Author Topic: POIS is not due to autologous semen allergy  (Read 5631 times)

fernab

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POIS is not due to autologous semen allergy
« on: March 28, 2019, 12:42:03 PM »
All forum members who already know POIS is not due to autologous semen allergy can post here any reference to places in this Forum. Or serious web sites on the internet that state clearly it is NOT an auto-allergy.

I have just found this web site stating it:

https://www.ncbi.nlm.nih.gov/m/pubmed/25630453/

Original copy: https://www.jsm.jsexmed.org/article/S1743-6095(15)30963-2/fulltext

Apart from that, two well known members of this Forum told me that it was already proven by a chinese group of Drs or Researchers (can be seen who they are in previous links).

This two members if I am not wrong were Observer and Quantum. They warned me about that just recently added to this Forum. Because I wanted to do my own auto allergy pric test. Indeed I did It before they warned me about this test was not useful at all.

« Last Edit: March 28, 2019, 11:18:30 PM by demografx »

Nas

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Re: POIS is not due to autologous semen allergy
« Reply #1 on: March 28, 2019, 03:31:40 PM »
"POIS is not associated with increased total serum IgE concentrations. On the contrary, there are indications that POIS is triggered by specific cytokines that are released by an auto-immune reaction to the man’s seminal fluid. Indirect clinical evidence suggests that the antigen (Ag) triggering the POIS systemic reaction is not bound to spermatozoa but to seminal fluid produced by prostatic tissue." (Waldinger, 2016)

"the mean serum total IgE in the non-atopic males was 27 kU/L (range, 6?78 kU/L), indicating that in these men this immunological marker was normal" (2016)

Ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001999/
« Last Edit: March 28, 2019, 05:57:51 PM by demografx »

nanna1

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Re: POIS is not due to autologous semen allergy
« Reply #2 on: March 28, 2019, 04:52:11 PM »
"Skin prick tests and intracutaneous tests with autologous diluted semen with negative results were performed. Immunoblotting and western blot of the patient's autologous semen showed negative results...
...To complete the study, we intended to rule out other possible causes such as urological, hormonal, or neuropsychiatric disorders."

-Negative allergy study in a case of postorgasmic illness syndrome (POIS) (N. Depreux, et al, 2018)

Here is a useful POIS literature review (post).
« Last Edit: March 28, 2019, 06:29:58 PM by nanna1 »
POIS clusters: 1,3,4,5,7
POIS criteria: 1,2,3,4,5
2 stacks that give me complete relief of POIS symptoms are listed here: POIS cure: theory & supplement stack
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demografx

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Re: POIS is not due to autologous semen allergy
« Reply #3 on: March 28, 2019, 06:09:28 PM »
...there are no IgE concentration so maybe they're already aware of that?
Let’s not assume anything.
I wouldn't, but that's what POIS papers say. Beside the fact that it doesn't make sense that you have IgE concentrations for your own semen.
Nas, I meant let’s not assume that the investigators are already aware of that.


« Last Edit: March 28, 2019, 11:19:53 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: POIS is not due to autologous semen allergy
« Reply #4 on: March 28, 2019, 11:13:58 PM »
Fernab I think every single paper on POIS refuted the involvement of serum IgE concentrations in POISers.
Naive question perhaps: does IgE concentration mean that autologous semen allergy exists or doesn’t? Thanks.


« Last Edit: March 28, 2019, 11:15:31 PM by demografx »
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

fernab

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Re: POIS is not due to autologous semen allergy
« Reply #5 on: March 29, 2019, 03:24:29 AM »
IgE is the type E of inmunoglobuline. There are 5 different types A, G, M, D and E. Ig is the abreviation of Inmunoglobuline. Inmunoglobuline type E is the one involved in allergies and also some types of infections (for instance some parasitic infections). Inmunoglobulines are antibodies from the inmune system. When a Dr says POIS is not IgE mediated he is also saying POIS it's not caused by an auto-allergy.


demografx

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Re: POIS is not due to autologous semen allergy
« Reply #6 on: March 29, 2019, 09:20:34 AM »
Thank you, fernab.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: POIS is not due to autologous semen allergy
« Reply #7 on: March 30, 2019, 11:54:55 AM »
fernab, one problem I see is the sample size of the Chinese study. Are there any studies with meaningful, projectable samples to adequately refute auto-allergy?
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

fernab

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Re: POIS is not due to autologous semen allergy
« Reply #8 on: March 30, 2019, 12:09:32 PM »
To be honest, It is something I assumed as true. As when I entered this Forum around one year ago... Observer and Quantum told me that POIS was already proven not to be an auto-allergy. Apart from that. The first Dr who told me that maybe my Illness could be POIS, told me that it was not IgE mediated.

Even though he told me that. I remember I wanted to check it myself with my own seminal sample. Doing a prick test. So I went to a different allergologist and did It with him. And my own seminal sample on my skin resulted to be Negative.

