent lack of hormones and conversion pathways to keep this rise in check like everyone else does upon orgasm.

For those suffering more in relation to anxiety / fight-or-flight activation / euro-transmitter burnout (depression / derealization) my understanding it's too much of the inflammatory Prostaglandin E2 / COX2 and not enough Prostaglandin E1/E3 and Nitric Oxide to counter-balance. It's very likely that "low" oxytocin after orgasm is more related to POIS conditions.

For those who suffer more in the realm of "flu-like symptoms" (congestion, etc) it's more about the h1H histamine receptor binding and over-stimulation.


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I know the effects of Oxytocine. I know that by nature it's suppoused to have more of contrary effects. However the article stated that with male rodents that experienced childhood trauma, it may have anxiety-generating effects. As far as I remember it also stated that it was more specific to male rodents, and females didn't have that problem, which even more got me into idea it might be my (and many more people's) POIS variant underlying symptom.

Unfortunatelly I don't have link to this article. Was hoping that maybe somebody here heard of it or has enough familiarity with medical knowledge resources, that might be able to help to find it. I was trying to look for it again back in the days but didn't manage to find it. I might give it another try however if nobody replies.


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Re: Oxytocine effect on male adult rodents that experienced childhood trauma
« Reply #3 on: September 14, 2020, 04:39:59 PM »
I can?t explain why , but this chimes with me.

For me, I haven?t had POIS symptoms that I recall when I have been in a relationship with someone I care for and we have got physical... PE has sometimes made they physical relationship awkward but that is a different story.

I have only experienced POIS that I can recall after solo activity.

Maybe the oxytocin that is released, when there isn?t someone to share the experience with , causes the brain , to say ... sort it out , find someone so that your sperm can do what it?s is there for and reproduce ?

Maybe ?


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Re: Oxytocine effect on male adult rodents that experienced childhood trauma
« Reply #4 on: September 14, 2020, 06:29:31 PM »
I think the reason why a lot of us don't get much symptoms from sex is actually because there is increased blood flow/circulation and also a much stronger and natural orgasm