agitation and irritability !!

[Labyrinth]

Any medications or supplement that can reduce agitation or irritability? 

[FernandoPOIS]

Thinking conservatively ... things that worked for me .. medicines: promethazine or hydroxyzine (antihistamines).
Phytotherapy: kava kava and passiflora.
B Vitamins and Magnesium
Dipirone: analgesic and makes me a little drowsy ....
Muscle relaxant at low doses such as cyclobenzaprine .. Use at most 5 mg.
I have never used benzodiazepine and when I am very tense, alcohol also works but I only take it in the last case.
Weaker antihistamines such as fexofenadine and ebastine help but do not act as intensely as CNS sedatives.

[swell]

sorry to break it, but its called "Thyroid".  Treat your thyroid, you wouldn't have agitation or irritability or gut problems for this ridiculous 7 day POIS.

That said, milder approach is: Ashwaghanda (however its spelled).  You'll feel chill after taking it.  Its adaptogen so works on both hypo and hyper thyroid.