So I shared this info with Observer. And he told me that this test was not useful at all. And that It was already proven by a chinese group. I accepted that without further ado. And after that I also read a post of Quantum saying almost the same.

And of course my own negative result....

Maybe the information nanna1 gave us can clarify It??

Edit: Don't have much more that serves as strong evidence....
« Last Edit: March 30, 2019, 12:14:26 PM by fernab »

demografx

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Re: POIS is not due to autologous semen allergy
« Reply #9 on: March 30, 2019, 12:15:28 PM »
Thanks, fernab!

I’m just concerned about asking our investigative team to drop the auto-allergy route because of merely a handful of cases. That won’t be sufficient evidence. Personally, I am deeply skeptical of auto-allergy, but that’s not enough.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

fernab

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Re: POIS is not due to autologous semen allergy
« Reply #10 on: March 30, 2019, 12:24:56 PM »
If you think that the number of poisers for which the auto allergy was negative it is important to be big enough to be able to confirm, that it is not an auto-allergy.... Maybe It is worthy to re-check it again. Except in the case there is already a scientific and serious research result stating it. But honestly, apart the web site I found and what nanna1 and Observer, Quantum, and others told me I don't know were to search for it. That is the truth.... So maybe It is something to openly talk with the investigative team.....

What do you think?

Any other opinions from other members?

fernab

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Re: POIS is not due to autologous semen allergy
« Reply #11 on: March 30, 2019, 12:28:28 PM »
By the way Demo, have you asked Dr L. If their intention was to re-check that It is not an auto-allergy?

Maybe It is not their intention.... It is as easy to ask her... don't you think so?

demografx

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Re: POIS is not due to autologous semen allergy
« Reply #12 on: March 30, 2019, 12:31:18 PM »
fernab, thanks for soliciting more members’ opinions and input.

Is there a not-too-difficult way to see the *total number of POISers* who comprise the negative-auto-allergy Group? Also, is there any credible data that support the possibility of a positive auto-allergy outlook?
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: POIS is not due to autologous semen allergy
« Reply #13 on: March 30, 2019, 12:33:58 PM »
By the way Demo, have you asked Dr L. If their intention was to re-check that It is not an auto-allergy?

Maybe It is not their intention.... It is as easy to ask her... don't you think so?
I’d like to ask as little as possible at this time. They have not officially started, and are weeks away from UNL authorization, so they were magnanimous in giving that first reply to your question.
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

fernab

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Re: POIS is not due to autologous semen allergy
« Reply #14 on: March 30, 2019, 12:40:33 PM »

I’d like to ask as little as possible at this time. They have not officially started, and are weeks away from UNL authorization, so they were magnanimous in giving that first reply to your question.

Ok. I understand.

fernab

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Re: POIS is not due to autologous semen allergy
« Reply #15 on: March 30, 2019, 12:49:27 PM »

Is there a not-too-difficult way to see the *total number of POISers* who comprise the negative-auto-allergy Group? Also, is there any credible data that support the possibility of a positive auto-allergy outlook?

Don't know were to search that info Demo. Could try to read posts in this Forum. But without any guarantee that we will find a sufficient and adequate number to consider it conclusive. How many cases would be necessary?

It could take a lot of time to check in all the Forum this info. And in the case we could find It here. How many cases would be necessary? Can we accept them as valid? As a scientific point of view???

demografx

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Re: POIS is not due to autologous semen allergy
« Reply #16 on: March 30, 2019, 12:56:39 PM »
It just means adding up the number of POISers in the studies. I think the Chinese study is only...1!

Let’s just assume the total number is...too low! (I’m sure it’s not even 25 POISers), so the question remains: do we have any other credible hypotheses, ideas, etc., that warrant keeping the auto-allergy alive and worth re-analyzing???
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

demografx

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Re: POIS is not due to autologous semen allergy
« Reply #17 on: March 30, 2019, 01:03:15 PM »
Don't know were to search that info Demo. Could try to read posts ...
Not necessary. I just meant to add up the # of study subjects :)
10 years of significant POIS-reduction, treatment consisting of daily (365 days/year) testosterone patches.

TRT must be checked out carefully with your doctor due to fertility, cardiac and other risks.

40+ years of severe 4-days-POIS, married, raised a family, started/ran a business

fernab

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Re: POIS is not due to autologous semen allergy
« Reply #18 on: March 30, 2019, 01:08:39 PM »
Maybe other members can add their opinion.

I do not have the appropriate knowledge to be able to answer that question from a serious and rigorous point of view to be taken into account scientifically ... and when in doubt I would try to check it again following a valid and solid scientific method.

That is my humble opinion Demo.

fernab

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Re: POIS is not due to autologous semen allergy
« Reply #19 on: March 30, 2019, 01:11:57 PM »
Don't know were to search that info Demo. Could try to read posts ...
Not necessary. I just meant to add up the # of study subjects :)

Ok, the chinese case is 1... I will try to follow other references added by nanna1 and will try to sum they up.

Ok?